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chr10:103,527,782-105,647,095

Best TWAS P=2.19e-12 · Best GWAS P=2.19e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
35	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	7.0	-7.0	2.2e-12	-1.00	0.01	0.92	TRUE
4	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	6.8	6.8	8.3e-12	0.95	0.01	0.98	TRUE
11	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-4.7	5.5	4.8e-08	0.51	0.04	0.06	TRUE
23	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	6.1	5.4	6.0e-08	0.22	0.81	0.19	TRUE
20	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	5.1	-5.2	1.5e-07	-0.38	0.65	0.12	TRUE
3	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	6.8	-6.9	4.3e-12	-0.95	0.02	0.94	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.3	-6.9	6.3e-12	-0.80	0.07	0.92	FALSE
7	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	6.5	6.8	1.1e-11	0.82	0.06	0.80	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	5.1	6.8	1.1e-11	0.60	0.05	0.35	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	6.5	6.7	1.7e-11	0.81	0.18	0.82	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	6.8	-6.6	4.2e-11	-0.94	0.02	0.79	FALSE
19	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.3	6.6	5.6e-11	0.82	0.14	0.78	FALSE
5	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	6.5	6.5	7.4e-11	0.57	0.10	0.78	FALSE
18	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.3	6.5	1.1e-10	0.83	0.10	0.87	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.3	-6.3	2.8e-10	-0.85	0.10	0.87	FALSE
2	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	3.9	6.3	3.2e-10	0.63	0.12	0.67	FALSE
10	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	5.9	6.3	3.3e-10	0.64	0.11	0.41	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	6.6	-6.2	4.5e-10	-0.75	0.05	0.91	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.3	6.2	6.7e-10	0.84	0.10	0.61	FALSE
6	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-1.8	-6.1	1.3e-09	-0.46	0.06	0.39	FALSE
30	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	6.8	-6.0	1.5e-09	-0.92	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.3	-6.0	1.5e-09	-0.85	0.30	0.70	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	6.6	5.9	3.0e-09	0.62	0.06	0.77	FALSE
8	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	5.9	5.9	4.3e-09	0.70	0.10	0.32	FALSE
17	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-4.9	-5.7	9.4e-09	-0.46	0.55	0.31	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	5.8	5.7	9.4e-09	0.37	0.84	0.16	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.3	-5.6	2.4e-08	-0.82	0.11	0.89	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-4.9	5.5	4.6e-08	0.42	0.21	0.12	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	3.8	5.4	5.2e-08	0.74	0.06	0.71	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-3.6	5.4	7.3e-08	0.62	0.38	0.33	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	3.8	-5.4	7.8e-08	-0.79	0.06	0.81	FALSE
16	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-1.2	-5.2	1.7e-07	-0.52	0.06	0.20	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	7.0	-5.2	1.9e-07	-0.88	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-4.9	5.2	2.3e-07	0.39	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	6.3	-5.2	2.3e-07	-0.84	0.16	0.84	FALSE