TWAS hub - CHRNB4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0191	0.0113	2.4e-03	0.005	0.004	0.007	NA	0.006	0.03200	3.8e-02	1.3e-02	NA	1.8e-02
2	TCGA	Thyroid Carcinoma	0.0640	0.0370	4.8e-05	0.031	0.050	0.055	NA	0.055	0.00045	1.1e-05	4.9e-06	NA	4.4e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pack years adult smoking proportion	57.4	87.5	123.2	-7.2	11.1
Pack years of smoking	49.1	72.1	102.0	-6.5	10.1
Chronic bronchitis/emphysema (mother)	18.3	21.4	25.4	-4.2	5.0
Angina (self-reported)	10.8	14.1	25.7	1.6	-5.1
Angina	9.8	12.9	23.8	1.4	-4.9
Lung cancer (father)	9.5	11.1	19.9	-1.5	4.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.3	19.7	29.6	3.1	-5.4
Mouth/teeth dental problems: Mouth ulcers	8.4	13.3	13.4	-3.7	3.6
Qualifications: CSEs or equivalent	6.8	9.0	12.4	-2.4	3.5
Chronic bronchitis/emphysema (father)	6.5	7.6	13.1	-1.5	3.6
Father’s age at death	6.3	8.5	9.7	2.7	-3.1
Bilateral oophorectomy (both ovaries removed)	5.8	6.7	7.3	2.5	-2.7
Type 2 Diabetes (T2D) (2012)	5.7	6.6	8.4	2.2	-2.9
Illnesses of father: Heart disease	5.6	7.8	14.3	1.1	-3.8
Diverticular disease/diverticulitis (self-reported)	5.2	6.2	7.1	-2.3	2.7
Medication: Aspirin	4.8	6.2	9.4	1.8	-3.1
Medication: Aspirin	4.5	5.9	8.9	1.7	-3.0
Back pain experienced in last month	4.5	6.5	7.7	2.8	-2.3
Heart disease (mother)	4.4	5.3	10.5	0.4	-3.2
Bipolar Disorder (2011)	4.3	4.2	5.0	-2.2	1.8
Exposure to tobacco smoke at home	4.1	4.6	6.9	1.5	-2.6
Pain type(s) experienced in last month: Hip pain	3.7	4.7	5.0	2.2	-2.1
Emphysema/chronic bronchitis	3.6	4.1	7.1	-1.0	2.7
Wheeze or whistling in the chest in last year	3.4	6.1	6.5	-2.5	2.4
Vitamin and mineral supplements	3.3	4.5	6.2	-1.7	2.5
Loud music exposure frequency	3.0	3.3	3.7	1.9	-1.7
Blood clot in the leg (DVT)	3.0	3.8	4.7	2.2	-1.7
Average weekly fortified wine intake	2.9	3.4	4.1	-2.0	1.6
Alzheimer’s Disease (in mother)	2.8	3.3	3.9	-1.6	2.0
Medication: Atenolol	2.8	3.5	3.5	1.8	-1.9
Prostate Cancer	2.7	3.8	3.9	2.0	-1.9
Hayfever/allergic rhinitis (self-reported)	2.7	3.5	5.5	1.2	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	4.5	2.1	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	4.4	2.1	-1.6
Ovarian Cancer	2.6	3.4	4.7	2.2	-1.5
Mouth/teeth dental problems: Dentures	2.6	4.3	5.9	-1.7	2.4
Eye problems/disorders: Glaucoma	2.6	3.0	4.9	2.2	-1.1
Medication: Atorvastatin	2.5	3.1	4.8	1.2	-2.2
Coronary Artery Disease (CAD)	2.4	2.9	4.2	-2.0	-1.3
Diabetes (mother)	2.4	3.1	5.2	1.0	-2.3
Schizophrenia (2018)	2.3	4.8	8.1	-1.2	2.8
Reaction Time	2.3	4.4	6.1	-2.5	1.7
Smoking Status	2.3	5.4	7.6	2.7	-1.8
Multivitamins +/- minerals	2.3	3.0	4.3	1.3	-2.1
Depression (self-reported)	2.3	2.8	3.8	-1.3	2.0
Intelligence (Savage-Jansen 2018)	2.2	6.9	10.0	3.2	-1.9
Systolic blood pressure, automated reading	2.2	6.4	7.3	2.7	-2.3
Age at first live birth	2.0	3.6	4.3	-2.1	1.7
Body Mass Index (BMI) (2010)	1.9	2.6	3.3	1.3	-1.8
Neuroticism (2016)	1.9	2.8	3.4	1.4	-1.9
Heart attack	1.9	2.4	4.3	0.8	-2.1
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.8	1.9	-0.9
Financial situation satisfaction	1.9	2.4	3.4	1.2	-1.8
Bipolar Disorder or Schizophrenia	1.8	4.4	8.2	-0.8	2.9
Mineral and other dietary supplements	1.8	2.4	3.8	-1.0	2.0
Medication: Blood pressure	1.8	3.4	6.8	-0.2	2.6
Ulcerative Colitis (UC)	1.7	3.1	4.3	1.4	-2.1
Ulcerative Colitis	1.7	2.5	3.5	1.9	-1.3
Medication: Amlodipine	1.7	2.4	4.5	-0.6	2.1
Family relationship satisfaction	1.7	2.1	2.1	-1.4	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	2.7	-1.2	1.6
Diastolic blood pressure, automated reading	1.7	5.3	9.8	3.1	0.9
Alcohol intake versus 10 years previously	1.6	2.4	2.8	1.5	-1.7
Length of working week for main job	1.6	1.8	2.2	1.2	-1.5
Number of full brothers	1.6	2.0	2.1	-1.4	1.4
Age started oral contraceptive pill	1.6	2.0	2.5	1.6	-1.2
Alzheimer’s Disease (including proxy)	1.5	2.1	2.4	-1.5	1.4
Lupus	1.5	2.3	2.4	-1.5	1.5
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.6	0.5	-1.9
Hayfever, allergic rhinitis or eczema	1.4	3.0	4.5	1.2	-2.1
Mouth/teeth dental problems	1.4	2.1	2.2	1.5	-1.4
Had major operations	1.4	1.7	1.9	1.2	-1.4
Age at last live birth	1.4	2.1	2.4	-1.3	1.6
Knee pain experienced in last month	1.4	2.1	2.3	1.4	-1.5
Ever depressed for a whole week	1.4	1.8	2.3	-1.1	1.5
Supplements: Zinc	1.3	1.4	1.4	1.2	-1.2
Severe depression (siblings)	1.3	1.4	2.1	0.9	-1.4
Whole body fat mass	1.3	5.3	8.1	2.8	-1.6
Smoking status: Current	1.3	2.1	3.7	1.9	-0.7
Pain experienced in last month	1.3	2.2	2.2	-1.5	1.4
Alcohol drinker status: Previous	1.3	1.5	1.9	1.4	-1.0
Schizophrenia (2014)	1.2	2.6	5.2	-0.3	2.3
Hearing difficulty/problems: Yes	1.2	1.9	3.3	0.7	-1.8
Trunk fat percentage	1.2	5.0	7.2	2.7	-1.6
Age when periods started (menarche)	1.2	2.8	4.8	0.9	-2.2
Trunk fat mass	1.2	5.2	7.8	2.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	4.7	1.7	-2.2
Body fat percentage	1.2	4.8	7.2	2.7	-1.5
Average weekly champagne plus white wine intake	1.2	1.7	2.5	1.0	-1.6
Commuting to job workplace: Cycle	1.2	1.4	2.0	-0.9	1.4
Supplements: Calcium	1.2	1.4	1.6	1.1	-1.3
Breast Cancer	1.1	2.6	3.7	1.2	-1.9
Lung FEV1/FVC ratio	1.1	5.8	8.4	2.9	-1.8
Maternal smoking around birth	1.1	1.6	3.1	1.8	-0.0
Financial difficulties in last 2 years	1.1	1.4	1.4	1.2	-1.2
Hip circumference	1.1	4.6	8.5	2.9	-0.8
Falls in the last year	1.1	1.4	2.1	1.5	-0.9
Exposure to tobacco smoke outside home	1.1	1.4	1.5	1.1	-1.2
Supplements: Vitamin C	1.1	1.3	1.9	0.8	-1.4
Smoking status: Previous	1.1	1.7	1.9	1.2	-1.4
Mother’s age at death	1.1	1.4	1.5	1.2	-1.2
Medication: Bendroflumethiazide	1.1	1.6	3.0	0.6	1.7
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.4	-0.5	1.6
Supplements: Glucosamine	1.0	1.3	2.2	0.6	-1.5
Medication: Ramipril	1.0	1.3	1.4	1.1	-1.2
Time employed in main current job	1.0	1.2	1.8	0.8	-1.3
Health satisfaction	1.0	1.3	2.6	-0.1	1.6
Neck or shoulder pain in last month	1.0	1.4	1.7	1.0	-1.3
Alcohol intake frequency.	1.0	2.3	4.4	2.1	-0.5
Average weekly red wine intake	1.0	1.5	2.8	0.3	-1.7
Medication for cholesterol	1.0	1.5	2.9	0.2	-1.7
Vascular/heart problems diagnosed by doctor	1.0	2.7	4.3	-2.1	1.0
Lung FVC	0.9	4.4	5.4	1.8	-2.3
Relative age voice broke	0.9	1.4	1.8	-1.3	1.0
Body mass index (BMI)	0.9	4.0	6.5	2.5	-1.2
Allergy	0.9	2.1	2.3	-1.4	1.5
Arm fat mass (right)	0.9	3.6	5.9	2.4	-1.1
Medication: Blood pressure	0.9	1.5	2.6	1.6	-0.7
Mean time to correctly identify matches	0.9	1.7	2.7	-1.6	0.8
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.2	0.2	-1.5
Risk taking	0.9	1.3	2.5	-0.1	-1.6
Leg fat mass (left)	0.9	3.4	5.3	2.3	-1.2
BMI	0.8	4.9	6.9	2.6	-1.7
Waist Hip Ratio (WHR)	0.8	3.4	6.9	-2.6	0.0
Allergy or Eczema	0.8	2.2	3.2	1.1	-1.8
Hypothyroidism (self reported)	0.8	1.9	2.5	-1.1	1.6
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.0	-1.0	1.0
Medication: Co-codamol	0.8	0.9	1.8	1.3	-0.1
Current tobacco smoking	0.8	1.3	2.5	1.6	0.1
Waist circumference	0.8	3.1	4.2	2.0	-1.4
Weight	0.8	3.8	6.6	2.6	-1.0
Leg fat mass (right)	0.8	3.2	5.2	2.3	-1.1
Leg pain on walking	0.8	0.9	1.1	1.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.3	-1.1	0.9
Illnesses of siblings: Diabetes	0.8	0.9	1.5	1.2	-0.6
Arm fat mass (left)	0.8	3.2	5.4	2.3	-1.0
Alcohol drinker status: Never	0.8	1.0	1.9	1.4	-0.3
Average weekly beer plus cider intake	0.8	1.2	1.9	-0.6	1.4
LDL Cholesterol	0.7	1.0	1.4	-0.8	1.2
Rheumatoid Arthritis	0.7	1.0	1.3	1.1	-0.8
Neuroticism	0.7	1.7	2.8	-1.7	0.7
Fed-up feelings	0.7	1.2	1.7	-1.3	0.8
Number of incorrect matches in round	0.7	1.1	1.4	-0.9	1.2
Had other major operations	0.7	0.8	1.6	1.3	-0.2
Arm fat percentage (right)	0.7	2.8	4.8	2.2	-1.0
Noisy workplace	0.7	0.9	0.9	0.9	-0.9
Breastfed as a baby	0.7	0.8	1.5	1.2	-0.4
Tense / ‘highly strung’	0.7	1.1	1.8	0.6	-1.4
Pulse wave reflection index	0.7	0.9	1.0	0.9	1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	4.0	1.2	-2.0
Comparative body size at age 10	0.7	2.0	3.3	-0.8	1.8
Commuting to job workplace: Walk	0.7	0.8	1.0	-0.7	1.0
Miserableness	0.7	1.2	1.3	-1.0	1.1
Leg fat percentage (left)	0.7	2.5	4.1	2.0	-1.0
Arm fat-free mass (left)	0.7	3.6	5.7	2.4	-1.2
Heart disease (siblings)	0.7	0.8	1.5	-0.4	-1.2
Major Depression (MDD)	0.6	0.8	0.8	0.9	-0.9
HbA1C	0.6	0.7	0.8	-0.9	0.7
Blood Red Count	0.6	5.8	7.7	2.0	-2.8
Average weekly spirits intake	0.6	0.8	1.2	1.1	-0.6
Stomach or abdominal pain in last month	0.6	0.8	0.9	0.8	-0.9
Sitting height	0.6	4.4	5.2	1.9	-2.3
Had menopause	0.6	0.7	1.4	1.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.5	-1.6	0.1
Medication: Cholesterol lowering	0.6	1.0	1.8	0.4	-1.3
Prospective memory result	0.6	0.8	1.5	-0.2	-1.2
Leg fat percentage (right)	0.6	2.1	3.9	2.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	0.7	-0.8	0.8
Medication: Omeprazole	0.6	0.7	1.2	-0.5	1.1
Suffer from ‘nerves’	0.6	0.9	1.0	-1.0	0.9
Unable to work because of sickness or disability	0.6	0.8	1.6	1.3	-0.1
Arm predicted mass (left)	0.6	2.8	4.7	2.2	-1.0
Sensitivity / hurt feelings	0.5	0.8	1.2	0.7	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.7	-0.7	0.9
High blood pressure	0.5	1.5	2.9	1.7	-0.2
Pain all over the body in last month	0.5	0.6	1.1	1.1	0.0
Pulse rate	0.5	0.8	1.4	-1.2	0.4
Impedance of arm (left)	0.5	2.4	3.1	-1.8	1.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.1	1.1	-0.8
Number of children fathered	0.5	0.5	1.0	-1.0	0.2
Migraine (self-reported)	0.5	0.6	1.2	-0.2	1.1
Medication: Allopurinol	0.5	0.6	0.7	0.8	-0.8
Arm fat percentage (left)	0.5	2.0	3.5	1.9	-0.7
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.9	-1.0	0.5
Bipolar Disorder (2018)	0.4	0.6	1.1	0.2	1.1
Depressed Affect (Nagel 2018)	0.4	0.7	1.3	-1.2	0.4
Irritable Bowel Disease (IBD)	0.4	1.0	1.9	0.4	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.5	1.2	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.4	-1.1
Medication for hormone replacement therapy	0.4	0.4	0.5	-0.7	0.6
Townsend deprivation index at recruitment	0.4	0.5	1.1	-0.0	1.0
Alcohol usually taken with meals	0.4	0.7	1.3	-1.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	-0.6	0.9
Qualifications: None of the above	0.4	0.9	0.9	0.9	-0.9
Illnesses of siblings	0.4	0.5	0.6	-0.7	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.0	0.9	-1.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.5	-0.9
Medication: Paracetamol	0.4	0.6	0.9	-0.6	0.9
Birth weight	0.4	0.9	1.0	0.9	-1.0
Arm fat-free mass (right)	0.4	2.0	3.4	1.8	-0.8
Qualifications: College or University degree	0.4	1.2	1.6	-1.3	0.9
Hypertension (Self-reported)	0.4	1.0	1.8	1.4	0.4
Friendships satisfaction	0.4	0.5	0.7	-0.6	0.8
Breast cancer (self-reported)	0.4	0.5	0.5	-0.7	-0.7
Osteoporosis (self-reported)	0.4	0.5	0.7	0.8	-0.6
Ever taken oral contraceptive pill	0.4	0.5	0.8	0.4	-0.9
Basal metabolic rate	0.4	2.0	3.6	1.9	-0.7
Worry (Nagel 2018)	0.3	0.6	0.9	-1.0	0.5
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.5	0.6
Blood Platelet Count	0.3	3.5	6.6	-0.6	-2.6
Cardiovascular Disease	0.3	1.1	2.2	-0.2	1.5
Respiratory disease	0.3	0.8	1.1	-1.1	0.7
Number of treatments/medications taken	0.3	0.5	1.0	1.0	0.2
Impedance of leg (right)	0.3	1.2	1.7	-1.3	0.8
Leg fat-free mass (left)	0.3	1.7	3.2	1.8	-0.5
Leg predicted mass (left)	0.3	1.5	2.8	1.7	-0.4
Nervous feelings	0.3	0.6	1.0	-1.0	0.6
Hearing difficulty/problems with background noise	0.3	0.4	0.9	-0.2	-0.9
Impedance of arm (right)	0.3	1.4	1.7	-1.3	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.6	-0.8	0.5
Hair/balding pattern: Pattern 3	0.3	0.5	0.9	0.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.5	0.8
Hair/balding pattern: Pattern 4	0.3	0.8	1.0	-1.0	0.7
High blood pressure (siblings)	0.3	0.4	0.6	0.4	-0.8
Worry too long after embarrassment	0.3	0.5	0.8	0.5	-0.9
Pulse wave peak to peak time	0.3	0.3	0.6	-0.8	0.0
Shortness of breath walking on level ground	0.3	0.4	0.6	0.8	0.3
Arm predicted mass (right)	0.3	1.7	2.8	1.7	-0.7
Leg fat-free mass (right)	0.3	1.6	2.8	1.7	-0.7
Loneliness, isolation	0.3	0.4	0.7	0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.5	-0.6
Whole body water mass	0.3	1.4	2.6	1.6	-0.5
Leg predicted mass (right)	0.3	1.6	2.8	1.7	-0.7
Guilty feelings	0.3	0.5	0.8	-0.4	-0.9
Hearing aid user	0.3	0.3	0.5	-0.2	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.4	0.7
Irritability	0.3	0.5	0.9	0.2	-0.9
Cholesterol lowering medication	0.3	0.4	0.8	0.9	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	0.8	0.1
Impedance of whole body	0.3	1.3	2.2	-1.5	0.7
Depression (Nagel 2018)	0.2	0.3	0.5	0.0	-0.7
Neuroticism (Nagel 2018)	0.2	0.4	0.7	-0.8	-0.5
Crohns Disease (2012)	0.2	0.3	0.6	0.1	-0.8
HDL Cholesterol	0.2	0.4	0.6	0.4	-0.8
Systolic Blood Pressure	0.2	1.2	2.2	1.5	-0.4
Hand grip strength (left)	0.2	0.4	0.5	-0.6	0.7
Relative age of first facial hair	0.2	0.4	0.9	-0.9	0.2
Diabetes (father)	0.2	0.3	0.6	0.0	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.7	-0.1
Impedance of leg (left)	0.2	1.1	2.0	-1.4	0.5
Forced vital capacity (FVC)	0.2	0.7	1.4	0.3	-1.2
Fluid intelligence score	0.2	0.3	0.5	0.7	0.4
Neuroticism score	0.2	0.4	0.7	-0.9	0.3
Trunk fat-free mass	0.2	1.1	1.9	1.4	-0.5
Medication: Lansoprazole	0.2	0.3	0.5	-0.2	0.7
Illnesses of mother	0.2	0.2	0.3	0.4	-0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.7	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.5	-0.7	0.5
Glaucoma (self-reported)	0.2	0.2	0.3	0.5	0.4
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.3	-0.6	0.5
Pulse rate, automated reading	0.2	0.5	1.0	-1.0	0.1
Overall health rating	0.2	0.5	1.0	-0.2	1.0
Whole body fat-free mass	0.2	1.4	2.5	1.6	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.2	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.2	0.7
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	0.7	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.3	-0.5	0.5
Medication: Lisinopril	0.2	0.2	0.4	0.6	-0.2
Ever smoked	0.2	0.4	0.8	0.9	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	-0.3
Crohns Disease (2017)	0.1	0.3	0.5	-0.7	-0.2
Age at First Birth	0.1	0.1	0.2	0.0	0.4
Mean Putamen Volume	0.1	0.1	0.1	-0.2	0.3
Fasting Glucose	0.1	0.1	0.2	-0.4	0.3
Triglycerides	0.1	0.1	0.1	-0.4	0.4
Blood White Count	0.1	0.4	0.7	0.1	-0.9
Height	0.1	1.2	2.2	1.5	-0.5
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	0.3	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	0.5	-0.2
Ever had hysterectomy (womb removed)	0.1	0.2	0.2	-0.5	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.4	0.4
Medication: Metformin	0.1	0.2	0.3	0.2	-0.6
Hand grip strength (right)	0.1	0.2	0.3	0.4	-0.6
Taking other prescription medications	0.1	0.2	0.2	0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	-0.0	0.8
Medication: Levothyroxine sodium	0.1	0.1	0.1	0.4	0.4
High blood pressure (mother)	0.1	0.1	0.2	-0.3	0.4
Past tobacco smoking	0.1	0.2	0.3	-0.6	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	0.6	0.2
Medication: Simvastatin	0.1	0.1	0.1	0.3	-0.3
Worrier / anxious feelings	0.1	0.1	0.3	0.5	-0.1
Number of live births	0.1	0.1	0.3	0.0	-0.5
Happiness	0.1	0.1	0.1	0.3	-0.3
Trunk predicted mass	0.1	0.9	1.5	1.2	-0.4
Birth weight of first child	0.1	0.1	0.1	0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.6	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.5	0.2
Comparative height size at age 10	0.1	0.6	1.2	1.1	-0.0
Chest pain or discomfort	0.1	0.1	0.3	-0.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	-0.3	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.3	0.3
Mood swings	0.1	0.3	0.4	-0.6	-0.4
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.4	0.5
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	-0.1
Wears glasses or contact lenses	0.1	0.1	0.1	0.4	0.1
High cholesterol (Self-reported)	0.1	0.1	0.2	-0.4	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.2	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.2	-0.4
Myopia	0.1	0.1	0.2	-0.5	-0.3
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.3	0.0
Blood Eosinophil Count	0.0	0.1	0.1	-0.1	-0.3
Heel T-Score	0.0	0.2	0.5	0.7	-0.2
Chronotype (morning person)	0.0	0.1	0.2	-0.1	0.4
Hair Pigment	0.0	1.4	2.5	-0.4	-1.6
Tanning	0.0	0.3	0.4	0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.2	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.3	0.1
Diabetes (self-reported)	0.0	0.0	0.0	-0.0	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	0.2
Asthma	0.0	0.0	0.0	-0.1	-0.1
Standing height	0.0	0.1	0.2	0.5	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.2	0.1
Headache pain in last month	0.0	0.1	0.1	0.2	0.3
Gout (self-reported)	0.0	0.0	0.0	0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.3	0.0
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.0	-0.1
Medication: Ibuprofen	0.0	0.0	0.0	0.2	-0.1
Medication: Seretide 50 evohaler	0.0	0.1	0.1	0.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	0.0
Number of full sisters	0.0	0.1	0.1	0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.1	0.1	-0.1	-0.4
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.1	-0.1
Asthma (self-reported)	0.0	0.1	0.1	0.0	-0.4
Osteoarthritis (self-reported)	0.0	0.0	0.0	0.1	0.2
Medication: Gliclazide	0.0	0.0	0.1	0.1	0.3
Medication: Paracetamol	0.0	0.1	0.1	-0.1	0.3
Number of operations (self-reported)	0.0	0.1	0.1	0.3	-0.0

Hub : Genes

CHRNB4

Models

Trait associations