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chr17:65,123,352-66,885,526

Best TWAS P=1.52e-18 · Best GWAS P=5.44e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf58	0.02	0.02	lasso	2	0.01	1.8e-02	8.8	8.8	1.5e-18	1.00	0.00	0.76	TRUE
21	YFS	Blood	KPNA2	0.01	0.01	blup	312	0.01	2.8e-04	7.9	-8.6	1.1e-17	-0.86	0.05	0.93	FALSE
6	GTEx	Brain Cortex	C17orf58	0.34	0.09	lasso	6	0.13	2.4e-04	8.8	8.6	1.2e-17	0.95	0.03	0.95	FALSE
5	GTEx	Brain Cerebellum	BPTF	0.22	-0.01	lasso	10	-0.01	6.9e-01	7.8	-8.5	2.7e-17	-0.85	0.03	0.49	FALSE
7	GTEx	Cells Transformed fibroblasts	LINC00674	0.30	0.31	enet	10	0.32	1.5e-24	7.5	8.2	2.1e-16	0.86	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	SH3GL1P3	0.26	0.31	lasso	7	0.31	1.5e-23	7.5	8.2	3.4e-16	0.90	0.99	0.01	FALSE
8	GTEx	Cells Transformed fibroblasts	LRRC37A16P	0.50	0.46	lasso	8	0.47	1.1e-38	7.5	7.7	1.1e-14	0.84	1.00	0.00	FALSE
17	GTEx	Nerve Tibial	LRRC37A16P	0.09	0.08	lasso	4	0.06	2.7e-05	7.5	7.7	1.8e-14	0.84	0.11	0.77	FALSE
3	GTEx	Adipose Subcutaneous	SH3GL1P3	0.08	0.06	lasso	5	0.04	2.5e-04	7.5	7.2	6.4e-13	0.80	0.06	0.91	FALSE
15	GTEx	Lung	LINC00674	0.14	0.03	enet	22	0.08	2.1e-06	8.6	7.1	1.1e-12	0.80	0.12	0.88	FALSE
1	GTEx	Adipose Subcutaneous	LINC00674	0.12	0.13	enet	6	0.14	9.9e-12	7.5	7.1	1.2e-12	0.79	0.96	0.04	FALSE
10	GTEx	Colon Sigmoid	LINC00674	0.42	0.09	lasso	8	0.12	5.5e-05	7.9	7.1	1.2e-12	0.80	0.14	0.67	FALSE
12	GTEx	Esophagus Muscularis	LINC00674	0.11	0.04	lasso	6	0.07	7.9e-05	3.8	7.0	3.7e-12	0.77	0.18	0.79	FALSE
18	GTEx	Skin Sun Exposed Lower leg	BPTF	0.10	0.01	enet	14	0.03	2.7e-03	7.6	-6.8	1.1e-11	-0.69	0.04	0.80	FALSE
13	GTEx	Esophagus Muscularis	LRRC37A16P	0.12	0.03	enet	21	0.02	3.2e-02	8.7	6.5	5.9e-11	0.64	0.02	0.78	FALSE
14	GTEx	Heart Atrial Appendage	LINC00674	0.14	0.08	lasso	17	0.09	1.1e-04	3.8	6.3	3.0e-10	0.73	0.05	0.87	FALSE
19	GTEx	Spleen	C17orf58	0.30	-0.01	lasso	8	-0.01	4.6e-01	3.6	6.0	1.8e-09	0.81	0.03	0.35	FALSE
4	GTEx	Adipose Visceral Omentum	LINC00674	0.29	0.03	enet	40	0.03	6.9e-03	7.9	5.9	4.1e-09	0.63	0.07	0.56	FALSE
2	GTEx	Adipose Subcutaneous	LRRC37A16P	0.10	0.10	enet	10	0.14	2.9e-11	7.5	5.7	1.6e-08	0.60	0.95	0.04	FALSE
16	GTEx	Nerve Tibial	LINC00674	0.09	0.01	enet	13	0.03	2.2e-03	3.8	5.4	6.5e-08	0.65	0.19	0.27	FALSE
20	GTEx	Stomach	RP11-147L13.8	0.23	-0.01	enet	9	0.01	8.1e-02	2.4	5.4	8.4e-08	0.57	0.04	0.18	FALSE
11	GTEx	Esophagus Mucosa	LRRC37A16P	0.11	0.06	enet	13	0.08	7.5e-06	5.6	-5.2	1.5e-07	-0.67	0.14	0.80	FALSE