Best TWAS P=5.8e-11 · Best GWAS P=1.16e-09 conditioned to 0.0074
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NLRX1 | 0.04 | 0.03 | enet | 14 | 0.02 | 1.2e-03 | -4.3 | -5.3 | 9.5e-08 | 0.02 | 0.20 | 0.29 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | NLRX1 | 0.14 | 0.03 | lasso | 5 | 0.03 | 9.6e-03 | 5.4 | -6.5 | 5.8e-11 | 0.05 | 0.01 | 0.95 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | OAF | 0.19 | 0.00 | enet | 23 | 0.02 | 4.2e-02 | -5.7 | -5.4 | 5.7e-08 | 0.65 | 0.03 | 0.83 | TRUE |
| 4 | GTEx | Muscle Skeletal | RP11-110I1.14 | 0.24 | 0.12 | lasso | 9 | 0.15 | 2.4e-14 | 4.6 | -5.2 | 2.5e-07 | 0.02 | 0.25 | 0.73 | FALSE |
| 5 | GTEx | Vagina | HMBS | 0.23 | 0.14 | lasso | 4 | 0.12 | 1.1e-03 | 4.7 | 5.3 | 1.1e-07 | -0.01 | 0.10 | 0.30 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HINFP | 0.05 | 0.01 | blup | 46 | 0.02 | 1.3e-02 | 3.7 | 5.1 | 2.9e-07 | 0.03 | 0.02 | 0.27 | FALSE |
| 7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | HMBS | 0.08 | 0.03 | blup | 38 | 0.04 | 1.7e-04 | 4.8 | 6.2 | 5.9e-10 | -0.04 | 0.00 | 0.85 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NLRX1 | 0.05 | 0.03 | enet | 5 | 0.05 | 2.4e-06 | 4.3 | -5.5 | 4.6e-08 | -0.01 | 0.02 | 0.72 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HMBS | 0.13 | 0.04 | lasso | 2 | 0.04 | 9.0e-06 | 4.8 | 5.2 | 2.7e-07 | -0.02 | 0.00 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HMBS | 0.30 | 0.18 | blup | 38 | 0.18 | 1.0e-18 | 4.4 | 5.8 | 7.8e-09 | -0.02 | 0.01 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Rectum Adenocarcinoma | HMBS | 0.24 | 0.08 | blup | 38 | 0.04 | 3.6e-02 | 4.8 | 5.2 | 1.5e-07 | 0.02 | 0.00 | 0.22 | FALSE |