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chr11:63,295,034-69,703,103

Best TWAS P=1.03e-23 · Best GWAS P=1.01e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-10.0	-10.0	1.0e-23	1.00	0.00	1.00	TRUE
22	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-10.0	-7.6	2.2e-14	0.92	0.00	1.00	TRUE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-5.1	6.8	8.6e-12	0.00	0.13	0.87	TRUE
1	CommonMind	Brain Pre-frontal Cortex	FIBP	0.08	0.11	enet	20	0.12	8.1e-14	4.6	6.5	7.4e-11	-0.06	1.00	0.00	TRUE
52	GTEx	Uterus	PACS1	0.21	-0.01	enet	21	0.05	3.6e-02	4.2	-6.2	5.4e-10	0.15	0.07	0.32	TRUE
9	GTEx	Artery Tibial	IGHMBP2	0.31	0.16	enet	24	0.25	3.0e-19	6.2	5.9	3.4e-09	0.05	0.94	0.06	TRUE
77	The Cancer Genome Atlas	Glioblastoma Multiforme	IGHMBP2	0.35	0.16	blup	60	0.20	1.4e-06	4.6	5.8	5.2e-09	0.04	0.03	0.95	TRUE
104	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS6KB2	0.12	0.06	blup	35	0.05	5.4e-03	-4.8	5.8	5.4e-09	-0.16	0.01	0.72	TRUE
32	GTEx	Esophagus Muscularis	CTD-3074O7.5	0.22	0.02	enet	17	0.09	3.7e-06	-1.3	5.5	4.2e-08	-0.03	0.32	0.42	TRUE
109	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CTSW	0.24	0.21	enet	21	0.24	2.9e-07	4.6	-5.5	4.2e-08	0.08	0.94	0.01	TRUE
94	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	VEGFB	0.04	0.04	blup	47	0.02	8.9e-03	-4.6	5.4	5.4e-08	0.08	0.02	0.47	TRUE
17	GTEx	Breast Mammary Tissue	IGHMBP2	0.49	0.47	enet	28	0.50	8.1e-29	4.7	5.3	8.6e-08	0.04	1.00	0.00	TRUE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POLA2	0.12	0.03	enet	9	0.05	2.5e-04	-4.8	5.3	1.0e-07	0.04	0.00	0.54	TRUE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CNIH2	0.03	0.00	enet	4	0.02	6.4e-03	-4.2	5.3	1.2e-07	-0.22	0.06	0.13	TRUE
13	GTEx	Brain Cerebellar Hemisphere	EFEMP2	0.35	0.15	enet	5	0.09	2.2e-03	4.7	5.2	2.2e-07	-0.08	0.34	0.06	TRUE
48	GTEx	Skin Sun Exposed Lower leg	KCNK7	0.07	0.03	lasso	5	0.02	1.6e-02	5.2	5.2	2.6e-07	-0.06	0.26	0.49	TRUE
105	The Cancer Genome Atlas	Thyroid Carcinoma	CCND1	0.05	0.03	lasso	2	0.02	8.8e-03	-5.3	5.1	3.1e-07	0.00	0.02	0.38	TRUE
41	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-10.0	-10.0	2.1e-23	0.99	0.00	1.00	FALSE
50	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-10.0	-10.0	2.2e-23	1.00	0.00	1.00	FALSE
29	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-10.0	-9.9	4.6e-23	0.99	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-10.0	-9.8	9.1e-23	0.97	0.00	1.00	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-10.0	-8.1	5.0e-16	0.89	0.00	1.00	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	CDK2AP2	0.03	0.02	enet	11	0.03	1.6e-04	-4.4	7.3	2.1e-13	-0.48	0.27	0.60	FALSE
27	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-4.8	7.2	8.0e-13	-0.43	0.18	0.17	FALSE
25	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-10.0	-7.1	1.5e-12	0.88	0.00	1.00	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	PPP6R3	0.04	0.01	blup	421	0.02	3.2e-04	-6.5	6.7	2.1e-11	-0.03	0.14	0.85	FALSE
30	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-5.6	6.6	4.5e-11	0.02	0.02	0.85	FALSE
37	GTEx	Liver	CDK2AP2	0.30	-0.01	lasso	7	-0.01	4.9e-01	-3.6	-6.5	7.0e-11	0.46	0.02	0.47	FALSE
39	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-10.0	-6.5	7.5e-11	0.83	0.00	0.99	FALSE
28	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	4.6	6.2	4.0e-10	0.05	0.58	0.33	FALSE
76	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	5.1	-6.2	4.0e-10	0.09	0.39	0.17	FALSE
102	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX32	0.12	0.13	blup	60	0.13	1.2e-09	4.6	6.2	6.0e-10	-0.08	0.98	0.02	FALSE
24	GTEx	Colon Transverse	DPF2	0.19	0.01	lasso	4	0.05	1.6e-03	4.2	6.0	1.7e-09	-0.01	0.09	0.12	FALSE
18	GTEx	Breast Mammary Tissue (Male)	GSTP1	0.11	-0.01	lasso	2	-0.01	7.7e-01	-4.1	6.0	1.8e-09	-0.40	0.02	0.42	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	FIBP	0.02	0.01	blup	45	0.02	1.3e-03	4.9	6.0	2.2e-09	-0.11	0.04	0.61	FALSE
68	YFS	Blood	RAD9A	0.08	0.02	lasso	7	0.04	5.4e-12	-10.0	-6.0	2.6e-09	0.78	0.00	1.00	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX32	0.14	0.09	blup	60	0.13	8.8e-15	5.2	5.9	3.3e-09	-0.07	0.94	0.06	FALSE
55	METSIM	Adipose	FIBP	0.05	0.02	blup	344	0.02	1.0e-03	4.6	5.9	4.0e-09	-0.13	0.96	0.01	FALSE
93	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNX32	0.08	0.10	blup	60	0.11	6.0e-08	5.2	5.8	7.3e-09	-0.09	0.94	0.05	FALSE
11	GTEx	Brain Cerebellar Hemisphere	GSTP1	0.25	0.15	enet	16	0.20	8.7e-06	-4.0	5.8	7.9e-09	-0.33	0.53	0.34	FALSE
100	The Cancer Genome Atlas	Soft Tissue Sarcoma	IGHMBP2	0.10	0.09	blup	60	0.09	4.1e-06	4.6	5.8	8.0e-09	0.04	0.03	0.95	FALSE
101	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX32	0.08	0.08	lasso	2	0.10	1.5e-06	5.4	5.8	8.4e-09	-0.07	0.75	0.17	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	FIBP	0.04	0.00	blup	45	0.02	8.0e-03	3.8	5.8	9.1e-09	-0.16	0.02	0.07	FALSE
33	GTEx	Heart Atrial Appendage	IGHMBP2	0.26	0.27	lasso	4	0.26	3.9e-12	5.1	5.7	1.0e-08	0.03	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFEMP2	0.01	0.00	blup	45	0.01	3.0e-02	3.5	5.7	1.3e-08	-0.09	0.04	0.07	FALSE
40	GTEx	Nerve Tibial	IGHMBP2	0.45	0.47	enet	44	0.48	2.0e-38	4.7	5.7	1.6e-08	0.04	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	CTSW	0.13	0.08	lasso	12	0.06	3.0e-03	5.1	-5.6	1.9e-08	0.05	0.31	0.18	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	AP003419.16	0.15	0.08	lasso	5	0.08	6.2e-05	-4.8	5.6	1.9e-08	-0.21	0.50	0.02	FALSE
15	GTEx	Brain Cerebellum	NDUFV1	0.19	0.01	enet	29	0.05	1.7e-02	3.5	-5.6	2.0e-08	0.30	0.07	0.06	FALSE
23	GTEx	Cells Transformed fibroblasts	EFEMP2	0.06	0.06	lasso	3	0.07	7.8e-06	5.4	5.6	2.6e-08	-0.06	0.81	0.01	FALSE
51	GTEx	Thyroid	IGHMBP2	0.32	0.40	enet	23	0.42	5.7e-35	4.7	5.6	2.7e-08	0.05	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MRPL21	0.07	0.06	blup	45	0.07	1.4e-06	4.7	-5.6	2.7e-08	-0.05	0.50	0.50	FALSE
8	GTEx	Artery Aorta	IGHMBP2	0.32	0.32	lasso	5	0.36	5.1e-21	4.7	5.5	2.9e-08	0.05	1.00	0.00	FALSE
57	METSIM	Adipose	KLC2	0.06	0.06	blup	323	0.05	1.2e-08	5.0	-5.5	3.0e-08	0.05	1.00	0.00	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	FIBP	0.40	0.21	enet	26	0.29	4.3e-10	4.6	5.5	3.9e-08	-0.07	0.99	0.00	FALSE
35	GTEx	Heart Atrial Appendage	PTPRCAP	0.14	0.11	lasso	10	0.09	5.1e-05	-4.5	5.5	3.9e-08	-0.24	0.67	0.03	FALSE
38	GTEx	Liver	CTSW	0.27	0.03	lasso	13	0.02	1.0e-01	4.6	-5.5	4.0e-08	0.08	0.07	0.07	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	4.9	-5.5	4.2e-08	0.00	0.60	0.02	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KB2	0.11	0.00	lasso	6	0.00	2.3e-01	-5.2	5.5	4.8e-08	-0.25	0.04	0.05	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PTPRCAP	0.05	0.04	enet	3	0.03	1.2e-02	-5.4	5.5	4.8e-08	-0.20	0.00	0.92	FALSE
56	METSIM	Adipose	IGHMBP2	0.21	0.31	enet	28	0.33	3.8e-50	4.7	5.4	5.6e-08	0.04	1.00	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	IGHMBP2	0.23	0.22	lasso	3	0.16	8.4e-05	4.9	5.4	6.1e-08	0.02	0.20	0.06	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	PACS1	0.02	0.02	blup	77	0.02	8.5e-05	5.0	-5.4	6.7e-08	0.09	0.50	0.12	FALSE
5	GTEx	Adipose Visceral Omentum	IGHMBP2	0.36	0.37	enet	23	0.39	9.8e-22	4.7	5.4	7.4e-08	0.06	1.00	0.00	FALSE
99	The Cancer Genome Atlas	Rectum Adenocarcinoma	IGHMBP2	0.30	0.20	enet	9	0.26	9.9e-07	4.9	5.4	7.5e-08	0.05	0.02	0.95	FALSE
84	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FIBP	0.05	0.01	blup	44	0.02	1.5e-02	5.2	5.4	8.4e-08	-0.08	0.06	0.04	FALSE
14	GTEx	Brain Cerebellar Hemisphere	AP003419.16	0.20	0.01	lasso	4	0.05	1.7e-02	-5.4	5.3	9.2e-08	-0.20	0.04	0.17	FALSE
19	GTEx	Breast Mammary Tissue (Male)	NEAT1	0.27	0.01	enet	29	0.03	6.3e-02	4.9	5.3	9.4e-08	0.10	0.05	0.16	FALSE
75	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL21	0.23	0.30	blup	45	0.32	4.8e-19	4.7	-5.3	9.9e-08	-0.05	0.82	0.18	FALSE
16	GTEx	Brain Cortex	PACS1	0.19	0.11	lasso	9	0.08	2.9e-03	4.9	-5.3	1.0e-07	0.05	0.26	0.29	FALSE
31	GTEx	Esophagus Muscularis	YIF1A	0.11	0.05	enet	11	0.04	2.4e-03	4.5	-5.3	1.0e-07	0.05	0.83	0.15	FALSE
59	NTR	Blood	MRPL21	0.06	0.07	enet	19	0.07	7.0e-23	4.7	-5.3	1.0e-07	-0.03	1.00	0.00	FALSE
95	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MRPL21	0.43	0.39	enet	17	0.39	1.1e-17	4.7	-5.3	1.0e-07	-0.06	0.82	0.18	FALSE
96	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CTSW	0.16	0.10	enet	24	0.15	1.9e-06	4.6	-5.3	1.0e-07	0.06	0.70	0.03	FALSE
42	GTEx	Pancreas	TMEM134	0.17	0.04	enet	20	0.03	1.5e-02	-4.0	5.3	1.1e-07	-0.16	0.06	0.05	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	FIBP	0.04	0.04	lasso	3	0.04	1.2e-05	5.2	5.3	1.2e-07	-0.03	0.93	0.02	FALSE
108	The Cancer Genome Atlas	Thyroid Carcinoma	SNX32	0.23	0.26	lasso	7	0.25	6.4e-24	5.2	5.3	1.2e-07	-0.04	0.76	0.24	FALSE
47	GTEx	Skin Sun Exposed Lower leg	IGHMBP2	0.35	0.38	lasso	6	0.38	6.1e-33	4.7	5.3	1.3e-07	0.05	1.00	0.00	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	IGHMBP2	0.18	0.09	enet	10	0.17	1.2e-17	4.7	5.3	1.3e-07	0.04	0.03	0.96	FALSE
26	GTEx	Esophagus Mucosa	PLCB3	0.28	0.24	lasso	6	0.23	1.1e-15	-5.2	5.3	1.4e-07	0.08	0.00	0.99	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	TEX40	0.25	0.23	lasso	3	0.23	2.5e-29	-5.3	5.3	1.4e-07	0.07	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf20	0.07	0.07	lasso	4	0.07	6.4e-08	-5.3	5.3	1.4e-07	0.06	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	DPF2	0.03	0.02	blup	28	0.02	1.2e-03	-4.8	5.3	1.4e-07	0.06	0.00	0.82	FALSE
107	The Cancer Genome Atlas	Thyroid Carcinoma	PRDX5	0.05	0.04	lasso	3	0.02	1.6e-03	-5.2	5.3	1.4e-07	0.07	0.00	0.93	FALSE
3	GTEx	Adipose Subcutaneous	IGHMBP2	0.42	0.44	lasso	16	0.45	3.2e-40	4.7	5.2	1.5e-07	0.06	1.00	0.00	FALSE
49	GTEx	Skin Sun Exposed Lower leg	RP11-867G23.1	0.06	0.06	enet	7	0.02	1.3e-02	5.0	-5.2	1.7e-07	0.07	0.25	0.50	FALSE
54	METSIM	Adipose	EFEMP2	0.07	0.05	lasso	8	0.04	4.2e-06	4.6	5.2	1.7e-07	-0.11	1.00	0.00	FALSE
58	METSIM	Adipose	PTPRCAP	0.03	0.02	lasso	4	0.02	1.7e-04	-5.4	5.2	1.7e-07	-0.17	0.74	0.01	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	RP11-783K16.10	0.07	0.05	lasso	6	0.06	9.6e-08	-5.3	5.2	1.7e-07	0.07	0.00	0.99	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP2	0.04	0.02	lasso	5	0.02	1.4e-05	5.0	5.2	1.7e-07	-0.09	0.86	0.04	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	IGHMBP2	0.44	0.37	lasso	7	0.43	1.9e-25	4.7	5.2	1.8e-07	0.05	1.00	0.00	FALSE
21	GTEx	Cells Transformed fibroblasts	IGHMBP2	0.27	0.37	enet	10	0.37	5.0e-29	4.7	5.2	1.9e-07	0.05	1.00	0.00	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	CTSW	0.27	0.22	lasso	12	0.22	1.9e-12	4.6	-5.2	1.9e-07	0.06	1.00	0.00	FALSE
97	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNX32	0.30	0.19	lasso	1	0.14	3.9e-06	5.2	5.2	1.9e-07	-0.02	0.74	0.15	FALSE
103	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IGHMBP2	0.30	0.27	blup	60	0.22	2.8e-08	4.8	5.2	1.9e-07	0.05	0.02	0.96	FALSE
53	GTEx	Uterus	PTPRCAP	0.28	0.15	lasso	5	0.15	5.5e-04	-5.4	5.2	2.0e-07	-0.17	0.14	0.07	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX32	0.15	0.17	blup	60	0.17	2.9e-34	5.2	5.2	2.0e-07	-0.04	0.79	0.21	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf20	0.06	0.03	lasso	3	0.02	7.2e-04	-5.2	5.2	2.0e-07	0.06	0.00	0.98	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX32	0.15	0.11	blup	60	0.15	6.0e-17	5.2	5.2	2.0e-07	-0.05	0.78	0.22	FALSE
6	GTEx	Adipose Visceral Omentum	TRPT1	0.16	0.05	lasso	5	0.04	3.0e-03	-4.3	-5.2	2.3e-07	-0.06	0.06	0.45	FALSE
36	GTEx	Heart Left Ventricle	FIBP	0.12	0.09	lasso	3	0.07	9.8e-05	4.6	5.2	2.3e-07	-0.06	0.87	0.01	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SNX32	0.05	0.05	blup	60	0.03	1.1e-03	5.2	5.2	2.3e-07	-0.07	0.55	0.05	FALSE
34	GTEx	Heart Atrial Appendage	KLC2	0.10	0.04	lasso	8	0.09	1.1e-04	5.0	-5.2	2.5e-07	0.00	0.26	0.43	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	IGHMBP2	0.30	0.16	lasso	6	0.18	5.9e-20	4.6	5.2	2.6e-07	0.06	0.04	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNX32	0.46	0.36	lasso	8	0.39	1.9e-50	5.2	5.1	2.8e-07	-0.04	1.00	0.00	FALSE
67	YFS	Blood	FIBP	0.04	0.02	bslmm	343	0.03	6.4e-09	4.6	5.1	2.8e-07	-0.15	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSW	0.25	0.39	blup	44	0.41	7.3e-91	4.6	-5.1	2.8e-07	0.05	1.00	0.00	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	IGHMBP2	0.19	0.19	enet	17	0.20	3.9e-25	4.8	5.1	2.9e-07	0.07	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPF2	0.07	0.04	blup	28	0.04	2.9e-05	-4.8	5.1	2.9e-07	0.09	0.00	0.93	FALSE