Best TWAS P=4.49e-11 · Best GWAS P=6.07e-11 conditioned to 0.0104
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MDM4 | 0.09 | 0.02 | lasso | 4 | 0.02 | 4.3e-03 | -5.6 | -5.7 | 1.0e-08 | 0.91 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Esophagus Muscularis | MDM4 | 0.14 | 0.05 | lasso | 4 | 0.05 | 8.6e-04 | -6.2 | -6.2 | 5.5e-10 | 0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | MDM4 | 0.11 | 0.09 | lasso | 1 | 0.07 | 1.6e-05 | -5.6 | -5.6 | 1.9e-08 | 0.90 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Testis | PIK3C2B | 0.17 | 0.09 | lasso | 5 | 0.03 | 1.5e-02 | -5.4 | -5.6 | 2.8e-08 | 0.84 | 0.02 | 0.97 | FALSE |
| 5 | YFS | Blood | MDM4 | 0.12 | 0.08 | bslmm | 636 | 0.12 | 2.0e-36 | 4.9 | 6.6 | 4.5e-11 | -0.72 | 0.96 | 0.04 | TRUE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MDM4 | 0.02 | 0.03 | enet | 4 | 0.03 | 5.5e-04 | -5.2 | -5.2 | 1.8e-07 | 0.83 | 0.20 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | MDM4 | 0.05 | 0.06 | lasso | 1 | 0.04 | 1.6e-04 | -5.6 | -5.6 | 1.9e-08 | 0.90 | 0.04 | 0.95 | FALSE |