Hub : Traits :

Frequency of tiredness / lethargy in last 2 weeks

185 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48012797 50267837 19 1 7.2e-12 3.4e-11 1.000 100 USP4
2 3 166760899 168242895 1 1 1.4e-08 1.4e-05 0.262 93 SERPINI1
3 4 3006043 3514695 1 1 3.1e-08 4.2e-08 0.035 85 C4orf44
4 9 95502571 96898436 1 1 6.8e-09 1.4e-08 1.000 100 RP11-165J3.6
5 11 46033104 47419663 1 1 2.3e-09 3.8e-07 0.072 88 ZNF408
6 11 56742853 58178587 2 2 2.2e-07 4.8e-07 0.271 95 MED19 ZDHHC5
7 12 108763672 110704487 5 1 4.0e-11 2.3e-10 0.029 88 KCTD10
8 14 69272125 69954376 2 2 3.3e-08 6.6e-10 0.093 93 DCAF5 EXD2
9 17 1594359 3287175 3 2 7.1e-09 2.4e-09 0.091 92 PAFAH1B1 RP1-59D14.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 10.05 9 4 8.9 0.98 2.2e-06 DCAF5 EXD2 KCTD10 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Depression (Nagel 2018) 9.49 7 1 2.2 0.99 1.1e-05 C4orf44 DCAF5 EXD2 MED19 RP11-165J3.6 ZDHHC5 ZNF408
Intelligence (Savage-Jansen 2018) 1.71 1 0 0.0 0.00 1.0e+00 ZDHHC5
Neuroticism (Nagel 2018) 11.42 10 5 11.1 0.98 1.1e-06 DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Schizophrenia (2018) 2.28 1 0 0.0 0.00 1.0e+00 ZDHHC5
Schizophrenia vs Biploar Disorder 2.16 1 0 0.0 0.00 1.0e+00 ZDHHC5
Worry (Nagel 2018) 6.16 4 2 4.4 0.99 5.7e-03 KCTD10 RP11-165J3.6 ZDHHC5 ZNF408
Major Depression (MDD) 5.43 2 0 0.0 0.00 1.0e+00 USP4 ZDHHC5
Verbal and Numeric Reasoning (VNR) 2.10 1 0 0.0 0.00 1.0e+00 ZDHHC5
HDL Cholesterol 3.19 1 1 2.2 0.00 1.0e+00 KCTD10
Neuroticism (2016) 6.51 4 0 0.0 0.99 8.3e-03 KCTD10 PAFAH1B1 RP1-59D14.1 ZNF408
Schizophrenia (2014) 2.42 1 0 0.0 0.00 1.0e+00 ZDHHC5
Triglycerides 2.19 1 0 0.0 0.00 1.0e+00 ZNF408
Blood Eosinophil Count 1.58 4 2 4.4 0.36 6.4e-01 KCTD10 MED19 USP4 ZDHHC5
Blood Platelet Count 2.17 4 4 8.9 1.00 2.5e-03 C4orf44 MED19 RP1-59D14.1 ZDHHC5
Blood Red Count 1.31 6 0 0.0 0.26 6.2e-01 DCAF5 EXD2 MED19 RP1-59D14.1 USP4 ZDHHC5
Blood White Count 1.37 2 1 2.2 0.00 1.0e+00 C4orf44 SERPINI1
Heel T-Score 4.28 5 3 6.7 -0.43 4.7e-01 MED19 RP1-59D14.1 USP4 ZDHHC5 ZNF408
BMI 1.51 2 0 0.0 0.00 1.0e+00 C4orf44 EXD2
Height 0.73 4 2 4.4 -0.32 6.8e-01 C4orf44 PAFAH1B1 RP11-165J3.6 ZDHHC5
Waist Hip Ratio (WHR) 1.18 2 1 2.2 0.00 1.0e+00 C4orf44 USP4
Systolic Blood Pressure 4.47 5 4 8.9 0.09 8.9e-01 C4orf44 MED19 PAFAH1B1 ZDHHC5 ZNF408
Smoking Status 2.93 2 1 2.2 0.00 1.0e+00 EXD2 USP4
Cardiovascular Disease 2.11 3 2 4.4 0.00 1.0e+00 C4orf44 SERPINI1 ZNF408
Lung FEV1/FVC ratio 1.27 1 1 2.2 0.00 1.0e+00 ZDHHC5
Neuroticism 11.18 10 6 13.3 0.99 2.1e-07 DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Chronotype (morning person) 2.30 2 0 0.0 0.00 1.0e+00 USP4 ZDHHC5
Hand grip strength (left) 1.34 1 0 0.0 0.00 1.0e+00 ZDHHC5
Sensitivity / hurt feelings 7.25 5 3 6.7 1.00 2.0e-04 DCAF5 EXD2 KCTD10 RP11-165J3.6 ZDHHC5
Frequency of depressed mood in last 2 weeks 8.63 5 0 0.0 1.00 1.3e-04 MED19 PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Hearing difficulty/problems: Yes 3.62 2 0 0.0 0.00 1.0e+00 C4orf44 KCTD10
Systolic blood pressure, automated reading 3.52 4 1 2.2 0.04 9.6e-01 MED19 PAFAH1B1 ZDHHC5 ZNF408
Pack years adult smoking proportion 4.41 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 USP4
Impedance of leg (right) 1.25 1 1 2.2 0.00 1.0e+00 RP1-59D14.1
Leg fat-free mass (left) 0.70 1 0 0.0 0.00 1.0e+00 ZNF408
Trunk fat percentage 2.73 5 0 0.0 1.00 6.3e-06 C4orf44 EXD2 MED19 RP1-59D14.1 ZDHHC5
Townsend deprivation index at recruitment 3.48 1 0 0.0 0.00 1.0e+00 ZDHHC5
Current tobacco smoking 4.76 1 0 0.0 0.00 1.0e+00 EXD2
Fed-up feelings 8.48 6 1 2.2 0.98 7.6e-04 DCAF5 EXD2 PAFAH1B1 USP4 ZDHHC5 ZNF408
Frequency of unenthusiasm / disinterest in last 2 weeks 8.72 5 0 0.0 0.99 4.4e-04 DCAF5 EXD2 MED19 RP11-165J3.6 ZDHHC5
Relative age voice broke 2.26 1 0 0.0 0.00 1.0e+00 USP4
Age when periods started (menarche) 2.74 1 1 2.2 0.00 1.0e+00 USP4
Heel bone mineral density (BMD) T-score, automated (left) 3.37 2 1 2.2 0.00 1.0e+00 USP4 ZNF408
High blood pressure 2.58 2 1 2.2 0.00 1.0e+00 SERPINI1 ZNF408
Stomach or abdominal pain in last month 3.25 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Supplements: Glucosamine 2.61 1 0 0.0 0.00 1.0e+00 ZNF408
Sitting height 1.14 3 1 2.2 0.00 1.0e+00 RP11-165J3.6 ZDHHC5 ZNF408
Body mass index (BMI) 1.91 2 1 2.2 0.00 1.0e+00 C4orf44 EXD2
Impedance of leg (left) 1.34 2 1 2.2 0.00 1.0e+00 RP1-59D14.1 USP4
Leg predicted mass (left) 0.71 1 0 0.0 0.00 1.0e+00 ZNF408
Trunk fat mass 1.76 3 0 0.0 0.00 1.0e+00 C4orf44 EXD2 MED19
Waist circumference 1.71 1 1 2.2 0.00 1.0e+00 C4orf44
Alcohol usually taken with meals 6.00 2 2 4.4 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Nervous feelings 3.92 2 0 0.0 0.00 1.0e+00 KCTD10 ZNF408
Frequency of tenseness / restlessness in last 2 weeks 7.24 4 1 2.2 1.00 5.4e-05 KCTD10 RP11-165J3.6 USP4 ZNF408
Hearing difficulty/problems with background noise 3.34 3 0 0.0 0.00 1.0e+00 KCTD10 PAFAH1B1 ZNF408
Forced vital capacity (FVC) 1.52 1 0 0.0 0.00 1.0e+00 ZNF408
Heel bone mineral density (BMD) T-score, automated (right) 3.81 2 1 2.2 0.00 1.0e+00 USP4 ZNF408
Ever unenthusiastic/disinterested for a whole week 3.03 1 0 0.0 0.00 1.0e+00 USP4
Qualifications: None of the above 3.79 2 0 0.0 0.00 1.0e+00 C4orf44 ZDHHC5
Mouth/teeth dental problems 3.61 1 0 0.0 0.00 1.0e+00 KCTD10
Heart attack 2.36 1 0 0.0 0.00 1.0e+00 EXD2
Allergy 1.05 1 0 0.0 0.00 1.0e+00 KCTD10
Medication: Simvastatin 2.14 1 0 0.0 0.00 1.0e+00 C4orf44
Illnesses of siblings 2.19 1 0 0.0 0.00 1.0e+00 C4orf44
Neuroticism score 11.07 10 6 13.3 0.98 2.5e-07 DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Impedance of arm (right) 1.89 3 1 2.2 0.00 1.0e+00 C4orf44 USP4 ZDHHC5
Arm fat percentage (right) 2.75 4 0 0.0 1.00 4.0e-04 C4orf44 EXD2 MED19 ZDHHC5
Trunk fat-free mass 1.21 2 0 0.0 0.00 1.0e+00 ZDHHC5 ZNF408
Worrier / anxious feelings 5.75 4 1 2.2 0.99 1.1e-02 KCTD10 MED19 RP11-165J3.6 ZDHHC5
Falls in the last year 2.16 1 0 0.0 0.00 1.0e+00 KCTD10
Forced expiratory volume in 1-second (FEV1) 1.89 1 0 0.0 0.00 1.0e+00 ZDHHC5
Pulse rate 2.99 2 0 0.0 0.00 1.0e+00 EXD2 USP4
Mouth/teeth dental problems: Dentures 3.05 1 0 0.0 0.00 1.0e+00 C4orf44
Asthma 1.76 1 0 0.0 0.00 1.0e+00 C4orf44
Medication: Cholesterol lowering 3.04 2 0 0.0 0.00 1.0e+00 C4orf44 EXD2
Forced expiratory volume in 1-second (FEV1), Best measure 2.10 2 0 0.0 0.00 1.0e+00 ZDHHC5 ZNF408
Impedance of arm (left) 2.11 2 1 2.2 0.00 1.0e+00 USP4 ZDHHC5
Arm fat mass (right) 1.91 4 0 0.0 1.00 4.5e-03 C4orf44 EXD2 MED19 SERPINI1
Trunk predicted mass 1.19 2 0 0.0 0.00 1.0e+00 ZDHHC5 ZNF408
Standing height 0.95 5 1 2.2 -0.51 3.8e-01 C4orf44 PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Tense / 'highly strung' 3.88 3 1 2.2 0.00 1.0e+00 RP11-165J3.6 USP4 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 5.62 3 0 0.0 0.00 1.0e+00 RP11-165J3.6 USP4 ZNF408
Birth weight of first child 1.36 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Peak expiratory flow (PEF) 1.82 2 0 0.0 0.00 1.0e+00 KCTD10 ZDHHC5
Medication: Paracetamol 4.95 4 0 0.0 1.00 5.2e-04 DCAF5 KCTD10 RP11-165J3.6 USP4
Headache pain in last month 4.49 1 1 2.2 0.00 1.0e+00 MED19
Medication: Amlodipine 2.72 1 0 0.0 0.00 1.0e+00 ZNF408
Forced vital capacity (FVC), Best measure 1.81 2 0 0.0 0.00 1.0e+00 EXD2 ZNF408
Body fat percentage 3.05 5 1 2.2 1.00 2.9e-04 C4orf44 EXD2 MED19 RP1-59D14.1 ZDHHC5
Leg fat percentage (right) 3.81 4 2 4.4 1.00 4.4e-03 C4orf44 DCAF5 EXD2 RP1-59D14.1
Comparative body size at age 10 1.81 1 1 2.2 0.00 1.0e+00 RP11-165J3.6
Number of full brothers 2.89 1 0 0.0 0.00 1.0e+00 USP4
Worry too long after embarrassment 8.35 6 3 6.7 0.67 1.5e-01 C4orf44 KCTD10 MED19 PAFAH1B1 RP1-59D14.1 ZDHHC5
Wheeze or whistling in the chest in last year 2.44 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Age at first live birth 3.00 2 0 0.0 0.00 1.0e+00 C4orf44 USP4
Qualifications: College or University degree 3.84 6 2 4.4 -1.00 1.8e-05 C4orf44 DCAF5 EXD2 MED19 RP1-59D14.1 ZDHHC5
Medication for pain relief, constipation, heartburn 3.56 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Neck or shoulder pain in last month 4.35 2 0 0.0 0.00 1.0e+00 EXD2 USP4
Medication: Blood pressure 1.29 1 0 0.0 0.00 1.0e+00 ZNF408
Mean time to correctly identify matches 2.34 1 0 0.0 0.00 1.0e+00 ZNF408
Whole body fat mass 1.91 2 0 0.0 0.00 1.0e+00 C4orf44 EXD2
Leg fat mass (right) 2.30 2 1 2.2 0.00 1.0e+00 C4orf44 EXD2
Pulse rate, automated reading 3.88 5 2 4.4 0.38 5.2e-01 C4orf44 KCTD10 RP1-59D14.1 USP4 ZDHHC5
Alcohol intake frequency. 4.45 4 1 2.2 0.99 1.2e-02 C4orf44 DCAF5 MED19 ZDHHC5
Comparative height size at age 10 0.98 2 0 0.0 0.00 1.0e+00 KCTD10 PAFAH1B1
Suffer from 'nerves' 3.12 1 0 0.0 0.00 1.0e+00 ZNF408
Overall health rating 7.91 8 3 6.7 0.97 9.5e-05 DCAF5 EXD2 RP11-165J3.6 RP1-59D14.1 SERPINI1 USP4 ZDHHC5 ZNF408
Chest pain or discomfort 4.04 1 0 0.0 0.00 1.0e+00 USP4
Hypertension (Self-reported) 2.44 1 1 2.2 0.00 1.0e+00 ZNF408
Whole body fat-free mass 0.93 1 0 0.0 0.00 1.0e+00 ZNF408
Leg fat-free mass (right) 0.72 1 0 0.0 0.00 1.0e+00 ZNF408
Arm fat percentage (left) 2.54 4 0 0.0 1.00 1.8e-03 C4orf44 EXD2 MED19 ZDHHC5
Average weekly red wine intake 5.54 3 1 2.2 0.00 1.0e+00 MED19 RP1-59D14.1 ZDHHC5
Mood swings 7.00 5 0 0.0 0.99 6.5e-04 EXD2 KCTD10 RP11-165J3.6 USP4 ZNF408
Loneliness, isolation 6.54 3 0 0.0 0.00 1.0e+00 RP11-165J3.6 ZDHHC5 ZNF408
Qualifications: nursing, teaching 2.33 1 0 0.0 0.00 1.0e+00 ZDHHC5
Osteoarthritis (self-reported) 2.02 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Smoking status: Current 4.25 1 0 0.0 0.00 1.0e+00 EXD2
Whole body water mass 0.90 1 0 0.0 0.00 1.0e+00 ZNF408
Leg predicted mass (right) 0.74 1 0 0.0 0.00 1.0e+00 ZNF408
Arm fat mass (left) 1.82 2 0 0.0 0.00 1.0e+00 C4orf44 MED19
Number of self-reported non-cancer illnesses 3.39 2 0 0.0 0.00 1.0e+00 SERPINI1 ZNF408
Miserableness 8.67 5 4 8.9 0.99 8.0e-04 KCTD10 PAFAH1B1 RP11-165J3.6 USP4 ZNF408
Guilty feelings 6.27 3 0 0.0 0.00 1.0e+00 MED19 PAFAH1B1 ZDHHC5
Medication: Blood pressure 1.78 1 0 0.0 0.00 1.0e+00 ZNF408
High cholesterol (Self-reported) 2.78 1 0 0.0 0.00 1.0e+00 C4orf44
Medication: Paracetamol 3.75 1 0 0.0 0.00 1.0e+00 USP4
Medication: Lisinopril 3.16 2 0 0.0 0.00 1.0e+00 SERPINI1 ZNF408
Ever smoked 1.85 1 0 0.0 0.00 1.0e+00 USP4
Basal metabolic rate 0.75 1 0 0.0 0.00 1.0e+00 ZNF408
Leg fat percentage (left) 3.82 5 2 4.4 0.98 2.5e-03 C4orf44 DCAF5 EXD2 PAFAH1B1 RP1-59D14.1
Irritability 5.27 4 1 2.2 1.00 5.4e-05 KCTD10 MED19 PAFAH1B1 USP4
Ever had prostate specific antigen (PSA) test 2.62 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Diastolic blood pressure, automated reading 1.92 2 0 0.0 0.00 1.0e+00 PAFAH1B1 ZNF408
Ever depressed for a whole week 3.23 1 0 0.0 0.00 1.0e+00 USP4
Unable to work because of sickness or disability 3.17 1 0 0.0 0.00 1.0e+00 ZDHHC5
Commuting to job workplace: Cycle 4.00 1 0 0.0 0.00 1.0e+00 RP1-59D14.1
Vascular/heart problems diagnosed by doctor 2.85 2 1 2.2 0.00 1.0e+00 SERPINI1 ZNF408
Pain experienced in last month 5.91 4 0 0.0 -1.00 1.3e-04 DCAF5 EXD2 KCTD10 RP11-165J3.6
Alcohol drinker status: Previous 3.01 1 0 0.0 0.00 1.0e+00 C4orf44
Pack years of smoking 4.07 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 USP4
Impedance of whole body 1.68 2 1 2.2 0.00 1.0e+00 RP1-59D14.1 USP4
Leg fat mass (left) 2.26 3 1 2.2 0.00 1.0e+00 C4orf44 DCAF5 EXD2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.7
GTEx Adipose Visceral Omentum 4 0.196 1.7
GTEx Adrenal Gland 0 0.000 1.6
GTEx Artery Aorta 4 0.134 1.7
GTEx Artery Coronary 3 0.254 1.7
GTEx Artery Tibial 4 0.106 1.6
GTEx Brain Caudate basal ganglia 3 0.326 1.6
GTEx Brain Cerebellar Hemisphere 1 0.067 1.6
GTEx Brain Cerebellum 2 0.101 1.6
GTEx Brain Cortex 2 0.193 1.7
GTEx Brain Frontal Cortex BA9 4 0.433 1.7
GTEx Brain Hippocampus 1 0.191 1.6
GTEx Brain Hypothalamus 1 0.169 1.6
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.5
GTEx Brain Putamen basal ganglia 2 0.321 1.6
GTEx Breast Mammary Tissue 4 0.203 1.7
GTEx Breast Mammary Tissue (Male) 0 0.000 1.6
GTEx Breast Mammary Tissue (Female) 2 0.122 1.6
GTEx Cells EBV-transformed lymphocytes 3 0.211 1.8
GTEx Cells Transformed fibroblasts 6 0.143 1.7
GTEx Colon Sigmoid 4 0.274 1.7
GTEx Colon Transverse 6 0.291 1.7
GTEx Esophagus Gastroesophageal Junction 3 0.208 1.7
GTEx Esophagus Mucosa 6 0.181 1.6
GTEx Esophagus Muscularis 2 0.062 1.7
GTEx Heart Atrial Appendage 2 0.127 1.7
GTEx Heart Left Ventricle 2 0.131 1.8
GTEx Liver 1 0.139 1.8
GTEx Lung 7 0.244 1.7
GTEx Muscle Skeletal 3 0.104 1.7
GTEx Nerve Tibial 6 0.139 1.7
GTEx Ovary 3 0.330 1.8
GTEx Pancreas 1 0.061 1.7
GTEx Pituitary 3 0.269 1.6
GTEx Prostate 1 0.120 1.6
GTEx Skin Not Sun Exposed Suprapubic 6 0.244 1.8
GTEx Skin Sun Exposed Lower leg 9 0.247 1.7
GTEx Small Intestine Terminal Ileum 1 0.217 1.8
GTEx Spleen 1 0.071 1.6
GTEx Stomach 2 0.138 1.6
GTEx Testis 1 0.032 1.6
GTEx Thyroid 11 0.275 1.7
GTEx Uterus 2 0.353 1.7
GTEx Vagina 1 0.157 1.7
GTEx Whole Blood 2 0.100 1.7
METSIM Adipose 2 0.043 1.6
NTR Blood 1 0.042 1.6
ROSMAP Brain Pre-frontal Cortex 5 0.114 1.6
YFS Blood 4 0.087 1.6
CommonMind Brain Pre-frontal Cortex 3 0.056 1.6
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.6
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.7
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.8
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.6
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.6
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.195 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 4 0.136 1.6
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.6
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.6
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.065 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.5
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.6
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4