Hub : Traits :

Frequency of tiredness / lethargy in last 2 weeks

185 significantly associated models · 35 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	48012797	50267837	19	1	7.2e-12	3.4e-11	1.000	100	USP4
2	3	166760899	168242895	1	1	1.4e-08	1.4e-05	0.262	93	SERPINI1
3	4	3006043	3514695	1	1	3.1e-08	4.2e-08	0.035	85	C4orf44
4	9	95502571	96898436	1	1	6.8e-09	1.4e-08	1.000	100	RP11-165J3.6
5	11	46033104	47419663	1	1	2.3e-09	3.8e-07	0.072	88	ZNF408
6	11	56742853	58178587	2	2	2.2e-07	4.8e-07	0.271	95	MED19 ZDHHC5
7	12	108763672	110704487	5	1	4.0e-11	2.3e-10	0.029	88	KCTD10
8	14	69272125	69954376	2	2	3.3e-08	6.6e-10	0.093	93	DCAF5 EXD2
9	17	1594359	3287175	3	2	7.1e-09	2.4e-09	0.091	92	PAFAH1B1 RP1-59D14.1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Neuroticism (Nagel 2018)	11.42	10	5	11.1	0.98	1.1e-06	DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Neuroticism	11.18	10	6	13.3	0.99	2.1e-07	DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Neuroticism score	11.07	10	6	13.3	0.98	2.5e-07	DCAF5 EXD2 KCTD10 MED19 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Depressed Affect (Nagel 2018)	10.05	9	4	8.9	0.98	2.2e-06	DCAF5 EXD2 KCTD10 PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Depression (Nagel 2018)	9.49	7	1	2.2	0.99	1.1e-05	C4orf44 DCAF5 EXD2 MED19 RP11-165J3.6 ZDHHC5 ZNF408
Frequency of unenthusiasm / disinterest in last 2 weeks	8.72	5	0	0.0	0.99	4.4e-04	DCAF5 EXD2 MED19 RP11-165J3.6 ZDHHC5
Miserableness	8.67	5	4	8.9	0.99	8.0e-04	KCTD10 PAFAH1B1 RP11-165J3.6 USP4 ZNF408
Frequency of depressed mood in last 2 weeks	8.63	5	0	0.0	1.00	1.3e-04	MED19 PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Fed-up feelings	8.48	6	1	2.2	0.98	7.6e-04	DCAF5 EXD2 PAFAH1B1 USP4 ZDHHC5 ZNF408
Worry too long after embarrassment	8.35	6	3	6.7	0.67	1.5e-01	C4orf44 KCTD10 MED19 PAFAH1B1 RP1-59D14.1 ZDHHC5
Overall health rating	7.91	8	3	6.7	0.97	9.5e-05	DCAF5 EXD2 RP11-165J3.6 RP1-59D14.1 SERPINI1 USP4 ZDHHC5 ZNF408
Sensitivity / hurt feelings	7.25	5	3	6.7	1.00	2.0e-04	DCAF5 EXD2 KCTD10 RP11-165J3.6 ZDHHC5
Frequency of tenseness / restlessness in last 2 weeks	7.24	4	1	2.2	1.00	5.4e-05	KCTD10 RP11-165J3.6 USP4 ZNF408
Mood swings	7.00	5	0	0.0	0.99	6.5e-04	EXD2 KCTD10 RP11-165J3.6 USP4 ZNF408
Loneliness, isolation	6.54	3	0	0.0	0.00	1.0e+00	RP11-165J3.6 ZDHHC5 ZNF408
Neuroticism (2016)	6.51	4	0	0.0	0.99	8.3e-03	KCTD10 PAFAH1B1 RP1-59D14.1 ZNF408
Guilty feelings	6.27	3	0	0.0	0.00	1.0e+00	MED19 PAFAH1B1 ZDHHC5
Worry (Nagel 2018)	6.16	4	2	4.4	0.99	5.7e-03	KCTD10 RP11-165J3.6 ZDHHC5 ZNF408
Alcohol usually taken with meals	6.00	2	2	4.4	0.00	1.0e+00	RP1-59D14.1 ZDHHC5
Pain experienced in last month	5.91	4	0	0.0	-1.00	1.3e-04	DCAF5 EXD2 KCTD10 RP11-165J3.6
Worrier / anxious feelings	5.75	4	1	2.2	0.99	1.1e-02	KCTD10 MED19 RP11-165J3.6 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression	5.62	3	0	0.0	0.00	1.0e+00	RP11-165J3.6 USP4 ZNF408
Average weekly red wine intake	5.54	3	1	2.2	0.00	1.0e+00	MED19 RP1-59D14.1 ZDHHC5
Major Depression (MDD)	5.43	2	0	0.0	0.00	1.0e+00	USP4 ZDHHC5
Irritability	5.27	4	1	2.2	1.00	5.4e-05	KCTD10 MED19 PAFAH1B1 USP4
Medication: Paracetamol	4.95	4	0	0.0	1.00	5.2e-04	DCAF5 KCTD10 RP11-165J3.6 USP4
Current tobacco smoking	4.76	1	0	0.0	0.00	1.0e+00	EXD2
Headache pain in last month	4.49	1	1	2.2	0.00	1.0e+00	MED19
Systolic Blood Pressure	4.47	5	4	8.9	0.09	8.9e-01	C4orf44 MED19 PAFAH1B1 ZDHHC5 ZNF408
Alcohol intake frequency.	4.45	4	1	2.2	0.99	1.2e-02	C4orf44 DCAF5 MED19 ZDHHC5
Pack years adult smoking proportion	4.41	2	0	0.0	0.00	1.0e+00	RP1-59D14.1 USP4
Neck or shoulder pain in last month	4.35	2	0	0.0	0.00	1.0e+00	EXD2 USP4
Heel T-Score	4.28	5	3	6.7	-0.43	4.7e-01	MED19 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Smoking status: Current	4.25	1	0	0.0	0.00	1.0e+00	EXD2
Pack years of smoking	4.07	2	0	0.0	0.00	1.0e+00	RP1-59D14.1 USP4
Chest pain or discomfort	4.04	1	0	0.0	0.00	1.0e+00	USP4
Commuting to job workplace: Cycle	4.00	1	0	0.0	0.00	1.0e+00	RP1-59D14.1
Nervous feelings	3.92	2	0	0.0	0.00	1.0e+00	KCTD10 ZNF408
Tense / 'highly strung'	3.88	3	1	2.2	0.00	1.0e+00	RP11-165J3.6 USP4 ZDHHC5
Pulse rate, automated reading	3.88	5	2	4.4	0.38	5.2e-01	C4orf44 KCTD10 RP1-59D14.1 USP4 ZDHHC5
Qualifications: College or University degree	3.84	6	2	4.4	-1.00	1.8e-05	C4orf44 DCAF5 EXD2 MED19 RP1-59D14.1 ZDHHC5
Leg fat percentage (left)	3.82	5	2	4.4	0.98	2.5e-03	C4orf44 DCAF5 EXD2 PAFAH1B1 RP1-59D14.1
Heel bone mineral density (BMD) T-score, automated (right)	3.81	2	1	2.2	0.00	1.0e+00	USP4 ZNF408
Leg fat percentage (right)	3.81	4	2	4.4	1.00	4.4e-03	C4orf44 DCAF5 EXD2 RP1-59D14.1
Qualifications: None of the above	3.79	2	0	0.0	0.00	1.0e+00	C4orf44 ZDHHC5
Medication: Paracetamol	3.75	1	0	0.0	0.00	1.0e+00	USP4
Hearing difficulty/problems: Yes	3.62	2	0	0.0	0.00	1.0e+00	C4orf44 KCTD10
Mouth/teeth dental problems	3.61	1	0	0.0	0.00	1.0e+00	KCTD10
Medication for pain relief, constipation, heartburn	3.56	1	0	0.0	0.00	1.0e+00	RP11-165J3.6
Systolic blood pressure, automated reading	3.52	4	1	2.2	0.04	9.6e-01	MED19 PAFAH1B1 ZDHHC5 ZNF408
Townsend deprivation index at recruitment	3.48	1	0	0.0	0.00	1.0e+00	ZDHHC5
Number of self-reported non-cancer illnesses	3.39	2	0	0.0	0.00	1.0e+00	SERPINI1 ZNF408
Heel bone mineral density (BMD) T-score, automated (left)	3.37	2	1	2.2	0.00	1.0e+00	USP4 ZNF408
Hearing difficulty/problems with background noise	3.34	3	0	0.0	0.00	1.0e+00	KCTD10 PAFAH1B1 ZNF408
Stomach or abdominal pain in last month	3.25	1	0	0.0	0.00	1.0e+00	RP11-165J3.6
Ever depressed for a whole week	3.23	1	0	0.0	0.00	1.0e+00	USP4
HDL Cholesterol	3.19	1	1	2.2	0.00	1.0e+00	KCTD10
Unable to work because of sickness or disability	3.17	1	0	0.0	0.00	1.0e+00	ZDHHC5
Medication: Lisinopril	3.16	2	0	0.0	0.00	1.0e+00	SERPINI1 ZNF408
Suffer from 'nerves'	3.12	1	0	0.0	0.00	1.0e+00	ZNF408
Mouth/teeth dental problems: Dentures	3.05	1	0	0.0	0.00	1.0e+00	C4orf44
Body fat percentage	3.05	5	1	2.2	1.00	2.9e-04	C4orf44 EXD2 MED19 RP1-59D14.1 ZDHHC5
Medication: Cholesterol lowering	3.04	2	0	0.0	0.00	1.0e+00	C4orf44 EXD2
Ever unenthusiastic/disinterested for a whole week	3.03	1	0	0.0	0.00	1.0e+00	USP4
Alcohol drinker status: Previous	3.01	1	0	0.0	0.00	1.0e+00	C4orf44
Age at first live birth	3.00	2	0	0.0	0.00	1.0e+00	C4orf44 USP4
Pulse rate	2.99	2	0	0.0	0.00	1.0e+00	EXD2 USP4
Smoking Status	2.93	2	1	2.2	0.00	1.0e+00	EXD2 USP4
Number of full brothers	2.89	1	0	0.0	0.00	1.0e+00	USP4
Vascular/heart problems diagnosed by doctor	2.85	2	1	2.2	0.00	1.0e+00	SERPINI1 ZNF408
High cholesterol (Self-reported)	2.78	1	0	0.0	0.00	1.0e+00	C4orf44
Arm fat percentage (right)	2.75	4	0	0.0	1.00	4.0e-04	C4orf44 EXD2 MED19 ZDHHC5
Age when periods started (menarche)	2.74	1	1	2.2	0.00	1.0e+00	USP4
Trunk fat percentage	2.73	5	0	0.0	1.00	6.3e-06	C4orf44 EXD2 MED19 RP1-59D14.1 ZDHHC5
Medication: Amlodipine	2.72	1	0	0.0	0.00	1.0e+00	ZNF408
Ever had prostate specific antigen (PSA) test	2.62	1	0	0.0	0.00	1.0e+00	PAFAH1B1
Supplements: Glucosamine	2.61	1	0	0.0	0.00	1.0e+00	ZNF408
High blood pressure	2.58	2	1	2.2	0.00	1.0e+00	SERPINI1 ZNF408
Arm fat percentage (left)	2.54	4	0	0.0	1.00	1.8e-03	C4orf44 EXD2 MED19 ZDHHC5
Wheeze or whistling in the chest in last year	2.44	1	0	0.0	0.00	1.0e+00	RP11-165J3.6
Hypertension (Self-reported)	2.44	1	1	2.2	0.00	1.0e+00	ZNF408
Schizophrenia (2014)	2.42	1	0	0.0	0.00	1.0e+00	ZDHHC5
Heart attack	2.36	1	0	0.0	0.00	1.0e+00	EXD2
Mean time to correctly identify matches	2.34	1	0	0.0	0.00	1.0e+00	ZNF408
Qualifications: nursing, teaching	2.33	1	0	0.0	0.00	1.0e+00	ZDHHC5
Chronotype (morning person)	2.30	2	0	0.0	0.00	1.0e+00	USP4 ZDHHC5
Leg fat mass (right)	2.30	2	1	2.2	0.00	1.0e+00	C4orf44 EXD2
Schizophrenia (2018)	2.28	1	0	0.0	0.00	1.0e+00	ZDHHC5
Relative age voice broke	2.26	1	0	0.0	0.00	1.0e+00	USP4
Leg fat mass (left)	2.26	3	1	2.2	0.00	1.0e+00	C4orf44 DCAF5 EXD2
Triglycerides	2.19	1	0	0.0	0.00	1.0e+00	ZNF408
Illnesses of siblings	2.19	1	0	0.0	0.00	1.0e+00	C4orf44
Blood Platelet Count	2.17	4	4	8.9	1.00	2.5e-03	C4orf44 MED19 RP1-59D14.1 ZDHHC5
Schizophrenia vs Biploar Disorder	2.16	1	0	0.0	0.00	1.0e+00	ZDHHC5
Falls in the last year	2.16	1	0	0.0	0.00	1.0e+00	KCTD10
Medication: Simvastatin	2.14	1	0	0.0	0.00	1.0e+00	C4orf44
Cardiovascular Disease	2.11	3	2	4.4	0.00	1.0e+00	C4orf44 SERPINI1 ZNF408
Impedance of arm (left)	2.11	2	1	2.2	0.00	1.0e+00	USP4 ZDHHC5
Verbal and Numeric Reasoning (VNR)	2.10	1	0	0.0	0.00	1.0e+00	ZDHHC5
Forced expiratory volume in 1-second (FEV1), Best measure	2.10	2	0	0.0	0.00	1.0e+00	ZDHHC5 ZNF408
Osteoarthritis (self-reported)	2.02	1	0	0.0	0.00	1.0e+00	RP11-165J3.6
Diastolic blood pressure, automated reading	1.92	2	0	0.0	0.00	1.0e+00	PAFAH1B1 ZNF408
Body mass index (BMI)	1.91	2	1	2.2	0.00	1.0e+00	C4orf44 EXD2
Arm fat mass (right)	1.91	4	0	0.0	1.00	4.5e-03	C4orf44 EXD2 MED19 SERPINI1
Whole body fat mass	1.91	2	0	0.0	0.00	1.0e+00	C4orf44 EXD2
Impedance of arm (right)	1.89	3	1	2.2	0.00	1.0e+00	C4orf44 USP4 ZDHHC5
Forced expiratory volume in 1-second (FEV1)	1.89	1	0	0.0	0.00	1.0e+00	ZDHHC5
Ever smoked	1.85	1	0	0.0	0.00	1.0e+00	USP4
Peak expiratory flow (PEF)	1.82	2	0	0.0	0.00	1.0e+00	KCTD10 ZDHHC5
Arm fat mass (left)	1.82	2	0	0.0	0.00	1.0e+00	C4orf44 MED19
Forced vital capacity (FVC), Best measure	1.81	2	0	0.0	0.00	1.0e+00	EXD2 ZNF408
Comparative body size at age 10	1.81	1	1	2.2	0.00	1.0e+00	RP11-165J3.6
Medication: Blood pressure	1.78	1	0	0.0	0.00	1.0e+00	ZNF408
Trunk fat mass	1.76	3	0	0.0	0.00	1.0e+00	C4orf44 EXD2 MED19
Asthma	1.76	1	0	0.0	0.00	1.0e+00	C4orf44
Intelligence (Savage-Jansen 2018)	1.71	1	0	0.0	0.00	1.0e+00	ZDHHC5
Waist circumference	1.71	1	1	2.2	0.00	1.0e+00	C4orf44
Impedance of whole body	1.68	2	1	2.2	0.00	1.0e+00	RP1-59D14.1 USP4
Blood Eosinophil Count	1.58	4	2	4.4	0.36	6.4e-01	KCTD10 MED19 USP4 ZDHHC5
Forced vital capacity (FVC)	1.52	1	0	0.0	0.00	1.0e+00	ZNF408
BMI	1.51	2	0	0.0	0.00	1.0e+00	C4orf44 EXD2
Blood White Count	1.37	2	1	2.2	0.00	1.0e+00	C4orf44 SERPINI1
Birth weight of first child	1.36	1	0	0.0	0.00	1.0e+00	PAFAH1B1
Hand grip strength (left)	1.34	1	0	0.0	0.00	1.0e+00	ZDHHC5
Impedance of leg (left)	1.34	2	1	2.2	0.00	1.0e+00	RP1-59D14.1 USP4
Blood Red Count	1.31	6	0	0.0	0.26	6.2e-01	DCAF5 EXD2 MED19 RP1-59D14.1 USP4 ZDHHC5
Medication: Blood pressure	1.29	1	0	0.0	0.00	1.0e+00	ZNF408
Lung FEV1/FVC ratio	1.27	1	1	2.2	0.00	1.0e+00	ZDHHC5
Impedance of leg (right)	1.25	1	1	2.2	0.00	1.0e+00	RP1-59D14.1
Trunk fat-free mass	1.21	2	0	0.0	0.00	1.0e+00	ZDHHC5 ZNF408
Trunk predicted mass	1.19	2	0	0.0	0.00	1.0e+00	ZDHHC5 ZNF408
Waist Hip Ratio (WHR)	1.18	2	1	2.2	0.00	1.0e+00	C4orf44 USP4
Sitting height	1.14	3	1	2.2	0.00	1.0e+00	RP11-165J3.6 ZDHHC5 ZNF408
Allergy	1.05	1	0	0.0	0.00	1.0e+00	KCTD10
Comparative height size at age 10	0.98	2	0	0.0	0.00	1.0e+00	KCTD10 PAFAH1B1
Standing height	0.95	5	1	2.2	-0.51	3.8e-01	C4orf44 PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Whole body fat-free mass	0.93	1	0	0.0	0.00	1.0e+00	ZNF408
Whole body water mass	0.90	1	0	0.0	0.00	1.0e+00	ZNF408
Basal metabolic rate	0.75	1	0	0.0	0.00	1.0e+00	ZNF408
Leg predicted mass (right)	0.74	1	0	0.0	0.00	1.0e+00	ZNF408
Height	0.73	4	2	4.4	-0.32	6.8e-01	C4orf44 PAFAH1B1 RP11-165J3.6 ZDHHC5
Leg fat-free mass (right)	0.72	1	0	0.0	0.00	1.0e+00	ZNF408
Leg predicted mass (left)	0.71	1	0	0.0	0.00	1.0e+00	ZNF408
Leg fat-free mass (left)	0.70	1	0	0.0	0.00	1.0e+00	ZNF408

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Cells EBV-transformed lymphocytes	3	0.211	1.8
GTEx	Heart Left Ventricle	2	0.131	1.8
GTEx	Liver	1	0.139	1.8
GTEx	Ovary	3	0.330	1.8
GTEx	Skin Not Sun Exposed Suprapubic	6	0.244	1.8
GTEx	Small Intestine Terminal Ileum	1	0.217	1.8
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.8
GTEx	Adipose Subcutaneous	6	0.172	1.7
GTEx	Adipose Visceral Omentum	4	0.196	1.7
GTEx	Artery Aorta	4	0.134	1.7
GTEx	Artery Coronary	3	0.254	1.7
GTEx	Brain Cortex	2	0.193	1.7
GTEx	Brain Frontal Cortex BA9	4	0.433	1.7
GTEx	Breast Mammary Tissue	4	0.203	1.7
GTEx	Cells Transformed fibroblasts	6	0.143	1.7
GTEx	Colon Sigmoid	4	0.274	1.7
GTEx	Colon Transverse	6	0.291	1.7
GTEx	Esophagus Gastroesophageal Junction	3	0.208	1.7
GTEx	Esophagus Muscularis	2	0.062	1.7
GTEx	Heart Atrial Appendage	2	0.127	1.7
GTEx	Lung	7	0.244	1.7
GTEx	Muscle Skeletal	3	0.104	1.7
GTEx	Nerve Tibial	6	0.139	1.7
GTEx	Pancreas	1	0.061	1.7
GTEx	Skin Sun Exposed Lower leg	9	0.247	1.7
GTEx	Thyroid	11	0.275	1.7
GTEx	Uterus	2	0.353	1.7
GTEx	Vagina	1	0.157	1.7
GTEx	Whole Blood	2	0.100	1.7
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.7
GTEx	Adrenal Gland	0	0.000	1.6
GTEx	Artery Tibial	4	0.106	1.6
GTEx	Brain Caudate basal ganglia	3	0.326	1.6
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.6
GTEx	Brain Cerebellum	2	0.101	1.6
GTEx	Brain Hippocampus	1	0.191	1.6
GTEx	Brain Hypothalamus	1	0.169	1.6
GTEx	Brain Putamen basal ganglia	2	0.321	1.6
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.6
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.6
GTEx	Esophagus Mucosa	6	0.181	1.6
GTEx	Pituitary	3	0.269	1.6
GTEx	Prostate	1	0.120	1.6
GTEx	Spleen	1	0.071	1.6
GTEx	Stomach	2	0.138	1.6
GTEx	Testis	1	0.032	1.6
METSIM	Adipose	2	0.043	1.6
NTR	Blood	1	0.042	1.6
ROSMAP	Brain Pre-frontal Cortex	5	0.114	1.6
YFS	Blood	4	0.087	1.6
CommonMind	Brain Pre-frontal Cortex	3	0.056	1.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.6
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.6
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.195	1.6
The Cancer Genome Atlas	Lung Adenocarcinoma	4	0.136	1.6
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.6
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.6
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4