Best TWAS P=4.48e-10 · Best GWAS P=1.67e-09 conditioned to 8.48e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RPL13 | 0.19 | 0.03 | lasso | 2 | 0.06 | 3.0e-04 | 5.1 | -5.5 | 2.9e-08 | 0.00 | 0.05 | 0.84 | FALSE |
| 2 | GTEx | Artery Aorta | RPL13 | 0.19 | 0.20 | lasso | 5 | 0.17 | 1.7e-09 | 5.0 | -5.4 | 8.3e-08 | -0.05 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | DBNDD1 | 0.32 | 0.20 | enet | 36 | 0.20 | 1.2e-14 | -4.1 | -5.5 | 3.4e-08 | 0.13 | 0.92 | 0.07 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | RPL13 | 0.10 | 0.08 | enet | 8 | 0.09 | 3.7e-07 | 5.3 | -6.2 | 5.2e-10 | -0.01 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Colon Transverse | RPL13 | 0.23 | 0.17 | lasso | 4 | 0.16 | 3.7e-08 | 5.9 | -6.2 | 4.5e-10 | -0.06 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Esophagus Muscularis | RPL13 | 0.17 | 0.12 | lasso | 3 | 0.11 | 2.4e-07 | 5.9 | -5.8 | 6.1e-09 | -0.04 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Muscle Skeletal | RPL13 | 0.10 | 0.09 | lasso | 5 | 0.10 | 3.3e-10 | 5.0 | -5.4 | 6.7e-08 | -0.03 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Nerve Tibial | RPL13 | 0.10 | 0.07 | lasso | 3 | 0.07 | 2.0e-05 | 5.5 | -5.2 | 1.9e-07 | -0.02 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | RPL13 | 0.16 | 0.15 | lasso | 4 | 0.15 | 2.0e-08 | 5.5 | -5.7 | 1.2e-08 | -0.02 | 0.03 | 0.97 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | SPG7 | 0.09 | 0.05 | lasso | 2 | 0.03 | 1.5e-03 | 5.9 | -5.6 | 1.8e-08 | -0.03 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Testis | RPL13 | 0.25 | 0.22 | lasso | 5 | 0.21 | 1.6e-09 | 5.0 | -5.3 | 1.0e-07 | -0.04 | 0.03 | 0.97 | FALSE |
| 12 | GTEx | Thyroid | RPL13 | 0.13 | 0.05 | enet | 10 | 0.06 | 1.4e-05 | 5.7 | -5.4 | 5.4e-08 | -0.08 | 0.02 | 0.98 | FALSE |
| 13 | GTEx | Whole Blood | SPG7 | 0.06 | 0.05 | lasso | 3 | 0.05 | 3.9e-05 | 5.6 | -5.5 | 5.0e-08 | -0.08 | 0.04 | 0.94 | FALSE |
| 14 | GTEx | Whole Blood | CTD-2555A7.3 | 0.10 | 0.00 | lasso | 5 | 0.01 | 1.0e-01 | 3.2 | 5.5 | 4.8e-08 | -0.39 | 0.04 | 0.70 | TRUE |
| 15 | METSIM | Adipose | RPL13 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.0e-07 | 5.6 | -5.6 | 2.1e-08 | -0.04 | 0.02 | 0.98 | FALSE |
| 16 | NTR | Blood | RPL13 | 0.02 | 0.01 | bslmm | 365 | 0.01 | 5.9e-05 | 5.9 | 5.5 | 3.6e-08 | -0.01 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SPG7 | 0.05 | 0.03 | lasso | 3 | 0.03 | 1.8e-03 | 5.4 | -5.4 | 6.9e-08 | -0.03 | 0.02 | 0.86 | FALSE |
| 18 | The Cancer Genome Atlas | Colon Adenocarcinoma | SPG7 | 0.13 | 0.01 | blup | 59 | 0.03 | 5.8e-03 | -3.1 | -5.5 | 4.9e-08 | 0.05 | 0.01 | 0.36 | FALSE |
| 19 | The Cancer Genome Atlas | Esophageal Carcinoma | RPL13 | 0.14 | 0.07 | lasso | 3 | 0.04 | 2.6e-02 | 5.4 | -5.6 | 1.9e-08 | -0.04 | 0.01 | 0.82 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SPG7 | 0.05 | 0.05 | lasso | 5 | 0.05 | 1.9e-06 | 5.4 | -5.5 | 5.0e-08 | -0.03 | 0.03 | 0.97 | FALSE |
| 21 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPL13 | 0.03 | 0.01 | blup | 41 | 0.02 | 8.5e-03 | 5.2 | -5.2 | 1.8e-07 | -0.06 | 0.01 | 0.72 | FALSE |
| 22 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SPG7 | 0.11 | 0.09 | lasso | 2 | 0.08 | 2.5e-04 | 5.7 | -5.7 | 1.2e-08 | -0.03 | 0.02 | 0.95 | FALSE |
| 23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RPL13 | 0.04 | 0.03 | blup | 41 | 0.03 | 2.2e-03 | 5.0 | -5.8 | 6.1e-09 | -0.03 | 0.02 | 0.86 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | SPG7 | 0.10 | 0.09 | lasso | 4 | 0.11 | 1.9e-10 | 5.7 | -5.6 | 2.5e-08 | 0.05 | 0.01 | 0.99 | FALSE |