[Hub]/) : Traits : Forced vital capacity (FVC), Best measure :

chr2:35,883,253-37,567,226

Best TWAS P=1.28e-12 · Best GWAS P=1.99e-11 conditioned to 5.57e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FEZ2 0.16 0.24 lasso 2 0.22 1.3e-26 6.0 -6.1 1.3e-09 0.06 0.03 0.97 FALSE
2 GTEx Adipose Subcutaneous AC007401.1 0.10 0.02 lasso 4 0.02 5.4e-03 5.7 6.5 1.1e-10 -0.12 0.05 0.90 FALSE
3 GTEx Artery Tibial CRIM1 0.10 0.04 lasso 4 0.05 1.4e-04 5.7 -6.8 8.5e-12 0.20 0.06 0.92 FALSE
4 GTEx Artery Tibial RP11-78I14.1 0.10 0.08 enet 16 0.07 4.2e-06 5.7 -7.1 1.3e-12 0.19 0.26 0.62 TRUE
5 GTEx Brain Cerebellar Hemisphere CRIM1 0.36 0.21 lasso 5 0.16 5.4e-05 5.0 5.4 7.7e-08 -0.01 0.15 0.59 FALSE
6 GTEx Brain Cerebellar Hemisphere FEZ2 0.41 0.30 lasso 6 0.28 8.6e-08 5.4 5.4 7.9e-08 -0.03 0.21 0.74 FALSE
7 GTEx Brain Cerebellar Hemisphere AC007401.1 0.40 0.26 lasso 4 0.22 2.3e-06 5.0 5.2 1.7e-07 0.00 0.26 0.64 FALSE
8 GTEx Brain Cerebellar Hemisphere RP11-490M8.1 0.37 0.18 lasso 4 0.15 1.2e-04 5.3 5.3 1.0e-07 -0.05 0.14 0.50 FALSE
9 GTEx Brain Cerebellum AC007401.1 0.27 0.21 enet 5 0.20 1.5e-06 5.0 5.2 1.6e-07 0.00 0.34 0.50 FALSE
10 GTEx Brain Cerebellum RP11-490M8.1 0.21 0.21 lasso 4 0.20 1.4e-06 5.1 5.2 1.6e-07 -0.04 0.20 0.68 FALSE
11 GTEx Skin Sun Exposed Lower leg RP11-78I14.1 0.14 0.06 enet 8 0.04 6.0e-04 -6.2 -5.2 1.7e-07 0.17 0.05 0.86 FALSE
12 GTEx Spleen FEZ2 0.42 0.16 enet 25 0.17 3.9e-05 5.1 6.3 2.6e-10 -0.20 0.10 0.72 FALSE
13 GTEx Whole Blood AC007401.1 0.06 0.06 lasso 5 0.05 4.6e-05 5.4 5.5 4.9e-08 -0.06 0.31 0.61 FALSE
14 NTR Blood CRIM1 0.09 0.10 lasso 6 0.11 3.1e-32 6.3 -5.9 3.5e-09 0.07 0.08 0.92 FALSE
15 ROSMAP Brain Pre-frontal Cortex FEZ2 0.41 0.55 lasso 5 0.58 3.1e-93 5.3 -5.7 1.2e-08 0.06 0.68 0.32 FALSE
16 The Cancer Genome Atlas Breast Invasive Carcinoma FEZ2 0.01 0.01 blup 85 0.01 1.0e-03 5.3 -6.8 7.7e-12 0.13 0.02 0.95 FALSE
17 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FEZ2 0.06 0.05 lasso 4 0.04 3.3e-03 5.8 -5.6 2.0e-08 0.06 0.04 0.79 FALSE
18 The Cancer Genome Atlas Prostate Adenocarcinoma CRIM1 0.05 0.04 lasso 2 0.03 3.2e-04 -5.2 -5.2 2.4e-07 0.32 0.26 0.08 FALSE
19 The Cancer Genome Atlas Prostate Adenocarcinoma FEZ2 0.06 0.05 blup 87 0.08 1.4e-08 5.3 -5.6 2.2e-08 0.06 0.16 0.84 FALSE
20 The Cancer Genome Atlas Testicular Germ Cell Tumors FEZ2 0.18 0.21 lasso 6 0.21 5.3e-08 -6.2 -6.8 1.0e-11 0.20 0.02 0.98 FALSE