Hub : Genes

CALCOCO2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.2470 0.0830 3.0e-03 0.078 NA 0.108 NA 0.094 2.6e-03 NA 4.3e-04 NA 1.0e-03
2 GTEx Testis 0.2600 0.0790 3.8e-04 0.243 NA 0.205 NA 0.236 4.0e-11 NA 1.7e-09 NA 8.2e-11
3 TCGA Brain Lower Grade Glioma 0.0259 0.0147 2.4e-03 0.002 0.011 0.007 NA 0.005 1.6e-01 2.0e-02 4.7e-02 NA 8.8e-02
4 TCGA Lung Adenocarcinoma 0.0362 0.0220 3.2e-03 0.028 0.021 0.013 NA 0.019 2.9e-04 1.6e-03 1.0e-02 NA 2.6e-03
5 TCGA Prostate Adenocarcinoma 0.0773 0.0315 1.1e-07 0.028 0.067 0.062 NA 0.026 5.4e-04 1.4e-07 5.0e-07 NA 9.6e-04
6 TCGA Thyroid Carcinoma 0.0710 0.0340 7.6e-06 0.045 0.056 0.061 NA 0.050 3.1e-05 4.0e-06 1.3e-06 NA 1.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.4 0.9 -1.0 -0.6 0.7 -0.4 0.1 0.5
Bipolar Disorder or Schizophrenia 0.4 1.1 3.0 -0.1 -1.2 1.7 -0.9 -0.7 0.9
Depressed Affect (Nagel 2018) 0.5 1.1 2.3 -0.2 1.1 1.5 0.9 0.6 1.2
Depression (Nagel 2018) 1.3 2.0 2.7 -1.0 1.5 0.9 1.7 1.6 1.5
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.6 -0.6 1.3 -1.9 1.2 1.1 -0.8
Neuroticism (Nagel 2018) 0.7 1.6 5.9 -0.2 0.7 2.4 0.4 0.5 1.7
Schizophrenia (2018) 0.5 1.1 2.7 0.6 -1.0 1.7 -0.8 -1.0 0.7
Schizophrenia vs Biploar Disorder 1.6 2.1 6.9 0.0 -0.3 2.6 0.7 0.2 2.2
Worry (Nagel 2018) 0.4 0.7 2.5 -0.1 -0.6 1.6 -0.9 -0.1 0.9
Alzheimer’s Disease (in mother) 0.9 1.0 2.4 0.7 1.6 -1.3 0.2 -0.3 -1.3
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.2 0.2 0.0 0.4 0.5 0.6
Alzheimer’s Disease (including proxy) 0.6 0.8 2.9 0.4 1.7 -0.6 1.0 0.5 -0.3
Crohns Disease (2017) 4.0 8.9 16.3 -3.1 2.2 1.3 4.0 3.7 2.6
Irritable Bowel Disease (IBD) 1.2 2.8 5.9 -1.4 1.9 0.2 2.4 1.9 1.4
Ulcerative Colitis (UC) 0.2 0.3 0.9 0.6 0.9 -0.7 0.1 -0.2 -0.3
Major Depression (MDD) 0.1 0.1 0.5 0.3 0.2 0.7 -0.1 -0.1 -0.2
Reaction Time 0.3 0.5 1.4 -1.2 0.0 -0.8 0.1 0.9 -0.0
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.2 -0.6 0.9 -1.5 0.7 0.8 -0.9
Breast Cancer 0.0 0.1 0.3 0.5 0.0 -0.2 -0.4 -0.3 0.1
Ovarian Cancer 0.8 1.0 2.4 -1.5 0.1 0.3 0.6 1.6 1.0
Prostate Cancer 0.6 0.8 2.1 -0.4 0.1 -1.4 0.8 0.0 -1.4
Age at First Birth 1.2 1.7 3.2 0.6 -1.5 -1.1 -1.8 -1.5 -1.1
Bipolar Disorder (2011) 0.2 0.2 0.5 -0.2 0.1 -0.7 -0.1 0.3 -0.5
Body Mass Index (BMI) (2010) 2.8 3.8 4.8 -2.2 0.9 2.0 2.0 2.1 2.2
Coronary Artery Disease (CAD) 1.9 2.2 10.8 0.2 0.5 3.3 0.0 0.2 1.5
Crohns Disease (2012) 7.5 12.1 19.0 -3.3 2.8 2.2 4.3 4.4 3.4
Mean Putamen Volume 0.4 0.4 0.9 -1.0 -0.3 -0.5 0.9 0.6 0.2
Fasting Glucose 0.6 0.7 1.3 1.1 -0.9 0.0 -0.5 -1.0 -0.8
HbA1C 1.0 1.1 2.3 -0.2 1.5 1.4 1.5 0.5 -0.1
HDL Cholesterol 1.4 2.3 4.5 1.4 -1.1 -2.1 -1.2 -1.4 -1.7
LDL Cholesterol 0.2 0.3 0.9 -0.6 -0.4 1.0 -0.2 0.2 0.3
Lupus 1.5 2.3 4.1 1.4 -0.8 -2.0 -0.8 -1.6 -2.0
Neuroticism (2016) 0.7 1.1 2.4 0.3 -1.2 1.5 -1.1 -1.0 0.5
Primary Biliary Cirrhosis 1.0 1.4 3.6 -1.9 0.3 -0.0 1.3 1.4 0.9
Rheumatoid Arthritis 1.1 1.5 4.1 -0.6 1.5 0.3 2.0 1.4 0.6
Schizophrenia (2014) 0.6 1.4 4.4 -0.2 -1.3 2.1 -0.4 -0.5 1.2
Triglycerides 0.8 1.2 3.1 -0.6 1.8 0.2 1.4 1.3 0.5
Type 2 Diabetes (T2D) (2012) 1.4 1.6 7.2 0.0 -0.3 2.7 -0.4 -0.2 1.4
Ulcerative Colitis 0.4 0.6 1.8 0.8 1.4 -0.9 0.5 0.1 0.1
Blood Eosinophil Count 0.6 4.9 17.3 0.0 1.6 -4.2 2.2 1.0 -2.0
Blood Platelet Count 1.5 17.7 41.7 2.0 -3.0 -6.5 -3.0 -3.9 -5.3
Blood Red Count 0.6 6.1 9.8 -2.4 1.4 2.8 2.1 2.6 3.1
Blood White Count 0.7 5.4 12.5 3.5 -1.4 -0.1 -2.4 -3.1 -1.5
Heel T-Score 0.4 3.0 6.4 1.9 -1.6 0.3 -2.5 -2.1 -0.7
BMI 5.4 31.5 60.7 -4.8 2.0 7.8 4.5 4.8 7.6
Height 2.6 50.9 141.6 -2.0 6.8 -11.9 8.0 4.5 -5.4
Waist Hip Ratio (WHR) 1.1 4.9 7.7 2.0 -1.5 -2.0 -2.8 -2.4 -2.5
Systolic Blood Pressure 1.2 5.8 13.1 3.3 -1.0 2.1 -2.4 -3.6 -0.5
Smoking Status 1.1 2.6 4.5 -1.3 0.3 2.1 1.9 1.3 1.9
Allergy or Eczema 0.0 0.1 0.5 -0.2 -0.2 0.7 -0.0 0.0 -0.0
Cardiovascular Disease 2.3 7.5 28.2 -0.7 -0.5 5.3 0.3 0.4 4.0
Hypothyroidism (self reported) 4.5 10.3 18.7 -2.8 1.4 4.0 2.6 3.3 4.3
Respiratory disease 0.4 1.0 2.3 -0.2 1.0 -1.5 0.9 0.5 -1.2
Type 2 Diabetes (T2D) (2018) 1.3 2.5 10.6 1.0 -0.6 3.3 -0.3 -0.4 1.6
Lung FEV1/FVC ratio 0.8 4.0 11.9 3.5 -0.6 0.2 -2.0 -2.7 -0.7
Lung FVC 0.1 0.7 2.9 -0.4 1.7 0.4 0.7 0.8 0.2
Neuroticism 0.7 1.8 6.5 -0.3 -1.1 2.5 -0.5 -0.3 1.6
Chronotype (morning person) 7.4 17.0 23.3 -4.2 2.1 3.7 4.6 4.7 4.8
Hair Pigment 0.0 0.6 1.7 1.3 -0.0 -0.2 0.9 0.9 0.6
Tanning 0.4 5.1 12.2 2.0 -0.1 -3.5 -1.4 -1.9 -2.9
Hand grip strength (left) 2.8 7.4 13.2 -2.4 2.9 0.1 3.1 3.6 2.8
Number of treatments/medications taken 2.0 3.6 9.0 -1.5 0.5 3.0 1.5 1.5 2.3
Average weekly spirits intake 2.1 2.6 4.7 -2.0 -0.1 1.8 1.3 1.5 2.2
Sensitivity / hurt feelings 2.2 3.8 13.7 -0.5 0.1 3.7 0.4 0.5 2.9
Frequency of depressed mood in last 2 weeks 2.2 3.1 5.3 -2.3 0.2 1.9 1.3 1.8 2.2
Hearing difficulty/problems: Yes 1.8 2.8 4.7 -1.3 2.1 0.7 2.0 2.2 1.2
Relative age of first facial hair 0.9 1.8 4.9 0.3 2.2 -0.7 1.8 1.3 0.4
Other serious medical condition/disability diagnosed by doctor 1.9 2.5 6.6 -1.2 1.8 0.2 2.6 1.7 0.8
Ever used hormone-replacement therapy (HRT) 2.7 3.4 5.2 2.2 -0.8 -2.2 -1.3 -1.9 -2.3
Ever had hysterectomy (womb removed) 2.2 2.5 3.9 1.5 -2.0 -0.5 -1.8 -2.0 -1.3
Systolic blood pressure, automated reading 1.1 3.2 7.5 2.6 -0.5 1.2 -1.6 -2.7 -0.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.1 0.9 0.6 0.7 0.4 -0.2
Angina 0.7 0.9 1.8 0.1 0.7 1.3 1.3 0.7 0.8
Medication for hormone replacement therapy 2.8 3.1 5.8 2.1 -1.2 -1.2 -1.5 -1.9 -2.4
Vitamin and mineral supplements 0.2 0.3 1.0 1.0 0.8 -0.4 0.2 -0.2 -0.1
Supplements: Zinc 1.6 1.7 3.1 -1.8 1.0 0.8 1.4 1.6 1.0
Medication: Co-codamol 1.4 1.6 3.2 -0.4 1.0 1.8 0.9 1.6 1.3
Medication: Metformin 0.9 1.3 3.7 1.0 -1.4 1.9 -0.6 -1.0 0.1
Diabetes (father) 3.5 4.3 12.0 -0.4 1.0 3.5 1.2 0.8 3.2
Diabetes (mother) 1.0 1.2 3.6 1.9 1.7 0.6 0.2 -0.5 0.1
Severe depression (siblings) 0.9 1.0 2.0 0.9 -1.0 -0.5 -0.8 -1.4 -0.9
Pack years adult smoking proportion 1.2 1.8 7.0 -0.1 -0.0 2.6 -0.2 0.1 2.0
Impedance of leg (right) 5.9 28.4 44.2 5.6 -1.5 -6.2 -4.4 -5.9 -6.7
Leg fat-free mass (left) 6.1 32.3 59.3 -5.7 4.5 2.3 7.7 7.2 5.0
Trunk fat percentage 1.0 4.0 7.3 -1.4 0.6 2.7 2.5 1.3 2.5
Hand grip strength (right) 1.1 3.0 5.7 -1.2 2.4 -1.4 1.9 2.1 0.9
Townsend deprivation index at recruitment 2.5 3.6 5.8 1.4 -2.4 -1.0 -2.2 -2.3 -1.5
Current tobacco smoking 1.9 3.0 7.8 -1.4 -1.3 2.8 0.9 0.9 2.3
Average weekly fortified wine intake 0.1 0.1 0.1 -0.0 -0.3 -0.2 -0.3 -0.1 -0.4
Maternal smoking around birth 0.6 0.9 2.4 1.6 0.4 -0.3 -0.8 -1.3 -0.5
Fed-up feelings 0.9 1.7 6.9 -0.2 -0.4 2.6 0.1 -0.4 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.3 -0.6 0.5 1.2 0.7 0.9 1.5
Relative age voice broke 0.3 0.5 1.4 0.1 1.2 0.2 1.0 0.5 0.2
Taking other prescription medications 0.4 0.6 1.6 -0.4 0.1 1.3 1.0 0.5 0.8
Age when periods started (menarche) 0.1 0.2 0.6 0.8 0.1 -0.1 -0.6 -0.7 0.2
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.0 0.5 -0.3 1.0 -0.6 -0.7 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.3 2.1 1.4 -1.1 -0.4 -1.0 -1.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 0.6 -1.3 -0.8 -1.1 -1.5 -1.0
Qualifications: CSEs or equivalent 0.4 0.5 1.5 0.9 1.2 0.7 -0.3 -0.5 -0.3
Serious illness, injury or assault to yourself 0.4 0.4 0.8 -0.8 0.2 0.9 0.6 0.4 0.8
High blood pressure 2.7 7.4 24.2 -1.8 0.1 4.9 1.6 1.3 3.6
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.3 -0.6 -0.2 1.1 0.0 0.5 0.7
Multivitamins +/- minerals 0.4 0.5 1.8 -1.3 -0.2 0.5 0.4 0.8 0.4
Stomach or abdominal pain in last month 0.6 0.8 1.8 -0.8 1.3 0.4 1.0 1.0 0.4
Supplements: Glucosamine 1.1 1.4 3.5 -0.6 -1.1 -1.9 0.1 -0.3 -1.8
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.6 -0.0 1.6 0.3 1.4 0.8 0.4
Medication: Atenolol 1.5 1.8 4.8 -1.4 -0.7 2.2 0.4 1.1 1.6
Medication: Levothyroxine sodium 3.0 5.1 7.8 -1.3 2.0 2.8 2.3 2.1 2.7
Sitting height 2.8 20.1 44.1 0.2 5.9 -6.6 5.2 2.8 -2.5
Chronic bronchitis/emphysema (father) 0.4 0.4 1.6 0.8 1.3 0.1 0.6 0.2 0.1
High blood pressure (mother) 4.2 5.8 21.5 -1.5 -2.0 4.6 -0.5 0.2 2.6
Body mass index (BMI) 4.1 17.6 36.1 -3.9 0.6 6.0 3.2 3.5 5.7
Impedance of leg (left) 7.1 34.5 49.6 6.3 -2.2 -6.3 -5.4 -6.7 -7.0
Leg predicted mass (left) 6.2 33.1 60.1 -5.8 4.6 2.3 7.8 7.3 5.0
Trunk fat mass 2.1 9.2 19.1 -2.7 1.9 2.4 4.4 3.1 3.2
Waist circumference 2.1 7.5 11.9 -2.9 0.6 3.1 2.8 2.6 3.4
Number of incorrect matches in round 2.4 4.0 8.3 2.9 -1.1 0.0 -2.3 -2.4 -1.7
Past tobacco smoking 1.5 2.7 6.3 1.7 -0.8 -1.4 -2.5 -1.7 -1.4
Alcohol usually taken with meals 1.2 1.9 5.0 1.7 1.2 -2.2 0.2 -0.5 -1.3
Nervous feelings 0.8 1.5 4.4 -0.7 -1.2 2.1 -0.7 -0.0 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.2 -0.2 0.2 0.5 0.3 0.2 0.4
Hearing difficulty/problems with background noise 2.4 3.8 8.1 -1.6 1.1 2.8 1.6 1.7 2.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 -0.3 -0.6 -0.1 -0.3 -0.1 0.0
Had menopause 0.6 0.7 1.6 1.0 0.2 -1.2 -0.2 -0.7 -1.3
Had other major operations 0.1 0.1 0.4 0.2 -0.6 -0.1 -0.1 -0.3 -0.2
Forced vital capacity (FVC) 2.1 8.1 15.6 -1.7 4.0 -2.6 3.8 3.0 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 5.2 2.3 1.3 -1.6 -0.6 -1.1 -1.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 0.2 1.4 -0.9 1.0 0.7 -0.3
Qualifications: None of the above 1.3 2.8 6.7 1.6 -1.5 2.6 -1.4 -1.3 1.2
Financial difficulties in last 2 years 0.2 0.3 0.7 0.3 -0.8 -0.2 -0.5 -0.7 -0.4
Mouth/teeth dental problems 1.1 1.7 4.1 -0.1 1.9 -2.0 1.0 1.1 -0.5
Heart attack 2.2 2.8 4.5 -1.0 1.2 2.1 1.5 1.8 2.0
Allergy 0.2 0.6 1.4 1.2 0.2 -0.9 -0.4 -0.8 -0.5
Pain all over the body in last month 1.8 1.9 3.4 1.8 -0.6 -0.9 -1.6 -1.8 -1.2
Diabetes (self-reported) 0.8 1.2 5.8 0.6 0.1 2.4 0.3 0.1 1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.1 -0.4 -0.0 -1.0 -0.4 0.0 -0.4
Medication: Ramipril 0.9 1.1 2.6 -1.0 0.2 1.6 0.6 0.6 1.5
Medication: Simvastatin 2.1 3.1 9.2 -0.5 -2.3 3.0 -0.9 -0.4 1.6
Fluid intelligence score 0.6 1.3 2.2 -0.5 1.5 -1.4 1.3 1.1 -0.6
Illnesses of siblings 0.9 1.3 4.9 -0.7 -1.0 -2.2 -0.5 0.1 -1.1
Neuroticism score 0.9 1.8 6.6 -0.3 -0.8 2.6 -0.4 -0.3 1.8
Weight 4.2 20.5 39.6 -4.6 3.3 2.3 6.3 5.3 4.2
Impedance of arm (right) 3.1 14.6 22.7 4.2 -1.3 -3.9 -3.2 -4.5 -4.8
Arm fat percentage (right) 2.4 9.3 25.4 -2.4 -0.2 5.0 2.1 1.7 4.2
Trunk fat-free mass 4.7 26.7 55.2 -5.2 4.7 -0.4 7.4 6.8 3.1
Hip circumference 2.9 12.4 21.2 -3.8 1.8 2.6 4.6 3.9 3.7
Time employed in main current job 3.6 4.2 9.9 -1.5 1.9 0.9 3.1 2.5 1.7
Alcohol intake versus 10 years previously 0.2 0.3 0.7 0.4 -0.6 0.6 -0.8 -0.7 0.1
Father’s age at death 0.9 1.2 3.9 -0.1 1.1 -2.0 0.8 0.2 -1.1
Worrier / anxious feelings 0.9 1.7 4.2 1.3 -0.8 1.3 -2.0 -1.3 0.4
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 10.3 0.3 -1.6 3.2 -1.2 -1.1 1.7
Falls in the last year 0.3 0.4 1.7 -0.1 -0.3 1.3 0.3 0.0 0.8
Hair/balding pattern: Pattern 3 0.2 0.4 0.6 -0.5 0.8 0.4 0.3 0.6 0.8
Number of live births 0.2 0.3 0.8 0.6 0.0 0.9 -0.3 -0.7 -0.1
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 8.8 -0.3 3.0 -2.4 2.3 1.7 -0.5
Pulse rate 1.0 1.6 4.4 0.9 -2.1 0.3 -1.5 -1.5 -0.1
Happiness 0.7 0.9 2.0 -0.9 0.3 1.4 0.5 1.0 1.0
Noisy workplace 1.5 1.8 3.5 -0.8 0.8 1.9 1.0 1.3 1.8
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.7 -1.0 -0.8 -1.3 -0.6 -0.1 -0.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.9 -1.7 -0.3 0.6 0.8 1.2 1.1
Mouth/teeth dental problems: Dentures 1.1 1.8 4.1 -1.0 -1.6 2.0 0.6 0.5 1.5
Asthma 0.4 0.9 2.9 -0.5 0.3 -1.7 0.7 0.4 -1.2
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 3.3 -1.6 0.9 0.6 1.1 1.8 0.8
Medication: Cholesterol lowering 1.7 2.6 6.8 -0.9 -2.4 2.6 -0.9 -0.3 1.1
Depression (self-reported) 0.4 0.5 1.8 1.4 0.2 0.3 -0.2 -0.7 -0.6
Medication: Lansoprazole 1.1 1.2 4.3 0.8 2.1 -0.5 1.3 0.6 -0.2
Prospective memory result 0.3 0.4 0.5 0.7 -0.7 0.7 -0.6 -0.6 -0.2
Lung cancer (father) 0.6 0.7 1.4 -1.2 -0.7 0.7 1.0 0.9 0.3
Illnesses of mother 2.3 2.8 11.5 -0.2 0.8 -3.4 1.0 0.8 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 5.6 -1.0 2.4 -1.4 2.3 1.9 0.2
Pulse wave Arterial Stiffness index 0.1 0.1 0.4 -0.2 0.0 -0.2 0.4 -0.1 -0.7
Impedance of arm (left) 3.8 17.7 27.6 4.6 -1.4 -4.5 -3.6 -4.8 -5.3
Arm fat mass (right) 3.6 15.0 22.9 -3.8 1.4 4.4 4.2 3.7 4.8
Trunk predicted mass 4.6 26.2 54.2 -5.2 4.6 -0.3 7.4 6.7 3.1
Standing height 3.1 30.8 64.3 -1.9 6.1 -8.0 7.1 4.3 -3.1
Length of working week for main job 0.2 0.2 1.0 -1.0 -0.2 -0.5 0.3 0.3 0.0
Exposure to tobacco smoke at home 0.2 0.2 1.0 1.0 -0.2 -0.2 -0.2 -0.4 0.1
Breastfed as a baby 2.8 3.5 9.6 1.1 -0.7 -3.1 -1.0 -1.5 -2.5
Tense / ‘highly strung’ 0.0 0.1 0.2 -0.4 -0.1 -0.0 0.1 0.4 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.8 1.2 -0.3 0.1 -1.1 -1.2 -1.3
Hair/balding pattern: Pattern 4 2.1 5.1 9.5 2.2 -2.6 -0.7 -2.2 -3.1 -2.0
Birth weight of first child 1.5 2.7 5.4 -1.5 1.8 -0.6 2.3 2.3 0.5
Peak expiratory flow (PEF) 1.6 3.8 9.1 1.9 2.8 -3.0 0.5 -0.2 -1.4
Pulse wave reflection index 1.4 1.7 3.0 -1.7 1.0 0.6 1.5 1.7 0.8
Ever highly irritable/argumentative for 2 days 1.7 2.1 3.8 -1.7 1.1 0.6 1.6 2.0 1.3
Loud music exposure frequency 1.8 1.9 3.8 -1.4 1.3 -0.4 1.8 2.0 1.0
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 6.1 1.2 1.3 -2.5 -0.7 -0.6 -2.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 -0.6 -0.4 1.0 -0.8 -0.0 0.4
Blood clot in the leg (DVT) 0.8 1.0 3.6 -0.7 -1.9 1.2 -0.5 -0.4 0.5
Medication: Paracetamol 2.0 3.4 5.2 -2.3 1.4 1.4 1.9 2.2 1.8
Headache pain in last month 1.3 2.3 3.6 -1.6 1.4 1.2 1.9 1.8 1.0
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 6.3 0.7 1.5 -2.5 0.2 0.3 -1.2
Glaucoma (self-reported) 0.8 1.0 3.4 1.9 1.2 0.1 0.3 -0.7 -0.6
Gout (self-reported) 0.3 0.4 1.2 1.1 -0.3 -0.3 -0.6 -0.4 0.5
Hypothyroidism/myxoedema (self-reported) 4.9 9.5 17.1 -1.8 2.4 3.7 2.8 3.0 4.1
Medication: Amlodipine 1.5 2.0 8.4 -0.2 -0.7 2.9 -1.1 -0.4 1.4
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.3 0.6 -0.7 -0.4 -0.8 -1.1 -0.9
Birth weight 1.0 2.2 6.1 -2.5 0.7 -0.2 1.7 1.8 0.6
Chronic bronchitis/emphysema (mother) 0.8 1.0 3.9 -0.6 0.3 2.0 0.6 0.3 0.9
High blood pressure (siblings) 1.1 1.6 5.1 1.4 1.2 2.3 0.2 -0.4 0.8
Forced vital capacity (FVC), Best measure 2.4 8.7 16.5 -2.0 4.0 -1.9 4.1 3.4 0.4
Body fat percentage 1.3 5.1 11.8 -1.7 0.2 3.4 2.2 1.3 3.0
Leg fat percentage (right) 1.0 3.5 11.0 -1.1 -0.0 3.3 1.4 0.7 2.5
Arm fat-free mass (right) 5.3 27.3 53.9 -5.3 4.5 0.9 7.3 6.8 3.9
Exposure to tobacco smoke outside home 0.4 0.6 1.5 1.2 -0.2 0.3 -0.9 -0.9 -0.2
Comparative body size at age 10 3.4 9.4 16.9 -4.1 0.1 3.2 1.9 3.3 3.8
Number of full brothers 0.4 0.5 1.3 0.3 1.1 0.9 0.6 0.5 0.2
Worry too long after embarrassment 1.3 2.1 7.2 -1.1 0.4 2.7 0.4 0.6 1.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 0.4 0.9 -0.3 0.7 0.4 -0.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.4 -0.1 -0.5 -0.4 0.1 -0.6 -0.6
Number of children fathered 0.8 0.9 2.3 0.9 0.8 -1.5 -0.0 0.0 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 0.3 -0.2 0.2 -0.2 0.1 0.0
Age at first live birth 0.6 1.1 4.1 0.4 0.1 -2.0 -0.5 -0.2 -1.4
Pulse wave peak to peak time 0.1 0.1 0.2 0.0 0.4 -0.3 0.1 0.4 0.4
Health satisfaction 1.3 1.7 4.7 -1.3 -0.7 2.2 0.7 0.8 1.5
Shortness of breath walking on level ground 0.2 0.3 0.6 0.6 0.8 0.4 -0.1 -0.1 0.8
Qualifications: College or University degree 0.9 2.7 11.0 0.6 1.3 -3.3 0.1 -0.1 -1.8
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.3 0.3 -0.7 -0.1 -0.0 -0.6
Mouth/teeth dental problems: Loose teeth 0.7 0.8 3.6 -0.2 0.5 1.9 0.2 0.0 1.0
Emphysema/chronic bronchitis 0.2 0.2 0.6 0.8 0.8 0.1 0.4 -0.0 0.3
Medication for pain relief, constipation, heartburn 2.1 3.5 7.0 1.9 -0.6 -2.7 -1.4 -1.7 -2.3
Neck or shoulder pain in last month 0.3 0.5 2.0 -0.0 -0.3 1.4 -0.4 -0.0 0.7
Medication: Blood pressure 2.5 4.3 14.1 -1.8 -0.9 3.8 0.9 0.6 2.6
Angina (self-reported) 0.8 1.0 2.1 0.1 0.7 1.4 1.4 0.9 0.9
Migraine (self-reported) 1.8 2.2 4.7 -0.7 2.2 -0.1 1.9 2.0 0.5
Medication: Ibuprofen 0.5 0.6 1.5 -1.2 0.2 0.4 0.5 1.1 0.5
Medication: Allopurinol 0.4 0.6 1.3 0.8 -1.1 -0.2 -1.0 -0.5 0.4
Medication: Omeprazole 0.7 0.8 2.9 0.1 0.4 1.7 0.1 0.3 1.2
Medication: Seretide 50 evohaler 2.3 2.7 7.4 -0.4 2.7 -0.3 2.2 1.7 0.5
Mean time to correctly identify matches 0.5 0.9 2.5 0.4 -0.4 -1.6 -0.7 -0.5 -1.3
Heart disease (mother) 1.4 1.8 3.3 1.3 -0.9 1.5 -1.8 -1.5 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.2 2.0 0.4 -0.7 -0.9 -1.1 -0.7
Whole body fat mass 2.6 10.8 18.2 -3.0 1.8 3.2 4.3 3.2 3.7
Leg fat mass (right) 2.5 9.5 13.8 -2.8 1.4 3.4 3.7 2.9 3.7
Arm predicted mass (right) 4.9 25.1 50.6 -5.0 4.5 0.6 7.1 6.5 3.6
Pulse rate, automated reading 0.9 2.9 6.2 1.4 -2.5 0.3 -2.0 -2.2 -0.2
Alcohol intake frequency. 2.3 5.3 14.1 -1.3 0.6 3.8 1.4 1.3 3.5
Comparative height size at age 10 4.2 22.9 54.3 -4.8 4.3 -2.1 7.4 6.1 1.0
Number of full sisters 0.8 0.9 2.2 -0.0 -1.5 1.5 -0.9 -0.6 0.5
Suffer from ‘nerves’ 0.1 0.1 0.3 0.5 0.3 -0.3 -0.2 -0.2 -0.1
Overall health rating 1.2 2.5 10.1 -0.7 -0.5 3.2 0.0 0.2 2.1
Chest pain or discomfort 1.5 2.1 6.8 0.2 -2.6 0.6 -1.6 -1.5 -0.8
Had major operations 0.6 0.7 2.3 -0.1 -0.8 1.5 0.3 0.5 1.1
Age at last live birth 0.1 0.1 0.4 -0.6 -0.0 0.0 -0.1 0.2 0.1
Family relationship satisfaction 0.4 0.4 0.9 -0.7 -0.3 0.9 -0.1 0.6 0.9
Leg pain on walking 1.5 1.8 4.8 -1.2 -0.4 2.2 0.8 0.9 1.8
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 6.1 -2.5 0.9 1.2 1.8 2.0 1.5
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.9 -0.3 1.4 0.0 0.8 0.7 0.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 2.7 1.6 -0.5 -1.3 -0.9 -1.2 -1.6
Medication: Aspirin 1.0 1.3 5.3 0.7 -0.5 2.3 -0.3 -0.9 1.0
Supplements: Vitamin C 0.2 0.2 0.8 0.3 -0.0 0.9 -0.0 -0.0 0.8
Knee pain experienced in last month 1.0 1.6 3.8 0.3 1.2 1.9 1.1 0.6 1.7
Hypertension (Self-reported) 2.7 7.5 23.5 -2.1 -0.0 4.8 1.6 1.4 3.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.4 0.8 0.8 0.0 0.9 -0.7 -0.6 0.5
Illnesses of father: Heart disease 1.2 1.7 6.8 -0.2 0.3 2.6 0.0 0.4 1.8
Illnesses of siblings: Diabetes 0.4 0.5 2.4 -0.1 -0.6 1.5 0.1 -0.1 0.4
Smoking status: Previous 0.3 0.5 1.7 -0.6 0.4 -0.2 1.3 0.6 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.7 11.2 -2.1 2.6 -1.5 3.4 3.0 0.3
Whole body fat-free mass 5.4 30.7 61.0 -5.6 4.8 0.8 7.8 7.2 4.1
Leg fat-free mass (right) 5.6 29.8 52.3 -5.6 4.2 2.3 7.2 7.0 4.9
Arm fat percentage (left) 2.2 8.9 22.8 -2.4 0.0 4.8 2.2 1.9 4.1
Average weekly red wine intake 0.8 1.2 2.0 1.2 0.2 -1.2 -1.2 -0.8 -1.4
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.1 -1.6 -2.0 0.3 -0.5 0.2 0.4
Mood swings 0.2 0.4 1.4 0.3 1.2 0.2 0.4 0.7 0.5
Loneliness, isolation 0.5 0.6 2.0 -0.3 -0.2 1.2 0.3 0.1 1.4
Long-standing illness, disability or infirmity 0.1 0.2 0.7 0.9 0.1 0.1 0.1 -0.5 -0.2
Ever had bowel cancer screening 0.2 0.3 0.7 0.8 0.8 -0.0 -0.0 -0.0 -0.7
Diabetes diagnosed by doctor 0.9 1.5 7.5 0.7 -0.1 2.7 0.0 -0.1 1.0
Ever had stillbirth, spontaneous miscarriage or termination 2.8 3.0 4.5 -1.6 1.9 0.6 2.1 2.1 1.7
Friendships satisfaction 0.2 0.3 0.9 -0.1 -1.0 0.2 -0.7 -0.2 -0.4
Qualifications: nursing, teaching 1.7 2.6 5.4 0.5 -1.2 -2.3 -1.4 -1.3 -2.2
Commuting to job workplace: Walk 0.4 0.5 0.9 -0.6 -0.7 -1.0 -0.6 -0.1 -0.8
Eye problems/disorders: Cataract 0.6 0.7 1.9 -1.4 -1.4 0.2 -0.1 0.5 0.0
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.0 0.8 -1.1 0.2 -1.1 -1.7 -1.1
Medication for cholesterol 0.4 0.6 1.7 -0.8 0.6 -1.3 0.6 0.5 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.6 0.4 -1.6 1.2 -1.2 -1.2 -0.1
Back pain experienced in last month 0.6 0.9 1.9 1.4 -0.3 -0.3 -0.9 -1.2 -1.2
Mineral and other dietary supplements 0.3 0.3 0.8 0.6 0.9 0.4 -0.3 -0.1 0.8
Breast cancer (self-reported) 0.2 0.2 0.6 -0.5 -0.1 0.8 0.2 0.0 0.6
Asthma (self-reported) 0.6 1.1 4.2 -0.2 0.2 -2.1 0.3 0.1 -1.5
Osteoporosis (self-reported) 0.7 0.8 3.2 -0.2 -1.8 1.0 -0.2 -0.6 0.4
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.8 0.3 -0.3 0.8 0.8 -0.3
Medication: Aspirin 1.0 1.3 5.7 0.3 -0.6 2.4 -0.2 -0.7 1.1
Medication: Gliclazide 0.9 1.0 2.7 0.6 -1.1 1.6 -0.0 -0.4 1.4
Illnesses of father: None of the above (group 1) 2.0 2.5 6.4 0.4 -1.1 -2.5 -1.1 -1.1 -2.2
Smoking status: Current 1.9 3.0 7.6 -1.4 -1.3 2.8 0.9 0.9 2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.7 0.7 0.9 -0.6 -0.1 -0.2 -0.6
Whole body water mass 5.5 31.6 62.3 -5.8 4.7 0.9 7.9 7.3 4.2
Leg predicted mass (right) 5.5 29.3 51.3 -5.6 4.1 2.3 7.2 6.9 4.9
Arm fat mass (left) 3.2 13.1 19.4 -3.5 1.4 4.0 4.1 3.5 4.4
Number of self-reported non-cancer illnesses 0.8 1.5 4.6 -0.1 0.4 2.1 0.7 0.5 1.8
Average weekly champagne plus white wine intake 1.6 2.2 8.3 -0.3 1.2 -2.9 0.8 0.9 -1.4
Miserableness 0.1 0.1 0.2 0.4 0.2 0.0 -0.1 -0.5 -0.4
Guilty feelings 0.1 0.1 0.4 0.6 0.3 0.4 0.0 -0.2 0.2
Wears glasses or contact lenses 0.6 0.6 1.8 -0.2 0.4 -1.3 1.1 0.7 -0.4
Ever taken oral contraceptive pill 1.6 1.8 2.6 -1.5 1.5 -1.2 1.3 1.6 0.5
Hearing aid user 0.4 0.5 1.0 0.0 -0.7 -1.0 -0.6 -0.5 -0.8
Mother’s age at death 3.6 4.5 6.7 0.6 -2.3 -2.6 -2.1 -1.9 -2.6
Financial situation satisfaction 0.4 0.5 1.3 -0.2 -0.5 1.1 -0.8 -0.2 0.7
Tinnitus: Yes, now most or all of the time 1.7 2.0 3.2 -1.8 0.3 1.8 0.7 1.4 1.8
Commuting to job workplace: Public transport 1.8 2.1 3.2 -1.5 0.4 1.7 1.0 1.8 1.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 0.7 0.1 0.3 0.4 -0.3 -0.2
Medication: Blood pressure 0.4 0.8 3.1 -0.4 0.4 1.8 0.6 0.6 0.9
Pain type(s) experienced in last month: Hip pain 0.8 1.0 2.0 1.2 1.4 1.2 1.0 0.2 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.7 -0.0 -1.3 -0.8 -0.7 -0.6 -1.1
High cholesterol (Self-reported) 1.2 2.1 4.3 0.2 -1.9 2.1 -1.6 -0.8 1.2
Medication: Bendroflumethiazide 0.6 0.9 2.2 -0.1 1.1 1.5 0.9 0.2 1.1
Medication: Paracetamol 0.8 1.2 2.9 -1.7 0.3 1.1 0.7 1.1 1.0
Medication: Lisinopril 0.3 0.4 1.3 -0.2 1.1 0.2 0.8 0.4 0.5
Medication: Atorvastatin 0.6 0.7 1.5 -0.4 1.1 0.4 1.2 1.1 0.5
Illnesses of father: High blood pressure 0.8 1.0 2.2 1.5 0.5 1.1 -0.9 -1.0 0.5
Alcohol drinker status: Never 2.3 2.8 6.5 -1.7 -1.0 2.5 0.2 0.7 2.5
Ever smoked 1.8 3.2 4.3 -2.1 0.3 2.0 2.0 1.8 1.9
Basal metabolic rate 5.3 29.1 57.0 -5.5 4.4 1.3 7.5 6.9 4.3
Leg fat percentage (left) 0.8 3.0 10.9 -0.6 -0.3 3.3 0.9 0.3 2.4
Arm fat-free mass (left) 5.2 26.6 52.1 -5.4 4.1 1.2 7.2 6.6 4.1
Number of operations (self-reported) 0.8 1.2 3.1 0.9 -1.7 1.1 -1.1 -1.1 0.3
Average weekly beer plus cider intake 0.1 0.1 0.3 -0.3 -0.3 -0.4 -0.1 0.0 -0.6
Irritability 0.8 1.3 4.1 0.7 -0.6 2.0 -0.9 -0.6 1.2
Risk taking 1.5 2.2 5.7 -0.7 1.9 0.0 2.4 1.8 0.8
Ever had prostate specific antigen (PSA) test 0.9 1.1 1.8 -1.3 0.6 0.6 1.3 1.3 0.8
Fractured/broken bones in last 5 years 0.4 0.5 1.4 -0.3 -0.1 0.4 1.2 0.3 1.0
Age started oral contraceptive pill 0.9 1.1 2.9 0.7 0.4 -1.6 -0.5 -0.7 -1.7
Diastolic blood pressure, automated reading 1.1 3.4 11.0 -0.9 1.0 3.3 0.9 0.9 2.5
Ever depressed for a whole week 1.2 1.5 3.2 -1.5 0.7 0.8 1.1 1.8 1.0
Unable to work because of sickness or disability 0.3 0.4 0.9 0.9 0.4 0.9 -0.3 -0.4 0.6
Commuting to job workplace: Cycle 0.5 0.6 2.2 1.0 1.5 -0.7 0.4 -0.2 0.1
Myopia 2.5 3.6 8.1 2.8 -0.1 -0.7 -2.1 -2.4 -1.7
Vascular/heart problems diagnosed by doctor 2.4 6.6 21.7 1.6 -0.1 -4.7 -1.3 -1.3 -3.5
Cholesterol lowering medication 0.3 0.5 1.9 0.3 0.4 1.4 0.1 0.2 0.9
Medication: Omeprazole (e.g. Zanprol) 1.0 1.2 3.2 0.6 1.8 1.0 0.9 0.6 1.2
Pain experienced in last month 2.1 3.5 4.7 0.9 -2.1 -1.8 -2.1 -2.2 -1.7
Supplements: Calcium 0.4 0.4 1.0 0.2 -1.0 -0.3 -0.7 -0.7 -0.6
Basal cell carcinoma (self-reported) 0.7 0.8 2.2 -1.5 0.0 0.4 0.7 1.1 0.9
Heart attack/myocardial infarction (self-reported) 2.3 3.0 5.0 -1.1 1.3 2.2 1.5 1.9 2.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.6 -0.6 -1.6 1.3 -0.2 -0.1 0.8
Heart disease (siblings) 0.2 0.2 0.4 0.6 0.4 0.5 0.1 -0.3 -0.6
Alcohol drinker status: Previous 0.5 0.6 1.2 0.4 -0.9 0.6 -1.1 -1.0 -0.3
Pack years of smoking 0.9 1.3 5.1 0.2 0.1 2.3 -0.2 -0.1 1.6
Impedance of whole body 5.5 28.0 41.7 5.8 -1.9 -5.6 -4.6 -6.1 -6.5
Leg fat mass (left) 2.4 9.4 13.9 -2.7 1.4 3.5 3.6 2.9 3.7
Arm predicted mass (left) 5.2 26.3 51.8 -5.3 4.2 1.2 7.2 6.5 4.0