TWAS hub - PDE4C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.144	0.0310	7.8e-13	0.156	0.120	0.148	0.135	0.154	1.4e-18	2.0e-14	1.3e-17	4.5e-16	2.8e-18
2	GTEx	Brain Caudate basal ganglia	0.320	0.1200	1.2e-03	-0.009	NA	0.086	NA	0.008	7.2e-01	NA	1.9e-03	NA	1.8e-01
3	GTEx	Brain Putamen basal ganglia	0.405	0.1420	5.0e-03	-0.012	NA	0.020	NA	-0.011	8.1e-01	NA	1.1e-01	NA	7.1e-01
4	GTEx	Esophagus Mucosa	0.281	0.0730	4.2e-05	0.174	NA	0.119	NA	0.139	1.0e-11	NA	2.3e-08	NA	1.6e-09
5	GTEx	Muscle Skeletal	0.111	0.0321	2.6e-06	0.050	NA	0.061	NA	0.063	1.0e-05	NA	1.2e-06	NA	7.7e-07
6	GTEx	Testis	0.390	0.0650	7.6e-11	0.437	NA	0.399	NA	0.433	3.5e-21	NA	5.7e-19	NA	5.8e-21
7	ROSMAP	Brain Pre-frontal Cortex	0.184	0.0351	0.0e+00	0.121	0.150	0.193	0.182	0.189	3.0e-15	7.4e-19	3.3e-24	8.4e-23	1.0e-23
8	TCGA	Bladder Urothelial Carcinoma	0.055	0.0310	2.5e-03	0.070	0.030	0.050	NA	0.062	1.5e-06	1.4e-03	4.7e-05	NA	5.5e-06
9	TCGA	Cervical Squamous Cell Carcinoma	0.131	0.0680	2.1e-03	0.116	0.063	0.089	NA	0.100	2.4e-06	4.9e-04	3.9e-05	NA	1.3e-05
10	TCGA	Colon Adenocarcinoma	0.460	0.0870	1.2e-14	0.385	0.325	0.383	NA	0.385	1.5e-23	2.2e-19	2.2e-23	NA	1.6e-23
11	TCGA	Lung Adenocarcinoma	0.058	0.0248	5.4e-06	0.061	0.057	0.073	NA	0.078	1.1e-07	3.2e-07	6.2e-09	NA	2.1e-09
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.105	0.0500	5.5e-05	0.080	0.068	0.077	NA	0.104	4.6e-06	2.2e-05	6.6e-06	NA	1.5e-07
13	TCGA	Pancreatic Adenocarcinoma	0.469	0.0920	4.2e-12	0.386	0.317	0.350	NA	0.376	2.9e-17	6.8e-14	1.7e-15	NA	9.5e-17
14	TCGA	Rectum Adenocarcinoma	0.341	0.1360	1.3e-03	0.041	0.089	0.111	NA	0.086	4.0e-02	4.2e-03	1.4e-03	NA	4.7e-03
15	TCGA	Stomach Adenocarcinoma	0.075	0.0370	4.8e-04	0.082	0.056	0.063	NA	0.074	1.5e-06	7.1e-05	2.4e-05	NA	4.8e-06
16	TCGA	Uterine Corpus Endometrial Carcinoma	0.203	0.1060	7.1e-03	0.241	0.054	0.124	NA	0.162	2.3e-07	1.3e-02	2.5e-04	NA	2.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8	9	10	11	12	13	14	15	16
Body Mass Index (BMI) (2010)	4.1	5.6	9.9	0.6	0.5	3.0	0.6	-2.4	-0.6	2.9	3.0	2.9	2.6	3.1	2.9	2.6	2.9	2.9
Waist Hip Ratio (WHR)	3.8	17.0	94.9	-7.9	-4.4	0.2	-9.1	-0.9	-9.7	0.4	0.5	0.6	-3.1	0.3	0.2	-0.1	-0.3	0.2
Migraine (self-reported)	3.8	4.7	7.7	1.4	1.4	2.6	0.7	-2.1	0.6	2.7	2.8	2.8	2.3	1.9	2.7	2.5	2.7	2.7
Gout (self-reported)	3.7	5.1	9.8	0.6	0.6	2.8	-0.2	-2.6	-1.1	2.8	2.8	2.9	1.9	3.1	2.8	1.9	2.8	2.8
Myopia	3.7	5.4	16.1	3.0	0.2	2.1	4.0	0.0	3.5	2.1	2.2	2.0	3.0	1.6	2.1	2.3	2.3	2.1
Mouth/teeth dental problems: Dentures	3.6	6.1	13.0	2.0	2.2	2.5	1.6	-3.6	0.8	2.6	2.5	2.5	2.5	3.1	2.5	3.4	2.6	2.5
Mouth/teeth dental problems	3.5	5.4	8.7	-2.2	-1.7	-2.5	-2.8	2.6	-1.6	-2.3	-2.1	-2.3	-2.7	-2.8	-2.3	-2.9	-2.5	-2.3
Number of self-reported non-cancer illnesses	3.2	5.5	9.3	1.5	1.8	2.8	1.4	-1.2	0.6	2.8	2.9	2.8	3.0	2.4	2.8	2.9	2.9	2.8
Average weekly beer plus cider intake	3.2	4.6	6.9	1.7	2.5	2.6	1.2	-2.1	0.8	2.6	2.6	2.6	1.9	2.3	2.5	1.9	2.6	2.5
Waist circumference	2.9	10.5	34.5	-2.4	-1.5	2.6	-4.5	-5.4	-5.9	2.9	3.1	3.1	0.6	3.7	2.9	1.7	2.6	2.9
Time employed in main current job	2.9	3.3	6.0	-2.0	-0.8	-2.1	-1.9	1.3	-1.7	-2.0	-2.3	-2.0	-2.4	-1.7	-2.0	-1.5	-2.1	-2.0
Leg fat percentage (right)	2.9	10.7	37.9	-2.7	-1.2	2.3	-4.8	-5.7	-6.2	2.7	2.9	3.0	0.3	3.8	2.7	1.5	2.5	2.7
Body fat percentage	2.8	10.9	37.7	-2.6	-1.6	2.4	-4.8	-5.8	-6.1	2.8	3.1	3.1	0.1	3.8	2.8	1.4	2.5	2.8
Leg fat mass (right)	2.8	11.0	34.3	-1.9	-0.8	2.8	-4.1	-5.9	-5.4	3.1	3.3	3.4	1.1	4.2	3.1	2.1	2.9	3.1
Arm fat percentage (left)	2.8	11.0	38.6	-1.2	-0.9	3.0	-3.4	-6.2	-4.7	3.3	3.5	3.5	1.1	4.3	3.3	2.3	3.1	3.3
Trunk fat percentage	2.7	10.7	41.2	-3.1	-1.6	2.2	-5.2	-5.4	-6.4	2.6	2.9	2.9	-0.1	3.5	2.6	1.0	2.3	2.6
Leg fat percentage (left)	2.7	9.7	33.6	-2.3	-0.9	2.2	-4.5	-5.7	-5.8	2.6	2.8	2.9	0.3	3.8	2.6	1.4	2.4	2.6
Leg fat mass (left)	2.7	10.7	36.0	-1.5	-0.7	2.8	-3.8	-6.0	-5.2	3.1	3.3	3.3	1.1	4.3	3.1	2.0	2.9	3.1
Arm fat percentage (right)	2.6	10.2	34.6	-1.7	-1.0	2.7	-3.9	-5.9	-5.0	3.0	3.3	3.3	0.7	3.9	3.0	2.1	2.8	3.0
Length of working week for main job	2.6	2.9	4.8	1.3	0.5	2.1	1.3	-1.3	0.6	2.0	2.0	2.0	2.1	2.2	2.0	1.8	2.0	2.0
BMI	2.5	14.3	46.2	0.7	0.7	3.7	-1.6	-6.8	-2.9	4.2	4.6	4.5	2.7	5.1	4.3	2.7	4.2	4.3
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.1	-2.0	0.2	-1.8	-2.0	1.8	-1.8	-1.7	-1.6	-1.7	-1.7	-1.6	-1.7	-1.4	-1.8	-1.7
Trunk fat mass	2.5	10.8	34.2	-2.4	-1.2	2.5	-4.6	-5.6	-5.8	2.9	3.2	3.2	0.6	4.0	2.9	1.6	2.7	2.9
Whole body fat mass	2.5	10.5	35.6	-1.9	-1.1	2.6	-4.2	-6.0	-5.4	3.0	3.2	3.2	0.7	4.0	3.0	1.8	2.7	3.0
Illnesses of father: High blood pressure	2.5	3.1	5.1	2.3	1.5	1.7	1.9	-1.6	1.5	1.8	2.0	1.9	2.1	1.9	1.9	0.9	2.0	1.9
Exposure to tobacco smoke at home	2.4	2.7	4.9	-0.9	1.4	-1.8	-0.4	1.6	-0.1	-1.9	-2.2	-2.0	-1.5	-1.7	-2.0	-1.9	-2.0	-2.0
Arm fat mass (left)	2.4	9.8	34.5	-0.9	-0.4	2.9	-3.1	-5.9	-4.2	3.2	3.4	3.4	1.4	4.1	3.2	2.2	3.0	3.2
Medication: Gliclazide	2.3	2.6	4.1	1.2	0.4	1.9	1.8	-1.0	0.9	1.9	1.9	1.9	1.9	1.8	1.9	1.6	2.0	1.9
Number of operations (self-reported)	2.3	3.4	11.0	2.1	-0.2	2.0	1.1	-3.3	0.8	2.0	2.0	2.0	1.5	1.8	1.9	2.1	2.0	1.9
Arm fat mass (right)	2.2	8.9	34.0	-1.1	-0.4	2.5	-3.3	-5.8	-4.3	2.9	3.1	3.1	1.1	3.9	2.9	1.9	2.7	2.9
Age at First Birth	2.1	3.1	5.5	-0.0	0.5	-2.1	0.8	2.2	1.3	-2.2	-2.3	-2.3	-1.8	-2.1	-2.2	-1.2	-2.1	-2.2
Ever had hysterectomy (womb removed)	2.1	2.3	3.8	0.0	1.6	1.8	-0.1	-1.4	-0.6	1.9	1.9	2.0	1.3	1.9	1.9	1.4	1.9	1.9
Average weekly fortified wine intake	2.1	2.4	6.4	-1.2	-2.5	-1.7	-1.4	0.9	-0.8	-1.7	-1.5	-1.7	-1.9	-1.6	-1.7	-1.1	-1.8	-1.7
Body mass index (BMI)	2.1	9.0	36.2	0.3	0.4	2.9	-1.8	-6.0	-2.9	3.1	3.4	3.3	1.9	4.2	3.2	2.4	3.1	3.2
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	7.3	2.4	0.9	2.2	2.7	0.1	2.2	1.7	1.5	1.5	2.3	1.4	1.6	2.6	1.7	1.6
Had major operations	2.1	2.5	3.7	1.2	-0.4	1.9	1.1	-1.9	0.8	1.8	1.8	1.8	1.9	1.9	1.8	1.6	1.9	1.8
Supplements: Vitamin C	2.1	2.5	4.5	-1.2	-0.4	-1.6	-1.0	1.8	-0.3	-1.9	-2.0	-2.0	-1.4	-2.1	-1.9	-1.5	-2.0	-1.9
Reaction Time	2.0	3.9	8.4	1.4	2.9	-2.0	1.9	1.4	2.8	-2.0	-2.0	-2.1	-1.2	-2.4	-2.0	-1.5	-1.9	-2.0
Prostate Cancer	2.0	2.8	4.6	1.8	-1.6	2.0	1.3	-1.9	0.7	1.8	1.8	1.8	2.0	2.1	1.8	1.6	1.9	1.8
Medication: Metformin	2.0	2.8	4.9	0.9	0.1	2.0	1.2	-0.8	0.2	2.1	2.1	2.1	1.9	2.0	2.1	1.6	2.2	2.1
Bilateral oophorectomy (both ovaries removed)	2.0	2.4	4.2	0.9	-0.9	1.6	0.3	-1.9	-0.6	1.9	2.0	2.0	1.3	1.9	1.9	1.1	1.9	1.9
Impedance of arm (right)	2.0	9.4	21.3	-4.6	-3.5	-2.7	-4.0	3.2	-3.2	-2.4	-2.4	-2.4	-4.2	-3.3	-2.5	-2.9	-2.7	-2.5
Ever smoked	2.0	3.4	10.1	1.6	0.7	-1.7	1.8	1.8	3.2	-1.9	-2.0	-2.0	-0.7	-2.9	-1.9	-0.9	-1.8	-1.9
Schizophrenia vs Biploar Disorder	1.9	2.6	4.8	-1.6	-0.3	0.0	-1.1	1.1	-1.4	-2.0	-1.9	-1.9	-2.2	-1.9	-1.9	-1.6	-2.0	-1.9
Ovarian Cancer	1.9	2.5	5.5	2.1	1.1	1.4	2.4	-1.1	1.9	1.6	1.8	1.6	1.7	1.5	1.7	0.6	1.8	1.7
Pain all over the body in last month	1.9	2.1	5.1	-2.0	-1.7	-1.7	-2.3	0.3	-2.2	-1.2	-1.0	-1.1	-1.7	-0.9	-1.1	-1.4	-1.2	-1.1
Medication: Allopurinol	1.9	2.5	4.3	0.7	-0.0	2.0	0.5	-1.2	-0.1	2.0	2.1	2.0	1.7	1.9	2.0	1.5	2.0	2.0
Supplements: Zinc	1.8	1.9	4.0	-0.2	-2.0	-1.6	-0.2	0.9	0.5	-1.7	-1.7	-1.7	-1.3	-1.9	-1.7	-0.7	-1.7	-1.7
Taking other prescription medications	1.8	2.8	4.6	1.5	1.9	1.9	1.4	-1.9	0.1	1.7	1.7	1.7	2.1	2.0	1.7	2.0	1.8	1.7
Number of incorrect matches in round	1.8	2.9	7.6	-1.9	1.4	-1.9	-1.1	2.8	-0.7	-1.7	-1.7	-1.7	-1.6	-2.0	-1.7	-1.9	-1.8	-1.7
Hearing difficulty/problems with background noise	1.8	2.9	4.9	-1.6	0.7	-2.2	-0.2	2.2	-0.0	-2.1	-1.9	-2.0	-1.5	-2.2	-2.0	-2.0	-1.9	-2.0
Commuting to job workplace: Walk	1.8	1.9	6.0	2.5	0.9	1.3	2.5	-0.8	2.3	1.0	1.1	1.0	1.5	0.8	1.1	1.0	1.2	1.1
Impedance of whole body	1.8	9.0	21.8	-4.7	-3.3	-2.5	-4.0	3.3	-3.5	-2.2	-2.2	-2.2	-4.0	-3.0	-2.3	-3.2	-2.5	-2.3
LDL Cholesterol	1.7	2.7	8.4	-2.2	-2.7	1.3	-2.3	-1.0	-2.9	1.3	1.2	1.3	0.3	1.2	1.2	1.9	1.1	1.2
Average weekly spirits intake	1.7	2.2	10.0	-1.6	-2.6	-0.7	-2.5	-2.0	-3.2	-0.4	-0.3	-0.3	-1.4	0.6	-0.3	-1.3	-0.5	-0.3
Impedance of leg (right)	1.7	8.1	26.8	-5.2	-2.8	-2.1	-4.5	2.9	-4.4	-1.7	-1.7	-1.7	-3.4	-2.2	-1.8	-2.9	-2.1	-1.8
Impedance of leg (left)	1.7	8.3	22.4	-4.7	-2.4	-2.4	-4.0	3.2	-3.9	-2.1	-2.1	-2.0	-3.5	-2.4	-2.1	-3.3	-2.4	-2.1
Falls in the last year	1.7	2.3	4.1	-0.4	-0.2	-1.9	-0.0	0.8	-0.3	-2.0	-1.9	-2.0	-1.9	-1.5	-2.0	-1.3	-2.0	-2.0
Prospective memory result	1.7	2.1	4.5	-1.0	-0.5	-1.6	-1.1	-0.2	-1.0	-1.6	-1.6	-1.6	-2.1	-1.6	-1.7	-1.8	-1.7	-1.7
Loud music exposure frequency	1.7	1.9	4.1	1.8	2.0	1.4	1.9	-1.3	1.9	1.1	1.1	1.1	1.3	1.3	1.1	1.2	1.2	1.1
Qualifications: College or University degree	1.7	5.3	25.1	2.7	2.8	-0.9	4.2	3.0	5.0	-1.4	-1.5	-1.7	0.6	-1.8	-1.4	-0.2	-1.2	-1.4
Weight	1.6	7.8	26.9	-0.5	-0.0	2.6	-2.5	-5.2	-3.5	2.9	3.1	3.0	1.6	3.9	2.9	2.0	2.7	2.9
Hip circumference	1.6	7.0	28.9	1.3	0.6	2.6	-0.4	-5.4	-1.4	2.8	3.0	2.9	2.1	3.8	2.8	2.0	2.8	2.8
Breastfed as a baby	1.6	2.0	5.2	1.3	-0.1	1.4	1.6	1.1	1.6	1.4	1.3	1.3	2.3	1.2	1.5	2.1	1.4	1.5
Pulse rate, automated reading	1.6	5.3	18.8	-3.7	-1.8	-1.8	-4.3	-0.2	-4.1	-1.6	-1.7	-1.5	-2.9	-1.0	-1.6	-1.8	-1.8	-1.6
Illnesses of siblings: Diabetes	1.6	2.0	3.7	-0.0	1.2	1.5	0.0	-1.1	-0.5	1.8	1.7	1.9	1.4	1.9	1.8	0.9	1.8	1.8
Frequency of depressed mood in last 2 weeks	1.5	2.0	3.0	-1.7	0.7	-1.6	-0.9	1.5	-1.1	-1.6	-1.5	-1.6	-1.6	-1.1	-1.6	-1.6	-1.6	-1.6
Diabetes (mother)	1.5	1.9	4.3	-1.7	0.2	-1.3	-1.4	0.4	-1.4	-1.5	-1.5	-1.5	-2.1	-1.5	-1.6	-1.2	-1.6	-1.6
Lung cancer (father)	1.5	1.7	3.8	1.0	0.4	1.5	0.4	-1.9	0.4	1.6	1.6	1.6	1.0	1.7	1.6	1.1	1.6	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.4	1.3	2.1	1.5	2.0	-0.3	1.5	1.6	1.6	1.6	1.9	1.3	1.6	1.0	1.7	1.6
Mean time to correctly identify matches	1.5	2.9	12.0	2.1	3.5	-1.2	2.7	0.4	3.1	-1.2	-1.2	-1.3	-0.4	-1.3	-1.2	-0.5	-1.0	-1.2
Supplements: Calcium	1.5	1.6	4.3	-0.1	0.3	-1.3	0.1	1.4	0.7	-1.6	-1.7	-1.7	-0.7	-2.1	-1.7	-0.9	-1.6	-1.7
Severe depression (siblings)	1.4	1.5	7.7	2.4	1.1	0.5	2.7	0.0	2.8	0.2	0.1	0.1	1.3	-0.1	0.2	0.6	0.4	0.2
Worry too long after embarrassment	1.4	2.3	8.3	-0.7	-0.0	-2.2	0.1	0.7	-0.3	-1.9	-1.6	-1.8	-1.6	-1.0	-1.8	-2.9	-1.7	-1.8
Osteoarthritis (self-reported)	1.4	1.8	4.0	1.0	-0.5	1.8	0.3	-1.7	-0.1	1.5	1.5	1.4	1.5	2.0	1.4	2.0	1.4	1.4
Average weekly champagne plus white wine intake	1.4	1.9	9.1	2.5	0.3	0.8	2.9	-0.5	3.0	0.5	0.4	0.4	1.3	0.2	0.5	1.4	0.7	0.5
Mother’s age at death	1.4	1.7	3.7	-1.9	-0.8	-1.0	-1.8	1.1	-1.2	-1.1	-1.3	-1.1	-1.6	-1.9	-1.1	-1.2	-1.2	-1.1
Depression (Nagel 2018)	1.3	1.9	4.9	-2.2	0.1	-1.4	-1.7	1.0	-2.0	-1.3	-1.3	-1.3	-1.8	-0.7	-1.3	-1.1	-1.4	-1.3
Impedance of arm (left)	1.3	6.0	14.2	-3.8	-3.2	-1.9	-3.3	2.8	-2.6	-1.7	-1.7	-1.7	-3.3	-2.6	-1.7	-2.5	-2.0	-1.7
Health satisfaction	1.3	1.6	4.8	0.8	1.8	1.5	0.7	-1.1	0.4	1.3	1.1	1.2	1.4	1.5	1.2	2.2	1.3	1.2
Age at last live birth	1.3	1.9	5.3	1.1	-0.6	-0.9	1.6	1.7	2.3	-1.4	-1.5	-1.6	-0.3	-2.0	-1.5	0.1	-1.4	-1.5
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.9	-1.3	-0.4	-1.3	-1.5	0.8	-1.3	-1.5	-1.7	-1.5	-1.3	-1.3	-1.6	-0.9	-1.6	-1.6
Basal cell carcinoma (self-reported)	1.3	1.5	3.6	1.9	0.6	1.0	1.6	-1.3	1.7	1.1	1.0	1.1	1.3	0.9	1.1	1.4	1.2	1.1
Rheumatoid Arthritis	1.2	1.7	4.2	1.2	1.3	1.1	2.1	0.5	1.6	1.0	1.2	0.9	2.0	1.0	1.0	1.9	1.1	1.0
Chronotype (morning person)	1.2	2.7	8.4	2.9	2.5	0.7	2.9	-1.0	2.6	0.8	1.3	0.9	1.8	1.0	1.0	1.5	1.1	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.2	-1.0	0.4	-1.7	-0.6	1.8	-0.4	-1.5	-1.4	-1.4	-1.3	-1.4	-1.4	-1.4	-1.4	-1.4
Alcohol usually taken with meals	1.2	1.9	4.6	-1.4	-1.4	-1.5	-0.4	2.1	-0.2	-1.6	-1.5	-1.5	-1.2	-1.7	-1.5	-1.3	-1.5	-1.5
Happiness	1.2	1.5	3.7	-0.7	1.3	-1.2	-0.2	1.4	0.1	-1.3	-1.6	-1.4	-1.1	-1.4	-1.4	-1.9	-1.3	-1.4
Qualifications: A levels/AS levels or equivalent	1.2	2.8	12.6	2.5	1.7	0.9	3.4	1.2	3.5	0.5	0.5	0.3	1.9	0.3	0.5	1.8	0.7	0.5
Number of children fathered	1.2	1.4	4.5	-1.7	-2.1	0.5	-1.9	-1.2	-2.1	0.8	0.9	0.9	-0.0	1.0	0.8	-0.2	0.7	0.8
Age at first live birth	1.2	2.2	7.4	0.5	-1.0	-1.2	1.2	2.7	1.9	-1.5	-1.5	-1.6	-0.7	-2.2	-1.6	-0.7	-1.5	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	8.5	1.4	1.4	1.0	2.9	0.4	2.6	0.7	0.7	0.5	2.0	0.8	0.7	1.4	0.8	0.7
Medication: Atorvastatin	1.2	1.5	3.8	-1.3	-0.7	1.4	-1.3	-0.5	-2.0	1.4	1.2	1.4	0.7	1.2	1.3	1.3	1.1	1.3
Alcohol drinker status: Never	1.2	1.4	2.9	-0.8	-0.5	-1.6	-0.8	1.3	-0.4	-1.4	-1.2	-1.3	-1.5	-1.7	-1.3	-1.3	-1.3	-1.3
Alcohol drinker status: Previous	1.2	1.4	5.9	2.1	1.9	0.4	2.4	-0.4	2.4	0.3	0.4	0.3	0.9	0.1	0.4	0.1	0.5	0.4
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.8	0.3	-0.3	1.9	1.2	0.4	0.5	1.8	1.7	1.7	1.9	1.4	1.8	1.9	1.8	1.8
Hair/balding pattern: Pattern 2	1.1	1.4	3.7	0.3	-1.9	-1.5	0.2	0.0	0.0	-1.4	-1.5	-1.4	-1.3	-0.9	-1.3	-1.6	-1.3	-1.3
Pulse rate	1.1	1.9	7.8	-2.0	-1.3	-1.1	-2.8	-0.5	-2.5	-1.0	-1.0	-0.9	-1.8	-0.3	-1.0	-0.7	-1.1	-1.0
Arm fat-free mass (right)	1.1	5.5	15.1	1.8	1.9	2.4	0.4	-3.9	-0.5	2.4	2.5	2.5	2.7	3.4	2.5	2.1	2.5	2.5
Illnesses of father: Heart disease	1.1	1.5	6.4	0.5	2.5	-0.9	1.1	1.4	1.5	-1.2	-1.0	-1.2	0.0	-1.2	-1.2	-1.1	-1.1	-1.2
Commuting to job workplace: Public transport	1.1	1.3	3.6	1.9	0.3	0.9	1.5	-1.9	1.5	0.9	1.0	0.9	0.8	0.8	0.9	1.4	1.0	0.9
Crohns Disease (2017)	1.0	2.1	4.8	-1.8	-2.1	-1.5	-0.7	0.7	-0.8	-1.6	-1.4	-1.6	-1.5	-0.8	-1.6	-2.2	-1.6	-1.6
HbA1C	1.0	1.1	2.0	-0.4	1.2	-1.2	-0.5	0.9	-0.2	-1.3	-1.3	-1.4	-1.0	-1.4	-1.4	-0.4	-1.4	-1.4
Sensitivity / hurt feelings	1.0	1.7	4.6	-1.5	-0.3	-1.4	-1.8	-1.3	-2.1	-1.1	-1.0	-1.0	-1.6	-0.6	-1.1	-1.8	-1.1	-1.1
Medication: Levothyroxine sodium	1.0	1.6	7.0	1.6	2.2	0.4	2.6	1.6	2.4	0.2	0.2	0.1	1.5	-0.2	0.3	0.5	0.4	0.3
Pulse wave reflection index	1.0	1.2	5.6	1.5	-0.6	0.5	1.2	-2.4	0.2	0.9	1.0	1.0	0.8	1.7	1.0	0.2	1.1	1.0
Smoking status: Previous	1.0	1.6	6.7	2.6	1.1	0.5	2.4	-0.7	2.6	0.2	0.1	0.0	1.0	-0.1	0.1	1.7	0.3	0.1
Average weekly red wine intake	1.0	1.5	2.8	-0.3	-1.5	-1.1	0.4	1.4	0.5	-1.5	-1.7	-1.6	-1.4	-1.3	-1.5	-0.4	-1.5	-1.5
Miserableness	1.0	1.7	4.9	-2.0	0.2	-1.3	-1.6	-0.3	-2.2	-1.1	-1.1	-1.1	-1.4	-0.2	-1.1	-2.1	-1.1	-1.1
High cholesterol (Self-reported)	1.0	1.8	11.4	-2.8	-0.9	0.1	-2.9	0.9	-3.4	0.2	0.1	0.2	-0.4	0.2	0.2	-0.3	-0.0	0.2
Commuting to job workplace: Cycle	1.0	1.3	2.8	0.7	-0.2	-1.1	1.0	1.3	1.4	-1.3	-1.2	-1.3	-0.7	-1.7	-1.3	-0.8	-1.2	-1.3
Cholesterol lowering medication	1.0	1.5	7.1	-2.2	-0.8	-0.7	-2.7	-0.0	-2.7	-0.4	-0.4	-0.3	-1.4	-0.4	-0.4	-1.3	-0.5	-0.4
Primary Biliary Cirrhosis	0.9	1.2	4.8	1.6	1.6	0.9	2.2	0.1	1.8	0.7	0.8	0.6	1.5	0.7	0.7	0.3	0.8	0.7
Heel T-Score	0.9	7.3	13.3	1.5	-0.2	3.2	3.3	-1.1	2.1	3.2	3.3	3.2	3.6	2.8	3.2	1.7	3.4	3.2
Hypothyroidism (self reported)	0.9	2.0	10.6	2.1	0.9	-0.6	3.3	1.9	2.8	-0.6	-0.5	-0.7	1.3	-0.5	-0.5	0.2	-0.3	-0.5
Past tobacco smoking	0.9	1.7	8.6	-2.4	-1.4	0.4	-2.3	0.0	-2.9	0.7	0.7	0.8	-0.3	1.3	0.7	-0.7	0.5	0.7
Medication: Simvastatin	0.9	1.3	3.1	-1.8	0.1	-1.0	-1.7	1.7	-1.4	-0.9	-0.8	-0.9	-1.0	-1.1	-0.9	-1.1	-1.0	-0.9
Illnesses of siblings	0.9	1.2	10.6	-0.6	-3.3	-0.8	-0.4	0.4	-0.3	-0.9	-0.9	-0.9	-1.1	-1.0	-0.9	-0.7	-0.9	-0.9
Shortness of breath walking on level ground	0.9	1.1	2.0	-1.0	-0.9	0.8	-1.3	-0.3	-1.4	1.2	1.4	1.3	0.7	0.8	1.3	0.1	1.2	1.3
Medication: Aspirin	0.9	1.2	4.0	-0.1	1.0	1.6	0.0	0.3	-0.6	1.3	1.2	1.2	1.2	0.8	1.2	2.0	1.2	1.2
Illnesses of father: None of the above (group 1)	0.9	1.1	6.4	-1.6	-2.5	-0.6	-1.5	0.6	-1.3	-0.4	-0.5	-0.3	-1.3	-0.5	-0.4	-0.9	-0.5	-0.4
Ever taken oral contraceptive pill	0.9	1.0	5.2	1.7	0.4	0.7	2.0	0.4	2.3	0.4	0.4	0.3	1.3	0.2	0.4	0.7	0.5	0.4
Depressed Affect (Nagel 2018)	0.8	1.7	10.2	-2.5	1.2	-0.3	-2.4	-1.1	-3.2	0.0	-0.0	0.1	-0.7	0.9	0.0	-1.1	-0.1	0.0
Coronary Artery Disease (CAD)	0.8	1.0	2.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.4	-1.3	-1.4	-0.8	-1.4	-1.4	-1.1	-1.4	-1.4
Crohns Disease (2012)	0.8	1.3	2.1	-1.4	-1.2	-1.2	-0.7	0.0	-1.0	-1.3	-1.2	-1.4	-1.4	-0.6	-1.4	-1.3	-1.4	-1.4
Blood Eosinophil Count	0.8	6.5	16.1	-0.6	0.7	-3.2	0.4	4.0	0.9	-3.1	-3.1	-3.1	-1.6	-3.4	-3.0	-2.4	-3.0	-3.0
Respiratory disease	0.8	1.8	3.0	1.1	-0.2	1.4	0.8	-1.0	0.2	1.7	1.6	1.7	1.7	1.4	1.7	1.5	1.7	1.7
Leg fat-free mass (left)	0.8	4.3	13.3	1.0	0.4	2.2	-0.4	-3.6	-0.9	2.3	2.3	2.4	2.1	2.9	2.3	2.1	2.3	2.3
Relative age voice broke	0.8	1.2	7.2	1.9	0.5	-0.4	2.7	0.3	2.7	-0.4	-0.3	-0.5	0.6	-0.1	-0.4	-0.5	-0.2	-0.4
Leg predicted mass (left)	0.8	4.2	13.4	0.9	0.4	2.2	-0.4	-3.7	-0.9	2.2	2.3	2.3	2.0	2.9	2.3	2.1	2.2	2.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	1.9	0.0	1.2	-1.4	0.4	1.2	0.7	-1.4	-1.3	-1.4	-1.0	-1.3	-1.4	-1.1	-1.3	-1.4
Qualifications: None of the above	0.8	1.7	9.5	-2.3	-1.1	-0.7	-2.8	-1.0	-3.1	-0.1	0.0	0.0	-1.3	0.1	-0.1	-0.6	-0.2	-0.1
Overall health rating	0.8	1.8	5.2	-2.3	-0.1	-1.2	-1.9	1.0	-1.8	-1.3	-1.2	-1.3	-1.4	-1.0	-1.3	-0.8	-1.4	-1.3
Chest pain or discomfort	0.8	1.2	5.0	-2.2	-0.2	-0.9	-2.1	1.3	-2.0	-0.4	-0.0	-0.2	-0.5	-0.3	-0.3	-1.4	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.1	-0.4	-1.4	0.7	-1.1	-1.0	-1.4	1.1	1.2	1.2	0.2	0.9	1.1	-0.3	1.0	1.1
Basal metabolic rate	0.8	4.3	13.3	0.9	1.0	2.2	-0.4	-3.6	-1.0	2.2	2.3	2.3	2.1	3.0	2.3	2.1	2.2	2.3
Fasting Glucose	0.7	0.9	3.6	-0.3	-1.4	-0.9	-0.2	1.9	0.4	-0.9	-0.9	-0.9	-0.3	-1.5	-0.9	-0.7	-0.9	-0.9
Lung FEV1/FVC ratio	0.7	3.5	18.6	-2.0	-0.7	1.2	-3.1	-2.8	-4.3	1.3	1.2	1.4	-0.5	2.0	1.2	1.2	1.1	1.2
Medication: Co-codamol	0.7	0.8	5.6	-0.0	2.4	-0.8	-0.3	-0.2	0.3	-0.8	-0.7	-0.8	-0.9	-0.9	-0.8	-0.9	-0.8	-0.8
Neuroticism score	0.7	1.5	4.2	-2.1	1.3	-1.2	-1.2	0.3	-1.7	-1.1	-1.0	-1.0	-1.1	-0.3	-1.0	-2.0	-1.0	-1.0
Asthma	0.7	1.4	2.4	1.3	0.3	1.2	0.9	-1.1	0.5	1.3	1.3	1.3	1.6	1.3	1.3	1.6	1.3	1.3
Depression (self-reported)	0.7	0.9	5.5	0.5	2.3	0.8	1.1	0.0	0.8	0.8	0.7	0.7	1.0	0.7	0.8	0.9	0.8	0.8
Medication: Lansoprazole	0.7	0.8	3.0	-1.4	-1.4	0.6	-1.6	-0.3	-1.7	0.8	0.8	0.8	0.2	0.4	0.7	0.4	0.7	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.6	-0.5	0.1	-1.1	-0.6	0.0	-0.6	-1.1	-1.2	-1.1	-1.3	-0.7	-1.2	-0.9	-1.1	-1.2
Arm predicted mass (right)	0.7	3.6	11.5	1.1	1.6	1.9	-0.3	-3.4	-0.9	1.9	2.0	2.0	2.1	2.8	2.0	1.6	1.9	2.0
Number of full sisters	0.7	0.8	3.1	-0.9	0.0	-0.9	-0.4	1.8	0.4	-0.8	-0.9	-0.8	-0.6	-1.6	-0.8	-1.2	-0.8	-0.8
Whole body fat-free mass	0.7	3.8	10.4	1.4	1.3	2.0	0.2	-3.2	-0.2	2.0	2.0	2.1	2.3	2.7	2.0	2.1	2.1	2.0
Risk taking	0.7	1.0	5.4	0.8	0.7	-0.5	1.7	1.5	2.3	-0.7	-0.7	-0.8	-0.0	-0.8	-0.7	0.3	-0.5	-0.7
Arm predicted mass (left)	0.7	3.3	11.4	1.0	1.7	1.8	-0.2	-3.4	-0.8	1.8	1.9	1.9	1.9	2.6	1.8	1.8	1.8	1.8
Blood Platelet Count	0.6	6.7	13.2	-0.4	-1.6	-3.6	0.4	1.9	1.3	-3.2	-3.0	-3.1	-2.8	-3.2	-3.1	-3.2	-2.9	-3.1
Blood White Count	0.6	4.5	8.1	-1.6	-0.7	-2.6	-1.4	0.9	-0.8	-2.5	-2.7	-2.5	-2.9	-2.4	-2.5	-2.5	-2.5	-2.5
Systolic Blood Pressure	0.6	2.8	6.7	0.6	2.6	-1.8	0.4	0.7	1.3	-2.0	-2.0	-2.1	-1.6	-1.9	-2.0	-1.4	-1.9	-2.0
Lung FVC	0.6	3.1	17.2	3.7	0.9	-0.3	4.1	-1.1	3.4	-0.6	-0.7	-0.8	0.9	0.2	-0.6	1.0	-0.4	-0.6
Townsend deprivation index at recruitment	0.6	0.8	6.0	-0.4	-0.0	-0.8	-0.3	2.4	0.5	-0.7	-0.4	-0.6	-0.1	-1.3	-0.6	-1.3	-0.6	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.7	2.2	1.3	0.2	2.1	-0.3	2.0	0.4	0.4	0.4	1.5	0.2	0.5	0.6	0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.6	1.2	0.9	0.7	1.6	0.6	1.4	0.8	0.9	0.8	1.1	0.3	0.9	0.4	0.9	0.9
Trunk fat-free mass	0.6	3.5	8.0	1.6	1.8	1.9	0.7	-2.8	0.4	1.8	1.8	1.9	2.4	2.6	1.9	2.1	1.9	1.9
Father’s age at death	0.6	0.8	3.4	-0.4	-0.8	0.9	-1.2	-1.8	-1.8	0.6	0.5	0.6	0.2	0.8	0.5	1.0	0.4	0.5
Trunk predicted mass	0.6	3.5	8.2	1.6	1.8	1.9	0.7	-2.9	0.3	1.8	1.8	1.9	2.4	2.6	1.9	2.1	1.9	1.9
Hair/balding pattern: Pattern 4	0.6	1.6	5.0	2.2	1.5	1.0	1.6	-1.3	2.0	0.9	1.0	0.9	0.9	1.0	0.9	1.2	1.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	5.6	1.1	1.6	0.2	2.4	1.7	1.7	0.2	0.3	0.1	1.7	0.1	0.2	0.7	0.3	0.2
Comparative body size at age 10	0.6	1.8	7.6	2.8	2.3	0.3	1.7	-2.6	1.9	-0.0	-0.1	-0.1	0.1	0.8	-0.0	1.1	0.1	-0.0
Emphysema/chronic bronchitis	0.6	0.6	2.5	-1.5	-1.5	-0.3	-1.0	0.7	-1.6	-0.1	-0.0	-0.0	-0.8	-0.5	-0.1	-0.6	-0.2	-0.1
Neck or shoulder pain in last month	0.6	0.9	2.6	-0.6	-1.3	-1.0	0.2	1.6	-0.6	-1.0	-1.1	-1.0	-0.1	-0.8	-1.0	-0.9	-1.0	-1.0
Comparative height size at age 10	0.6	3.3	20.6	-3.0	-0.2	0.1	-4.0	-1.8	-4.5	0.4	0.2	0.5	-1.4	0.7	0.4	-0.9	0.1	0.4
Leg pain on walking	0.6	0.8	4.5	1.4	2.1	0.3	1.4	-1.2	1.1	0.0	-0.1	-0.1	0.5	0.7	-0.0	0.9	0.1	-0.0
Knee pain experienced in last month	0.6	0.9	2.3	-0.8	-1.2	-0.8	-1.0	-0.3	-1.2	-1.0	-1.0	-1.0	-1.5	-0.3	-1.0	-0.9	-1.0	-1.0
Leg fat-free mass (right)	0.6	3.1	10.0	1.5	0.7	1.8	0.2	-3.2	-0.1	1.8	1.9	1.9	1.9	2.4	1.9	1.8	1.9	1.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	3.0	1.4	0.5	-0.7	1.2	0.3	1.7	-0.8	-0.7	-0.9	-0.1	-0.9	-0.8	-0.6	-0.7	-0.8
Eye problems/disorders: Cataract	0.6	0.7	4.2	-1.4	-0.4	0.6	-1.3	0.0	-2.0	0.6	0.5	0.6	0.4	0.6	0.6	-0.2	0.5	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	5.6	1.2	2.4	0.3	1.0	-0.7	1.2	0.2	0.2	0.1	0.8	0.3	0.2	1.1	0.2	0.2
Whole body water mass	0.6	3.7	10.3	1.3	1.4	2.0	0.2	-3.2	-0.3	2.0	2.0	2.0	2.3	2.7	2.0	2.1	2.0	2.0
Arm fat-free mass (left)	0.6	2.9	11.4	0.6	1.7	1.6	-0.7	-3.4	-1.3	1.6	1.7	1.7	1.6	2.6	1.6	1.5	1.6	1.6
Intelligence (Savage-Jansen 2018)	0.5	1.7	7.5	1.2	1.4	-0.2	2.1	2.7	2.6	-0.5	-0.5	-0.6	0.9	-1.3	-0.5	0.6	-0.3	-0.5
Neuroticism (Nagel 2018)	0.5	1.1	3.2	-1.7	1.6	-0.9	-1.4	-1.0	-1.8	-0.6	-0.4	-0.5	-1.0	0.2	-0.6	-1.6	-0.6	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.3	5.9	1.6	0.8	0.6	2.3	1.4	2.4	0.4	0.4	0.3	1.3	-0.3	0.4	1.1	0.6	0.4
Breast Cancer	0.5	1.2	2.7	0.8	-1.6	-0.9	1.1	1.2	1.4	-1.1	-1.2	-1.2	-0.4	-1.3	-1.1	-0.6	-1.1	-1.1
Triglycerides	0.5	0.8	2.8	-1.3	-1.7	-0.6	-1.2	0.3	-1.2	-0.5	-0.7	-0.5	-1.2	-1.0	-0.5	-0.7	-0.6	-0.5
Ulcerative Colitis	0.5	0.7	2.2	0.9	-0.9	1.0	0.4	-0.9	0.6	0.9	0.9	0.9	0.7	0.7	0.9	1.5	0.9	0.9
Number of treatments/medications taken	0.5	0.9	4.8	1.0	2.2	0.8	1.1	-0.9	0.3	0.6	0.6	0.6	1.1	0.7	0.6	1.3	0.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	0.5	0.9	0.9	0.7	-0.3	0.6	0.9	0.9	0.8	0.7	0.8	0.8	1.0	0.9	0.8
Vitamin and mineral supplements	0.5	0.6	4.8	0.1	-0.6	0.3	-0.3	-2.2	-0.9	0.6	0.7	0.7	-0.3	1.2	0.6	-0.2	0.7	0.6
Fed-up feelings	0.5	1.0	4.7	-1.4	2.2	0.0	-1.3	-1.0	-2.1	0.1	0.1	0.1	-0.2	0.9	0.0	-0.8	0.0	0.0
Age when periods started (menarche)	0.5	1.2	6.4	0.6	-0.9	-0.6	1.4	2.5	2.0	-0.8	-0.7	-0.9	0.4	-1.3	-0.8	0.2	-0.7	-0.8
Multivitamins +/- minerals	0.5	0.6	2.3	1.2	1.3	0.4	1.4	0.7	1.5	0.1	0.1	0.0	1.0	-0.0	0.1	1.1	0.2	0.1
Supplements: Glucosamine	0.5	0.6	3.1	1.6	0.3	0.0	1.5	0.3	1.7	-0.3	-0.3	-0.4	0.5	-0.0	-0.3	0.7	-0.2	-0.3
Fluid intelligence score	0.5	1.0	5.8	1.5	0.2	0.4	2.1	1.4	2.4	0.3	0.4	0.2	1.0	-0.4	0.3	0.6	0.4	0.3
Alcohol intake versus 10 years previously	0.5	0.8	1.6	-0.8	-0.6	-1.2	-0.3	1.3	-0.4	-1.0	-0.9	-1.0	-0.8	-1.0	-1.0	-0.9	-1.0	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	4.0	0.7	2.0	0.4	0.7	-1.2	0.0	0.5	0.5	0.6	0.3	0.9	0.6	0.2	0.6	0.6
Blood clot in the leg (DVT)	0.5	0.7	3.1	-0.7	-1.8	-0.5	-1.5	-0.9	-1.5	-0.3	-0.1	-0.2	-1.1	0.0	-0.2	-0.7	-0.3	-0.2
Headache pain in last month	0.5	0.8	3.9	2.0	0.5	0.4	2.0	-0.7	1.6	0.2	0.2	0.1	1.0	0.6	0.2	0.2	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.5	0.9	1.6	-0.7	0.8	-0.8	1.1	-0.7	-0.5	-0.7	-0.2	-0.3	-0.6	-0.8	-0.5	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.4	0.5	0.8	0.2	1.5	1.7	1.8	-0.1	-0.5	-0.2	0.3	-0.5	-0.2	0.1	-0.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	3.2	-1.1	-1.2	-0.1	-1.5	-0.3	-1.8	-0.2	-0.3	-0.3	-0.3	0.7	-0.3	-0.2	-0.4	-0.3
Ever had bowel cancer screening	0.5	0.6	1.8	-0.9	-0.2	0.7	-0.5	-0.0	-1.3	0.7	0.8	0.7	0.9	0.9	0.7	0.9	0.7	0.7
Diabetes diagnosed by doctor	0.5	0.8	2.0	0.1	1.0	1.2	0.6	0.5	-0.0	1.1	0.8	1.0	1.0	0.7	1.0	1.4	1.0	1.0
Friendships satisfaction	0.5	0.6	3.2	0.3	0.8	-0.3	1.3	1.4	1.8	-0.5	-0.6	-0.6	0.1	-0.6	-0.5	-0.0	-0.4	-0.5
Breast cancer (self-reported)	0.5	0.6	2.7	-0.5	-0.6	0.6	-1.6	-0.7	-1.4	0.7	0.6	0.8	-0.1	0.7	0.7	0.1	0.6	0.7
Leg predicted mass (right)	0.5	2.9	9.4	1.5	0.8	1.8	0.2	-3.1	-0.1	1.7	1.8	1.8	1.9	2.3	1.8	1.7	1.8	1.8
Medication: Blood pressure	0.5	1.0	3.0	-1.5	0.2	-0.6	-1.7	0.5	-1.7	-0.7	-1.1	-0.8	-1.3	-0.7	-0.8	-1.0	-0.9	-0.8
Fractured/broken bones in last 5 years	0.5	0.6	2.6	1.3	1.3	-0.5	1.3	0.3	1.6	-0.6	-0.6	-0.6	-0.2	-0.5	-0.6	-0.0	-0.5	-0.6
Alzheimer’s Disease (in father)	0.4	0.4	1.6	-0.9	-0.7	-0.5	-0.4	0.4	-1.2	-0.5	-0.5	-0.5	-0.7	-0.4	-0.5	-1.2	-0.6	-0.5
Ulcerative Colitis (UC)	0.4	0.7	1.5	0.4	-0.2	0.8	-0.0	-1.0	-0.1	1.1	1.1	1.1	0.6	1.2	1.1	1.1	1.1	1.1
Lupus	0.4	0.6	3.6	0.7	0.8	0.2	1.9	0.3	1.4	0.2	0.4	0.2	1.2	0.5	0.3	0.3	0.5	0.3
Allergy or Eczema	0.4	1.0	2.7	1.6	1.5	0.6	1.6	-0.7	1.3	0.6	0.4	0.5	1.4	0.6	0.6	1.2	0.7	0.6
Relative age of first facial hair	0.4	0.7	1.4	0.7	-1.2	-1.1	1.1	0.8	1.2	-1.0	-0.8	-0.9	-0.1	-0.7	-0.8	-0.8	-0.8	-0.8
Angina	0.4	0.5	2.1	-1.5	-0.5	0.7	-1.1	1.1	-0.9	0.7	0.7	0.7	0.4	-0.2	0.6	0.2	0.6	0.6
Current tobacco smoking	0.4	0.6	1.7	-0.5	-0.3	-1.0	-0.9	0.1	-0.4	-0.8	-0.7	-0.7	-1.0	-0.9	-0.8	-1.3	-0.8	-0.8
Maternal smoking around birth	0.4	0.6	2.7	1.6	0.4	-0.7	1.1	-1.2	1.2	-0.7	-0.5	-0.7	-0.4	-0.2	-0.7	-0.6	-0.6	-0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	-0.2	-0.5	0.7	0.1	-0.2	-0.4	0.8	0.9	0.8	0.8	0.7	0.9	1.2	0.9	0.9
Nervous feelings	0.4	0.8	8.4	0.5	2.9	0.1	1.2	-0.9	0.8	0.3	0.4	0.3	0.6	0.7	0.3	-0.1	0.4	0.3
Forced vital capacity (FVC)	0.4	1.5	2.3	0.7	-1.2	-1.2	1.3	1.3	1.1	-1.5	-1.5	-1.5	-0.5	-1.2	-1.4	-1.0	-1.4	-1.4
Heart attack	0.4	0.5	2.4	-0.2	1.5	0.8	0.3	1.4	0.5	0.5	0.4	0.4	0.8	0.1	0.4	0.8	0.4	0.4
Number of live births	0.4	0.6	2.7	-0.4	-0.7	0.6	-1.1	-1.4	-1.7	0.5	0.2	0.5	0.2	0.7	0.4	1.0	0.3	0.4
Pulse wave Arterial Stiffness index	0.4	0.4	4.6	0.7	-0.5	0.1	0.0	-2.1	-0.4	0.4	0.4	0.5	0.3	0.6	0.4	-0.1	0.4	0.4
Birth weight of first child	0.4	0.8	2.6	0.5	-0.1	0.7	-0.5	-1.6	-0.7	1.0	1.1	1.1	0.7	1.1	1.1	0.8	1.0	1.1
Peak expiratory flow (PEF)	0.4	0.8	6.8	-0.9	-2.6	-0.5	-1.1	-0.1	-1.7	-0.4	-0.5	-0.4	-0.7	-0.1	-0.4	-0.4	-0.5	-0.4
Medication: Amlodipine	0.4	0.5	1.1	1.0	0.6	0.7	0.8	-0.2	0.9	0.7	0.8	0.7	0.9	0.4	0.7	1.0	0.8	0.7
Birth weight	0.4	0.9	2.1	0.2	1.4	1.2	-0.4	-0.7	-0.9	1.0	0.7	1.0	1.3	1.1	1.0	1.1	0.9	1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.3	0.3	-1.1	0.2	0.2	-1.3	-0.7	0.5	0.7	0.6	0.7	1.5	0.6	0.1	0.6	0.6
High blood pressure (siblings)	0.4	0.6	5.5	0.9	2.3	0.3	0.6	-0.6	0.3	0.4	0.4	0.4	0.8	0.7	0.4	-0.1	0.5	0.4
Forced vital capacity (FVC), Best measure	0.4	1.6	3.8	1.5	-0.5	-1.3	1.9	0.1	1.8	-1.5	-1.5	-1.6	-0.4	-0.9	-1.5	-0.4	-1.4	-1.5
Exposure to tobacco smoke outside home	0.4	0.5	1.5	0.8	1.2	-0.7	0.8	-0.0	0.2	-0.8	-0.8	-0.8	-0.6	-0.5	-0.8	-0.5	-0.7	-0.8
Number of full brothers	0.4	0.5	1.9	-0.5	0.4	1.0	-0.6	0.1	-0.2	0.8	0.8	0.8	0.9	0.4	0.8	1.4	0.7	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.6	0.7	1.2	0.5	1.3	0.1	1.1	0.5	0.6	0.5	1.0	0.4	0.6	0.0	0.6	0.6
Pulse wave peak to peak time	0.4	0.5	4.9	-0.9	0.6	-0.1	-0.3	2.2	0.2	-0.3	-0.4	-0.4	-0.2	-0.6	-0.4	0.1	-0.4	-0.4
Medication: Blood pressure	0.4	0.7	2.4	1.1	0.3	0.8	1.5	0.6	1.1	0.8	0.9	0.8	1.1	0.4	0.8	0.8	0.9	0.8
Angina (self-reported)	0.4	0.5	1.1	-1.1	-0.2	0.9	-0.6	0.9	-0.5	0.8	0.8	0.8	0.6	-0.0	0.8	0.3	0.8	0.8
Family relationship satisfaction	0.4	0.4	1.1	-0.0	1.0	-0.3	0.7	0.8	1.0	-0.6	-0.8	-0.6	-0.3	-0.9	-0.6	-0.7	-0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	5.3	-0.2	-2.3	-0.5	0.1	0.4	0.4	-0.5	-0.5	-0.5	-0.6	-0.7	-0.5	-0.4	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.0	-1.7	-2.0	-0.2	-1.8	1.3	-1.4	-0.0	0.0	0.1	-0.2	-0.5	0.0	-0.3	-0.1	0.0
Mood swings	0.4	0.7	3.1	-1.3	1.6	-0.2	-1.3	-1.0	-1.8	-0.2	-0.3	-0.3	-0.3	0.4	-0.3	-0.2	-0.3	-0.3
Qualifications: nursing, teaching	0.4	0.6	2.0	0.8	0.3	0.4	1.4	1.1	1.3	0.1	0.1	-0.0	1.1	0.0	0.1	1.4	0.1	0.1
Back pain experienced in last month	0.4	0.5	3.5	-1.2	-0.9	0.0	-1.2	-0.1	-1.9	0.0	-0.0	0.1	-0.6	0.3	0.0	-0.7	-0.1	0.0
Asthma (self-reported)	0.4	0.8	1.4	1.2	0.5	0.7	0.8	-1.1	0.5	0.8	0.9	0.9	1.1	0.9	0.9	1.2	0.9	0.9
Guilty feelings	0.4	0.6	2.7	1.1	1.6	-0.6	1.3	0.5	1.6	-0.4	-0.1	-0.4	0.2	-0.3	-0.3	-0.9	-0.2	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	-0.2	-0.7	-0.6	0.6	1.2	0.6	-0.9	-0.8	-0.9	-0.3	-0.7	-0.9	-0.2	-0.8	-0.9
Irritability	0.4	0.7	4.3	-2.1	-0.8	-0.1	-1.4	1.1	-1.7	-0.1	-0.2	-0.0	-0.5	-0.4	-0.1	-0.6	-0.1	-0.1
Ever depressed for a whole week	0.4	0.4	2.2	1.2	1.0	-0.1	1.5	0.1	1.5	0.0	0.1	0.1	0.2	-0.0	0.1	-0.4	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.5	0.3	1.5	-0.0	0.2	-1.6	-0.2	0.4	0.7	0.6	0.5	0.8	0.6	-0.8	0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.3	-0.2	1.5	0.8	0.4	1.4	0.5	0.5	0.3	0.3	0.8	0.1	0.3	0.8	0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	3.8	-0.5	-1.9	-0.0	-1.2	-0.9	-1.2	0.2	0.3	0.3	-0.6	0.3	0.2	-0.4	0.1	0.2
Heart disease (siblings)	0.4	0.4	1.2	0.7	0.8	0.8	0.6	0.1	0.9	0.6	0.6	0.5	0.9	0.4	0.5	1.1	0.6	0.5
Bipolar Disorder (2018)	0.3	0.4	1.0	-0.1	-0.9	0.8	-0.5	-0.4	-0.1	0.8	0.7	0.8	0.6	0.8	0.7	1.0	0.7	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-0.5	0.3	1.0	-0.6	-1.0	-0.8	1.0	1.1	1.1	0.7	1.4	1.0	1.1	1.0	1.0
Schizophrenia (2018)	0.3	0.6	1.5	-0.6	1.2	0.6	-0.3	-1.0	-1.0	0.7	0.8	0.8	0.4	1.1	0.7	0.7	0.8	0.7
Worry (Nagel 2018)	0.3	0.7	7.3	-0.7	2.7	0.0	0.1	-1.3	-0.7	0.0	0.2	0.1	-0.2	0.9	0.1	-0.1	0.1	0.1
Alzheimer’s Disease (in mother)	0.3	0.3	2.3	0.3	-0.0	0.1	0.4	1.5	1.3	-0.1	-0.2	-0.2	0.1	-0.8	-0.2	0.6	-0.1	-0.2
Mean Putamen Volume	0.3	0.3	0.8	0.2	-0.3	0.9	0.3	-0.1	-0.0	0.7	0.6	0.6	0.6	0.7	0.6	0.9	0.6	0.6
HDL Cholesterol	0.3	0.4	1.1	0.9	0.3	0.6	1.1	0.1	0.7	0.5	0.5	0.5	0.8	0.8	0.5	1.0	0.6	0.5
Schizophrenia (2014)	0.3	0.7	1.6	-0.6	0.1	0.6	-0.6	-1.2	-1.2	0.8	0.9	0.8	0.3	1.3	0.8	1.1	0.8	0.8
Neuroticism	0.3	0.8	3.0	-1.7	1.6	-0.5	-1.3	-0.7	-1.6	-0.3	-0.2	-0.2	-0.5	0.3	-0.2	-1.4	-0.2	-0.2
Systolic blood pressure, automated reading	0.3	0.8	6.2	0.0	2.5	-0.7	-1.0	-0.4	-0.4	-0.7	-0.8	-0.7	-0.8	-0.6	-0.7	-0.5	-0.7	-0.7
Medication for hormone replacement therapy	0.3	0.4	1.4	0.9	0.4	-0.1	1.2	-0.9	0.7	-0.2	-0.3	-0.3	-0.0	0.3	-0.3	1.2	-0.2	-0.3
Diabetes (father)	0.3	0.4	1.4	-0.9	0.8	-0.2	-1.1	1.0	-0.8	0.1	0.2	0.2	-0.2	-0.5	0.2	-1.2	0.1	0.2
Pack years adult smoking proportion	0.3	0.4	2.8	1.2	1.7	0.1	0.4	-0.6	1.1	0.0	0.0	-0.0	-0.1	-0.4	-0.0	-0.6	0.0	-0.0
Stomach or abdominal pain in last month	0.3	0.3	1.3	-0.0	0.3	-1.0	0.2	0.4	0.5	-0.7	-0.4	-0.7	-0.1	-0.6	-0.6	-1.1	-0.6	-0.6
Medication: Atenolol	0.3	0.4	0.7	-0.6	0.5	0.6	-0.4	0.4	-0.5	0.8	0.8	0.8	0.4	0.2	0.8	0.6	0.7	0.8
Sitting height	0.3	2.1	4.0	-1.1	-1.0	1.4	-1.4	-0.9	-1.8	1.7	1.7	1.8	1.1	2.0	1.7	0.5	1.6	1.7
Had menopause	0.3	0.4	1.7	-0.7	0.9	-0.5	-0.6	-0.7	-1.3	-0.3	-0.2	-0.3	-0.8	0.4	-0.3	-0.7	-0.3	-0.3
Had other major operations	0.3	0.4	1.6	-0.1	0.8	0.6	-1.2	-1.3	-0.8	0.5	0.5	0.5	-0.2	0.1	0.4	0.6	0.3	0.4
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.5	1.2	-0.6	-0.1	1.2	0.2	-0.6	-0.4	-0.6	-0.1	-0.8	-0.5	-0.7	-0.5	-0.5
Diabetes (self-reported)	0.3	0.4	1.1	-0.1	0.8	0.8	0.4	0.5	-0.4	0.8	0.6	0.7	0.7	0.7	0.7	1.0	0.7	0.7
Worrier / anxious feelings	0.3	0.7	1.6	-0.3	0.7	-1.3	0.3	-1.3	-0.7	-1.0	-0.8	-0.9	-0.8	0.2	-0.9	-0.8	-0.8	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.8	-0.5	0.9	-0.2	1.0	-1.0	0.6	0.6	0.5	0.8	0.3	0.5	1.0	0.5	0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.3	-0.7	-0.6	0.6	1.0	1.1	-0.7	-0.7	-0.7	-0.6	-0.8	-0.7	-0.5	-0.6	-0.7
Medication: Ibuprofen	0.3	0.4	2.4	-1.0	-0.5	-0.1	-1.1	-0.7	-1.5	0.1	0.1	0.2	0.1	0.5	0.2	0.2	0.1	0.2
Medication: Omeprazole	0.3	0.3	2.6	0.2	1.6	-0.2	0.1	-0.8	0.1	0.2	0.5	0.4	0.4	0.4	0.4	-1.1	0.4	0.4
Suffer from ‘nerves’	0.3	0.5	6.6	-0.1	2.6	-0.4	0.5	0.5	0.7	-0.2	-0.0	-0.1	0.1	-0.4	-0.1	-0.7	-0.1	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.7	-0.6	1.3	-0.3	-0.7	-0.6	-1.2	-0.0	0.3	0.1	-0.6	0.1	0.1	-1.0	0.0	0.1
Long-standing illness, disability or infirmity	0.3	0.5	1.2	-1.1	0.8	-0.6	-0.3	1.1	-0.7	-0.7	-0.7	-0.7	-0.4	-0.9	-0.7	-0.2	-0.7	-0.7
Smoking status: Current	0.3	0.5	1.2	-0.4	0.1	-0.9	-0.7	-0.1	-0.4	-0.8	-0.7	-0.8	-0.8	-0.8	-0.8	-1.1	-0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.7	0.4	-1.3	-1.0	0.3	-0.2	0.4	-1.2	-1.1	-1.2	-0.5	-0.2	-1.2	-0.2	-1.1	-1.2
Wears glasses or contact lenses	0.3	0.3	1.7	0.9	0.5	0.1	0.6	-1.3	0.3	0.2	0.3	0.2	0.3	0.7	0.2	0.9	0.2	0.2
Hearing aid user	0.3	0.3	1.1	-0.2	0.3	-0.4	0.0	0.2	-0.6	-0.5	-0.5	-0.6	-1.1	-0.5	-0.6	-0.9	-0.5	-0.6
Financial situation satisfaction	0.3	0.4	1.0	-0.7	-0.9	-0.6	-1.0	0.5	-0.5	-0.6	-0.4	-0.6	-0.8	-0.8	-0.6	-0.5	-0.6	-0.6
Unable to work because of sickness or disability	0.3	0.4	2.6	-0.1	1.6	-0.5	-0.2	0.9	0.4	-0.5	-0.4	-0.5	-0.5	-0.4	-0.5	0.1	-0.5	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	1.4	-0.5	-0.8	-0.1	-0.1	1.2	-0.1	-0.3	-0.5	-0.4	-0.5	-0.9	-0.4	-0.2	-0.4	-0.4
Blood Red Count	0.2	2.0	4.7	-1.9	-1.8	-1.2	-1.7	0.7	-2.2	-1.2	-1.4	-1.2	-1.5	-0.9	-1.2	-1.7	-1.3	-1.2
Smoking Status	0.2	0.5	2.7	1.7	0.0	-0.2	1.2	-1.2	1.4	-0.3	-0.3	-0.3	0.3	-0.2	-0.3	0.6	-0.2	-0.3
Hand grip strength (left)	0.2	0.6	1.6	-1.2	0.6	-0.7	-0.7	1.3	-0.8	-0.6	-0.7	-0.6	-0.4	-0.5	-0.6	-1.1	-0.6	-0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	-0.9	1.0	-0.0	-0.6	1.0	-0.8	-0.1	-0.1	-0.2	-0.1	-0.3	-0.2	0.8	-0.3	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	1.1	0.7	1.0	-0.5	0.8	-0.6	0.5	-0.4	-0.2	-0.4	-0.1	-0.1	-0.4	0.3	-0.2	-0.4
Hand grip strength (right)	0.2	0.4	0.9	-0.7	0.9	-0.7	-0.5	0.4	-0.7	-0.7	-0.8	-0.7	-0.5	-0.2	-0.7	-0.7	-0.7	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	1.2	-0.6	0.5	-0.5	-0.4	1.1	-0.6	-0.4	-0.3	-0.4	-0.1	-0.1	-0.4	-0.5	-0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.2	0.9	1.1	-0.2	0.5	-0.6	0.5	-0.1	-0.1	-0.1	-0.2	-0.1	-0.1	-0.3	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.8	-0.9	0.5	0.8	-0.7	0.7	0.5	0.7	0.6	0.9	0.5	0.6	0.3	0.6	0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.1	0.6	1.1	0.3	0.7	-0.3	0.4	0.4	0.5	0.4	0.4	0.5	0.4	0.5	0.5	0.4
Allergy	0.2	0.5	2.3	-1.5	-0.6	-0.2	-1.1	1.1	-0.8	-0.4	-0.5	-0.6	-0.9	-0.4	-0.6	-0.4	-0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	3.0	-0.4	1.7	-0.1	0.6	0.7	-0.2	-0.2	-0.2	-0.3	0.3	0.4	-0.2	0.1	-0.2	-0.2
Hair/balding pattern: Pattern 3	0.2	0.4	1.1	0.3	0.7	0.8	0.5	0.1	0.5	0.6	0.6	0.6	1.0	0.3	0.6	0.8	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	2.2	-0.9	0.0	-0.0	-0.9	-0.1	-1.5	0.1	-0.0	0.1	0.1	0.5	0.1	0.2	0.0	0.1
Illnesses of mother	0.2	0.3	1.0	0.8	0.3	0.2	1.0	-0.4	0.6	0.4	0.6	0.5	0.7	0.4	0.5	0.4	0.5	0.5
Glaucoma (self-reported)	0.2	0.3	1.3	-1.0	-1.1	-0.2	-0.6	-0.1	-1.1	-0.2	-0.1	-0.2	-0.3	-0.1	-0.2	-0.3	-0.2	-0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.8	0.8	-0.5	-0.5	0.7	-0.6	0.3	-0.3	-0.0	-0.2	-0.3	-0.1	-0.1	-1.4	-0.1	-0.1
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.4	0.8	0.3	-0.7	-0.4	-0.9	0.6	0.7	0.7	0.3	0.5	0.6	0.6	0.6	0.6
Eye problems/disorders: None of the above	0.2	0.3	1.9	0.9	-0.3	-0.3	1.0	0.2	1.4	-0.3	-0.1	-0.3	-0.1	-0.4	-0.2	-0.4	-0.2	-0.2
Medication: Aspirin	0.2	0.3	1.9	-0.3	0.8	0.8	0.0	0.6	-0.3	0.5	0.4	0.4	0.5	-0.1	0.4	1.4	0.4	0.4
Loneliness, isolation	0.2	0.3	1.2	-1.1	0.1	0.2	-0.7	0.9	-0.6	0.4	0.4	0.4	0.3	0.3	0.4	-0.2	0.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.2	0.7	-0.2	-0.4	1.1	-0.3	0.7	-0.4	-0.5	-0.5	0.2	-0.3	-0.4	-0.3	-0.3	-0.4
Medication for cholesterol	0.2	0.3	2.0	0.7	-0.3	-0.3	0.9	0.8	1.4	-0.2	-0.1	-0.2	0.2	-0.7	-0.1	-0.7	-0.1	-0.1
Mineral and other dietary supplements	0.2	0.3	0.9	-1.0	-0.7	0.0	-0.6	-0.2	-0.7	0.5	0.6	0.6	-0.4	0.2	0.5	-0.7	0.5	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.7	0.9	-0.7	0.2	0.9	-0.7	0.3	0.2	0.4	0.2	0.6	0.6	0.2	0.2	0.3	0.2
Diastolic blood pressure, automated reading	0.2	0.5	5.1	0.5	0.6	0.3	-1.4	-2.3	-0.7	0.2	0.2	0.3	-0.1	0.5	0.2	-0.4	0.2	0.2
Pain experienced in last month	0.2	0.3	1.6	0.5	1.3	0.5	0.3	-0.2	1.2	0.4	0.5	0.4	0.3	-0.1	0.4	0.4	0.5	0.4
Pack years of smoking	0.2	0.3	2.0	0.9	1.4	-0.1	0.1	-0.6	0.7	-0.1	-0.1	-0.2	-0.4	-0.5	-0.2	-0.7	-0.1	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.8	-0.7	-1.3	-0.5	-0.3	-0.0	-0.3	-0.4	-0.3	-0.4	-0.5	-0.0	-0.4	-0.6	-0.4	-0.4
Neuroticism (2016)	0.1	0.2	1.7	0.0	1.3	-0.0	0.1	-0.8	0.0	0.0	0.0	-0.0	0.3	0.4	0.0	-0.3	0.0	0.0
Height	0.1	2.4	12.0	-3.3	1.1	0.2	-3.5	1.7	-3.3	0.3	0.1	0.3	-0.6	-0.1	0.3	-0.4	-0.1	0.3
Cardiovascular Disease	0.1	0.2	0.9	0.7	0.9	0.5	0.6	-0.8	0.1	0.4	0.2	0.3	0.3	0.4	0.3	0.0	0.4	0.3
Tanning	0.1	1.6	7.3	-2.7	-0.5	-0.6	-2.6	0.4	-2.2	-0.5	-0.6	-0.4	-1.5	-0.9	-0.5	-0.7	-0.7	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	1.0	-0.2	-1.0	0.1	0.4	-0.2	-0.6	0.1	0.2	0.1	0.1	0.3	0.1	0.0	0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.6	0.0	-0.8	0.4	0.1	-0.4	0.0	0.4	0.6	0.5	0.7	0.2	0.5	0.1	0.5	0.5
Qualifications: CSEs or equivalent	0.1	0.2	1.2	-0.3	-0.6	-0.4	-0.2	0.3	-0.2	-0.3	-0.2	-0.3	-0.1	-0.5	-0.3	-1.1	-0.3	-0.3
High blood pressure (mother)	0.1	0.1	0.8	0.1	0.9	0.3	0.2	0.7	0.3	-0.1	-0.5	-0.2	0.1	-0.3	-0.2	0.3	-0.2	-0.2
Medication: Ramipril	0.1	0.1	1.0	0.2	1.0	-0.2	0.5	0.6	0.3	-0.3	-0.3	-0.3	-0.1	0.0	-0.2	0.1	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	3.6	-0.2	-1.9	-0.5	0.1	0.4	-0.5	-0.7	-0.7	-0.7	-0.4	-0.3	-0.7	-0.2	-0.7	-0.7
Noisy workplace	0.1	0.2	1.7	-0.4	-0.7	-0.1	-0.5	0.2	-0.5	-0.0	0.2	0.0	0.2	0.1	0.0	-1.3	-0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.6	0.5	-1.3	-0.5	0.5	-0.7	-0.1	-0.7	-0.7	-0.7	-0.3	0.0	-0.7	0.1	-0.7	-0.7
Standing height	0.1	0.8	3.8	-1.9	-0.7	-0.1	-2.0	1.0	-1.8	-0.0	-0.1	0.0	-0.3	-0.1	-0.0	-0.4	-0.2	-0.0
Tense / ‘highly strung’	0.1	0.1	1.1	-0.7	1.0	-0.1	0.1	0.6	-0.1	-0.1	-0.0	-0.1	-0.2	0.0	-0.1	-0.2	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.9	-0.2	-0.9	0.5	0.2	-0.0	-0.3	0.3	0.2	0.3	0.1	0.3	0.3	-0.6	0.4	0.3
Medication: Paracetamol	0.1	0.2	1.3	0.2	-0.1	-0.2	-0.2	-1.2	-0.6	-0.1	-0.0	-0.0	-0.1	0.5	-0.1	-0.6	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.8	-0.1	0.9	-0.6	-0.3	-0.5	0.3	-0.4	-0.4	-0.3	-0.6	0.1	-0.3	-0.8	-0.3	-0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.7	0.8	0.2	-0.1	0.6	-0.4	0.8	0.2	0.2	0.3	0.0	-0.1	0.3	-0.6	0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	-0.5	-0.4	0.2	-0.3	0.8	-0.5	0.2	0.0	0.2	-0.0	0.1	0.2	0.4	0.2	0.2
Alcohol intake frequency.	0.1	0.3	1.4	-0.7	0.1	-0.7	-0.4	1.2	-0.2	-0.4	-0.3	-0.3	-0.3	-0.8	-0.4	-1.1	-0.4	-0.4
Hypertension (Self-reported)	0.1	0.2	0.8	0.0	0.9	-0.3	-0.0	0.4	-0.2	-0.4	-0.4	-0.4	-0.3	-0.5	-0.4	-0.8	-0.4	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.6	0.3	0.7	-0.0	-0.2	-0.4	0.1	-0.1	0.0	-0.1	-0.2	-0.2	-0.1	-0.4	-0.1	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	1.0	-1.0	0.1	0.0	-0.6	0.3	-0.8	-0.1	-0.2	-0.1	0.1	-0.2	-0.1	-0.1	-0.1	-0.1
Medication: Paracetamol	0.1	0.2	1.9	0.7	0.3	-0.4	0.2	-1.4	-0.0	-0.3	-0.2	-0.2	-0.3	0.2	-0.2	-0.6	-0.2	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	0.1	0.7	0.2	0.1	0.1	0.4	-0.1	-0.2	-0.2	0.4	-0.5	-0.2	0.7	-0.2	-0.2
Age started oral contraceptive pill	0.1	0.1	0.6	0.2	0.5	-0.5	0.3	0.4	0.8	-0.4	-0.1	-0.3	-0.1	-0.3	-0.3	-0.5	-0.3	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.1	1.2	-0.2	-1.1	-0.0	-0.3	-0.6	-0.2	0.1	0.2	0.2	-0.1	0.4	0.2	0.5	0.1	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.5	0.2	0.1	-0.2	0.1	0.1
Hair Pigment	0.0	0.7	8.6	0.1	-2.9	-0.1	-0.5	-0.4	-0.8	-0.2	-0.2	-0.2	-0.5	0.4	-0.2	-0.5	-0.2	-0.2
High blood pressure	0.0	0.1	0.7	0.2	0.8	-0.2	0.1	0.3	-0.1	-0.2	-0.3	-0.2	-0.2	-0.3	-0.2	-0.7	-0.2	-0.2
Heart disease (mother)	0.0	0.0	0.4	0.2	-0.2	0.2	-0.1	0.1	0.3	0.2	0.3	0.1	0.6	-0.0	0.1	-0.0	0.1	0.1
Medication: Bendroflumethiazide	0.0	0.1	0.5	-0.1	-0.7	-0.1	0.1	0.2	-0.5	-0.2	-0.2	-0.2	0.0	0.0	-0.2	-0.4	-0.2	-0.2
Medication: Lisinopril	0.0	0.1	0.7	0.1	0.8	0.1	0.2	-0.0	-0.3	-0.0	0.1	-0.0	0.1	0.2	-0.0	0.1	0.0	-0.0

Hub : Genes

PDE4C

Models

Trait associations