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chr10:101,548,177-103,493,226

Best TWAS P=1.02e-20 · Best GWAS P=1.41e-17 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	8.5	9.3	1.0e-20	0.96	0.00	0.99	TRUE
29	METSIM	Adipose	SFXN3	0.12	0.00	blup	415	0.04	1.6e-06	2.6	5.3	9.2e-08	0.15	0.16	0.06	TRUE
13	GTEx	Esophagus Mucosa	HIF1AN	0.14	0.08	lasso	7	0.09	2.2e-06	-5.1	5.2	1.6e-07	0.09	0.98	0.00	TRUE
15	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	8.5	8.5	1.3e-17	1.00	0.00	1.00	FALSE
4	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	8.5	8.5	2.9e-17	0.98	0.00	1.00	FALSE
14	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	8.3	8.3	9.8e-17	0.98	0.01	0.99	FALSE
5	GTEx	Artery Tibial	RP11-179B2.2	0.11	0.09	lasso	4	0.08	8.8e-07	8.5	8.1	6.7e-16	0.96	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	8.5	8.0	8.8e-16	0.99	0.01	0.99	FALSE
16	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	8.5	8.0	9.9e-16	0.99	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	RP11-179B2.2	0.16	-0.01	enet	4	-0.01	7.1e-01	-7.8	8.0	1.7e-15	0.77	0.04	0.44	FALSE
7	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	8.5	7.9	3.2e-15	0.98	0.01	0.97	FALSE
8	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	8.5	7.8	5.8e-15	0.96	0.01	0.98	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	RP11-179B2.2	0.27	0.15	enet	36	0.15	2.0e-08	8.5	7.3	2.6e-13	0.75	0.00	1.00	FALSE
26	GTEx	Thyroid	RP11-179B2.2	0.18	0.12	lasso	7	0.11	8.3e-09	6.6	7.3	3.2e-13	0.91	0.05	0.95	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL43	0.07	0.02	blup	52	0.00	1.7e-01	7.9	-7.2	4.6e-13	-0.80	0.01	0.83	FALSE
2	GTEx	Adipose Subcutaneous	RP11-179B2.2	0.15	0.08	lasso	6	0.08	3.2e-07	6.6	7.1	1.1e-12	0.90	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEMA4G	0.04	0.01	blup	52	0.02	1.2e-03	6.7	6.9	4.7e-12	0.83	0.01	0.78	FALSE
18	GTEx	Nerve Tibial	RP11-179B2.2	0.15	0.08	lasso	2	0.12	6.4e-09	8.3	6.3	3.1e-10	0.88	0.01	0.99	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RP11-179B2.2	0.12	0.09	lasso	2	0.08	1.7e-07	6.7	6.3	3.1e-10	0.86	0.06	0.94	FALSE
28	METSIM	Adipose	MRPL43	0.05	0.04	bslmm	422	0.04	1.9e-06	-2.9	5.7	1.1e-08	0.46	0.93	0.03	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA4G	0.03	0.01	blup	52	0.01	4.2e-02	8.3	5.7	1.2e-08	0.83	0.00	0.89	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM178A	0.14	0.08	lasso	2	0.08	5.9e-04	-6.6	-5.3	1.3e-07	-0.54	0.07	0.14	FALSE
25	GTEx	Testis	HIF1AN	0.12	0.08	lasso	3	0.06	1.6e-03	-5.2	5.2	1.7e-07	0.08	0.34	0.04	FALSE
30	NTR	Blood	HIF1AN	0.02	0.03	lasso	2	0.02	1.4e-07	-5.2	5.2	1.9e-07	0.05	1.00	0.00	FALSE
23	GTEx	Spleen	SEC31B	0.21	0.12	lasso	3	0.05	2.3e-02	-5.1	5.2	2.0e-07	0.05	0.28	0.09	FALSE
17	GTEx	Muscle Skeletal	HIF1AN	0.05	0.06	lasso	1	0.05	1.6e-05	-5.2	-5.2	2.1e-07	-0.06	0.94	0.00	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	1.3e-06	-5.1	5.2	2.1e-07	0.05	0.03	0.97	FALSE
27	GTEx	Whole Blood	HIF1AN	0.15	0.12	enet	7	0.12	8.7e-11	-5.2	5.2	2.2e-07	0.06	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC31B	0.14	0.10	lasso	7	0.10	1.6e-06	-5.2	5.2	2.3e-07	0.05	0.03	0.97	FALSE
19	GTEx	Prostate	SEC31B	0.18	0.14	lasso	2	0.12	6.7e-04	-5.2	5.2	2.4e-07	0.05	0.38	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SEC31B	0.13	0.21	lasso	3	0.20	4.1e-24	-5.2	5.2	2.6e-07	0.05	1.00	0.00	FALSE
24	GTEx	Testis	SEC31B	0.11	0.11	lasso	5	0.08	2.5e-04	-5.1	5.2	2.6e-07	0.05	0.84	0.01	FALSE
9	GTEx	Breast Mammary Tissue (Male)	SEC31B	0.13	0.08	lasso	4	0.10	3.0e-03	-5.1	5.1	2.9e-07	0.05	0.27	0.04	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	SEC31B	0.15	0.21	lasso	4	0.20	8.0e-08	-5.1	5.1	2.9e-07	0.05	0.96	0.00	FALSE
12	GTEx	Esophagus Mucosa	SEC31B	0.14	0.18	lasso	4	0.17	2.0e-11	-5.1	5.1	2.9e-07	0.05	1.00	0.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	SEC31B	0.15	0.16	lasso	4	0.15	8.3e-09	-5.1	5.1	2.9e-07	0.05	0.99	0.00	FALSE