Best TWAS P=1.26e-15 · Best GWAS P=9.84e-14 conditioned to 0.00965
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PPP2R3A | 0.05 | 0.02 | lasso | 4 | 0.05 | 7.7e-07 | 7.0 | 5.6 | 2.2e-08 | -0.32 | 0.18 | 0.74 | FALSE |
2 | GTEx | Artery Coronary | SLC35G2 | 0.16 | 0.03 | lasso | 8 | 0.05 | 6.4e-03 | 6.4 | -7.3 | 2.0e-13 | 0.51 | 0.15 | 0.40 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-731C17.2 | 0.16 | 0.02 | enet | 24 | 0.09 | 3.0e-03 | -6.2 | 6.6 | 4.7e-11 | -0.85 | 0.08 | 0.66 | FALSE |
4 | GTEx | Brain Cerebellum | RP11-85F14.5 | 0.13 | 0.10 | lasso | 7 | 0.07 | 4.1e-03 | -4.7 | 5.3 | 1.3e-07 | -0.55 | 0.49 | 0.14 | FALSE |
5 | GTEx | Brain Cerebellum | RP11-731C17.2 | 0.31 | 0.05 | enet | 39 | 0.12 | 2.3e-04 | -4.7 | 5.2 | 2.6e-07 | -0.42 | 0.34 | 0.13 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | RP11-85F14.5 | 0.08 | 0.12 | lasso | 1 | 0.06 | 1.6e-02 | 6.2 | 6.2 | 4.7e-10 | -0.22 | 0.08 | 0.11 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | RP11-85F14.5 | 0.10 | 0.08 | enet | 38 | 0.09 | 3.9e-07 | -4.7 | 6.6 | 4.6e-11 | -0.54 | 0.95 | 0.03 | FALSE |
8 | GTEx | Esophagus Mucosa | RP11-85F14.5 | 0.13 | 0.10 | lasso | 3 | 0.11 | 5.1e-08 | -5.9 | 5.9 | 3.2e-09 | -0.64 | 0.98 | 0.02 | FALSE |
9 | GTEx | Esophagus Muscularis | RP11-731C17.2 | 0.16 | 0.03 | enet | 13 | 0.06 | 1.1e-04 | 3.6 | 5.4 | 8.2e-08 | -0.11 | 0.44 | 0.33 | FALSE |
10 | GTEx | Lung | RP11-85F14.5 | 0.07 | 0.05 | lasso | 19 | 0.05 | 8.8e-05 | -5.9 | 6.2 | 5.5e-10 | -0.67 | 0.92 | 0.03 | FALSE |
11 | GTEx | Muscle Skeletal | RP11-85F14.5 | 0.10 | 0.08 | lasso | 17 | 0.09 | 6.3e-09 | -4.7 | 5.9 | 3.1e-09 | -0.39 | 0.95 | 0.05 | FALSE |
12 | GTEx | Muscle Skeletal | RP11-731C17.2 | 0.15 | 0.12 | lasso | 16 | 0.12 | 3.8e-12 | -4.7 | 6.1 | 8.5e-10 | -0.50 | 1.00 | 0.00 | FALSE |
13 | GTEx | Skin Sun Exposed Lower leg | RP11-85F14.5 | 0.04 | 0.01 | enet | 9 | 0.03 | 2.8e-03 | -4.6 | 5.9 | 3.6e-09 | -0.51 | 0.31 | 0.33 | FALSE |
14 | GTEx | Testis | SLC35G2 | 0.17 | 0.19 | lasso | 10 | 0.18 | 1.5e-08 | -4.6 | -5.4 | 5.4e-08 | 0.58 | 0.94 | 0.06 | FALSE |
15 | GTEx | Testis | RP11-85F14.5 | 0.12 | 0.03 | enet | 28 | 0.02 | 3.8e-02 | -4.6 | 6.3 | 3.3e-10 | -0.55 | 0.49 | 0.17 | FALSE |
16 | GTEx | Thyroid | PPP2R3A | 0.10 | 0.05 | enet | 18 | 0.06 | 1.3e-05 | 4.8 | 5.6 | 1.9e-08 | -0.35 | 0.36 | 0.61 | FALSE |
17 | GTEx | Thyroid | RP11-85F14.5 | 0.07 | 0.00 | lasso | 7 | 0.01 | 4.7e-02 | -5.9 | 8.0 | 1.3e-15 | -0.70 | 0.07 | 0.51 | TRUE |
18 | YFS | Blood | MSL2 | 0.02 | 0.04 | lasso | 2 | 0.03 | 9.9e-11 | 6.4 | -6.4 | 1.3e-10 | 0.30 | 0.19 | 0.81 | FALSE |
19 | YFS | Blood | NCK1 | 0.01 | 0.02 | enet | 4 | 0.02 | 2.2e-06 | -5.9 | 5.9 | 3.4e-09 | -0.64 | 0.95 | 0.04 | FALSE |