TWAS hub - ZNF169

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0300	8.3e-06	0.073	0.042	0.063	0.057	0.062	3.2e-09	6.2e-06	3.5e-08	1.6e-07	4.7e-08
2	GTEx	Colon Transverse	0.2400	0.0870	2.4e-03	0.135	NA	0.021	NA	0.122	5.7e-07	NA	3.5e-02	NA	2.0e-06
3	GTEx	Esophagus Muscularis	0.1390	0.0550	8.8e-04	-0.005	NA	0.001	NA	-0.003	9.8e-01	NA	2.5e-01	NA	5.7e-01
4	GTEx	Thyroid	0.0930	0.0410	2.7e-03	0.029	NA	0.042	NA	0.046	2.5e-03	NA	3.6e-04	NA	1.9e-04
5	NTR	Blood	0.0150	0.0072	8.1e-03	0.001	0.004	0.000	0.004	0.004	1.0e-01	1.8e-02	2.5e-01	1.9e-02	1.1e-02
6	ROSMAP	Brain Pre-frontal Cortex	0.1161	0.0331	8.4e-08	0.040	0.069	0.045	0.067	0.046	6.9e-06	2.9e-09	1.7e-06	4.8e-09	1.3e-06
7	YFS	Blood	0.0553	0.0196	1.9e-06	0.022	0.019	0.030	0.032	0.022	6.1e-08	4.4e-07	4.6e-10	8.0e-11	6.4e-08
8	TCGA	Brain Lower Grade Glioma	0.0643	0.0305	1.8e-04	0.002	0.033	0.038	NA	0.011	1.8e-01	1.1e-04	3.1e-05	NA	1.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8
Heel T-Score	4.5	35.5	151.3	-4.6	-1.9	-6.4	12.3	2.0	3.2	7.2
Heel bone mineral density (BMD) T-score, automated (right)	4.5	10.3	32.8	-1.9	-0.0	-3.6	5.7	2.4	2.8	4.4
Major Depression (MDD)	3.3	4.0	14.0	-3.2	-1.1	-0.6	1.0	1.6	3.7	1.7
Heel bone mineral density (BMD) T-score, automated (left)	3.3	7.5	25.7	-1.1	-0.6	-2.9	5.1	1.7	2.3	4.0
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	11.9	-1.0	-0.5	-1.5	1.8	2.8	1.3	3.5
Ever depressed for a whole week	2.6	3.3	15.0	-3.9	0.2	-1.3	-0.5	0.8	2.9	-0.2
Qualifications: A levels/AS levels or equivalent	2.5	5.4	13.5	2.0	1.6	2.0	-3.7	-2.4	-1.5	-3.4
Commuting to job workplace: Car/motor vehicle	2.5	2.8	8.1	-0.5	-0.1	-2.0	2.2	2.0	1.2	2.8
Medication: Lansoprazole	2.3	2.6	6.1	-0.1	0.8	-1.7	2.5	2.3	0.6	2.4
Birth weight of first child	2.3	4.2	17.1	1.2	-0.2	2.9	-4.1	-0.6	-1.6	-1.9
Blood clot in the leg (DVT)	2.3	3.0	11.5	-0.9	-0.4	-1.2	1.6	2.5	1.2	3.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	13.4	1.8	-0.6	1.7	-3.1	-1.9	-1.9	-3.7
Diabetes (mother)	2.1	2.6	8.1	-0.8	0.5	-1.2	2.8	1.8	1.7	2.2
Mouth/teeth dental problems	2.1	3.2	10.3	-2.9	1.3	-1.3	1.5	0.3	3.2	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	22.2	1.3	1.4	2.4	-4.7	-0.8	-2.5	-4.0
Sensitivity / hurt feelings	2.0	3.5	8.5	-2.9	-0.4	-2.3	2.7	1.4	1.3	1.7
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	23.9	0.7	1.8	2.1	-4.9	-0.6	-2.4	-3.9
Forced vital capacity (FVC), Best measure	2.0	7.5	28.8	1.1	1.1	3.2	-5.4	-0.1	-2.0	-3.8
Pulse wave peak to peak time	2.0	2.3	7.1	-0.3	-0.5	1.1	-2.7	-2.4	0.1	-2.0
Nervous feelings	1.9	3.6	13.4	-1.4	0.8	-2.2	3.7	0.7	0.6	2.6
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	9.9	-3.1	-0.5	-1.7	-0.3	1.0	2.0	0.5
Pulse wave Arterial Stiffness index	1.9	2.2	6.6	0.7	1.3	-1.0	2.1	2.6	-0.4	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	13.1	1.0	3.6	-1.9	-0.5	-0.3	-1.5	0.0
Relative age of first facial hair	1.8	3.7	8.7	2.1	1.3	1.4	-2.5	-1.9	-1.8	-3.0
Forced vital capacity (FVC)	1.8	6.9	27.2	0.3	1.6	2.8	-5.2	0.1	-1.7	-3.8
Number of full brothers	1.8	2.2	8.1	0.3	0.6	-0.8	2.8	1.4	0.6	2.5
Commuting to job workplace: Public transport	1.8	2.2	7.5	-0.7	-0.4	1.9	-1.6	-1.6	-0.5	-2.7
Neuroticism	1.7	4.1	10.8	-2.0	1.1	-3.0	3.3	1.3	0.3	2.5
Diabetes (father)	1.7	2.1	4.7	-2.2	1.0	-1.5	2.0	1.3	1.6	0.9
Chronic bronchitis/emphysema (father)	1.7	2.0	4.0	-1.4	-2.0	-0.7	0.9	1.2	1.8	2.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.3	1.4	-0.5	1.4	-1.8	-2.1	-1.6	-1.9
Birth weight	1.7	3.7	13.6	2.2	-0.2	2.0	-3.7	-0.8	-1.8	-1.8
Respiratory disease	1.6	3.5	19.6	-1.0	-1.6	-0.6	4.4	0.4	0.5	2.1
Standing height	1.6	15.7	60.1	1.2	5.3	3.6	-7.8	2.2	-1.8	-3.8
Overall health rating	1.6	3.4	12.9	-0.9	1.1	-2.6	3.6	0.2	-2.2	1.0
Back pain experienced in last month	1.6	2.4	11.7	0.3	-0.6	-1.0	3.4	-0.2	-0.7	2.3
Mean Putamen Volume	1.5	1.7	4.6	-1.7	-0.5	1.3	-0.6	-1.8	-1.0	-2.2
Height	1.5	29.3	116.6	2.7	6.2	5.3	-10.8	2.7	-2.8	-5.3
Hearing difficulty/problems with background noise	1.5	2.3	4.9	-1.1	0.7	-2.2	1.8	1.4	1.8	2.0
Neuroticism score	1.5	3.2	7.1	-2.5	1.0	-2.4	2.7	1.2	0.0	2.0
Hair/balding pattern: Pattern 3	1.5	2.2	7.8	2.1	-0.3	1.1	-1.1	-1.4	-2.8	-0.9
Mouth/teeth dental problems: Loose teeth	1.5	1.8	7.3	2.7	-0.4	1.7	-0.9	-0.1	-1.8	-0.5
Leg pain on walking	1.5	1.9	7.2	0.5	0.2	-1.5	1.8	0.3	1.4	2.7
Knee pain experienced in last month	1.5	2.3	5.3	1.4	2.3	-1.8	1.9	-0.3	-2.1	-0.0
Neuroticism (Nagel 2018)	1.4	3.2	7.7	-0.9	1.1	-2.6	2.8	1.6	0.2	2.6
Worry (Nagel 2018)	1.4	3.0	7.0	-1.0	2.1	-2.7	2.1	0.9	0.0	2.5
Type 2 Diabetes (T2D) (2012)	1.4	1.7	5.0	-0.6	1.2	-1.9	1.3	2.2	0.9	0.7
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.2	-0.8	1.0	-1.4	-2.0	-0.5	1.8	-0.9
Qualifications: College or University degree	1.4	4.3	14.9	-0.4	1.9	2.0	-3.9	-0.7	-0.1	-3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.0	-0.3	-0.7	-0.1	1.2	1.9	2.0	1.8
Relative age voice broke	1.3	1.9	6.1	1.6	1.1	0.6	-2.5	-1.2	-0.9	-1.7
Worrier / anxious feelings	1.3	2.4	7.3	-1.1	1.5	-2.7	1.6	0.5	-0.3	2.3
Leg fat percentage (right)	1.3	4.9	14.8	-2.4	0.9	-3.8	3.3	1.3	-1.6	1.7
Wheeze or whistling in the chest in last year	1.3	2.4	9.2	-0.1	-1.7	-0.5	3.0	1.4	-0.6	2.1
Diabetes diagnosed by doctor	1.3	2.2	5.0	-1.2	0.9	-1.7	2.2	1.9	1.4	1.3
Alcohol drinker status: Never	1.3	1.5	5.9	0.8	2.4	0.1	-1.4	-1.6	-0.5	-1.0
Leg fat percentage (left)	1.3	4.8	16.2	-2.1	0.8	-4.0	3.3	1.3	-1.5	1.6
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.6	-1.5	0.9	-1.7	2.4	1.9	1.4	0.6
Body mass index (BMI)	1.2	4.9	15.4	-0.5	1.5	-3.9	3.3	0.6	-1.8	2.6
Trunk fat-free mass	1.2	6.8	25.8	1.9	5.1	0.3	-4.2	1.0	-2.5	-0.9
Trunk predicted mass	1.2	7.1	25.8	2.0	5.1	0.4	-4.2	0.9	-2.7	-0.9
Worry too long after embarrassment	1.2	2.0	5.5	-2.4	-0.1	-1.7	1.6	1.7	0.7	1.2
Chest pain or discomfort	1.2	1.7	5.4	-0.2	-0.8	1.1	1.3	-0.9	-2.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	7.7	-0.2	2.1	1.4	-2.8	1.1	-0.4	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.3	-0.5	0.6	1.1	-1.4	-1.7	-0.7	-1.8
Age started oral contraceptive pill	1.2	1.5	3.0	-0.1	-1.7	0.5	1.7	0.4	1.6	1.7
Supplements: Calcium	1.2	1.3	5.8	0.1	2.4	-1.4	-0.6	1.4	0.2	-0.4
Depressed Affect (Nagel 2018)	1.1	2.4	5.9	-0.5	1.1	-2.3	1.9	1.7	0.0	2.4
Breast Cancer	1.1	2.6	8.2	1.6	0.9	1.5	0.4	-0.3	-2.9	-2.6
HDL Cholesterol	1.1	1.9	5.6	-0.6	-1.3	1.9	-1.4	-1.1	-1.0	-2.4
Neuroticism (2016)	1.1	1.6	3.4	-1.5	-1.5	-1.0	1.8	1.4	-0.7	1.1
Fed-up feelings	1.1	2.1	7.4	-1.7	-0.2	-1.2	2.7	1.4	-0.0	1.7
Waist circumference	1.1	4.1	9.7	-0.9	2.7	-3.1	2.4	1.7	-2.3	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	5.3	-1.1	1.1	-2.3	1.7	0.6	-1.5	0.7
Illnesses of mother	1.1	1.4	3.4	0.8	-0.6	1.2	-1.6	-1.1	-1.2	-1.9
Had major operations	1.1	1.3	3.9	0.1	2.0	-1.4	-0.6	-0.5	-1.6	-1.2
Family relationship satisfaction	1.1	1.3	3.8	1.3	2.0	-1.4	-0.5	-0.1	-1.7	-0.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.8	-1.3	-0.5	-1.3	2.2	0.3	-0.3	1.5
Pack years of smoking	1.1	1.6	5.0	-0.4	-2.2	-0.6	0.9	2.0	0.6	1.3
Ovarian Cancer	1.0	1.3	3.8	0.8	0.9	-1.2	1.7	1.9	-0.7	0.8
HbA1C	1.0	1.1	3.1	-0.9	1.3	-1.0	1.8	1.3	-0.5	0.8
Medication: Metformin	1.0	1.5	4.5	-1.1	0.5	-1.3	1.5	2.1	0.9	1.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.6	0.2	-1.4	0.0	1.9	-0.1	0.2	1.8
Financial difficulties in last 2 years	1.0	1.4	3.6	-1.7	0.2	-1.2	1.9	1.5	-0.1	0.9
Diabetes (self-reported)	1.0	1.5	3.7	-0.5	1.0	-1.6	1.8	1.9	0.7	1.0
Happiness	1.0	1.2	3.7	1.0	1.9	-1.3	-1.2	0.3	-0.7	1.2
Peak expiratory flow (PEF)	1.0	2.3	7.7	-0.5	1.1	0.8	-2.8	-0.1	-0.8	-2.8
Health satisfaction	1.0	1.3	4.8	-0.6	-0.3	-1.3	1.2	0.9	1.0	2.2
Comparative height size at age 10	1.0	5.6	25.5	0.1	3.5	1.6	-5.0	1.1	-0.2	-1.7
Supplements: Vitamin C	1.0	1.2	4.3	-2.1	0.4	-0.6	-0.8	1.0	-0.9	-1.4
Smoking status: Previous	1.0	1.4	3.9	-1.7	0.9	-1.2	0.9	2.0	0.9	0.8
Handedness (chirality/laterality): Left-handed	1.0	1.1	3.6	0.7	1.9	-0.5	1.0	0.4	0.7	1.8
Mood swings	1.0	1.8	5.0	-1.1	-0.0	-1.9	2.2	0.6	0.0	2.0
Illnesses of father: None of the above (group 1)	1.0	1.2	4.5	0.3	0.8	0.5	-0.7	-0.6	-1.9	-2.1
Smoking status: Current	1.0	1.6	2.8	1.2	-1.5	1.7	-1.4	-0.9	-1.0	-1.5
Ever smoked	1.0	1.7	3.7	0.7	-1.0	1.9	-1.8	-1.0	-1.3	-1.6
Cholesterol lowering medication	1.0	1.5	6.0	-1.1	-0.7	0.0	2.5	1.3	1.5	0.4
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.8	-1.4	0.2	-1.0	0.9	1.4	1.7	1.2
Heart disease (siblings)	1.0	1.2	4.2	1.0	-2.1	0.3	2.0	0.6	0.1	0.6
Coronary Artery Disease (CAD)	0.9	1.1	3.3	0.1	-1.8	0.6	0.8	0.6	1.7	1.1
Lupus	0.9	1.4	3.0	1.6	-1.7	1.1	-0.6	-1.0	-1.7	-0.2
Triglycerides	0.9	1.4	4.4	-0.4	1.1	-2.1	0.4	1.1	0.9	1.8
BMI	0.9	5.3	16.6	0.0	1.9	-4.1	3.2	-0.3	-1.2	3.2
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.9	-1.4	0.3	-1.5	2.0	1.0	-0.8	0.9
Supplements: Zinc	0.9	0.9	2.7	0.6	0.9	-0.3	-0.8	-0.3	-1.6	-1.6
Pack years adult smoking proportion	0.9	1.3	5.3	-0.4	-2.3	-0.5	0.7	1.7	0.6	1.1
Length of working week for main job	0.9	1.0	2.9	1.7	1.2	0.7	0.6	-0.8	-1.5	-0.3
Medication: Seretide 50 evohaler	0.9	1.1	2.6	-1.6	0.4	-1.6	1.4	0.0	0.6	0.9
Leg fat mass (right)	0.9	3.5	9.8	-1.3	2.1	-3.1	2.1	1.3	-2.0	1.4
Illnesses of siblings: Diabetes	0.9	1.1	6.7	-0.5	-0.8	0.2	2.6	-0.6	0.4	1.0
Whole body fat-free mass	0.9	5.1	21.9	1.5	4.7	-0.1	-3.3	1.0	-2.3	-0.1
Arm fat percentage (left)	0.9	3.6	11.0	-1.1	1.0	-3.3	3.1	0.8	-1.4	2.0
Ever had bowel cancer screening	0.9	1.1	2.0	-1.3	0.1	-1.2	0.9	1.4	1.4	0.8
Whole body water mass	0.9	5.0	21.6	1.6	4.6	-0.1	-3.2	0.9	-2.2	-0.1
Hearing aid user	0.9	1.0	2.8	1.1	-1.1	1.3	0.3	-1.7	-0.7	-1.0
High cholesterol (Self-reported)	0.9	1.5	5.2	-2.3	-0.8	0.2	1.4	1.1	1.7	-0.4
Arm fat-free mass (left)	0.9	4.5	22.5	1.0	4.7	-0.9	-2.4	0.9	-2.3	0.0
Pain experienced in last month	0.9	1.5	3.8	-1.3	-0.9	0.9	-1.9	0.8	1.9	-0.6
Leg fat mass (left)	0.9	3.5	10.2	-1.0	2.2	-3.2	2.0	1.3	-2.1	1.4
Arm predicted mass (left)	0.9	4.4	21.0	1.1	4.6	-0.8	-2.3	1.0	-2.5	0.0
Hearing difficulty/problems: Yes	0.8	1.2	3.4	0.6	0.4	-0.9	1.8	1.5	1.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	3.1	-0.1	-0.1	-0.5	0.2	1.8	1.4	1.1
Average weekly fortified wine intake	0.8	0.9	2.7	0.5	-0.8	1.7	-0.6	-0.4	-0.7	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	4.8	-0.9	-0.9	-0.4	2.2	1.0	-1.0	0.7
Sitting height	0.8	5.9	21.9	0.2	3.1	3.1	-4.7	1.2	-0.9	-1.9
Qualifications: None of the above	0.8	1.7	7.5	-0.3	0.1	-1.5	2.7	0.8	0.2	1.8
Allergy	0.8	1.9	7.2	2.7	0.3	0.5	-2.5	-1.1	0.3	-0.8
Arm fat percentage (right)	0.8	3.3	10.4	-0.9	1.0	-3.2	2.7	0.6	-1.7	2.0
Time employed in main current job	0.8	0.9	3.1	-0.7	-0.7	-0.0	1.8	0.1	1.4	1.1
Falls in the last year	0.8	1.0	3.0	1.4	0.3	-0.4	0.9	1.5	-1.7	0.0
Mouth/teeth dental problems: Dentures	0.8	1.3	4.3	1.7	0.1	-0.3	-1.4	0.7	-2.1	-0.9
Asthma	0.8	1.6	5.9	-1.9	-1.3	-0.1	2.4	0.2	1.1	0.7
Arm fat mass (right)	0.8	3.1	8.9	-0.4	2.2	-3.0	1.7	1.0	-2.0	1.7
Breastfed as a baby	0.8	1.0	2.5	0.3	1.6	-1.3	-0.5	0.9	-1.3	-0.8
Tense / ‘highly strung’	0.8	1.3	2.4	-1.1	1.5	-1.5	1.3	0.2	0.5	1.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.1	0.9	0.3	1.5	-1.6	-1.2	-0.5	-1.8
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.8	-0.0	-0.4	-0.5	1.6	0.3	0.5	2.2
Body fat percentage	0.8	3.1	8.5	-1.9	0.8	-2.9	2.7	1.0	-1.3	1.2
Arm fat-free mass (right)	0.8	4.1	20.3	1.2	4.5	-0.7	-2.2	1.1	-2.2	0.1
Arm predicted mass (right)	0.8	4.2	21.4	1.0	4.6	-0.6	-2.4	1.0	-2.0	-0.0
Commuting to job workplace: Walk	0.8	0.9	3.2	0.5	-0.1	0.9	-1.4	0.1	-0.9	-1.8
Eye problems/disorders: Cataract	0.8	0.9	3.4	0.6	-0.8	-0.5	1.9	0.1	-0.3	1.6
Mineral and other dietary supplements	0.8	1.1	4.4	0.1	-1.4	-0.3	1.3	0.2	0.6	2.1
Asthma (self-reported)	0.8	1.6	7.1	-1.8	-1.1	-0.3	2.7	0.4	0.9	0.6
Osteoarthritis (self-reported)	0.8	1.1	4.4	1.5	-0.1	-0.2	2.1	0.3	-0.9	1.0
Medication: Bendroflumethiazide	0.8	1.3	5.2	-0.5	-1.2	0.9	1.3	-2.3	-0.1	-0.9
Basal metabolic rate	0.8	4.3	20.8	1.0	4.6	-0.7	-2.3	1.2	-2.3	0.2
Risk taking	0.8	1.1	3.6	-1.9	0.4	-0.9	-0.3	-0.0	-1.7	-1.3
Commuting to job workplace: Cycle	0.8	1.0	3.0	0.8	1.5	-0.6	-0.5	-0.7	-1.0	-1.7
Ulcerative Colitis (UC)	0.7	1.3	4.1	-1.4	-0.8	0.0	2.0	1.7	0.5	0.5
Vitamin and mineral supplements	0.7	1.0	4.5	-0.7	-0.9	0.7	-0.3	-0.5	2.1	1.1
Taking other prescription medications	0.7	1.1	3.7	-1.7	-0.5	-0.6	1.9	0.9	0.6	0.4
Multivitamins +/- minerals	0.7	0.9	4.1	1.4	0.7	-0.7	0.1	-0.1	-2.0	-0.4
Supplements: Glucosamine	0.7	0.9	3.7	0.8	1.9	0.0	0.3	-0.1	-0.7	-1.5
Hair/balding pattern: Pattern 2	0.7	0.8	2.8	-1.1	0.7	-1.1	0.5	0.8	0.5	-1.7
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.3	-1.8	-0.8	-0.4	0.8	0.8	1.4	0.5
Medication: Ramipril	0.7	0.9	1.8	-0.8	-1.0	-0.3	1.4	1.1	0.9	1.3
Weight	0.7	3.6	14.6	-0.2	3.8	-2.3	-0.2	1.6	-2.3	0.9
Hip circumference	0.7	3.1	7.4	0.2	2.6	-2.2	1.3	0.6	-2.7	2.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.0	-1.4	-1.0	0.5	-1.2	0.4	1.2	-0.3
Shortness of breath walking on level ground	0.7	0.9	4.0	-0.8	-0.6	-0.4	2.0	0.6	0.6	0.9
Eye problems/disorders: None of the above	0.7	0.8	3.2	0.0	-0.8	1.0	-1.8	-0.2	0.8	-0.8
Whole body fat mass	0.7	2.8	7.0	-0.9	2.4	-2.6	1.5	1.2	-1.9	1.0
Medication: Aspirin	0.7	1.0	4.0	0.3	-2.0	1.1	0.6	-0.6	-1.1	-0.8
Illnesses of father: Heart disease	0.7	1.0	2.9	1.5	0.6	0.4	-1.4	-1.7	-0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.8	-0.2	-0.2	1.3	-1.7	0.0	-0.4	-1.4
Osteoporosis (self-reported)	0.7	0.9	2.1	-0.8	1.5	-1.1	-1.4	0.6	0.8	-0.7
Arm fat mass (left)	0.7	3.0	8.6	-0.4	2.3	-2.9	1.7	1.0	-2.0	1.5
Fractured/broken bones in last 5 years	0.7	0.9	2.2	0.8	0.7	0.4	-1.1	-1.1	-1.1	-1.5
Depression (Nagel 2018)	0.6	0.9	3.3	-0.7	-0.2	-0.5	1.8	1.5	-0.2	0.8
Alzheimer’s Disease (in mother)	0.6	0.7	3.1	1.7	-0.3	-0.0	1.3	0.5	-0.6	0.5
Ulcerative Colitis	0.6	0.8	3.8	-0.0	-1.0	1.9	1.2	-0.1	-0.4	0.1
Blood White Count	0.6	4.1	21.3	-1.8	-0.9	-1.0	4.6	-1.3	1.9	1.3
Waist Hip Ratio (WHR)	0.6	2.6	6.6	-2.6	0.9	-1.5	1.1	2.4	0.6	-1.9
Smoking Status	0.6	1.3	3.4	1.8	-1.6	1.8	-0.3	0.3	-0.7	-0.7
Allergy or Eczema	0.6	1.6	5.8	-2.4	0.8	-0.9	1.4	1.7	-0.9	-0.3
Hand grip strength (left)	0.6	1.5	5.2	0.2	2.3	-0.8	-1.4	1.9	-0.6	0.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.5	0.3	-0.5	-0.8	1.9	0.2	-0.9	1.0
Angina	0.6	0.8	2.7	-0.0	-0.8	1.2	-0.5	-0.4	-1.6	-1.2
Medication for hormone replacement therapy	0.6	0.6	1.3	0.3	-0.6	0.6	-1.1	-1.0	-0.8	-1.1
Leg fat-free mass (left)	0.6	3.1	15.1	0.9	3.9	-0.8	-1.6	0.8	-2.3	0.6
Current tobacco smoking	0.6	1.0	2.3	1.0	-1.5	1.1	-1.0	-0.8	-1.0	-1.2
Maternal smoking around birth	0.6	0.8	2.4	0.0	-1.5	1.4	-0.7	-1.2	0.2	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	1.9	0.4	-1.2	-0.0	0.9	1.4	1.0	1.2
Leg predicted mass (left)	0.6	3.2	15.3	0.9	3.9	-0.9	-1.6	0.8	-2.2	0.6
Medication: Simvastatin	0.6	0.9	3.2	-1.8	-0.3	-0.3	0.8	1.3	1.2	0.4
Pulse wave reflection index	0.6	0.7	1.7	0.5	1.0	-0.5	1.3	1.3	-0.4	1.0
Medication: Paracetamol	0.6	1.0	4.6	1.1	-0.2	-0.6	2.1	-0.5	-0.6	1.2
Headache pain in last month	0.6	1.1	2.2	0.8	-1.0	1.5	-1.2	-1.2	-1.1	-0.9
Comparative body size at age 10	0.6	1.7	7.8	0.5	0.3	-1.3	1.2	1.2	0.9	2.8
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	1.3	0.8	-0.7	-0.6	-0.2	-1.3	-0.6
Emphysema/chronic bronchitis	0.6	0.6	1.7	-1.2	0.2	-1.0	0.9	0.3	-0.2	1.3
Angina (self-reported)	0.6	0.8	3.3	-0.0	-1.0	1.2	-0.4	-0.2	-1.8	-1.0
Migraine (self-reported)	0.6	0.8	2.4	-1.0	0.1	-1.6	-0.6	0.8	1.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	3.2	-1.3	0.0	-0.3	-0.4	-0.9	1.8	0.2
Suffer from ‘nerves’	0.6	1.0	5.3	-0.6	0.3	-0.0	2.3	0.0	-0.2	1.3
Leg fat-free mass (right)	0.6	3.1	14.5	1.2	3.8	-0.7	-1.8	0.7	-2.1	0.5
Loneliness, isolation	0.6	0.9	1.5	0.6	1.0	-1.1	1.1	0.8	-1.2	1.1
Medication: Aspirin	0.6	0.8	3.0	0.1	-1.7	0.8	0.7	-0.5	-1.0	-0.9
Leg predicted mass (right)	0.6	3.0	14.3	1.1	3.8	-0.6	-1.8	0.6	-2.1	0.4
Number of self-reported non-cancer illnesses	0.6	1.0	4.5	-1.2	-0.8	-0.1	2.1	0.9	-0.5	0.0
Wears glasses or contact lenses	0.6	0.7	5.3	-0.3	0.5	0.1	0.2	0.3	-2.3	-0.4
Medication: Atorvastatin	0.6	0.7	2.3	-0.3	-0.5	0.5	-0.2	-1.5	-1.2	-1.1
Average weekly beer plus cider intake	0.6	0.9	2.4	0.9	1.6	0.2	-1.0	0.6	-0.2	-1.5
Irritable Bowel Disease (IBD)	0.5	1.1	2.7	-1.3	-1.4	1.0	1.6	1.0	0.6	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.4	0.7	1.1	-0.6	-1.8	1.2	1.4	1.0
Fasting Glucose	0.5	0.6	1.9	-0.6	1.4	0.4	0.8	1.1	0.7	-0.1
Blood Eosinophil Count	0.5	4.1	24.0	-1.8	-1.1	-1.3	4.9	-0.1	0.1	1.6
Number of treatments/medications taken	0.5	0.9	4.5	-0.3	-1.6	0.6	2.1	0.1	-0.2	-0.1
Medication: Co-codamol	0.5	0.6	1.7	-1.2	-1.3	0.5	0.7	1.0	0.0	-0.0
Impedance of leg (right)	0.5	2.5	5.9	-2.4	-1.1	1.9	-1.4	0.9	1.2	-2.3
Trunk fat percentage	0.5	2.1	5.1	-1.5	0.9	-2.2	2.3	1.1	-1.5	0.8
Hand grip strength (right)	0.5	1.4	6.3	-0.4	1.7	-0.8	-0.7	2.5	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	5.3	-2.3	-0.5	0.3	0.8	0.6	-1.0	-0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.3	-1.2	-0.1	1.2	0.4	0.6	1.3
Impedance of leg (left)	0.5	2.4	6.2	-2.0	-1.3	1.8	-1.1	0.9	1.2	-2.5
Trunk fat mass	0.5	2.3	5.3	-0.7	2.3	-2.1	1.0	1.3	-2.2	0.5
Had menopause	0.5	0.7	2.4	0.6	-0.7	0.8	0.7	-1.6	-0.7	-0.7
Had other major operations	0.5	0.7	3.0	0.2	1.1	0.3	-1.7	-0.2	-0.9	-0.5
Heart attack	0.5	0.7	1.7	-1.3	-0.9	0.8	-0.8	-0.7	-0.2	-1.0
Pain all over the body in last month	0.5	0.5	2.0	-0.7	-0.7	-0.1	1.4	1.1	0.2	0.2
Illnesses of siblings	0.5	0.6	2.1	-1.3	0.1	-1.5	-0.2	1.0	-0.0	0.2
Alcohol intake versus 10 years previously	0.5	0.7	2.2	-0.3	0.5	-1.3	1.0	0.3	-0.4	1.5
Noisy workplace	0.5	0.6	2.1	-1.1	-0.9	-0.1	1.4	-0.1	-1.0	0.1
Prospective memory result	0.5	0.6	1.3	-0.7	0.1	-0.9	0.9	1.1	-0.8	1.1
Lung cancer (father)	0.5	0.5	1.4	-1.2	-0.7	-0.4	1.0	1.1	0.2	-0.1
Impedance of arm (left)	0.5	2.1	5.3	-1.5	-1.9	2.3	-0.6	0.6	1.6	-1.5
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	3.0	-0.5	1.7	-0.8	-0.8	0.0	0.7	0.0
Qualifications: nursing, teaching	0.5	0.8	2.7	-0.1	1.6	-1.3	-0.1	-0.5	-1.0	-1.1
Medication for cholesterol	0.5	0.7	2.9	0.3	1.7	-0.3	-1.2	-0.4	-0.7	0.6
Medication: Gliclazide	0.5	0.5	1.8	0.8	0.8	-0.6	0.4	1.3	0.6	0.8
Average weekly champagne plus white wine intake	0.5	0.7	3.7	0.2	0.6	-0.0	-1.9	-0.2	0.6	-1.1
Financial situation satisfaction	0.5	0.6	2.0	-1.4	-1.0	-0.4	-0.5	-0.8	0.6	0.7
Medication: Blood pressure	0.5	0.9	3.6	-0.9	-0.7	-0.6	1.9	0.8	0.9	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	-1.2	-1.0	0.7	-0.9	-0.5	-0.0	-0.8
Impedance of whole body	0.5	2.5	5.0	-2.1	-1.8	2.2	-0.8	0.7	1.5	-2.1
Alzheimer’s Disease (including proxy)	0.4	0.6	2.1	1.5	-0.3	0.2	1.3	0.5	-0.1	0.9
Age at First Birth	0.4	0.6	2.1	0.1	0.7	-0.7	1.5	0.8	0.7	0.2
Body Mass Index (BMI) (2010)	0.4	0.6	1.8	0.7	0.7	-1.4	0.2	0.7	-0.9	0.5
Schizophrenia (2014)	0.4	1.0	3.3	0.2	1.2	0.3	-1.8	0.7	1.1	-1.1
Lung FEV1/FVC ratio	0.4	2.2	6.1	-0.3	1.2	-0.9	-0.4	-1.7	-2.5	-2.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.5	1.3	-1.3	-0.4	0.0	0.1	0.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	0.5	-1.2	0.3	1.0	0.6	-0.3	0.8
Severe depression (siblings)	0.4	0.5	1.3	-0.5	-0.7	1.1	-1.1	-0.0	0.4	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	2.1	-0.0	-0.4	0.6	-0.6	-0.7	-1.4	-0.8
Stomach or abdominal pain in last month	0.4	0.5	2.4	0.5	-0.2	-0.2	1.5	0.7	-0.6	0.6
Impedance of arm (right)	0.4	2.0	5.8	-1.1	-1.8	2.4	-1.3	0.3	1.0	-1.8
Number of live births	0.4	0.5	1.4	0.7	0.4	-0.9	0.6	1.2	0.3	0.9
Depression (self-reported)	0.4	0.5	1.5	-1.0	-0.1	-0.2	1.1	-0.3	-1.2	-0.1
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-1.3	-0.3	-1.3	1.5	-0.5	-0.4	1.5
Loud music exposure frequency	0.4	0.4	2.1	-0.6	-1.5	0.4	0.4	-0.5	0.6	0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	3.1	-0.6	0.3	-0.0	-0.5	0.9	1.8	-0.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.4	0.3	0.2	-0.4	0.3	1.5	0.5	0.9
Neck or shoulder pain in last month	0.4	0.5	1.7	0.2	1.3	-0.5	-0.5	-0.4	-1.1	-0.7
Mean time to correctly identify matches	0.4	0.7	2.9	0.6	-1.7	-0.6	0.2	-1.2	-0.5	0.2
Pulse rate, automated reading	0.4	1.3	4.4	1.6	0.5	-1.0	2.1	0.3	-1.2	0.7
Alcohol intake frequency.	0.4	0.9	1.9	-1.1	0.6	-1.4	1.1	0.0	-0.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.4	0.2	-0.6	0.0	1.6	0.0	-0.9	-0.8
Average weekly red wine intake	0.4	0.6	1.9	-0.7	-0.6	1.4	0.3	0.5	1.0	-0.7
Long-standing illness, disability or infirmity	0.4	0.6	3.0	-0.3	-0.0	-0.6	1.7	0.4	-0.7	0.9
Guilty feelings	0.4	0.7	2.7	-0.4	-0.0	-0.6	1.6	-0.1	-1.4	0.4
Ever taken oral contraceptive pill	0.4	0.4	1.0	-0.9	0.6	-0.9	0.5	1.0	-0.1	0.4
Eye problems/disorders: Glaucoma	0.4	0.5	2.6	-0.3	1.6	-0.5	0.4	0.7	-0.7	0.1
Medication: Paracetamol	0.4	0.7	3.0	0.8	-0.3	-0.6	1.7	-0.5	-0.6	0.9
Illnesses of father: High blood pressure	0.4	0.5	2.5	-0.0	0.3	-0.6	1.6	0.3	0.8	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.6	-0.1	1.0	0.1	0.2	1.6	-0.3	0.4
Basal cell carcinoma (self-reported)	0.4	0.5	2.2	-1.1	0.4	0.0	-0.5	0.2	1.5	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	2.4	-0.5	1.2	-0.5	0.1	1.6	0.8	-0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	5.2	0.7	1.4	-0.0	-2.3	-0.4	0.6	-0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	-0.5	0.0	0.0	-0.7	-0.1	1.0	-1.3
Crohns Disease (2017)	0.3	0.6	3.0	-0.7	-0.6	0.8	0.2	0.2	0.1	-1.7
Reaction Time	0.3	0.6	2.4	1.0	-1.0	-0.4	0.1	-1.5	-0.6	0.2
Primary Biliary Cirrhosis	0.3	0.4	1.7	1.1	-0.2	-0.2	-0.5	1.3	-0.6	0.0
Rheumatoid Arthritis	0.3	0.4	1.4	-0.0	-1.0	0.1	-1.2	-0.0	0.7	0.4
Blood Platelet Count	0.3	3.7	11.2	-2.2	1.3	-2.8	3.4	1.9	0.5	0.8
Chronotype (morning person)	0.3	0.8	2.3	-0.7	1.5	-1.2	-0.3	0.3	1.2	0.4
Age when periods started (menarche)	0.3	0.8	3.6	-1.3	-0.0	-0.2	0.3	1.9	0.0	-0.9
High blood pressure	0.3	0.8	4.1	-0.6	0.2	-0.1	0.2	-0.1	-1.3	-2.0
Medication: Atenolol	0.3	0.3	0.8	-0.5	-0.8	0.5	-0.5	-0.9	-0.5	0.1
Number of incorrect matches in round	0.3	0.5	2.3	1.5	-0.4	0.4	-0.4	-0.6	-0.4	0.9
Fluid intelligence score	0.3	0.6	3.6	0.9	0.6	-0.4	-1.9	0.2	0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.7	-0.9	-0.1	-0.7	1.6	-0.1	-0.5	0.1
Pulse rate	0.3	0.5	1.1	0.8	-0.2	-0.9	0.5	0.8	0.5	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.7	-0.5	0.6	0.3	-0.1	0.3	0.7	-1.3
Exposure to tobacco smoke at home	0.3	0.4	1.5	-0.1	0.3	-0.7	1.2	0.2	0.3	0.9
Gout (self-reported)	0.3	0.4	1.2	-0.0	0.6	-0.4	1.1	0.5	0.8	0.9
High blood pressure (siblings)	0.3	0.4	1.8	1.4	0.5	0.8	-0.6	-0.2	0.1	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.4	0.3	0.8	-0.7	1.2	-0.2	-0.8	0.3
Age at first live birth	0.3	0.5	1.1	-0.6	0.8	0.4	-1.0	-0.3	0.5	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	-1.0	0.3	-0.2	-0.8	0.6	1.4	-0.4
Medication: Omeprazole	0.3	0.3	1.7	-0.8	0.0	-0.2	0.2	0.4	1.3	0.3
Heart disease (mother)	0.3	0.4	1.6	-1.3	-0.1	-0.4	1.0	-0.6	0.4	0.1
Number of full sisters	0.3	0.4	1.1	-0.6	0.6	-1.0	-0.4	-0.1	-0.6	-1.0
Friendships satisfaction	0.3	0.4	0.9	0.5	0.9	-0.5	-0.5	0.4	-0.9	-0.6
Miserableness	0.3	0.5	1.4	-0.1	0.0	-0.8	1.2	1.0	-0.5	1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-1.1	0.7	-0.6	-0.4	0.2	-0.3	-0.6
Number of operations (self-reported)	0.3	0.5	1.4	-0.8	1.2	-1.0	-0.6	0.4	-0.2	-0.5
Irritability	0.3	0.5	2.3	-0.6	1.5	-0.0	-1.0	-0.2	0.5	-0.2
Unable to work because of sickness or disability	0.3	0.4	1.2	-0.3	-0.4	0.4	0.9	1.1	-0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	4.2	0.4	0.4	-0.5	-0.3	0.4	1.4	2.0
Alcohol drinker status: Previous	0.3	0.3	1.5	-1.2	-0.5	0.0	-0.2	-0.2	0.4	0.6
Bipolar Disorder (2018)	0.2	0.4	2.1	-0.2	0.4	-0.5	0.4	1.5	0.5	0.0
Schizophrenia (2018)	0.2	0.5	1.5	-0.5	1.2	-0.2	-0.1	0.8	0.6	-0.8
Crohns Disease (2012)	0.2	0.4	1.6	0.2	0.1	1.1	0.0	0.1	0.3	-1.3
Blood Red Count	0.2	1.8	4.4	-2.1	-1.3	-0.5	1.3	-1.7	1.2	1.4
Systolic Blood Pressure	0.2	1.2	3.0	-1.4	-1.7	1.2	0.1	0.0	1.3	-1.0
Cardiovascular Disease	0.2	0.5	1.9	-1.4	0.1	0.2	0.8	0.0	0.3	-1.2
Hypothyroidism (self reported)	0.2	0.4	1.9	1.4	-0.4	-0.3	0.7	-0.3	-0.3	0.3
Lung FVC	0.2	1.1	3.6	0.7	-1.0	0.9	-0.7	-0.9	-1.4	-1.9
Systolic blood pressure, automated reading	0.2	0.5	1.1	-0.8	-0.9	0.7	0.8	-0.2	-0.2	-1.1
Townsend deprivation index at recruitment	0.2	0.3	1.7	0.2	0.4	-0.3	0.5	-0.5	-1.3	-0.4
High blood pressure (mother)	0.2	0.2	1.0	-0.5	1.0	0.5	-0.2	0.4	0.3	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	1.1	-0.2	0.3	-0.2	0.1	-0.2	-1.0	0.6
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.9	-0.4	-0.3	0.3	0.6	-0.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.8	0.6	0.5	0.4	-0.3	-0.3	-1.4	0.1
Glaucoma (self-reported)	0.2	0.3	1.5	0.6	1.2	0.0	0.3	0.2	-0.4	-0.0
Medication: Amlodipine	0.2	0.2	0.8	-0.3	0.0	-0.1	-0.9	0.0	-0.8	-0.5
Number of children fathered	0.2	0.2	1.0	-0.4	1.0	0.2	0.1	0.5	-0.2	-0.1
Medication: Blood pressure	0.2	0.4	1.4	0.3	-0.5	0.6	0.2	-0.8	-1.2	-0.6
Medication: Allopurinol	0.2	0.3	0.9	0.2	0.2	-0.3	0.9	-0.6	-0.1	0.8
Age at last live birth	0.2	0.3	1.2	-1.1	0.2	-0.4	-0.3	0.2	0.4	-0.7
Hypertension (Self-reported)	0.2	0.6	3.2	-0.6	-0.1	0.1	0.6	-0.3	-0.9	-1.8
Breast cancer (self-reported)	0.2	0.3	1.0	0.6	-0.3	-0.0	0.6	0.1	-1.0	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.1	0.2	-0.7	0.5	1.0	0.3	0.0	-0.3
Medication: Lisinopril	0.2	0.3	1.2	0.8	-0.2	-0.4	-0.2	0.3	0.4	1.1
Diastolic blood pressure, automated reading	0.2	0.8	3.6	-0.7	0.5	-1.0	1.9	0.8	-0.3	0.2
Myopia	0.2	0.3	1.5	0.5	0.0	-0.1	-0.3	0.1	-1.2	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.2	-0.3	-0.1	0.5	0.5	-0.2	0.4
Bipolar Disorder (2011)	0.1	0.1	0.4	-0.2	0.4	-0.6	-0.1	0.3	0.6	-0.2
LDL Cholesterol	0.1	0.2	1.3	-1.1	0.3	-0.1	-0.4	-0.3	0.1	-0.5
Tanning	0.1	1.8	7.2	0.6	-0.0	1.8	-1.8	-2.7	0.2	-0.5
Average weekly spirits intake	0.1	0.1	0.5	-0.1	-0.0	-0.2	-0.3	-0.0	0.5	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.6	0.4	0.6	-0.5	0.8	0.4	-0.3	-0.2
Past tobacco smoking	0.1	0.1	0.4	0.4	-0.1	-0.3	0.4	-0.6	0.1	0.1
Alcohol usually taken with meals	0.1	0.2	0.7	-0.4	0.5	0.1	-0.1	0.8	0.4	-0.4
Father’s age at death	0.1	0.1	0.4	-0.3	-0.2	0.0	0.6	0.1	0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.4	0.6	0.3	-0.6	0.2	0.4	-0.1	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	-0.3	0.5	-0.2	-0.3	-0.1	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.9	-0.0	-0.9	0.5	0.5	0.1	-0.5	0.4
Mother’s age at death	0.1	0.1	0.3	0.1	-0.4	-0.1	0.5	0.5	0.2	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.1	4.2	0.9	0.4	-0.5	-0.4	1.3	-2.0	-1.2

Hub : Genes

ZNF169

Models

Trait associations