Hub : Genes

CHRNB4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0191 0.0113 2.4e-03 0.005 0.004 0.007 NA 0.006 0.03200 3.8e-02 1.3e-02 NA 1.8e-02
2 TCGA Thyroid Carcinoma 0.0640 0.0370 4.8e-05 0.031 0.050 0.055 NA 0.055 0.00045 1.1e-05 4.9e-06 NA 4.4e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.4 0.6 1.1 0.2 1.1
Bipolar Disorder or Schizophrenia 1.8 4.4 8.2 -0.8 2.9
Depressed Affect (Nagel 2018) 0.4 0.7 1.3 -1.2 0.4
Depression (Nagel 2018) 0.2 0.3 0.5 0.0 -0.7
Intelligence (Savage-Jansen 2018) 2.2 6.9 10.0 3.2 -1.9
Neuroticism (Nagel 2018) 0.2 0.4 0.7 -0.8 -0.5
Schizophrenia (2018) 2.3 4.8 8.1 -1.2 2.8
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 -0.3
Worry (Nagel 2018) 0.3 0.6 0.9 -1.0 0.5
Alzheimer’s Disease (in mother) 2.8 3.3 3.9 -1.6 2.0
Alzheimer’s Disease (in father) 0.3 0.3 0.4 -0.5 0.6
Alzheimer’s Disease (including proxy) 1.5 2.1 2.4 -1.5 1.4
Crohns Disease (2017) 0.1 0.3 0.5 -0.7 -0.2
Irritable Bowel Disease (IBD) 0.4 1.0 1.9 0.4 -1.4
Ulcerative Colitis (UC) 1.7 3.1 4.3 1.4 -2.1
Major Depression (MDD) 0.6 0.8 0.8 0.9 -0.9
Reaction Time 2.3 4.4 6.1 -2.5 1.7
Verbal and Numeric Reasoning (VNR) 0.4 1.0 1.5 1.2 -0.7
Breast Cancer 1.1 2.6 3.7 1.2 -1.9
Ovarian Cancer 2.6 3.4 4.7 2.2 -1.5
Prostate Cancer 2.7 3.8 3.9 2.0 -1.9
Age at First Birth 0.1 0.1 0.2 0.0 0.4
Bipolar Disorder (2011) 4.3 4.2 5.0 -2.2 1.8
Body Mass Index (BMI) (2010) 1.9 2.6 3.3 1.3 -1.8
Coronary Artery Disease (CAD) 2.4 2.9 4.2 -2.0 -1.3
Crohns Disease (2012) 0.2 0.3 0.6 0.1 -0.8
Mean Putamen Volume 0.1 0.1 0.1 -0.2 0.3
Fasting Glucose 0.1 0.1 0.2 -0.4 0.3
HbA1C 0.6 0.7 0.8 -0.9 0.7
HDL Cholesterol 0.2 0.4 0.6 0.4 -0.8
LDL Cholesterol 0.7 1.0 1.4 -0.8 1.2
Lupus 1.5 2.3 2.4 -1.5 1.5
Neuroticism (2016) 1.9 2.8 3.4 1.4 -1.9
Primary Biliary Cirrhosis 0.0 0.0 0.1 -0.3 0.0
Rheumatoid Arthritis 0.7 1.0 1.3 1.1 -0.8
Schizophrenia (2014) 1.2 2.6 5.2 -0.3 2.3
Triglycerides 0.1 0.1 0.1 -0.4 0.4
Type 2 Diabetes (T2D) (2012) 5.7 6.6 8.4 2.2 -2.9
Ulcerative Colitis 1.7 2.5 3.5 1.9 -1.3
Blood Eosinophil Count 0.0 0.1 0.1 -0.1 -0.3
Blood Platelet Count 0.3 3.5 6.6 -0.6 -2.6
Blood Red Count 0.6 5.8 7.7 2.0 -2.8
Blood White Count 0.1 0.4 0.7 0.1 -0.9
Heel T-Score 0.0 0.2 0.5 0.7 -0.2
BMI 0.8 4.9 6.9 2.6 -1.7
Height 0.1 1.2 2.2 1.5 -0.5
Waist Hip Ratio (WHR) 0.8 3.4 6.9 -2.6 0.0
Systolic Blood Pressure 0.2 1.2 2.2 1.5 -0.4
Smoking Status 2.3 5.4 7.6 2.7 -1.8
Allergy or Eczema 0.8 2.2 3.2 1.1 -1.8
Cardiovascular Disease 0.3 1.1 2.2 -0.2 1.5
Hypothyroidism (self reported) 0.8 1.9 2.5 -1.1 1.6
Respiratory disease 0.3 0.8 1.1 -1.1 0.7
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.3 0.4 -1.1
Lung FEV1/FVC ratio 1.1 5.8 8.4 2.9 -1.8
Lung FVC 0.9 4.4 5.4 1.8 -2.3
Neuroticism 0.7 1.7 2.8 -1.7 0.7
Chronotype (morning person) 0.0 0.1 0.2 -0.1 0.4
Hair Pigment 0.0 1.4 2.5 -0.4 -1.6
Tanning 0.0 0.3 0.4 0.6 0.6
Hand grip strength (left) 0.2 0.4 0.5 -0.6 0.7
Number of treatments/medications taken 0.3 0.5 1.0 1.0 0.2
Average weekly spirits intake 0.6 0.8 1.2 1.1 -0.6
Sensitivity / hurt feelings 0.5 0.8 1.2 0.7 -1.1
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.1 0.3 -0.4
Hearing difficulty/problems: Yes 1.2 1.9 3.3 0.7 -1.8
Relative age of first facial hair 0.2 0.4 0.9 -0.9 0.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 1.0 -1.0 1.0
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.5 -0.2
Ever had hysterectomy (womb removed) 0.1 0.2 0.2 -0.5 -0.3
Systolic blood pressure, automated reading 2.2 6.4 7.3 2.7 -2.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 -0.4 0.4
Angina 9.8 12.9 23.8 1.4 -4.9
Medication for hormone replacement therapy 0.4 0.4 0.5 -0.7 0.6
Vitamin and mineral supplements 3.3 4.5 6.2 -1.7 2.5
Supplements: Zinc 1.3 1.4 1.4 1.2 -1.2
Medication: Co-codamol 0.8 0.9 1.8 1.3 -0.1
Medication: Metformin 0.1 0.2 0.3 0.2 -0.6
Diabetes (father) 0.2 0.3 0.6 0.0 -0.8
Diabetes (mother) 2.4 3.1 5.2 1.0 -2.3
Severe depression (siblings) 1.3 1.4 2.1 0.9 -1.4
Pack years adult smoking proportion 57.4 87.5 123.2 -7.2 11.1
Impedance of leg (right) 0.3 1.2 1.7 -1.3 0.8
Leg fat-free mass (left) 0.3 1.7 3.2 1.8 -0.5
Trunk fat percentage 1.2 5.0 7.2 2.7 -1.6
Hand grip strength (right) 0.1 0.2 0.3 0.4 -0.6
Townsend deprivation index at recruitment 0.4 0.5 1.1 -0.0 1.0
Current tobacco smoking 0.8 1.3 2.5 1.6 0.1
Average weekly fortified wine intake 2.9 3.4 4.1 -2.0 1.6
Maternal smoking around birth 1.1 1.6 3.1 1.8 -0.0
Fed-up feelings 0.7 1.2 1.7 -1.3 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 0.7 -0.7 0.9
Relative age voice broke 0.9 1.4 1.8 -1.3 1.0
Taking other prescription medications 0.1 0.2 0.2 0.5 0.4
Age when periods started (menarche) 1.2 2.8 4.8 0.9 -2.2
Bilateral oophorectomy (both ovaries removed) 5.8 6.7 7.3 2.5 -2.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.7 -0.0 0.8
Tinnitus: Yes, but not now, but have in the past 0.0 0.0 0.0 0.2 0.0
Qualifications: CSEs or equivalent 6.8 9.0 12.4 -2.4 3.5
Serious illness, injury or assault to yourself 0.2 0.2 0.4 0.7 -0.1
High blood pressure 0.5 1.5 2.9 1.7 -0.2
Hayfever, allergic rhinitis or eczema 1.4 3.0 4.5 1.2 -2.1
Multivitamins +/- minerals 2.3 3.0 4.3 1.3 -2.1
Stomach or abdominal pain in last month 0.6 0.8 0.9 0.8 -0.9
Supplements: Glucosamine 1.0 1.3 2.2 0.6 -1.5
Diverticular disease/diverticulitis (self-reported) 5.2 6.2 7.1 -2.3 2.7
Medication: Atenolol 2.8 3.5 3.5 1.8 -1.9
Medication: Levothyroxine sodium 0.1 0.1 0.1 0.4 0.4
Sitting height 0.6 4.4 5.2 1.9 -2.3
Chronic bronchitis/emphysema (father) 6.5 7.6 13.1 -1.5 3.6
High blood pressure (mother) 0.1 0.1 0.2 -0.3 0.4
Body mass index (BMI) 0.9 4.0 6.5 2.5 -1.2
Impedance of leg (left) 0.2 1.1 2.0 -1.4 0.5
Leg predicted mass (left) 0.3 1.5 2.8 1.7 -0.4
Trunk fat mass 1.2 5.2 7.8 2.8 -1.6
Waist circumference 0.8 3.1 4.2 2.0 -1.4
Number of incorrect matches in round 0.7 1.1 1.4 -0.9 1.2
Past tobacco smoking 0.1 0.2 0.3 -0.6 -0.4
Alcohol usually taken with meals 0.4 0.7 1.3 -1.2 -0.1
Nervous feelings 0.3 0.6 1.0 -1.0 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.1 -0.3 0.1
Hearing difficulty/problems with background noise 0.3 0.4 0.9 -0.2 -0.9
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.4 -0.2
Had menopause 0.6 0.7 1.4 1.2 -0.1
Had other major operations 0.7 0.8 1.6 1.3 -0.2
Forced vital capacity (FVC) 0.2 0.7 1.4 0.3 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.6 0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.8 -0.6 0.9
Qualifications: None of the above 0.4 0.9 0.9 0.9 -0.9
Financial difficulties in last 2 years 1.1 1.4 1.4 1.2 -1.2
Mouth/teeth dental problems 1.4 2.1 2.2 1.5 -1.4
Heart attack 1.9 2.4 4.3 0.8 -2.1
Allergy 0.9 2.1 2.3 -1.4 1.5
Pain all over the body in last month 0.5 0.6 1.1 1.1 0.0
Diabetes (self-reported) 0.0 0.0 0.0 -0.0 -0.0
Hayfever/allergic rhinitis (self-reported) 2.7 3.5 5.5 1.2 -2.4
Medication: Ramipril 1.0 1.3 1.4 1.1 -1.2
Medication: Simvastatin 0.1 0.1 0.1 0.3 -0.3
Fluid intelligence score 0.2 0.3 0.5 0.7 0.4
Illnesses of siblings 0.4 0.5 0.6 -0.7 0.8
Neuroticism score 0.2 0.4 0.7 -0.9 0.3
Weight 0.8 3.8 6.6 2.6 -1.0
Impedance of arm (right) 0.3 1.4 1.7 -1.3 1.1
Arm fat percentage (right) 0.7 2.8 4.8 2.2 -1.0
Trunk fat-free mass 0.2 1.1 1.9 1.4 -0.5
Hip circumference 1.1 4.6 8.5 2.9 -0.8
Time employed in main current job 1.0 1.2 1.8 0.8 -1.3
Alcohol intake versus 10 years previously 1.6 2.4 2.8 1.5 -1.7
Father’s age at death 6.3 8.5 9.7 2.7 -3.1
Worrier / anxious feelings 0.1 0.1 0.3 0.5 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.6 -0.8 0.5
Falls in the last year 1.1 1.4 2.1 1.5 -0.9
Hair/balding pattern: Pattern 3 0.3 0.5 0.9 0.0 -1.0
Number of live births 0.1 0.1 0.3 0.0 -0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.0 0.9 -1.4
Pulse rate 0.5 0.8 1.4 -1.2 0.4
Happiness 0.1 0.1 0.1 0.3 -0.3
Noisy workplace 0.7 0.9 0.9 0.9 -0.9
Qualifications: A levels/AS levels or equivalent 0.6 1.2 2.5 -1.6 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 -0.0 0.2
Mouth/teeth dental problems: Dentures 2.6 4.3 5.9 -1.7 2.4
Asthma 0.0 0.0 0.0 -0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.6 0.7 -0.5
Medication: Cholesterol lowering 0.6 1.0 1.8 0.4 -1.3
Depression (self-reported) 2.3 2.8 3.8 -1.3 2.0
Medication: Lansoprazole 0.2 0.3 0.5 -0.2 0.7
Prospective memory result 0.6 0.8 1.5 -0.2 -1.2
Lung cancer (father) 9.5 11.1 19.9 -1.5 4.5
Illnesses of mother 0.2 0.2 0.3 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 4.7 1.7 -2.2
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.7 0.0
Impedance of arm (left) 0.5 2.4 3.1 -1.8 1.3
Arm fat mass (right) 0.9 3.6 5.9 2.4 -1.1
Trunk predicted mass 0.1 0.9 1.5 1.2 -0.4
Standing height 0.0 0.1 0.2 0.5 -0.1
Length of working week for main job 1.6 1.8 2.2 1.2 -1.5
Exposure to tobacco smoke at home 4.1 4.6 6.9 1.5 -2.6
Breastfed as a baby 0.7 0.8 1.5 1.2 -0.4
Tense / ‘highly strung’ 0.7 1.1 1.8 0.6 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.6 -0.5 0.8
Hair/balding pattern: Pattern 4 0.3 0.8 1.0 -1.0 0.7
Birth weight of first child 0.1 0.1 0.1 0.4 -0.3
Peak expiratory flow (PEF) 0.0 0.0 0.0 0.2 0.1
Pulse wave reflection index 0.7 0.9 1.0 0.9 1.0
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.0 0.2 0.1
Loud music exposure frequency 3.0 3.3 3.7 1.9 -1.7
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.1 1.1 -0.8
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.9 0.5 -0.9
Blood clot in the leg (DVT) 3.0 3.8 4.7 2.2 -1.7
Medication: Paracetamol 0.4 0.6 0.9 -0.6 0.9
Headache pain in last month 0.0 0.1 0.1 0.2 0.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.5 -0.7 0.5
Glaucoma (self-reported) 0.2 0.2 0.3 0.5 0.4
Gout (self-reported) 0.0 0.0 0.0 0.1 -0.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 0.6 0.3
Medication: Amlodipine 1.7 2.4 4.5 -0.6 2.1
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.5 0.2
Birth weight 0.4 0.9 1.0 0.9 -1.0
Chronic bronchitis/emphysema (mother) 18.3 21.4 25.4 -4.2 5.0
High blood pressure (siblings) 0.3 0.4 0.6 0.4 -0.8
Forced vital capacity (FVC), Best measure 0.7 2.7 4.0 1.2 -2.0
Body fat percentage 1.2 4.8 7.2 2.7 -1.5
Leg fat percentage (right) 0.6 2.1 3.9 2.0 -0.6
Arm fat-free mass (right) 0.4 2.0 3.4 1.8 -0.8
Exposure to tobacco smoke outside home 1.1 1.4 1.5 1.1 -1.2
Comparative body size at age 10 0.7 2.0 3.3 -0.8 1.8
Number of full brothers 1.6 2.0 2.1 -1.4 1.4
Worry too long after embarrassment 0.3 0.5 0.8 0.5 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.3 0.0
Wheeze or whistling in the chest in last year 3.4 6.1 6.5 -2.5 2.4
Number of children fathered 0.5 0.5 1.0 -1.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 0.7 -0.8 0.8
Age at first live birth 2.0 3.6 4.3 -2.1 1.7
Pulse wave peak to peak time 0.3 0.3 0.6 -0.8 0.0
Health satisfaction 1.0 1.3 2.6 -0.1 1.6
Shortness of breath walking on level ground 0.3 0.4 0.6 0.8 0.3
Qualifications: College or University degree 0.4 1.2 1.6 -1.3 0.9
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.7 -0.1
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.0 -0.1
Emphysema/chronic bronchitis 3.6 4.1 7.1 -1.0 2.7
Medication for pain relief, constipation, heartburn 0.2 0.3 0.3 -0.6 0.5
Neck or shoulder pain in last month 1.0 1.4 1.7 1.0 -1.3
Medication: Blood pressure 0.9 1.5 2.6 1.6 -0.7
Angina (self-reported) 10.8 14.1 25.7 1.6 -5.1
Migraine (self-reported) 0.5 0.6 1.2 -0.2 1.1
Medication: Ibuprofen 0.0 0.0 0.0 0.2 -0.1
Medication: Allopurinol 0.5 0.6 0.7 0.8 -0.8
Medication: Omeprazole 0.6 0.7 1.2 -0.5 1.1
Medication: Seretide 50 evohaler 0.0 0.1 0.1 0.3 -0.1
Mean time to correctly identify matches 0.9 1.7 2.7 -1.6 0.8
Heart disease (mother) 4.4 5.3 10.5 0.4 -3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.1 -0.2 0.0
Whole body fat mass 1.3 5.3 8.1 2.8 -1.6
Leg fat mass (right) 0.8 3.2 5.2 2.3 -1.1
Arm predicted mass (right) 0.3 1.7 2.8 1.7 -0.7
Pulse rate, automated reading 0.2 0.5 1.0 -1.0 0.1
Alcohol intake frequency. 1.0 2.3 4.4 2.1 -0.5
Comparative height size at age 10 0.1 0.6 1.2 1.1 -0.0
Number of full sisters 0.0 0.1 0.1 0.2 -0.2
Suffer from ‘nerves’ 0.6 0.9 1.0 -1.0 0.9
Overall health rating 0.2 0.5 1.0 -0.2 1.0
Chest pain or discomfort 0.1 0.1 0.3 -0.1 -0.5
Had major operations 1.4 1.7 1.9 1.2 -1.4
Age at last live birth 1.4 2.1 2.4 -1.3 1.6
Family relationship satisfaction 1.7 2.1 2.1 -1.4 1.5
Leg pain on walking 0.8 0.9 1.1 1.1 -0.9
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.0 2.7 -1.2 1.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.1 -0.3 0.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.3 -1.1 0.9
Medication: Aspirin 4.5 5.9 8.9 1.7 -3.0
Supplements: Vitamin C 1.1 1.3 1.9 0.8 -1.4
Knee pain experienced in last month 1.4 2.1 2.3 1.4 -1.5
Hypertension (Self-reported) 0.4 1.0 1.8 1.4 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.3 0.3
Illnesses of father: Heart disease 5.6 7.8 14.3 1.1 -3.8
Illnesses of siblings: Diabetes 0.8 0.9 1.5 1.2 -0.6
Smoking status: Previous 1.1 1.7 1.9 1.2 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.1 -0.1 -0.4
Whole body fat-free mass 0.2 1.4 2.5 1.6 -0.6
Leg fat-free mass (right) 0.3 1.6 2.8 1.7 -0.7
Arm fat percentage (left) 0.5 2.0 3.5 1.9 -0.7
Average weekly red wine intake 1.0 1.5 2.8 0.3 -1.7
Handedness (chirality/laterality): Left-handed 1.9 2.3 3.8 1.9 -0.9
Mood swings 0.1 0.3 0.4 -0.6 -0.4
Loneliness, isolation 0.3 0.4 0.7 0.9 -0.3
Long-standing illness, disability or infirmity 0.1 0.2 0.3 0.4 0.5
Ever had bowel cancer screening 0.1 0.1 0.2 0.4 -0.3
Diabetes diagnosed by doctor 0.1 0.1 0.2 0.4 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 4.5 2.1 -1.1
Friendships satisfaction 0.4 0.5 0.7 -0.6 0.8
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.2 -0.7
Commuting to job workplace: Walk 0.7 0.8 1.0 -0.7 1.0
Eye problems/disorders: Cataract 0.0 0.0 0.0 -0.1 -0.1
Mouth/teeth dental problems: Mouth ulcers 8.4 13.3 13.4 -3.7 3.6
Medication for cholesterol 1.0 1.5 2.9 0.2 -1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.4 0.5 -0.6
Back pain experienced in last month 4.5 6.5 7.7 2.8 -2.3
Mineral and other dietary supplements 1.8 2.4 3.8 -1.0 2.0
Breast cancer (self-reported) 0.4 0.5 0.5 -0.7 -0.7
Asthma (self-reported) 0.0 0.1 0.1 0.0 -0.4
Osteoporosis (self-reported) 0.4 0.5 0.7 0.8 -0.6
Osteoarthritis (self-reported) 0.0 0.0 0.0 0.1 0.2
Medication: Aspirin 4.8 6.2 9.4 1.8 -3.1
Medication: Gliclazide 0.0 0.0 0.1 0.1 0.3
Illnesses of father: None of the above (group 1) 0.2 0.2 0.4 -0.2 0.7
Smoking status: Current 1.3 2.1 3.7 1.9 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.3 19.7 29.6 3.1 -5.4
Whole body water mass 0.3 1.4 2.6 1.6 -0.5
Leg predicted mass (right) 0.3 1.6 2.8 1.7 -0.7
Arm fat mass (left) 0.8 3.2 5.4 2.3 -1.0
Number of self-reported non-cancer illnesses 0.2 0.3 0.4 0.7 0.5
Average weekly champagne plus white wine intake 1.2 1.7 2.5 1.0 -1.6
Miserableness 0.7 1.2 1.3 -1.0 1.1
Guilty feelings 0.3 0.5 0.8 -0.4 -0.9
Wears glasses or contact lenses 0.1 0.1 0.1 0.4 0.1
Ever taken oral contraceptive pill 0.4 0.5 0.8 0.4 -0.9
Hearing aid user 0.3 0.3 0.5 -0.2 -0.7
Mother’s age at death 1.1 1.4 1.5 1.2 -1.2
Financial situation satisfaction 1.9 2.4 3.4 1.2 -1.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.5 -0.4 0.7
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.5 0.5
Eye problems/disorders: Glaucoma 2.6 3.0 4.9 2.2 -1.1
Medication: Blood pressure 1.8 3.4 6.8 -0.2 2.6
Pain type(s) experienced in last month: Hip pain 3.7 4.7 5.0 2.2 -2.1
Supplements: Fish oil (including cod liver oil) 0.9 1.1 2.2 0.2 -1.5
High cholesterol (Self-reported) 0.1 0.1 0.2 -0.4 -0.2
Medication: Bendroflumethiazide 1.1 1.6 3.0 0.6 1.7
Medication: Paracetamol 0.0 0.1 0.1 -0.1 0.3
Medication: Lisinopril 0.2 0.2 0.4 0.6 -0.2
Medication: Atorvastatin 2.5 3.1 4.8 1.2 -2.2
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.2 0.4
Alcohol drinker status: Never 0.8 1.0 1.9 1.4 -0.3
Ever smoked 0.2 0.4 0.8 0.9 -0.2
Basal metabolic rate 0.4 2.0 3.6 1.9 -0.7
Leg fat percentage (left) 0.7 2.5 4.1 2.0 -1.0
Arm fat-free mass (left) 0.7 3.6 5.7 2.4 -1.2
Number of operations (self-reported) 0.0 0.1 0.1 0.3 -0.0
Average weekly beer plus cider intake 0.8 1.2 1.9 -0.6 1.4
Irritability 0.3 0.5 0.9 0.2 -0.9
Risk taking 0.9 1.3 2.5 -0.1 -1.6
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.9 -1.0 0.5
Fractured/broken bones in last 5 years 0.1 0.1 0.1 0.2 -0.4
Age started oral contraceptive pill 1.6 2.0 2.5 1.6 -1.2
Diastolic blood pressure, automated reading 1.7 5.3 9.8 3.1 0.9
Ever depressed for a whole week 1.4 1.8 2.3 -1.1 1.5
Unable to work because of sickness or disability 0.6 0.8 1.6 1.3 -0.1
Commuting to job workplace: Cycle 1.2 1.4 2.0 -0.9 1.4
Myopia 0.1 0.1 0.2 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 1.0 2.7 4.3 -2.1 1.0
Cholesterol lowering medication 0.3 0.4 0.8 0.9 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.4 -0.5 1.6
Pain experienced in last month 1.3 2.2 2.2 -1.5 1.4
Supplements: Calcium 1.2 1.4 1.6 1.1 -1.3
Basal cell carcinoma (self-reported) 0.3 0.3 0.6 0.8 0.1
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.6 0.5 -1.9
Deep venous thrombosis (DVT) (self-reported) 2.7 3.4 4.4 2.1 -1.6
Heart disease (siblings) 0.7 0.8 1.5 -0.4 -1.2
Alcohol drinker status: Previous 1.3 1.5 1.9 1.4 -1.0
Pack years of smoking 49.1 72.1 102.0 -6.5 10.1
Impedance of whole body 0.3 1.3 2.2 -1.5 0.7
Leg fat mass (left) 0.9 3.4 5.3 2.3 -1.2
Arm predicted mass (left) 0.6 2.8 4.7 2.2 -1.0