Hub : Genes

MAST3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Muscle Skeletal 0.0890 0.0377 6.3e-03 0.011 NA 0.031 NA 0.014 2.7e-02 NA 4.8e-04 NA 1.5e-02
2 YFS Blood 0.0558 0.0150 2.4e-08 0.036 0.024 0.032 0.032 0.037 8.4e-12 1.6e-08 1.0e-10 1e-10 4.3e-12
3 TCGA Kidney Renal Clear Cell Carcinoma 0.0403 0.0253 9.2e-03 0.023 0.005 0.002 NA 0.004 1.1e-03 7.3e-02 2.0e-01 NA 1.1e-01
4 TCGA Brain Lower Grade Glioma 0.0203 0.0120 9.4e-03 0.021 0.007 0.011 NA 0.012 1.7e-03 4.7e-02 1.7e-02 NA 1.5e-02
5 TCGA Thyroid Carcinoma 0.0370 0.0220 6.3e-03 0.018 -0.002 -0.002 NA 0.000 6.9e-03 5.2e-01 6.7e-01 NA 3.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.6 1.5 0.2 0.0 0.5 -1.2 -1.2
Bipolar Disorder or Schizophrenia 0.0 0.1 0.4 -0.6 0.0 0.2 -0.3 -0.3
Depressed Affect (Nagel 2018) 2.8 6.0 10.6 -1.6 -1.6 -1.9 -3.3 -3.3
Depression (Nagel 2018) 0.7 1.1 4.7 -2.2 -0.5 0.1 -0.5 -0.3
Intelligence (Savage-Jansen 2018) 5.6 17.3 36.5 -1.6 2.8 1.7 6.0 6.0
Neuroticism (Nagel 2018) 1.0 2.4 5.7 -2.4 -0.6 -0.5 -1.6 -1.7
Schizophrenia (2018) 0.1 0.3 0.5 -0.7 0.0 -0.2 0.7 0.6
Schizophrenia vs Biploar Disorder 3.7 4.8 8.7 -2.7 0.0 -0.3 3.0 2.9
Worry (Nagel 2018) 0.7 1.4 6.6 -2.6 0.5 0.6 -0.0 -0.1
Alzheimer’s Disease (in mother) 1.0 1.2 3.1 -0.5 1.4 1.8 0.6 0.5
Alzheimer’s Disease (in father) 1.8 2.0 6.2 -2.5 0.5 0.4 1.2 1.3
Alzheimer’s Disease (including proxy) 1.6 2.4 6.4 -2.5 1.1 1.6 0.9 0.9
Crohns Disease (2017) 0.3 0.8 1.2 -1.0 -0.3 0.5 -1.1 -1.1
Irritable Bowel Disease (IBD) 0.3 0.8 1.2 -0.7 -0.9 0.5 -1.1 -1.0
Ulcerative Colitis (UC) 0.3 0.7 1.8 0.2 -1.4 -0.1 -0.9 -0.8
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 3.6 7.0 12.2 0.4 2.8 1.6 3.5 3.5
Verbal and Numeric Reasoning (VNR) 3.2 7.6 16.0 -0.4 1.7 1.9 3.9 4.0
Breast Cancer 1.4 3.5 5.2 1.0 1.5 2.0 2.3 2.3
Ovarian Cancer 0.5 0.7 1.7 0.4 -1.3 -0.8 -0.6 -0.6
Prostate Cancer 2.3 3.3 10.3 3.2 0.1 -0.9 -1.6 -1.6
Age at First Birth 0.8 1.2 1.9 -1.0 1.0 1.4 1.0 1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 3.6 0.4 -1.3 -0.6 -1.9 -1.9
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.9 3.0 4.4 -2.0 0.0 1.6 -2.1 -2.0
Mean Putamen Volume 0.3 0.3 0.7 -0.2 -0.8 -0.8 -0.2 -0.3
Fasting Glucose 1.4 1.6 2.4 -1.2 1.5 1.5 1.0 1.0
HbA1C 0.4 0.4 0.7 -0.4 -0.1 -0.9 0.8 0.8
HDL Cholesterol 0.3 0.5 1.3 0.4 -1.2 -1.0 -0.2 -0.1
LDL Cholesterol 0.9 1.4 3.0 0.1 -1.7 -1.3 -1.1 -1.1
Lupus 2.9 4.5 9.9 -1.7 2.1 3.1 1.6 1.5
Neuroticism (2016) 1.8 2.5 6.2 -0.5 -0.6 0.1 -2.4 -2.5
Primary Biliary Cirrhosis 3.4 4.8 12.8 -0.5 3.6 2.0 1.9 1.9
Rheumatoid Arthritis 0.8 1.0 3.1 -0.1 1.8 0.5 0.9 1.0
Schizophrenia (2014) 0.1 0.1 0.3 -0.6 0.0 -0.2 0.4 0.4
Triglycerides 1.7 2.8 5.2 -1.9 1.2 2.3 1.4 1.4
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.2 0.3 0.7 0.9 0.0 0.3 -0.6 -0.6
Blood Eosinophil Count 4.1 31.2 68.9 -2.0 3.5 1.7 8.2 8.3
Blood Platelet Count 1.2 14.2 28.2 -0.6 3.7 5.3 3.7 3.8
Blood Red Count 0.3 3.2 9.2 1.4 -2.2 -3.0 -0.3 -0.3
Blood White Count 0.1 0.5 1.2 -1.1 -0.4 -0.1 -0.7 -0.6
Heel T-Score 1.0 8.0 27.2 2.1 2.8 5.2 0.3 0.3
BMI 7.2 41.9 66.3 2.1 -6.5 -5.6 -8.1 -8.1
Height 0.3 4.9 15.5 -0.1 -2.9 -3.9 0.6 0.5
Waist Hip Ratio (WHR) 6.4 28.8 62.6 -1.4 -7.9 -6.0 -4.7 -4.6
Systolic Blood Pressure 0.3 1.6 7.6 -0.2 2.8 0.5 -0.1 -0.2
Smoking Status 0.4 0.9 2.1 0.3 1.4 1.1 0.8 0.6
Allergy or Eczema 2.0 5.4 10.4 0.9 1.2 2.1 3.2 3.2
Cardiovascular Disease 0.5 1.6 3.3 1.0 0.5 0.5 -1.8 -1.8
Hypothyroidism (self reported) 3.9 9.0 12.0 -0.5 3.1 3.4 3.4 3.5
Respiratory disease 0.1 0.2 0.7 0.2 -0.9 -0.6 0.1 0.1
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.3 -0.3 0.5 1.5 1.0 1.1
Lung FEV1/FVC ratio 2.7 13.6 20.6 1.4 -4.5 -4.0 -3.8 -3.9
Lung FVC 1.1 5.5 8.9 3.0 1.9 2.6 2.1 2.0
Neuroticism 1.1 2.6 4.5 -2.0 -0.4 -0.3 -2.1 -2.1
Chronotype (morning person) 1.2 2.7 4.4 1.3 1.8 0.3 2.1 2.0
Hair Pigment 0.1 1.8 2.4 1.3 -1.6 -1.5 -1.2 -1.1
Tanning 0.2 2.1 3.2 -1.0 -1.4 -0.9 -1.8 -1.8
Hand grip strength (left) 0.7 1.9 4.5 -0.7 0.8 0.3 2.1 2.0
Number of treatments/medications taken 0.4 0.7 1.5 -0.1 -0.4 0.7 -1.2 -1.2
Average weekly spirits intake 6.9 8.5 15.2 -0.4 -2.9 -2.1 -3.9 -3.8
Sensitivity / hurt feelings 1.3 2.3 4.6 -0.1 -1.5 -0.2 -2.1 -2.1
Frequency of depressed mood in last 2 weeks 0.8 1.2 3.3 -1.8 0.4 0.4 1.0 1.1
Hearing difficulty/problems: Yes 0.5 0.7 1.2 -1.0 0.1 0.3 1.1 1.1
Relative age of first facial hair 1.5 3.2 6.2 0.1 1.9 0.3 2.4 2.5
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.6 -0.8 -0.6 0.5 0.4 0.4
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.5 1.2 0.5 0.2 0.1 0.2
Ever had hysterectomy (womb removed) 0.8 0.9 1.7 0.4 -1.1 -0.4 -1.3 -1.2
Systolic blood pressure, automated reading 0.6 1.6 3.6 0.7 0.3 -0.8 -1.8 -1.9
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 0.4 0.6 -0.3 0.6 0.5 0.5
Angina 0.9 1.2 4.7 -2.2 0.4 1.1 0.0 0.0
Medication for hormone replacement therapy 2.0 2.3 5.2 -0.3 2.3 2.3 -0.7 -0.6
Vitamin and mineral supplements 2.6 3.6 5.3 1.0 -2.0 -1.6 -2.3 -2.3
Supplements: Zinc 1.0 1.1 2.2 -0.6 1.5 0.5 1.2 1.2
Medication: Co-codamol 0.8 1.0 2.0 0.9 -0.1 0.2 -1.4 -1.4
Medication: Metformin 0.0 0.1 0.2 -0.2 -0.2 0.4 0.0 0.1
Diabetes (father) 0.4 0.5 1.4 -1.2 -0.9 0.3 -0.2 -0.2
Diabetes (mother) 0.5 0.7 3.1 -1.7 -0.4 -0.2 -0.3 -0.4
Severe depression (siblings) 3.6 4.1 8.9 0.1 3.0 2.6 1.6 1.5
Pack years adult smoking proportion 2.0 3.0 7.6 2.8 0.5 -0.5 -1.9 -1.9
Impedance of leg (right) 0.7 3.3 5.4 -2.3 -2.3 -2.0 0.9 1.0
Leg fat-free mass (left) 2.0 10.5 14.8 1.6 -3.0 -3.4 -3.8 -3.9
Trunk fat percentage 14.0 56.3 80.1 -0.1 -8.6 -6.9 -8.9 -8.9
Hand grip strength (right) 0.5 1.3 3.1 -0.9 -0.2 0.2 1.8 1.6
Townsend deprivation index at recruitment 2.6 3.7 6.2 0.3 2.5 0.8 2.5 2.3
Current tobacco smoking 0.2 0.3 0.8 0.9 0.0 -0.6 -0.4 -0.4
Average weekly fortified wine intake 0.3 0.3 0.9 -0.8 -1.0 0.0 -0.3 -0.2
Maternal smoking around birth 0.6 0.9 2.5 1.1 -0.4 -1.6 -0.5 -0.6
Fed-up feelings 2.3 4.1 8.1 -0.3 -1.2 -1.7 -2.9 -2.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.3 -1.8 0.5 0.4 0.9 1.1
Relative age voice broke 1.9 2.9 4.4 0.2 2.1 1.5 2.0 2.0
Taking other prescription medications 1.6 2.4 4.7 1.0 -1.2 0.6 -2.2 -2.1
Age when periods started (menarche) 6.2 14.8 30.6 -0.5 3.0 2.2 5.5 5.4
Bilateral oophorectomy (both ovaries removed) 4.4 5.0 7.7 1.6 -1.8 -2.2 -2.8 -2.7
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 1.7 1.1 0.4 0.5 -1.3 -1.3
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.5 -0.2 -0.7 -0.6 -0.6 -0.6
Qualifications: CSEs or equivalent 0.3 0.4 0.8 -0.9 0.6 0.7 0.3 0.2
Serious illness, injury or assault to yourself 0.2 0.3 0.8 -0.4 0.9 0.1 0.4 0.5
High blood pressure 0.3 0.9 1.8 0.8 0.3 0.1 -1.3 -1.3
Hayfever, allergic rhinitis or eczema 2.1 4.6 7.6 0.7 1.8 2.1 2.7 2.8
Multivitamins +/- minerals 1.9 2.4 3.7 -0.3 1.6 1.4 1.9 1.9
Stomach or abdominal pain in last month 0.2 0.2 0.6 -0.5 0.8 0.6 -0.0 0.0
Supplements: Glucosamine 0.6 0.8 1.3 1.1 0.7 0.3 1.0 1.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 2.7 0.2 -0.2 -0.7 -1.7 -1.5
Medication: Atenolol 0.3 0.4 0.9 -0.4 -0.1 -0.4 -0.9 -0.8
Medication: Levothyroxine sodium 4.8 8.2 10.9 0.3 3.2 3.0 3.3 3.3
Sitting height 0.4 2.7 7.9 0.8 -2.2 -2.8 -0.3 -0.4
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 -0.3 -1.0 -0.1 0.6 0.7
High blood pressure (mother) 0.8 1.1 2.7 0.4 -0.5 -0.1 -1.6 -1.5
Body mass index (BMI) 7.5 32.2 53.9 1.4 -5.7 -4.4 -7.3 -7.3
Impedance of leg (left) 0.6 2.7 4.5 -2.1 -1.9 -1.7 1.1 1.1
Leg predicted mass (left) 2.0 10.6 14.7 1.7 -3.0 -3.4 -3.8 -3.8
Trunk fat mass 12.4 53.3 74.7 0.4 -8.4 -6.9 -8.6 -8.6
Waist circumference 11.1 40.7 55.7 0.1 -7.5 -6.1 -7.5 -7.4
Number of incorrect matches in round 2.3 3.9 8.3 -2.9 2.2 0.3 1.8 1.7
Past tobacco smoking 2.7 5.0 7.4 -1.1 -2.5 -2.0 -2.7 -2.5
Alcohol usually taken with meals 1.1 1.7 3.0 -1.7 1.2 1.1 1.1 1.2
Nervous feelings 1.1 2.0 3.8 -2.0 1.9 1.3 0.7 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.3 -0.3 1.8 0.5 0.6 0.6
Hearing difficulty/problems with background noise 4.1 6.6 8.5 -2.9 2.8 2.4 2.4 2.4
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.4 -0.8 0.5 0.1 0.2
Had menopause 1.1 1.4 2.2 -0.1 -1.3 -1.0 -1.5 -1.4
Had other major operations 2.8 3.4 5.8 1.0 -1.9 -0.9 -2.4 -2.4
Forced vital capacity (FVC) 0.5 2.0 5.0 0.1 0.4 0.4 2.2 2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.7 1.3 0.2 0.9 -0.7 -0.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.9 -0.5 0.7 1.4 -0.3 -0.3
Qualifications: None of the above 1.4 3.1 4.0 0.3 -2.0 -1.9 -2.0 -2.0
Financial difficulties in last 2 years 1.9 2.6 6.8 -1.3 1.7 2.6 1.0 0.8
Mouth/teeth dental problems 2.0 3.0 6.8 -1.7 -2.0 -2.6 -0.9 -0.9
Heart attack 0.8 1.0 1.7 -1.2 1.1 1.3 0.5 0.6
Allergy 0.6 1.4 3.0 -0.8 -0.5 -0.1 -1.7 -1.7
Pain all over the body in last month 0.7 0.7 1.4 -0.9 -1.1 -1.2 0.2 0.0
Diabetes (self-reported) 0.3 0.5 1.6 -0.6 -0.5 1.3 0.4 0.5
Hayfever/allergic rhinitis (self-reported) 3.5 4.6 9.1 0.8 2.1 0.4 3.0 3.0
Medication: Ramipril 0.1 0.1 0.3 -0.6 -0.2 -0.0 0.1 -0.1
Medication: Simvastatin 0.0 0.0 0.1 -0.2 -0.3 0.0 0.0 0.1
Fluid intelligence score 1.7 3.6 7.9 0.8 1.2 0.7 2.8 2.8
Illnesses of siblings 0.5 0.7 1.7 -0.4 -0.9 -1.3 -0.6 -0.8
Neuroticism score 0.5 1.1 4.3 -2.1 0.7 0.4 -0.5 -0.6
Weight 6.2 30.4 42.5 1.3 -6.0 -5.5 -6.5 -6.5
Impedance of arm (right) 0.5 2.2 9.4 -3.1 -0.6 -0.6 0.6 0.6
Arm fat percentage (right) 12.0 47.5 77.1 0.5 -7.3 -5.5 -8.8 -8.7
Trunk fat-free mass 0.7 4.0 4.9 2.2 -1.6 -2.2 -1.9 -1.9
Hip circumference 4.4 18.9 32.7 1.0 -4.0 -3.5 -5.7 -5.7
Time employed in main current job 0.9 1.0 3.5 -1.9 -0.5 0.5 -0.8 -0.6
Alcohol intake versus 10 years previously 0.4 0.6 1.2 -0.7 0.9 1.1 0.6 0.5
Father’s age at death 5.0 6.7 9.3 1.6 -2.9 -2.1 -3.0 -3.1
Worrier / anxious feelings 0.6 1.1 3.7 -1.9 0.5 0.5 0.9 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 0.8 -0.9 -0.1 0.8 -0.7 -0.6
Falls in the last year 0.1 0.2 0.6 -0.7 -0.2 0.5 0.2 0.3
Hair/balding pattern: Pattern 3 0.5 0.8 1.9 -0.2 0.7 0.3 1.4 1.2
Number of live births 2.0 2.8 5.8 -0.1 -2.4 -0.6 -2.0 -2.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.3 0.4 -0.8 -0.5 1.2 1.1
Pulse rate 2.1 3.5 5.6 0.4 -2.4 -1.1 -2.3 -2.2
Happiness 2.7 3.3 7.8 -2.8 2.2 1.8 0.7 0.6
Noisy workplace 0.3 0.4 0.9 0.6 0.9 0.2 -0.6 -0.7
Qualifications: A levels/AS levels or equivalent 5.6 12.4 18.4 -0.5 4.0 3.0 4.2 4.3
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.9 -0.1 -2.0 -0.6 -0.8 -0.6
Mouth/teeth dental problems: Dentures 1.0 1.7 3.3 1.8 -0.8 0.6 -1.5 -1.5
Asthma 0.1 0.2 0.5 0.4 -0.7 -0.6 0.3 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.7 6.4 -2.5 -0.2 -1.1 0.8 0.8
Medication: Cholesterol lowering 0.5 0.8 1.5 -0.7 -0.1 0.6 1.2 1.2
Depression (self-reported) 0.8 1.0 2.0 0.4 1.4 1.4 0.7 0.6
Medication: Lansoprazole 1.6 1.9 4.6 -0.0 -2.1 -0.6 -1.4 -1.5
Prospective memory result 1.7 2.1 3.6 -1.8 0.6 0.1 -1.8 -1.9
Lung cancer (father) 0.9 1.1 4.7 2.2 -0.4 -0.7 -0.0 0.0
Illnesses of mother 2.1 2.6 5.4 -0.5 1.2 1.1 2.3 2.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 1.6 1.3 -1.0 -0.9 0.5 0.4
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 0.4 0.3 0.1 -1.0 -1.1
Impedance of arm (left) 0.4 1.7 6.7 -2.6 -0.7 -0.6 0.7 0.7
Arm fat mass (right) 10.1 41.6 65.2 0.9 -6.7 -5.7 -8.1 -8.0
Trunk predicted mass 0.7 3.9 5.0 2.2 -1.6 -2.2 -1.9 -1.9
Standing height 0.2 2.4 9.0 0.0 -1.5 -3.0 0.7 0.6
Length of working week for main job 0.6 0.7 1.2 1.1 -0.7 0.3 -1.0 -0.9
Exposure to tobacco smoke at home 1.6 1.8 4.8 -2.2 0.8 1.9 -0.2 -0.2
Breastfed as a baby 3.0 3.7 5.1 0.8 2.3 2.0 2.1 2.1
Tense / ‘highly strung’ 0.2 0.3 1.4 -0.2 1.2 0.1 0.3 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.9 -1.0 1.3 2.0 0.8 0.8
Hair/balding pattern: Pattern 4 0.9 2.2 6.2 2.5 0.1 -1.2 -1.2 -1.4
Birth weight of first child 1.0 1.8 4.5 0.6 -1.9 -2.1 -0.5 -0.5
Peak expiratory flow (PEF) 0.3 0.7 2.5 -0.2 -1.6 -0.8 -0.5 -0.6
Pulse wave reflection index 0.2 0.2 0.4 0.5 0.1 -0.5 -0.5 -0.6
Ever highly irritable/argumentative for 2 days 0.3 0.3 0.8 -0.9 0.5 -0.6 -0.3 -0.4
Loud music exposure frequency 1.6 1.7 3.4 1.9 1.5 1.0 -1.0 -1.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 5.0 0.9 0.7 1.4 2.1 2.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 -0.7 0.2 1.0 -0.5 -0.4
Blood clot in the leg (DVT) 2.3 3.0 5.2 0.4 -2.2 -2.3 -1.5 -1.6
Medication: Paracetamol 1.3 2.2 5.0 0.1 -0.7 -1.0 -2.2 -2.1
Headache pain in last month 0.4 0.8 1.9 1.4 0.8 0.8 -0.5 -0.5
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 -0.0 0.0 -0.7 -0.6 -0.6
Glaucoma (self-reported) 0.4 0.4 1.2 0.1 -1.1 -0.3 -0.6 -0.6
Gout (self-reported) 5.7 7.8 10.2 2.5 -2.2 -3.2 -3.0 -3.0
Hypothyroidism/myxoedema (self-reported) 3.1 6.0 9.9 -0.0 2.2 2.5 3.0 3.1
Medication: Amlodipine 0.6 0.8 2.1 0.9 0.1 -1.5 -0.7 -0.8
Medication: Ventolin 100micrograms inhaler 0.7 1.0 2.1 0.1 -1.5 -0.8 -1.0 -1.0
Birth weight 0.5 1.1 3.0 0.2 -1.7 -1.1 -0.8 -0.8
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.8 -0.3 -1.3 -0.6 -0.9 -0.8
High blood pressure (siblings) 0.5 0.7 1.3 0.9 1.2 0.7 0.5 0.7
Forced vital capacity (FVC), Best measure 0.5 1.7 3.6 1.2 0.3 -0.1 1.9 1.8
Body fat percentage 14.6 57.6 82.1 0.2 -8.8 -6.9 -9.1 -9.0
Leg fat percentage (right) 14.5 52.7 75.6 0.5 -8.7 -6.6 -8.5 -8.4
Arm fat-free mass (right) 2.0 10.5 12.8 2.8 -3.2 -3.6 -3.3 -3.3
Exposure to tobacco smoke outside home 0.7 1.0 3.0 -1.1 1.7 -0.4 0.6 0.5
Comparative body size at age 10 1.8 5.1 9.9 1.9 -1.2 -0.7 -3.1 -3.1
Number of full brothers 1.9 2.4 3.8 1.2 1.6 0.5 1.9 1.9
Worry too long after embarrassment 0.8 1.3 3.1 -1.8 1.1 0.8 1.0 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 2.8 -0.8 1.7 1.2 0.4 0.4
Wheeze or whistling in the chest in last year 0.7 1.2 2.8 -0.3 -1.7 -1.4 -0.6 -0.6
Number of children fathered 4.2 4.8 7.2 1.6 -2.3 -2.7 -2.1 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.6 0.4 0.8 0.5 -0.6 -0.6
Age at first live birth 1.1 1.9 3.4 -0.1 0.8 1.4 1.8 1.8
Pulse wave peak to peak time 0.6 0.7 1.4 -0.3 -0.7 -0.4 1.1 1.2
Health satisfaction 0.5 0.7 1.0 0.1 0.7 -1.0 -0.9 -1.0
Shortness of breath walking on level ground 0.7 0.9 1.4 0.0 -0.3 -1.2 -1.2 -1.2
Qualifications: College or University degree 5.7 18.0 25.5 -1.3 4.8 3.9 5.0 5.1
Eye problems/disorders: None of the above 0.2 0.2 0.5 0.5 0.7 0.4 0.4 0.3
Mouth/teeth dental problems: Loose teeth 5.7 6.8 9.9 0.2 2.7 3.1 2.9 2.9
Emphysema/chronic bronchitis 0.4 0.5 2.1 -1.5 -0.1 0.5 -0.0 0.0
Medication for pain relief, constipation, heartburn 0.3 0.5 0.8 0.3 0.8 0.9 0.7 0.7
Neck or shoulder pain in last month 2.0 2.9 7.7 -1.6 1.5 2.8 0.9 1.1
Medication: Blood pressure 0.6 1.0 3.4 0.2 1.1 1.9 0.4 0.4
Angina (self-reported) 0.8 1.1 3.7 -1.9 0.5 1.2 -0.1 -0.1
Migraine (self-reported) 0.7 0.9 2.2 1.5 0.1 -1.0 -0.7 -0.8
Medication: Ibuprofen 1.7 2.1 6.7 -2.6 -0.7 -1.6 0.5 0.5
Medication: Allopurinol 0.3 0.4 1.1 0.9 -0.2 -1.0 -0.3 -0.3
Medication: Omeprazole 0.1 0.2 0.4 0.2 0.5 0.6 -0.2 -0.3
Medication: Seretide 50 evohaler 0.8 0.9 2.3 1.5 -1.3 0.5 0.4 0.5
Mean time to correctly identify matches 3.0 5.8 10.0 0.3 2.4 1.7 3.1 3.2
Heart disease (mother) 0.1 0.1 0.2 0.1 -0.4 -0.2 -0.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.2 -0.8 -0.4 1.5 0.2 0.3
Whole body fat mass 12.2 51.1 71.7 0.8 -8.1 -6.9 -8.5 -8.4
Leg fat mass (right) 12.8 49.8 68.2 1.1 -8.2 -6.7 -8.3 -8.2
Arm predicted mass (right) 1.9 9.5 13.2 2.3 -3.1 -3.6 -3.1 -3.1
Pulse rate, automated reading 1.2 4.0 11.8 -0.3 -3.4 -1.1 -1.9 -1.8
Alcohol intake frequency. 0.6 1.3 3.4 -1.6 1.8 0.3 0.6 0.6
Comparative height size at age 10 2.1 11.3 23.2 -0.1 -4.4 -4.8 -2.6 -2.7
Number of full sisters 4.3 5.2 9.0 -1.1 2.0 1.8 3.0 3.0
Suffer from ‘nerves’ 2.6 4.1 5.7 -1.9 1.4 2.4 2.1 2.1
Overall health rating 0.9 2.0 3.2 -1.8 -0.8 -0.3 -1.8 -1.7
Chest pain or discomfort 0.9 1.3 3.7 -1.9 -0.4 -1.6 -0.3 -0.3
Had major operations 1.2 1.4 2.7 1.6 -1.0 0.3 -1.2 -1.3
Age at last live birth 2.8 4.0 7.3 0.0 1.6 1.9 2.7 2.6
Family relationship satisfaction 1.2 1.5 3.0 -0.9 1.7 1.4 0.9 0.8
Leg pain on walking 0.6 0.8 3.1 -0.4 1.8 0.7 -0.3 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.9 -0.3 -1.4 -0.9 -1.0 -0.9
Commuting to job workplace: Car/motor vehicle 5.0 5.7 10.4 0.2 -2.6 -1.3 -3.2 -3.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 0.7 0.8 -0.6 -0.2 -0.3
Medication: Aspirin 0.7 0.9 1.6 -0.9 0.6 1.3 0.9 1.0
Supplements: Vitamin C 1.3 1.6 3.9 -2.0 1.1 1.1 0.8 0.9
Knee pain experienced in last month 0.5 0.7 1.8 -0.4 0.1 -0.2 -1.3 -1.3
Hypertension (Self-reported) 0.3 0.9 2.1 0.6 0.2 -0.1 -1.4 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.9 -0.6 -0.2 -1.0 -0.4 -0.5
Illnesses of father: Heart disease 0.7 1.0 3.5 -0.7 1.9 1.0 -0.1 -0.0
Illnesses of siblings: Diabetes 0.3 0.3 0.8 -0.7 0.3 0.9 -0.4 -0.4
Smoking status: Previous 1.9 2.8 3.8 1.0 1.6 1.9 1.9 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 2.0 -0.8 -0.4 -1.4 0.5 0.4
Whole body fat-free mass 1.2 6.6 7.9 2.1 -2.3 -2.8 -2.8 -2.8
Leg fat-free mass (right) 1.4 7.2 10.4 1.8 -2.2 -2.7 -3.2 -3.2
Arm fat percentage (left) 11.8 47.1 76.7 0.7 -7.3 -5.4 -8.8 -8.7
Average weekly red wine intake 0.9 1.3 2.0 -1.4 0.0 1.4 1.2 1.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.3 1.2 0.8 0.4 0.8 0.8
Mood swings 1.4 2.5 5.3 -1.2 -0.2 -0.6 -2.3 -2.3
Loneliness, isolation 0.1 0.2 0.4 0.0 0.7 -0.3 0.3 0.5
Long-standing illness, disability or infirmity 1.1 1.7 4.2 -2.0 0.5 2.0 0.0 0.0
Ever had bowel cancer screening 0.1 0.1 0.2 -0.2 -0.0 0.0 0.5 0.5
Diabetes diagnosed by doctor 0.6 1.0 2.6 -0.4 -0.3 1.6 1.0 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.8 -0.5 0.9 1.3 0.8 0.9
Friendships satisfaction 4.7 5.9 8.1 -1.5 2.8 2.8 2.4 2.3
Qualifications: nursing, teaching 1.0 1.5 2.7 -0.6 1.0 1.0 1.6 1.6
Commuting to job workplace: Walk 4.0 4.3 5.2 2.3 2.0 1.4 2.3 2.3
Eye problems/disorders: Cataract 0.5 0.6 1.7 -0.5 -1.3 -1.1 0.0 0.1
Mouth/teeth dental problems: Mouth ulcers 5.8 9.3 21.6 0.2 4.6 4.0 2.1 2.1
Medication for cholesterol 2.3 3.5 8.5 -0.3 0.5 0.6 2.9 2.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.5 4.2 2.0 1.1 0.7 0.9 0.9
Back pain experienced in last month 1.8 2.6 4.4 -0.6 -1.2 -1.7 -2.1 -2.0
Mineral and other dietary supplements 0.3 0.4 0.8 -0.6 -0.9 -0.2 -0.6 -0.6
Breast cancer (self-reported) 2.5 3.0 8.0 -0.1 -2.8 -1.5 -1.6 -1.5
Asthma (self-reported) 0.1 0.2 0.3 0.1 -0.6 -0.5 0.5 0.5
Osteoporosis (self-reported) 0.5 0.6 1.2 0.1 -0.5 -0.6 -1.0 -1.1
Osteoarthritis (self-reported) 1.2 1.5 2.4 1.2 -0.9 -0.9 -1.5 -1.5
Medication: Aspirin 0.4 0.5 0.9 -0.5 0.2 0.9 0.7 0.8
Medication: Gliclazide 1.4 1.5 4.0 -1.7 0.6 2.0 0.4 0.4
Illnesses of father: None of the above (group 1) 0.2 0.2 0.6 -0.2 -0.8 -0.0 0.6 0.5
Smoking status: Current 0.1 0.2 0.5 0.7 0.4 -0.7 0.2 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 6.1 2.5 -0.3 -0.2 -0.6 -0.6
Whole body water mass 1.2 6.8 8.1 2.1 -2.3 -2.8 -2.8 -2.9
Leg predicted mass (right) 1.3 7.0 9.8 1.8 -2.2 -2.8 -3.1 -3.1
Arm fat mass (left) 10.3 42.1 66.9 1.1 -6.8 -5.6 -8.2 -8.1
Number of self-reported non-cancer illnesses 0.4 0.7 2.7 1.7 0.3 0.5 -0.5 -0.5
Average weekly champagne plus white wine intake 3.4 4.6 10.1 -0.8 2.2 3.2 1.8 2.0
Miserableness 1.1 1.8 5.8 -2.4 -0.8 -0.5 -1.1 -1.1
Guilty feelings 0.9 1.3 4.1 0.2 2.0 0.5 1.1 1.1
Wears glasses or contact lenses 0.2 0.2 0.6 0.7 -0.7 -0.3 -0.3 -0.2
Ever taken oral contraceptive pill 1.0 1.1 2.0 -0.3 1.4 1.4 0.9 0.8
Hearing aid user 0.6 0.6 1.7 -1.3 -0.6 0.7 -0.6 -0.5
Mother’s age at death 0.1 0.2 0.3 -0.5 0.0 -0.4 0.5 0.4
Financial situation satisfaction 1.2 1.5 4.0 0.7 2.0 1.1 1.1 0.9
Tinnitus: Yes, now most or all of the time 3.0 3.6 8.3 -0.5 2.9 2.2 1.5 1.4
Commuting to job workplace: Public transport 1.6 2.0 3.0 1.7 1.7 0.8 1.3 1.3
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 -0.2 -0.4 0.5 -0.3 -0.3
Medication: Blood pressure 1.6 3.0 6.0 -0.7 -1.1 -1.1 -2.4 -2.5
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.7 0.8 -0.3 -0.5 -0.4 -0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.9 -1.4 0.7 0.4 0.0 -0.0
High cholesterol (Self-reported) 0.9 1.6 3.8 0.0 -2.0 -1.6 -0.9 -0.9
Medication: Bendroflumethiazide 0.2 0.3 0.7 -0.3 -0.5 -0.2 -0.8 -0.8
Medication: Paracetamol 1.7 2.6 6.2 -0.0 -0.7 -0.7 -2.5 -2.4
Medication: Lisinopril 0.5 0.6 0.7 -0.9 0.8 0.6 0.8 0.8
Medication: Atorvastatin 0.2 0.2 0.7 -0.1 -0.5 -0.8 -0.2 -0.2
Illnesses of father: High blood pressure 1.5 1.8 5.5 2.3 0.5 -1.0 -1.1 -1.1
Alcohol drinker status: Never 0.1 0.2 0.7 -0.9 0.2 0.1 0.1 0.1
Ever smoked 4.0 7.1 10.9 0.9 3.3 2.4 3.1 2.9
Basal metabolic rate 1.9 10.4 13.4 1.9 -3.1 -3.4 -3.7 -3.7
Leg fat percentage (left) 13.8 50.0 70.1 0.6 -8.3 -6.5 -8.4 -8.3
Arm fat-free mass (left) 1.9 9.8 13.0 1.8 -3.1 -3.6 -3.4 -3.4
Number of operations (self-reported) 1.9 2.8 5.4 1.5 -0.7 -0.8 -2.3 -2.3
Average weekly beer plus cider intake 1.0 1.4 2.3 1.5 -1.0 -1.3 -1.0 -1.1
Irritability 0.4 0.6 2.7 -1.6 0.4 0.1 0.4 0.3
Risk taking 3.4 4.9 12.1 -0.5 3.5 3.0 1.2 1.2
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.9 -0.4 -0.3 -0.2 -0.9 -0.9
Fractured/broken bones in last 5 years 0.5 0.6 1.3 -0.5 0.4 -0.4 1.2 1.1
Age started oral contraceptive pill 0.7 0.8 2.5 0.1 0.5 -1.6 0.9 0.8
Diastolic blood pressure, automated reading 4.1 12.8 23.1 3.4 -2.0 -1.7 -4.8 -4.8
Ever depressed for a whole week 0.5 0.6 1.1 0.6 1.0 0.9 -0.6 -0.7
Unable to work because of sickness or disability 0.1 0.2 0.6 0.4 0.8 0.3 0.0 0.1
Commuting to job workplace: Cycle 2.1 2.6 3.3 -1.2 1.7 1.4 1.8 1.8
Myopia 4.7 6.9 10.8 -0.6 2.6 2.4 3.3 3.3
Vascular/heart problems diagnosed by doctor 0.2 0.5 1.1 -0.2 -1.1 -0.7 0.7 0.7
Cholesterol lowering medication 2.3 3.4 6.1 0.4 -1.4 -1.7 -2.4 -2.5
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.1 0.0 0.3 0.3 -0.2 -0.2
Pain experienced in last month 0.2 0.3 0.8 0.6 -0.9 -0.6 0.1 0.1
Supplements: Calcium 1.3 1.4 3.1 0.0 1.8 1.4 0.9 1.0
Basal cell carcinoma (self-reported) 0.7 0.8 2.0 1.0 1.4 0.8 -0.4 -0.5
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.7 -1.2 1.0 1.3 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.6 1.0 -2.0 -2.1 -1.3 -1.4
Heart disease (siblings) 0.8 1.0 1.6 0.5 1.1 0.8 1.2 1.3
Alcohol drinker status: Previous 1.5 1.7 6.2 0.4 2.5 1.3 0.4 0.4
Pack years of smoking 1.9 2.8 4.6 2.1 0.2 -0.6 -2.1 -2.1
Impedance of whole body 0.5 2.7 7.8 -2.8 -1.3 -1.2 1.1 1.1
Leg fat mass (left) 12.5 48.7 68.2 1.1 -8.0 -6.5 -8.3 -8.2
Arm predicted mass (left) 1.5 7.6 10.0 1.9 -2.8 -3.2 -2.9 -2.9