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chr2:26,223,547-29,344,127

Best TWAS P=3.96e-17 · Best GWAS P=2.53e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	4.1	-5.3	9.6e-08	0.74	0.94	0.06	FALSE
2	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	4.1	-5.4	5.9e-08	0.82	0.01	0.97	FALSE
3	GTEx	Skin Sun Exposed Lower leg	SLC35F6	0.10	0.04	lasso	4	0.05	4.2e-05	-5.2	5.8	7.6e-09	-0.01	0.38	0.21	FALSE
4	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	4.1	-5.4	6.7e-08	0.80	0.03	0.96	FALSE
5	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	3.3	-5.9	2.9e-09	0.85	0.05	0.94	FALSE
6	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	4.6	6.4	2.0e-10	-0.69	0.67	0.33	FALSE
7	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	4.4	-5.2	1.7e-07	0.15	0.14	0.74	TRUE
8	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	3.8	6.0	2.1e-09	-0.63	0.43	0.49	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	7.3	-7.6	3.0e-14	0.09	0.00	1.00	TRUE
10	ROSMAP	Brain Pre-frontal Cortex	SLC35F6	0.05	0.04	enet	11	0.04	8.0e-06	-5.2	5.9	4.5e-09	-0.07	0.22	0.78	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-7.0	-6.1	1.3e-09	0.54	0.00	0.99	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	PPP1CB	0.04	0.02	blup	39	0.02	1.6e-04	5.1	-5.2	2.0e-07	0.07	0.01	0.96	TRUE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	PPP1CB	0.05	0.02	blup	39	0.03	4.7e-03	5.0	-5.2	2.4e-07	0.06	0.01	0.92	FALSE
14	The Cancer Genome Atlas	Esophageal Carcinoma	C2orf18	0.20	0.02	blup	30	0.06	6.7e-03	4.3	5.6	1.6e-08	-0.04	0.01	0.39	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	5.6	7.1	1.5e-12	-0.40	0.17	0.21	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-8.2	8.4	4.0e-17	-0.99	0.00	0.96	TRUE
17	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	4.8	6.7	1.7e-11	-0.70	0.41	0.59	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	4.6	6.2	4.8e-10	-0.64	0.91	0.09	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	5.2	6.1	1.3e-09	-0.54	0.02	0.27	FALSE