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chr16:88,482,758-90,172,696

Best TWAS P=4.48e-10 · Best GWAS P=1.67e-09 conditioned to 8.48e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Colon Transverse	RPL13	0.23	0.17	lasso	4	0.16	3.7e-08	5.9	-6.2	4.5e-10	-0.06	0.01	0.99	TRUE
3	GTEx	Cells Transformed fibroblasts	DBNDD1	0.32	0.20	enet	36	0.20	1.2e-14	-4.1	-5.5	3.4e-08	0.13	0.92	0.07	TRUE
14	GTEx	Whole Blood	CTD-2555A7.3	0.10	0.00	lasso	5	0.01	1.0e-01	3.2	5.5	4.8e-08	-0.39	0.04	0.70	TRUE
4	GTEx	Cells Transformed fibroblasts	RPL13	0.10	0.08	enet	8	0.09	3.7e-07	5.3	-6.2	5.2e-10	-0.01	0.03	0.97	FALSE
6	GTEx	Esophagus Muscularis	RPL13	0.17	0.12	lasso	3	0.11	2.4e-07	5.9	-5.8	6.1e-09	-0.04	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPL13	0.04	0.03	blup	41	0.03	2.2e-03	5.0	-5.8	6.1e-09	-0.03	0.02	0.86	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	RPL13	0.16	0.15	lasso	4	0.15	2.0e-08	5.5	-5.7	1.2e-08	-0.02	0.03	0.97	FALSE
22	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPG7	0.11	0.09	lasso	2	0.08	2.5e-04	5.7	-5.7	1.2e-08	-0.03	0.02	0.95	FALSE
10	GTEx	Skin Sun Exposed Lower leg	SPG7	0.09	0.05	lasso	2	0.03	1.5e-03	5.9	-5.6	1.8e-08	-0.03	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Esophageal Carcinoma	RPL13	0.14	0.07	lasso	3	0.04	2.6e-02	5.4	-5.6	1.9e-08	-0.04	0.01	0.82	FALSE
15	METSIM	Adipose	RPL13	0.05	0.05	enet	5	0.05	1.0e-07	5.6	-5.6	2.1e-08	-0.04	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	SPG7	0.10	0.09	lasso	4	0.11	1.9e-10	5.7	-5.6	2.5e-08	0.05	0.01	0.99	FALSE
1	GTEx	Adipose Visceral Omentum	RPL13	0.19	0.03	lasso	2	0.06	3.0e-04	5.1	-5.5	2.9e-08	0.00	0.05	0.84	FALSE
16	NTR	Blood	RPL13	0.02	0.01	bslmm	365	0.01	5.9e-05	5.9	5.5	3.6e-08	-0.01	0.01	0.99	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	SPG7	0.13	0.01	blup	59	0.03	5.8e-03	-3.1	-5.5	4.9e-08	0.05	0.01	0.36	FALSE
13	GTEx	Whole Blood	SPG7	0.06	0.05	lasso	3	0.05	3.9e-05	5.6	-5.5	5.0e-08	-0.08	0.04	0.94	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPG7	0.05	0.05	lasso	5	0.05	1.9e-06	5.4	-5.5	5.0e-08	-0.03	0.03	0.97	FALSE
12	GTEx	Thyroid	RPL13	0.13	0.05	enet	10	0.06	1.4e-05	5.7	-5.4	5.4e-08	-0.08	0.02	0.98	FALSE
7	GTEx	Muscle Skeletal	RPL13	0.10	0.09	lasso	5	0.10	3.3e-10	5.0	-5.4	6.7e-08	-0.03	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SPG7	0.05	0.03	lasso	3	0.03	1.8e-03	5.4	-5.4	6.9e-08	-0.03	0.02	0.86	FALSE
2	GTEx	Artery Aorta	RPL13	0.19	0.20	lasso	5	0.17	1.7e-09	5.0	-5.4	8.3e-08	-0.05	0.02	0.98	FALSE
11	GTEx	Testis	RPL13	0.25	0.22	lasso	5	0.21	1.6e-09	5.0	-5.3	1.0e-07	-0.04	0.03	0.97	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPL13	0.03	0.01	blup	41	0.02	8.5e-03	5.2	-5.2	1.8e-07	-0.06	0.01	0.72	FALSE
8	GTEx	Nerve Tibial	RPL13	0.10	0.07	lasso	3	0.07	2.0e-05	5.5	-5.2	1.9e-07	-0.02	0.03	0.97	FALSE