TWAS hub - ACSS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.3140	0.1100	1.3e-03	0.242	NA	0.152	NA	0.159	6.7e-07	NA	1.0e-04	NA	7.1e-05
2	GTEx	Esophagus Mucosa	0.1460	0.0530	4.6e-04	0.051	NA	0.021	NA	0.033	2.6e-04	NA	1.5e-02	NA	2.8e-03
3	GTEx	Heart Atrial Appendage	0.1980	0.0700	3.8e-04	-0.006	NA	0.003	NA	-0.006	7.2e-01	NA	2.2e-01	NA	7.5e-01
4	GTEx	Heart Left Ventricle	0.3049	0.1337	4.6e-03	-0.004	NA	0.000	NA	0.012	5.8e-01	NA	3.2e-01	NA	7.5e-02
5	GTEx	Nerve Tibial	0.1322	0.0488	1.0e-03	0.069	NA	0.045	NA	0.054	1.3e-05	NA	3.7e-04	NA	1.1e-04
6	ROSMAP	Brain Pre-frontal Cortex	0.0372	0.0186	8.8e-03	0.043	0.008	0.025	0.020	0.030	2.6e-06	2.6e-02	2.7e-04	1.1e-03	8.7e-05
7	YFS	Blood	0.0896	0.0296	1.1e-06	0.009	0.020	0.029	0.023	0.015	4.3e-04	3.1e-07	7.2e-10	4.4e-08	8.4e-06
8	TCGA	Esophageal Carcinoma	0.1830	0.1000	6.4e-03	0.037	0.042	0.072	NA	0.065	2.5e-02	1.8e-02	2.6e-03	NA	4.3e-03
9	TCGA	Brain Lower Grade Glioma	0.1280	0.0409	5.7e-09	0.076	0.077	0.065	NA	0.070	5.6e-09	4.2e-09	7.7e-08	NA	2.3e-08
10	TCGA	Thyroid Carcinoma	0.0930	0.0570	6.3e-05	0.031	0.051	0.040	NA	0.040	5.4e-04	9.5e-06	8.0e-05	NA	7.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Age at First Birth	3.4	4.9	12.8	1.3	3.6	-2.8	0.9	-3.1	-2.5	-0.7	0.3	2.1	-2.3
Alcohol intake frequency.	3.4	7.9	25.4	5.0	2.9	1.2	1.0	-0.2	0.1	-4.2	2.9	4.0	1.3
Mouth/teeth dental problems: Loose teeth	2.8	3.3	9.9	-3.2	-2.3	-2.3	-1.2	1.3	1.2	1.0	-1.7	-2.0	-0.5
Family relationship satisfaction	2.8	3.4	7.0	-2.6	-2.5	0.7	-0.9	2.0	2.0	0.2	-2.4	-2.2	0.4
Friendships satisfaction	2.5	3.1	8.6	-2.0	-2.5	1.4	-0.5	1.9	2.9	-0.1	-1.5	-1.0	1.9
Leg fat mass (right)	2.4	9.5	28.6	-5.3	-1.8	4.0	0.4	1.5	0.9	3.2	-4.7	-3.2	-1.3
Leg fat mass (left)	2.4	9.2	29.6	-5.4	-1.8	3.7	0.4	1.5	0.9	2.9	-4.7	-3.1	-1.2
Alzheimer’s Disease (in mother)	2.3	2.7	7.0	-2.7	-1.8	-1.2	-2.1	0.4	0.5	0.8	-2.4	-1.7	-0.8
Breast cancer (self-reported)	2.3	2.8	13.2	2.1	1.5	-0.4	3.6	-1.1	-1.3	-1.3	0.5	1.6	0.1
Leg fat percentage (right)	2.2	7.9	25.6	-4.3	-1.6	5.1	0.1	2.0	1.5	2.5	-4.0	-2.1	-0.1
Whole body fat mass	2.2	9.4	29.7	-5.4	-2.5	3.9	-0.1	1.6	1.1	3.2	-4.3	-3.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	9.2	3.0	3.0	-2.0	2.6	-2.5	-1.5	-1.7	0.8	2.4	-0.2
Leg fat percentage (left)	2.2	7.8	21.1	-4.6	-1.8	4.6	0.1	2.2	1.7	2.0	-4.1	-2.1	0.0
Triglycerides	2.1	3.5	10.4	-3.2	-1.8	-2.4	-0.6	1.1	1.0	1.7	-1.9	-2.5	-0.4
Smoking Status	2.1	5.0	16.3	-3.7	-1.5	0.6	-1.5	1.8	1.2	1.7	-4.0	-2.8	-0.6
Trunk fat mass	2.1	8.9	26.0	-5.1	-2.4	4.1	0.1	1.7	1.3	3.2	-4.0	-2.9	-0.6
Arm fat mass (right)	2.1	8.6	27.3	-5.2	-2.3	3.5	0.2	1.9	1.2	3.0	-4.0	-3.2	-0.8
Unable to work because of sickness or disability	2.1	2.7	9.6	1.7	2.7	1.0	1.7	-0.4	-0.3	-1.7	-0.3	3.1	-0.1
Verbal and Numeric Reasoning (VNR)	2.0	4.7	14.8	-2.9	-0.9	0.6	0.4	-0.6	-0.9	2.6	-3.8	-3.4	-1.8
BMI	2.0	11.7	39.3	-6.3	-2.8	2.0	-1.1	2.4	1.1	4.3	-4.9	-3.7	-1.4
Body mass index (BMI)	2.0	8.4	28.6	-5.3	-2.0	3.3	0.4	2.2	1.3	2.2	-4.5	-2.9	-0.7
Loneliness, isolation	2.0	2.8	9.2	-3.0	-1.1	0.3	-1.7	1.0	0.8	0.4	-2.6	-2.1	-1.1
Arm fat mass (left)	2.0	8.0	24.8	-5.0	-2.1	3.7	0.4	1.6	1.1	3.0	-3.8	-3.0	-0.8
Weight	1.9	9.2	32.0	-5.7	-2.4	2.8	0.2	1.4	0.6	3.8	-4.0	-3.4	-1.4
Body fat percentage	1.9	7.7	21.6	-4.3	-2.3	4.6	-0.4	2.1	1.7	2.3	-3.7	-2.2	0.0
Osteoporosis (self-reported)	1.9	2.4	4.5	1.9	2.0	2.1	1.4	-1.5	-1.4	-0.2	1.5	1.8	-0.3
Prostate Cancer	1.8	2.5	4.7	0.4	2.0	-2.2	1.9	-1.4	-2.1	-1.1	0.8	0.4	-2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	7.2	1.7	1.7	0.9	2.7	-0.4	-0.3	-1.3	1.0	2.5	0.6
Trunk fat percentage	1.8	7.0	19.6	-4.1	-2.4	4.4	-0.1	1.9	1.7	2.2	-3.4	-2.2	0.3
Waist circumference	1.8	6.5	23.8	-4.9	-2.3	3.0	0.1	1.3	0.6	2.8	-3.0	-2.6	-1.1
Noisy workplace	1.8	2.2	7.6	-1.8	0.9	0.3	0.9	-0.2	-1.7	0.8	-2.5	0.0	-2.8
Medication: Lansoprazole	1.8	2.0	7.3	-2.7	-2.0	0.3	0.3	1.5	1.6	-0.0	-0.5	-1.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	12.5	3.5	2.9	-2.4	2.6	-2.9	-1.5	-0.9	2.7	2.1	-0.1
Age started oral contraceptive pill	1.8	2.2	6.4	1.5	2.0	0.1	1.3	-2.5	-2.3	-0.0	0.8	1.0	-0.9
LDL Cholesterol	1.7	2.6	7.2	-0.9	-2.0	2.3	-2.7	2.3	1.6	0.5	-0.2	-0.2	1.0
Had other major operations	1.7	2.1	6.5	0.4	1.5	0.1	1.3	-2.6	-2.3	0.8	0.4	0.6	-2.1
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	10.1	-0.7	-0.7	0.9	-0.2	-1.6	-1.3	0.1	-3.2	-1.8	-1.1
Arm fat percentage (right)	1.7	6.9	17.0	-4.1	-2.3	3.7	-0.6	2.2	1.7	2.1	-3.6	-2.6	-0.0
Qualifications: College or University degree	1.7	5.2	14.4	2.3	2.5	-3.2	0.5	-3.8	-3.1	0.1	1.6	1.0	-1.6
Number of operations (self-reported)	1.7	2.5	6.2	1.0	2.5	0.1	1.3	-2.0	-2.3	0.5	0.7	1.4	-2.1
Hand grip strength (left)	1.6	4.2	13.3	-3.6	-0.6	-1.6	0.7	-1.1	-1.5	2.7	-1.7	-1.9	-2.8
Severe depression (siblings)	1.6	1.8	5.1	-2.0	-0.5	0.8	-1.0	0.4	-0.2	1.2	-2.3	-2.0	-1.0
Falls in the last year	1.6	2.2	8.9	1.5	3.0	-0.5	0.9	0.2	0.0	-2.4	0.2	2.0	-0.5
Neck or shoulder pain in last month	1.6	2.2	5.9	0.7	0.4	0.5	1.4	1.6	1.2	-0.4	2.3	2.4	2.1
Arm fat percentage (left)	1.6	6.5	16.9	-4.1	-2.1	4.0	-0.4	1.8	1.4	2.2	-3.5	-2.5	-0.2
Long-standing illness, disability or infirmity	1.6	2.5	11.0	0.2	2.1	1.6	3.3	-0.3	-1.0	-1.2	-1.0	1.7	-0.1
Fractured/broken bones in last 5 years	1.6	2.1	7.0	0.9	1.7	0.8	2.7	-0.6	0.5	-1.7	0.1	2.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	1.9	4.9	-1.6	-1.9	-1.0	-1.7	0.0	0.1	2.0	-0.6	-2.2	0.1
Father’s age at death	1.5	2.0	4.6	2.0	1.8	-0.7	1.0	-2.1	-1.5	-0.0	0.6	1.6	-1.0
Depression (self-reported)	1.5	1.8	4.6	1.8	2.1	0.8	1.8	-1.3	-1.4	-0.1	-0.6	1.5	-0.3
Qualifications: nursing, teaching	1.5	2.3	5.7	-0.2	0.6	-2.4	-1.6	-1.7	-1.7	1.5	0.6	-0.7	-2.4
Smoking status: Current	1.5	2.4	6.0	-2.4	-1.7	1.1	-0.6	1.2	1.1	1.4	-2.1	-2.1	0.1
Ever taken oral contraceptive pill	1.5	1.7	8.4	0.8	1.8	1.5	2.9	-0.7	-0.1	-0.8	-0.3	0.7	0.9
Pain type(s) experienced in last month: Hip pain	1.5	1.9	8.9	1.6	3.0	0.7	1.2	0.4	-0.7	-1.2	0.5	2.0	-0.2
Leg fat-free mass (left)	1.4	7.3	23.6	-4.9	-1.3	0.8	1.0	0.1	-0.3	3.6	-3.8	-3.7	-2.2
Current tobacco smoking	1.4	2.4	5.3	-2.3	-1.7	1.2	-0.8	1.4	1.2	1.4	-2.1	-1.9	0.2
Average weekly fortified wine intake	1.4	1.7	7.4	-0.5	-0.3	-1.8	-1.0	-0.9	-1.1	2.7	1.2	-0.4	-1.0
Leg predicted mass (left)	1.4	7.4	24.1	-4.9	-1.3	0.8	1.0	0.2	-0.3	3.6	-3.9	-3.6	-2.2
Alcohol usually taken with meals	1.4	2.2	6.2	0.9	1.9	-1.9	1.6	-2.5	-1.8	0.2	1.0	-0.1	-1.1
Hip circumference	1.4	6.2	22.0	-4.7	-2.2	1.6	0.1	1.1	0.4	3.4	-2.9	-3.2	-0.9
Breastfed as a baby	1.4	1.7	4.4	1.5	1.2	-2.1	0.7	0.5	-0.1	-2.0	1.7	0.8	0.8
Exposure to tobacco smoke outside home	1.4	1.9	12.5	0.6	-0.7	3.5	-1.3	-0.2	0.5	0.8	-0.6	1.1	1.1
Alcohol drinker status: Previous	1.4	1.5	4.8	1.3	1.4	1.6	1.3	0.1	0.5	-2.2	-0.4	1.4	0.6
Body Mass Index (BMI) (2010)	1.3	1.8	4.6	-2.0	0.7	1.8	1.2	1.2	0.2	1.0	-2.1	-1.2	-0.4
Lung FVC	1.3	6.6	18.6	4.3	3.1	-2.5	1.2	-2.1	-0.9	-2.6	3.1	2.9	0.5
Hand grip strength (right)	1.3	3.6	11.8	-3.4	-0.9	-1.1	0.5	-1.1	-1.3	2.5	-1.6	-1.9	-2.6
Taking other prescription medications	1.3	2.1	11.2	-0.2	1.3	1.5	3.3	-1.1	-0.9	-0.2	-0.8	1.5	-0.7
Stomach or abdominal pain in last month	1.3	1.7	4.8	1.1	2.2	0.5	2.1	0.4	0.0	-1.3	0.5	2.0	0.2
Supplements: Vitamin C	1.3	1.5	5.8	1.8	0.5	2.4	-0.9	0.7	0.4	-0.6	0.4	1.3	1.6
Number of self-reported non-cancer illnesses	1.3	2.3	12.0	-1.4	0.8	2.2	3.5	-0.6	-0.4	0.4	-1.7	0.1	-0.3
Average weekly beer plus cider intake	1.3	1.9	4.7	-1.7	-1.4	1.9	-1.0	1.8	1.2	0.2	-2.2	-0.4	0.6
Supplements: Calcium	1.3	1.4	4.5	1.2	0.9	2.1	1.7	0.5	0.4	-1.2	-0.4	1.1	1.0
Supplements: Zinc	1.2	1.3	4.4	0.3	0.2	0.8	0.5	1.2	1.2	-1.6	-2.1	0.2	1.3
Medication: Levothyroxine sodium	1.2	2.0	5.5	-0.6	1.2	-0.3	2.4	-1.6	-2.2	0.8	0.3	0.3	-2.2
Sitting height	1.2	8.2	31.1	-3.8	-3.2	0.2	-1.1	-1.4	-0.7	5.6	-1.8	-4.0	-1.9
Had menopause	1.2	1.4	4.8	0.5	-0.5	2.1	-0.6	-0.0	-0.1	0.8	2.2	1.6	1.1
Alcohol intake versus 10 years previously	1.2	1.7	5.0	1.2	-0.3	1.8	-1.0	0.5	0.7	-1.1	1.8	2.2	1.2
Mouth/teeth dental problems: Dentures	1.2	2.1	10.2	0.4	0.0	3.2	-0.1	1.4	1.1	0.3	0.6	1.6	2.1
Leg fat-free mass (right)	1.2	6.4	22.7	-4.8	-1.4	0.1	0.8	0.3	-0.1	3.2	-3.6	-3.5	-1.9
Leg predicted mass (right)	1.2	6.2	21.9	-4.7	-1.3	0.1	0.9	0.2	-0.2	3.1	-3.6	-3.4	-1.9
Hearing aid user	1.2	1.4	3.5	1.7	1.9	1.5	1.2	-0.4	-1.1	-0.8	0.2	1.3	-0.4
Mother’s age at death	1.2	1.5	3.7	1.4	1.7	-1.1	0.1	-1.1	-1.6	-0.1	1.2	-0.2	-1.9
Basal metabolic rate	1.2	6.8	24.9	-5.0	-1.4	1.1	1.1	0.4	-0.2	3.7	-3.4	-3.1	-1.9
Myopia	1.2	1.7	3.5	1.7	0.2	-0.4	1.4	1.0	1.3	-1.6	1.1	1.5	1.9
Arm predicted mass (left)	1.2	6.1	23.8	-4.9	-1.5	1.4	1.1	0.5	-0.1	3.8	-2.8	-2.6	-1.7
Crohns Disease (2012)	1.1	1.8	5.8	0.6	2.4	0.3	0.9	-1.4	-1.6	0.1	-1.8	0.3	-1.8
Mean Putamen Volume	1.1	1.3	3.8	1.6	0.8	-0.3	1.0	-0.8	-1.0	-0.7	1.9	1.7	-0.0
Pack years adult smoking proportion	1.1	1.6	5.0	-2.0	-0.9	2.2	-0.8	-0.2	-0.1	0.9	-1.9	-1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	6.0	1.2	0.8	0.9	0.2	-0.8	0.3	0.2	2.4	1.0	1.4
Happiness	1.1	1.4	3.8	-1.3	-1.9	-0.7	-1.7	0.9	1.1	1.0	-0.3	-1.2	0.6
Forced vital capacity (FVC), Best measure	1.1	4.0	8.9	3.0	2.4	-2.8	1.7	-2.4	-1.3	-0.5	2.2	1.4	-0.4
Arm fat-free mass (right)	1.1	5.6	19.3	-4.4	-0.8	1.2	1.7	-0.6	-1.0	3.7	-2.6	-2.2	-2.2
Arm predicted mass (right)	1.1	5.7	20.0	-4.5	-0.6	1.4	1.6	-0.6	-1.2	3.5	-2.9	-2.1	-2.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.9	-0.9	-1.6	1.3	0.9	-0.5	0.5	2.2	-0.1	-0.5	0.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.5	0.6	0.7	-2.0	0.9	2.1	1.4	-1.1	0.2	-0.0	1.2
Arm fat-free mass (left)	1.1	5.5	20.9	-4.6	-1.3	1.6	1.6	0.5	-0.2	3.4	-2.7	-2.4	-1.7
Pack years of smoking	1.1	1.6	6.6	-2.0	-0.6	2.6	-0.5	-0.1	-0.1	1.0	-1.8	-0.8	-0.6
Depression (Nagel 2018)	1.0	1.5	4.5	-1.1	-1.1	-0.2	-1.7	0.3	0.5	2.1	-0.5	-2.1	0.2
HbA1C	1.0	1.2	2.8	-1.6	-0.4	-0.5	1.7	1.6	1.0	-0.1	-1.2	-0.9	-0.3
Ulcerative Colitis	1.0	1.4	3.3	1.2	0.7	-1.6	1.3	0.4	0.2	-1.0	1.7	1.8	0.4
Number of treatments/medications taken	1.0	1.9	5.1	0.3	0.7	1.6	2.3	0.9	1.3	-0.7	0.3	1.9	1.9
Medication: Co-codamol	1.0	1.2	3.0	-1.0	-1.4	-0.4	1.7	0.9	1.3	1.0	0.2	-0.1	1.5
Townsend deprivation index at recruitment	1.0	1.4	3.4	0.6	-0.4	1.4	0.1	1.7	1.8	-1.3	-0.1	-0.1	1.8
Maternal smoking around birth	1.0	1.4	9.1	-1.0	-0.4	3.0	-0.4	0.5	0.5	-0.1	-1.7	-0.4	0.6
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	4.3	0.4	-1.0	1.1	-1.0	0.5	0.7	0.7	1.3	0.3	2.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	-1.9	0.3	-0.6	1.7	0.0	-0.3	0.9	-1.8	-0.5	-0.9
Hearing difficulty/problems with background noise	1.0	1.5	6.9	-0.1	0.6	-1.8	-0.2	1.8	1.2	-2.6	-0.2	-0.0	0.4
Pain all over the body in last month	1.0	1.0	3.4	0.9	0.5	-1.0	0.6	-0.7	-1.4	-1.3	-0.7	-0.1	-1.9
Medication: Simvastatin	1.0	1.5	3.4	-1.3	-1.0	0.9	-0.8	1.9	1.5	1.1	1.0	0.1	1.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	6.9	2.3	1.9	-1.6	2.1	-2.6	-1.2	-1.1	2.1	1.9	-0.1
Length of working week for main job	1.0	1.2	3.9	-1.2	-0.8	0.9	-0.9	0.2	-0.1	0.8	-2.0	-1.4	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	6.6	1.0	1.1	0.6	0.8	-2.6	-1.7	0.0	0.1	-0.7	-1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.3	1.8	1.2	-0.8	1.1	-1.2	-1.8	-1.0	1.1	1.4	-0.3
Age at first live birth	1.0	1.8	4.9	0.1	1.4	-2.2	0.8	-1.6	-2.1	-0.3	0.7	0.1	-1.7
Health satisfaction	1.0	1.2	4.0	-2.0	-0.3	-0.2	0.5	-1.2	-0.7	1.3	-1.5	-1.0	-1.1
Medication: Omeprazole	1.0	1.2	4.3	-0.1	0.9	1.7	0.5	0.6	-0.3	-0.9	-2.1	0.9	-1.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.7	1.7	1.2	-1.1	-0.2	-1.1	-1.4	-1.0	0.4	1.3	-0.9
Whole body fat-free mass	1.0	5.9	20.9	-4.6	-0.9	0.6	1.2	0.0	-0.7	3.6	-3.0	-2.8	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	5.6	0.4	0.8	0.3	2.4	-0.9	-0.8	-0.8	1.9	-0.3	-0.0
Whole body water mass	1.0	5.6	19.6	-4.4	-0.9	0.6	1.2	0.0	-0.6	3.7	-2.8	-2.7	-2.1
Medication: Bendroflumethiazide	1.0	1.5	6.1	-2.5	-1.7	-0.3	-0.6	0.1	0.8	1.9	0.1	-1.0	0.1
Medication: Atorvastatin	1.0	1.2	2.5	-1.1	0.4	0.6	0.6	-1.3	-1.2	1.1	-1.6	-1.1	-1.3
Intelligence (Savage-Jansen 2018)	0.9	2.7	7.4	-2.4	-1.3	-1.4	0.2	0.4	0.5	1.8	-2.5	-2.7	0.4
Bipolar Disorder (2011)	0.9	0.9	3.2	0.6	0.7	1.0	1.6	0.6	-0.1	-1.8	-0.1	0.6	0.3
Respiratory disease	0.9	1.9	6.9	-2.6	-0.6	1.1	1.5	0.9	0.8	0.7	-1.8	-1.9	-0.1
Ever had hysterectomy (womb removed)	0.9	1.0	4.9	1.3	1.2	1.0	0.1	-0.2	0.0	-0.5	0.7	2.2	0.2
Number of incorrect matches in round	0.9	1.5	4.7	1.5	2.2	1.1	-0.2	-1.0	-1.3	-0.4	0.6	1.8	-0.7
Financial difficulties in last 2 years	0.9	1.3	3.2	-1.8	-1.0	0.8	1.6	0.4	0.7	-0.2	-1.6	-1.4	0.2
Illnesses of siblings	0.9	1.3	2.4	1.3	1.2	0.2	1.6	-1.4	-1.1	-1.4	1.5	0.6	-0.1
Trunk fat-free mass	0.9	5.0	17.7	-4.2	-0.7	0.6	1.2	-0.1	-0.8	3.7	-2.2	-2.4	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.7	-1.4	0.3	1.1	0.3	1.6	1.3	-0.8	-0.5	-0.5	0.9
Trunk predicted mass	0.9	5.1	18.1	-4.3	-0.9	0.6	1.1	0.0	-0.7	3.8	-2.2	-2.5	-2.1
Peak expiratory flow (PEF)	0.9	2.2	6.4	1.1	2.5	-0.1	1.6	-2.1	-1.5	-1.0	0.5	1.6	-0.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	5.2	1.0	0.9	-0.0	-1.3	0.5	0.7	-2.3	-0.7	1.0	0.7
Glaucoma (self-reported)	0.9	1.1	6.7	0.6	0.9	0.7	1.2	0.2	0.3	-2.6	0.5	0.9	0.2
Birth weight	0.9	1.9	4.3	-1.4	-2.1	1.0	-0.8	1.4	1.4	1.9	1.1	-0.5	1.5
Medication: Seretide 50 evohaler	0.9	1.0	4.0	0.9	-0.2	2.0	0.7	-0.1	0.0	-0.7	-0.3	1.9	0.5
Overall health rating	0.9	2.0	6.3	-1.1	-0.2	2.5	2.2	1.2	0.9	-1.1	-0.8	1.5	0.8
Knee pain experienced in last month	0.9	1.4	3.5	-1.2	-0.4	0.4	-0.9	1.9	1.5	1.3	-1.7	-0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.8	1.3	1.7	-0.1	0.6	-0.9	-0.8	0.3	-0.3	1.2	-1.4
Osteoarthritis (self-reported)	0.9	1.1	4.6	2.2	0.7	-1.4	0.9	0.1	-0.8	-0.4	1.0	1.2	-0.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	5.3	-0.6	-0.2	-2.3	-0.2	-0.4	-1.0	0.0	-1.0	-0.9	-1.3
Alcohol drinker status: Never	0.9	1.1	4.0	0.8	-0.6	-0.6	-2.0	0.2	0.6	0.9	2.0	0.3	0.5
Cholesterol lowering medication	0.9	1.3	4.5	-2.1	-1.2	0.5	0.3	0.7	0.3	1.6	-0.9	-1.5	-0.7
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.9	0.8	1.3	0.7	0.5	-0.9	-0.7	1.1	2.0	1.2	-0.3
Ulcerative Colitis (UC)	0.8	1.4	4.0	0.1	-0.3	-0.8	1.3	1.7	1.1	-0.4	1.2	1.6	2.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.8	-0.2	-0.0	-0.5	-0.1	-0.9	-1.5	1.1	-1.7	-0.6	-1.2
Allergy or Eczema	0.8	2.2	7.0	1.7	1.0	-2.7	-0.1	0.9	0.6	-1.3	2.4	0.9	1.3
Diabetes (father)	0.8	1.0	3.0	1.3	1.7	-0.8	1.3	-0.8	-1.1	0.0	0.5	0.9	-0.0
Serious illness, injury or assault to yourself	0.8	1.0	3.9	-0.8	0.7	1.3	2.0	0.7	0.2	-1.1	-0.9	0.8	-0.3
Hayfever, allergic rhinitis or eczema	0.8	1.8	7.7	0.8	0.7	-2.8	0.5	0.6	0.6	-0.8	2.2	1.0	1.1
Forced vital capacity (FVC)	0.8	2.9	5.9	2.0	1.8	-1.9	1.7	-2.4	-1.4	-1.2	1.7	1.7	-0.7
Heart attack	0.8	1.0	3.7	0.6	1.2	0.5	0.5	-1.1	-0.8	1.3	1.9	0.9	-0.4
Medication: Ramipril	0.8	1.0	3.1	-0.1	0.1	1.8	1.2	-1.5	-0.3	0.6	1.5	0.7	0.5
Worrier / anxious feelings	0.8	1.6	5.7	1.4	1.3	-0.7	0.4	-2.4	-1.8	-0.7	0.7	-0.5	-1.1
Lung cancer (father)	0.8	1.0	2.5	-1.6	-0.6	-0.1	0.4	-0.8	-0.9	0.1	-1.4	-1.4	-1.1
Medication: Amlodipine	0.8	1.2	2.4	-1.6	-0.8	-0.8	-1.6	0.6	0.0	1.2	-1.2	-1.5	0.2
High blood pressure (siblings)	0.8	1.1	2.6	-1.1	-1.6	-0.5	-1.3	0.7	0.9	1.5	-0.6	-1.2	0.0
Wheeze or whistling in the chest in last year	0.8	1.3	3.6	-1.9	-1.4	1.7	1.0	1.1	0.4	0.9	-0.9	-0.8	0.6
Angina (self-reported)	0.8	1.1	2.9	-1.7	-1.3	1.3	-0.2	1.5	1.0	0.8	-0.7	-0.4	0.2
Medication: Allopurinol	0.8	1.0	2.5	-0.8	-0.4	1.6	-1.3	1.4	1.2	-0.5	-0.8	0.2	0.9
Mineral and other dietary supplements	0.8	1.0	3.2	-0.3	-0.5	1.6	-1.2	-1.8	-1.0	0.8	0.4	0.8	-0.7
Commuting to job workplace: Public transport	0.8	1.0	3.6	1.6	0.7	-0.9	0.6	-0.3	-0.6	-0.3	1.9	1.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-0.5	0.9	1.4	1.0	0.3	-0.5	-0.7	-1.4	1.2	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.8	-1.7	-1.4	0.3	-1.1	0.1	0.3	1.6	-0.3	-1.2	-0.1
Systolic blood pressure, automated reading	0.7	1.9	6.2	-1.0	-2.1	1.8	-0.1	1.0	0.6	2.5	0.9	1.0	1.2
Age when periods started (menarche)	0.7	1.7	6.4	1.8	0.5	0.4	-1.9	-0.4	-1.1	1.1	2.5	0.7	-0.1
Multivitamins +/- minerals	0.7	0.9	2.7	-0.4	-1.0	-0.9	-0.1	1.2	1.1	-0.2	-1.1	-0.6	1.6
Chronic bronchitis/emphysema (father)	0.7	0.8	2.3	-0.2	-0.2	0.7	-1.5	1.1	0.6	-1.5	-0.4	1.1	0.1
Hair/balding pattern: Pattern 2	0.7	0.9	3.0	-0.1	-0.6	-1.4	-1.4	0.9	0.5	0.4	-0.5	-1.7	0.1
Qualifications: None of the above	0.7	1.4	7.0	-1.3	-0.8	2.7	0.1	1.5	1.5	-0.1	-0.5	0.4	0.3
Fluid intelligence score	0.7	1.5	5.6	-1.4	-1.3	0.3	0.1	0.0	0.3	1.1	-2.2	-2.4	0.0
Exposure to tobacco smoke at home	0.7	0.8	1.8	-1.4	-1.2	0.9	0.2	0.9	0.8	0.8	-0.5	-0.7	0.9
Blood clot in the leg (DVT)	0.7	0.9	2.6	-1.6	-1.1	0.2	-1.3	-0.0	0.4	1.4	-0.3	-1.1	-0.1
Gout (self-reported)	0.7	0.9	1.9	-1.2	-1.2	1.2	-0.8	0.7	1.2	0.5	0.5	-0.1	1.4
Number of children fathered	0.7	0.7	4.3	-1.1	-0.5	0.1	-0.2	1.0	0.1	2.1	0.8	0.1	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.9	-0.3	-1.2	0.4	-0.8	-1.5	-0.5	0.6	1.7	0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	4.2	-0.9	0.2	2.1	1.5	-0.3	-0.0	0.0	-1.1	-0.1	0.0
Eye problems/disorders: Cataract	0.7	0.8	2.5	-0.0	-0.4	-1.3	-0.2	-0.5	-0.5	1.6	1.6	1.0	-0.4
Medication: Blood pressure	0.7	1.4	3.3	-1.4	-0.7	-1.8	0.9	-1.0	-0.7	1.3	1.7	-0.9	-0.3
Schizophrenia vs Biploar Disorder	0.6	0.9	3.6	0.6	-0.2	-0.7	-0.8	0.0	-0.0	1.9	1.8	-0.3	-0.0
Alzheimer’s Disease (in father)	0.6	0.7	3.5	0.7	1.0	-0.8	0.7	0.4	-0.2	-0.7	-0.3	1.9	0.2
Crohns Disease (2017)	0.6	1.2	3.7	-0.5	1.5	0.5	0.3	-0.9	-1.3	1.1	-1.9	-0.6	-1.4
Fasting Glucose	0.6	0.7	1.5	0.7	1.2	-0.8	1.1	-0.2	-0.7	-0.8	-0.7	0.9	-0.5
Neuroticism (2016)	0.6	0.8	2.5	-1.4	-0.4	-1.0	1.2	0.0	0.2	-0.2	-1.0	-1.6	0.0
Hypothyroidism (self reported)	0.6	1.3	3.9	-1.9	-1.2	-1.1	0.6	-0.2	-0.4	2.0	-0.3	-1.4	-1.0
Tanning	0.6	7.1	32.7	-4.7	-0.5	0.9	0.7	2.1	1.5	-1.2	-5.7	-2.5	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.0	-1.4	-0.4	0.1	0.1	0.6	0.5	0.0	-1.6	-1.7	-0.0
Diabetes (mother)	0.6	0.8	3.0	-1.0	0.2	0.7	0.8	1.1	1.0	0.7	-1.7	-0.3	0.2
Impedance of leg (right)	0.6	2.8	9.2	3.0	0.7	1.6	-0.8	-0.8	-0.3	-1.1	2.6	2.4	1.1
Qualifications: CSEs or equivalent	0.6	0.9	4.4	-0.6	-2.1	0.2	0.2	0.0	0.7	1.0	-0.8	-1.1	0.4
Nervous feelings	0.6	1.2	3.7	1.2	-1.0	-1.0	0.5	-1.9	-0.8	-0.0	1.6	-1.0	-0.4
Mouth/teeth dental problems	0.6	1.0	2.9	-0.6	-0.5	-1.1	0.4	-1.0	-1.0	1.4	0.2	-1.7	-1.0
Time employed in main current job	0.6	0.7	1.6	-1.0	0.0	1.2	-1.3	0.5	-0.1	1.3	0.0	-1.0	-0.7
Impedance of arm (left)	0.6	2.7	10.8	3.3	-0.0	-0.4	-2.0	-0.4	0.3	-1.1	2.7	1.3	1.3
Headache pain in last month	0.6	1.1	4.0	1.4	1.3	0.1	0.9	-1.0	0.4	-0.8	2.0	0.5	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	0.2	1.1	-0.6	-0.6	-0.3	-1.5	0.6	0.1	-0.4	-1.3
Comparative body size at age 10	0.6	1.6	3.9	-1.6	-0.6	0.6	-1.9	-0.3	-0.7	1.9	-2.0	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.8	1.7	0.9	0.6	0.3	-0.9	-0.3	-1.3	0.7	1.0	-0.3
Eye problems/disorders: None of the above	0.6	0.6	2.1	0.6	0.4	1.0	0.6	-0.3	0.4	-1.5	-1.3	-0.2	0.8
Number of full sisters	0.6	0.7	4.3	-0.3	0.0	0.5	2.1	-0.6	-1.0	0.4	-0.7	-0.2	-0.4
Suffer from ‘nerves’	0.6	0.9	2.1	0.6	-1.4	0.5	-0.5	-1.0	-0.2	1.4	1.3	-1.0	0.3
Chest pain or discomfort	0.6	0.9	5.8	-0.8	-0.2	2.4	0.5	1.0	0.1	-0.4	-1.0	0.3	0.1
Average weekly red wine intake	0.6	0.8	2.3	-0.8	0.2	0.5	1.5	-0.5	0.2	0.7	1.4	0.3	1.4
Irritability	0.6	1.0	3.9	2.0	-0.4	-0.7	-0.7	0.3	1.1	-0.8	0.9	0.2	1.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.1	-0.4	1.8	-0.1	-0.3	-0.4	-0.9	0.2	-0.4	0.7	-1.5
Basal cell carcinoma (self-reported)	0.6	0.7	3.2	0.5	1.3	-0.7	0.4	-0.6	-0.1	1.8	0.4	0.2	-0.5
Worry (Nagel 2018)	0.5	1.0	2.5	1.1	-0.7	-0.6	-1.0	-1.6	-0.9	0.2	1.5	-1.0	-0.4
Ovarian Cancer	0.5	0.6	2.9	0.3	-0.9	0.2	-1.7	0.6	-0.0	-0.6	0.8	1.0	-0.2
Blood Red Count	0.5	5.2	17.1	2.9	1.1	2.4	1.2	-1.8	-0.8	-0.3	4.1	3.7	0.8
Chronotype (morning person)	0.5	1.1	2.2	1.2	1.1	-1.5	-0.4	-1.0	-1.1	-0.5	0.9	1.0	-1.2
Hearing difficulty/problems: Yes	0.5	0.8	3.0	0.2	0.5	-1.7	-0.9	1.2	0.6	-1.4	0.3	-0.1	0.4
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.3	0.4	-0.1	1.5	0.1	0.0	0.4	0.6	1.2	1.0	1.1
Angina	0.5	0.7	1.8	-1.3	-0.8	1.2	-0.0	1.4	0.7	0.5	-0.6	0.0	0.0
Medication for hormone replacement therapy	0.5	0.6	3.2	-0.1	0.3	-0.6	0.5	1.8	0.7	0.1	-0.4	0.8	0.9
Relative age voice broke	0.5	0.8	4.1	-0.2	-0.4	-1.1	-0.1	-0.1	-0.1	2.0	1.0	-1.2	0.0
High blood pressure (mother)	0.5	0.7	2.2	0.9	1.2	0.5	1.5	-0.4	-0.4	0.1	0.9	0.9	0.7
Impedance of leg (left)	0.5	2.6	7.5	2.7	0.1	1.0	-0.8	-0.2	0.2	-1.6	2.6	2.3	1.6
Impedance of arm (right)	0.5	2.5	9.4	3.1	-0.6	-0.5	-2.2	0.4	0.9	-1.0	2.1	0.7	1.7
Number of live births	0.5	0.7	2.1	-0.8	-0.5	1.4	-1.5	0.3	-0.2	1.0	-0.5	0.2	-0.6
Asthma	0.5	0.9	2.9	-1.4	-0.5	1.4	1.7	0.1	0.4	0.6	-0.6	-1.1	-0.0
Illnesses of mother	0.5	0.6	3.7	0.3	0.4	0.8	0.3	-0.3	0.2	-1.9	-0.9	0.5	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.8	-1.1	-0.6	0.8	-0.4	-0.3	0.2	1.0	-1.4	-0.8	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.7	-1.3	-0.7	1.0	-0.7	-0.4	-0.9	0.7	-0.8	-0.8	-0.7
Worry too long after embarrassment	0.5	0.8	2.1	0.5	1.0	-0.6	0.7	-1.4	-1.0	-0.7	-0.6	-0.7	-1.5
Mean time to correctly identify matches	0.5	0.9	3.2	-0.2	-1.8	1.2	-1.4	1.0	0.8	0.5	-0.7	-0.7	-0.0
Heart disease (mother)	0.5	0.6	2.6	0.6	-0.5	1.6	-0.4	0.1	0.7	0.7	0.7	0.5	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.7	2.1	-0.3	-1.2	1.1	-1.4	0.9	-0.2	0.5	0.1	-0.7	-0.5
Asthma (self-reported)	0.5	1.0	2.5	-1.6	-0.6	1.1	1.6	0.3	0.4	0.5	-0.8	-1.4	-0.1
High cholesterol (Self-reported)	0.5	0.8	3.3	-0.0	-0.5	1.1	-0.1	0.8	1.3	0.7	0.6	-0.3	1.8
Medication: Paracetamol	0.5	0.8	2.8	0.8	0.3	1.0	-0.4	0.6	1.1	-0.3	0.7	1.2	1.7
Medication: Lisinopril	0.5	0.7	2.8	-0.9	0.5	1.1	1.7	0.1	0.2	0.1	-1.1	0.8	0.5
Diastolic blood pressure, automated reading	0.5	1.5	4.3	-1.0	-2.1	1.4	-0.0	0.8	1.2	1.4	1.1	0.6	1.5
Impedance of whole body	0.5	2.7	10.0	3.2	-0.4	0.4	-1.6	-0.3	0.5	-1.0	2.7	1.5	1.8
Bipolar Disorder (2018)	0.4	0.6	1.5	0.6	-0.3	1.2	1.2	-0.8	-1.2	-0.3	-0.2	0.5	0.1
Schizophrenia (2018)	0.4	0.7	2.6	0.9	0.5	1.5	-0.6	0.5	-0.2	0.0	1.6	0.6	0.4
Alzheimer’s Disease (including proxy)	0.4	0.5	1.9	-0.6	-0.5	-1.1	-0.8	0.4	0.4	-0.6	-1.4	-0.0	0.1
Reaction Time	0.4	0.7	3.4	0.1	-1.9	0.9	-1.1	0.6	0.4	0.6	-0.4	-0.9	-0.3
Breast Cancer	0.4	1.0	2.6	-0.3	-0.4	0.9	-0.3	1.6	1.4	0.7	-1.5	-1.0	0.5
Rheumatoid Arthritis	0.4	0.6	3.4	0.1	0.4	-0.0	-0.5	-1.0	-0.8	1.8	-0.4	0.3	-0.6
Average weekly spirits intake	0.4	0.5	1.5	-0.3	0.8	0.4	-0.8	-0.7	-0.9	0.7	-0.6	-0.2	-1.2
Sensitivity / hurt feelings	0.4	0.7	2.5	-1.4	-1.0	0.1	-0.6	0.6	0.6	0.5	-0.5	-1.6	-0.1
Medication: Metformin	0.4	0.6	3.8	-1.0	0.6	-0.1	1.9	0.7	0.2	-0.3	-0.4	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.9	-0.5	0.9	-0.4	1.1	-0.2	-0.5	-1.0	-2.0	-1.0	-1.2
Supplements: Glucosamine	0.4	0.5	1.9	1.4	-0.5	-0.9	-0.6	0.3	0.7	-0.2	-0.1	-1.0	0.3
Diabetes (self-reported)	0.4	0.7	2.6	0.3	0.3	0.7	1.2	-0.1	0.7	-1.2	0.2	0.4	1.6
Pulse rate	0.4	0.6	2.4	0.4	-0.3	0.1	1.3	-0.9	-0.3	0.4	1.6	0.5	0.5
Medication: Cholesterol lowering	0.4	0.6	2.6	-0.3	0.7	0.9	-0.0	1.0	0.8	0.9	0.2	0.4	1.6
Prospective memory result	0.4	0.5	1.8	-0.4	0.3	-0.5	-1.1	-0.7	-0.5	1.4	0.2	-0.3	-1.0
Tense / ‘highly strung’	0.4	0.7	1.9	1.3	0.1	-0.5	-0.5	-0.8	-1.0	-0.6	1.4	0.4	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.4	-0.6	0.5	-1.3	-0.6	-0.7	1.1	0.3	0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	-1.5	-0.8	-0.1	1.1	-0.3	-0.8	1.0	-0.7	-0.3	-1.4
Pulse wave peak to peak time	0.4	0.5	1.9	0.9	0.3	-0.6	0.2	0.3	-0.3	-0.8	1.4	0.6	-0.3
Emphysema/chronic bronchitis	0.4	0.4	1.8	-1.3	0.0	0.5	0.3	0.0	-0.3	0.7	-0.7	-0.2	-1.0
Pulse rate, automated reading	0.4	1.3	5.1	0.7	-1.2	1.0	0.4	-1.4	-0.3	2.2	1.2	0.6	1.0
Comparative height size at age 10	0.4	2.4	10.8	-1.9	-0.4	0.2	-0.3	-1.3	-1.5	3.3	-0.1	-1.1	-2.1
Age at last live birth	0.4	0.6	2.0	0.1	0.7	-1.0	0.0	-1.4	-0.7	-0.2	1.2	0.3	-0.3
Hypertension (Self-reported)	0.4	1.1	3.3	-1.8	-1.3	-0.7	0.7	-0.6	-0.2	1.7	0.5	-1.0	0.1
Mood swings	0.4	0.8	2.1	0.7	0.0	1.3	0.3	-1.5	-0.5	-1.3	-0.1	0.5	-0.9
Ever had bowel cancer screening	0.4	0.5	1.9	0.4	1.4	-0.3	0.6	-1.1	-0.2	-0.7	-0.0	0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.5	1.0	0.8	-0.8	0.1	0.5	-0.1	-1.9	-0.2	0.5	-0.7
Medication for cholesterol	0.4	0.7	1.4	1.2	0.1	1.0	-1.0	0.5	0.9	-1.0	-0.2	0.9	0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.7	1.1	0.5	-0.3	-0.1	-1.3	-0.8	-0.2	0.7	1.2	0.1
Guilty feelings	0.4	0.6	3.2	-0.2	0.2	-0.3	-0.1	-0.5	-0.1	-0.2	-1.8	-1.5	-0.5
Financial situation satisfaction	0.4	0.5	1.5	-0.7	-0.5	0.7	0.8	0.1	0.3	-0.5	-1.2	-1.0	0.1
Illnesses of father: High blood pressure	0.4	0.5	1.6	0.2	0.6	-0.6	1.3	-0.8	-1.1	0.1	-0.5	-0.4	-0.5
Risk taking	0.4	0.7	1.8	0.7	0.5	1.3	-0.6	0.0	-0.4	1.3	1.3	-0.1	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.0	1.8	1.0	-0.1	-1.0	0.5	0.4	-2.0	-0.5	0.6	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.8	3.8	1.1	0.2	1.9	0.3	-0.1	-0.9	-0.1	1.1	0.9	0.5
Major Depression (MDD)	0.3	0.3	1.3	-1.0	0.0	1.1	0.3	-0.3	-0.3	0.6	-0.2	-0.1	-0.3
Primary Biliary Cirrhosis	0.3	0.5	2.2	-0.0	0.8	0.7	0.6	0.6	-0.0	0.2	-1.5	-0.2	-0.8
Blood Eosinophil Count	0.3	2.1	6.6	1.1	0.2	2.4	2.3	1.0	0.4	-2.6	0.5	0.6	0.1
Blood Platelet Count	0.3	3.9	13.0	0.2	-1.3	-0.5	-3.6	2.5	2.2	-0.1	1.6	1.6	2.8
Blood White Count	0.3	1.9	4.2	-0.9	-0.7	1.0	-0.1	1.8	2.0	-1.4	-2.0	0.7	1.5
Systolic Blood Pressure	0.3	1.3	3.0	-0.0	-0.9	1.7	1.3	0.1	0.4	1.1	1.0	1.6	1.7
Cardiovascular Disease	0.3	1.0	2.1	-0.9	0.8	-0.1	1.3	-1.4	-1.2	1.3	-0.8	-0.6	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.0	1.1	0.4	1.0	-0.3	0.7	-1.2	0.1	0.8	1.0
Relative age of first facial hair	0.3	0.6	2.9	0.2	-0.2	-0.8	-0.5	-0.4	-0.2	1.7	1.2	-0.7	-0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	2.5	0.4	0.2	1.6	0.4	0.1	0.1	-0.2	0.5	-0.6	-0.3
Vitamin and mineral supplements	0.3	0.4	2.2	0.0	0.4	-0.2	-0.1	-1.2	-0.5	-0.0	0.2	-0.4	-1.5
High blood pressure	0.3	0.8	2.1	-1.5	-1.2	-0.0	1.0	-0.3	0.0	1.4	0.6	-0.4	0.7
Past tobacco smoking	0.3	0.5	2.0	1.4	0.1	-0.9	0.1	-0.7	-0.6	0.6	0.9	-0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.3	-0.3	0.7	-0.6	0.8	0.0	-0.3	-1.3	-1.5	-0.6	-1.0
Allergy	0.3	0.7	2.3	0.9	0.2	1.5	-0.3	-0.8	-0.9	-0.1	-1.3	0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	2.2	0.0	0.4	-0.6	1.5	0.2	0.4	-0.7	0.6	0.5	0.6
Neuroticism score	0.3	0.6	2.1	0.1	-0.4	-0.4	-0.4	-1.5	-0.3	-0.5	-0.5	-1.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-0.4	0.4	-1.0	0.3	-0.1	-0.7	0.9	-0.5	-0.5	-1.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.7	-0.0	-0.7	-1.2	0.5	-1.0	-0.9	0.7	0.1	-1.3	-1.1
Pulse wave reflection index	0.3	0.4	2.7	-0.6	-0.1	-0.5	0.3	-0.5	0.4	-0.3	-1.6	-0.2	-0.5
Loud music exposure frequency	0.3	0.4	1.4	0.5	0.4	-0.2	-0.6	0.4	-0.4	1.2	0.8	0.7	0.1
Medication: Paracetamol	0.3	0.5	1.9	0.7	0.7	0.0	0.1	-0.1	0.7	-0.6	0.7	1.4	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.7	0.0	-0.4	-0.5	0.2	-0.1	-0.6	-0.9	-0.5	-0.7	-1.6
Number of full brothers	0.3	0.4	1.9	-0.1	-0.0	1.1	-0.5	1.4	0.2	-0.8	0.1	-0.0	-0.0
Shortness of breath walking on level ground	0.3	0.3	2.1	0.3	-0.2	-0.3	0.2	0.9	0.1	1.5	0.2	0.4	-0.0
Medication: Blood pressure	0.3	0.5	2.5	-0.6	-0.1	1.2	-0.0	-0.1	0.7	0.4	0.1	0.5	1.6
Had major operations	0.3	0.4	1.6	-0.1	0.7	-0.9	1.3	-0.4	-0.4	0.0	0.3	0.5	0.4
Leg pain on walking	0.3	0.4	1.1	-0.6	0.9	1.1	0.7	-0.3	-0.4	0.5	-0.3	0.4	-0.5
Illnesses of father: Heart disease	0.3	0.4	1.0	0.6	-0.5	-0.1	0.1	-0.6	0.6	0.2	0.8	0.9	1.0
Illnesses of siblings: Diabetes	0.3	0.4	1.6	-0.7	0.4	-0.2	0.3	1.3	0.5	-0.0	-0.8	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	-0.3	-1.0	-1.3	0.8	-0.4	-0.3	0.7	0.6	-0.9	-0.5
Diabetes diagnosed by doctor	0.3	0.5	1.9	0.0	0.9	0.6	1.4	-0.4	0.1	-1.1	-0.1	0.4	0.7
Commuting to job workplace: Walk	0.3	0.3	1.4	-0.7	-0.6	-1.2	-0.5	0.3	0.5	0.0	-0.2	-0.3	-0.1
Back pain experienced in last month	0.3	0.5	1.8	0.9	0.4	0.6	1.3	0.8	0.1	0.5	0.1	0.9	0.5
Medication: Gliclazide	0.3	0.3	1.0	-1.0	-0.6	-0.6	0.6	0.4	0.5	0.5	0.1	0.1	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	2.2	-0.8	-0.2	-0.3	0.1	-0.1	0.3	0.6	0.2	-1.5	-0.3
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.2	0.6	-0.8	0.2	0.1	-0.2	-1.0	0.6	-0.0	-1.0
Ever depressed for a whole week	0.3	0.4	0.9	0.1	-0.3	0.7	0.1	-0.9	-0.7	0.4	-0.7	-0.9	-0.2
Commuting to job workplace: Cycle	0.3	0.3	1.1	-0.3	0.6	-0.5	-0.1	0.3	0.6	-0.8	-0.7	-0.2	1.1
Pain experienced in last month	0.3	0.5	1.6	-0.6	0.4	-0.2	-0.7	-1.3	-1.2	-0.6	-0.0	-0.2	-1.0
Depressed Affect (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.4	0.6	-0.7	-0.6	0.2	0.1	-0.8	-0.7	-0.8
Neuroticism (Nagel 2018)	0.2	0.6	2.9	-0.4	-0.8	0.0	-1.0	-0.8	-0.0	0.2	-0.3	-1.7	-0.4
Irritable Bowel Disease (IBD)	0.2	0.5	2.2	-0.0	0.8	-0.5	1.5	0.6	0.1	0.2	-0.2	0.8	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.2	-0.6	0.9	-0.6	-0.7	0.0	-0.3	0.1	-0.0	-0.4
HDL Cholesterol	0.2	0.4	1.7	-0.0	-0.8	0.8	-1.3	-0.6	0.1	-0.2	0.1	0.1	0.5
Lupus	0.2	0.3	1.3	0.5	0.5	1.1	0.0	-0.4	-0.7	-0.5	-0.2	0.6	-0.4
Schizophrenia (2014)	0.2	0.3	1.5	0.3	0.4	0.6	-0.4	0.8	-0.4	-0.0	1.2	0.5	0.1
Height	0.2	4.4	18.5	-3.0	-2.3	0.5	-0.7	0.2	0.0	4.3	-0.2	-3.1	-0.5
Waist Hip Ratio (WHR)	0.2	0.9	3.6	-1.4	-1.1	1.9	-0.2	-0.5	-0.1	1.1	-0.3	-0.6	-0.3
Lung FEV1/FVC ratio	0.2	1.0	3.2	0.8	-0.8	0.1	0.3	-0.2	0.7	1.4	1.8	1.1	1.4
Neuroticism	0.2	0.5	1.5	-0.2	-0.1	0.3	-0.4	-1.2	-0.5	0.3	-0.7	-1.2	-1.1
Fed-up feelings	0.2	0.4	2.0	-0.4	0.4	0.2	0.2	0.4	1.1	-1.4	-0.6	-0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.1	-0.1	0.1	-0.0	-1.0	-0.6	-0.7	0.5	-1.0	-0.3	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	0.3	-0.5	0.9	0.2	-0.1	-0.6	-0.6	-1.0	0.1	-0.6
Standing height	0.2	2.5	13.5	-1.5	-1.2	-0.4	-0.3	-1.3	-1.1	3.7	0.5	-1.4	-1.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.7	-1.0	0.6	1.3	0.7	-0.2	0.1	-0.8	-0.4	-0.1	0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.0	-0.6	-0.9	-0.8	0.0	-0.2	-0.1	-0.8	-0.8	-0.3
Migraine (self-reported)	0.2	0.3	0.7	-0.2	0.8	-0.4	0.5	-0.2	-0.6	0.7	0.4	-0.0	-0.7
Medication: Ibuprofen	0.2	0.3	1.7	0.2	1.3	-0.4	0.7	-0.1	0.1	0.2	-0.4	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.0	0.2	-0.3	-0.6	-0.8	-0.8	0.7	0.3	0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.3	-0.8	0.3	0.1	0.6	-0.5	-0.2	-0.6	-0.3	0.2
Medication: Aspirin	0.2	0.2	0.5	0.2	0.5	0.2	-0.7	-0.4	0.2	0.7	0.6	-0.0	0.4
Smoking status: Previous	0.2	0.2	0.6	-0.7	0.1	0.1	-0.4	0.6	0.3	-0.8	-0.2	0.8	-0.1
Medication: Aspirin	0.2	0.2	0.8	0.1	0.4	0.1	-0.9	0.1	0.4	0.3	0.7	-0.1	0.6
Miserableness	0.2	0.3	0.8	-0.8	-0.6	0.9	0.0	-0.3	0.5	-0.6	-0.4	-0.3	-0.2
Ever smoked	0.2	0.3	1.6	-1.0	-0.0	1.3	-0.1	0.3	0.2	-0.1	-0.3	0.5	0.5
Heart disease (siblings)	0.2	0.3	1.9	-0.4	-0.5	-0.1	-0.1	0.1	0.2	0.6	-1.4	-0.3	-0.4
Heel T-Score	0.1	1.1	7.6	0.3	-0.0	-2.8	0.2	-0.1	-0.4	-0.4	-0.8	-1.4	-0.6
Hair Pigment	0.1	3.2	12.7	2.8	-0.6	-1.2	-2.6	-0.0	0.5	0.6	3.6	-0.0	1.5
Medication: Atenolol	0.1	0.2	0.6	-0.1	0.7	-0.1	0.8	0.1	-0.3	0.1	0.5	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.7	-0.1	0.8	-0.5	0.7	-0.2	0.4	-0.2	-0.1	-0.1	0.0
Birth weight of first child	0.1	0.2	0.6	-0.1	-0.3	0.7	-0.4	-0.2	-0.2	0.7	-0.5	0.8	-0.1
Wears glasses or contact lenses	0.1	0.1	0.8	0.2	0.4	-0.3	0.2	0.1	0.0	0.9	0.3	0.4	0.3

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