TWAS
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Usage
Models
Genes
Traits
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Traits
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chr2:99,468,341-101,731,705
Best TWAS P=4.88e-12 · Best GWAS P=7.42e-11 conditioned to 0.192
99.5M
100M
100.5M
101M
101.5M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Artery Aorta
AFF3
0.14
0.06
lasso
5
0.07
1.2e-04
-6.5
-6.9
4.9e-12
0.84
0.01
0.99
TRUE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
LONRF2
0.06
0.04
blup
69
0.04
3.4e-05
3.8
-5.3
9.5e-08
0.68
0.59
0.39
FALSE
2
GTEx
Thyroid
CHST10
0.05
0.05
lasso
5
0.03
2.6e-03
-4.0
-5.1
2.9e-07
0.60
0.39
0.40
FALSE