Best TWAS P=4.01e-11 · Best GWAS P=2.3e-10 conditioned to 0.0286
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MMAB | 0.12 | 0.09 | enet | 13 | 0.08 | 2.9e-10 | 6.3 | -6.3 | 2.6e-10 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | MMAB | 0.10 | -0.01 | lasso | 4 | 0.00 | 3.8e-01 | -5.3 | -5.4 | 8.7e-08 | -0.80 | 0.07 | 0.46 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | MMAB | 0.07 | 0.06 | enet | 9 | 0.05 | 7.3e-05 | 6.1 | -6.5 | 6.5e-11 | -0.79 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Colon Sigmoid | KCTD10 | 0.25 | 0.16 | lasso | 8 | 0.15 | 6.2e-06 | 6.3 | -5.8 | 5.2e-09 | -0.95 | 0.05 | 0.94 | FALSE |
| 5 | GTEx | Colon Transverse | KCTD10 | 0.22 | 0.12 | lasso | 11 | 0.13 | 1.1e-06 | -5.3 | -6.3 | 3.4e-10 | -0.90 | 0.15 | 0.85 | FALSE |
| 6 | GTEx | Colon Transverse | MMAB | 0.08 | 0.07 | lasso | 2 | 0.05 | 1.7e-03 | 6.3 | -6.2 | 5.4e-10 | -0.97 | 0.03 | 0.92 | FALSE |
| 7 | GTEx | Nerve Tibial | USP30 | 0.07 | 0.01 | lasso | 4 | 0.01 | 1.1e-01 | 4.8 | 6.1 | 1.0e-09 | 0.72 | 0.07 | 0.63 | FALSE |
| 8 | GTEx | Thyroid | KCTD10 | 0.06 | 0.02 | enet | 12 | 0.02 | 9.2e-03 | 6.1 | -5.9 | 2.7e-09 | -0.71 | 0.04 | 0.93 | FALSE |
| 9 | GTEx | Thyroid | MMAB | 0.07 | 0.00 | lasso | 6 | 0.02 | 5.4e-03 | -5.3 | -6.5 | 1.1e-10 | -0.85 | 0.06 | 0.84 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MMAB | 0.03 | 0.01 | blup | 57 | 0.02 | 6.5e-06 | 6.3 | -6.0 | 2.5e-09 | -0.78 | 0.01 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MMAB | 0.05 | 0.01 | blup | 57 | 0.02 | 5.8e-02 | 5.2 | -5.5 | 3.4e-08 | -0.63 | 0.04 | 0.30 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MMAB | 0.03 | 0.02 | blup | 57 | 0.02 | 2.2e-03 | 5.6 | -6.3 | 3.9e-10 | -0.86 | 0.02 | 0.87 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MMAB | 0.04 | 0.02 | blup | 53 | 0.02 | 5.2e-03 | 6.3 | -6.2 | 7.7e-10 | -0.95 | 0.00 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MMAB | 0.09 | 0.05 | blup | 57 | 0.09 | 6.3e-06 | 6.3 | -6.3 | 4.0e-10 | -0.77 | 0.01 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MVK | 0.06 | 0.02 | enet | 5 | 0.06 | 2.1e-04 | 5.9 | -5.3 | 9.1e-08 | -0.84 | 0.01 | 0.83 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MYO1H | 0.05 | 0.02 | blup | 87 | 0.04 | 2.1e-03 | -3.9 | 5.9 | 4.2e-09 | 0.72 | 0.06 | 0.56 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | MMAB | 0.03 | 0.02 | blup | 57 | 0.02 | 2.4e-03 | 5.2 | -5.4 | 6.2e-08 | -0.53 | 0.06 | 0.19 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MMAB | 0.07 | 0.00 | blup | 57 | 0.02 | 6.6e-03 | 3.0 | -5.3 | 1.3e-07 | -0.56 | 0.04 | 0.25 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MYO1H | 0.08 | 0.04 | lasso | 3 | 0.04 | 3.7e-05 | -5.2 | 5.4 | 5.7e-08 | 0.76 | 0.28 | 0.68 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MMAB | 0.07 | 0.02 | blup | 57 | 0.03 | 4.5e-03 | 5.1 | -5.2 | 1.9e-07 | -0.63 | 0.04 | 0.47 | FALSE |
| 21 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MYO1H | 0.19 | 0.09 | enet | 9 | 0.11 | 3.4e-05 | -4.9 | 5.3 | 1.5e-07 | 0.75 | 0.14 | 0.76 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KCTD10 | 0.30 | 0.20 | enet | 12 | 0.22 | 3.1e-22 | -4.9 | -5.4 | 7.9e-08 | -0.74 | 0.93 | 0.07 | FALSE |
| 23 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MYO1H | 0.09 | 0.12 | lasso | 5 | 0.12 | 5.2e-12 | -4.9 | -5.6 | 2.0e-08 | -0.72 | 0.93 | 0.07 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | KCTD10 | 0.15 | 0.08 | lasso | 6 | 0.08 | 2.1e-08 | 5.9 | -6.6 | 4.0e-11 | -0.74 | 0.04 | 0.96 | TRUE |