[Hub]/) : Traits : Weight :

chr6:41,005,502-42,934,620

Best TWAS P=1.13e-18 · Best GWAS P=1.35e-20 conditioned to 3.79e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MED20 0.15 0.11 blup 471 0.13 3.1e-15 -5.8 5.9 3.7e-09 0.61 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous MED20 0.08 0.07 enet 9 0.05 4.7e-05 6.6 6.5 8.2e-11 0.61 0.96 0.01 FALSE
3 GTEx Adipose Subcutaneous FRS3 0.15 0.04 enet 22 0.04 5.9e-04 7.9 5.8 6.9e-09 0.57 0.20 0.56 FALSE
4 GTEx Artery Tibial MED20 0.14 0.11 lasso 2 0.09 9.7e-08 6.7 6.7 2.0e-11 0.60 0.99 0.01 FALSE
5 GTEx Cells Transformed fibroblasts MED20 0.11 0.05 lasso 4 0.08 9.4e-07 -7.5 7.8 4.0e-15 0.46 0.86 0.09 FALSE
6 GTEx Cells Transformed fibroblasts USP49 0.13 0.02 lasso 4 0.02 2.4e-02 -6.8 -6.2 5.5e-10 -0.37 0.29 0.03 FALSE
7 GTEx Colon Transverse MED20 0.17 0.01 enet 10 0.06 6.0e-04 6.7 8.0 1.9e-15 0.69 0.17 0.62 FALSE
8 GTEx Esophagus Mucosa MED20 0.09 0.07 enet 10 0.02 2.7e-02 -5.8 6.1 8.9e-10 0.59 0.76 0.13 FALSE
9 GTEx Esophagus Muscularis MED20 0.15 0.05 lasso 7 0.04 1.0e-03 -5.8 6.5 5.7e-11 0.62 0.45 0.50 FALSE
10 GTEx Heart Atrial Appendage MED20 0.14 0.12 enet 11 0.09 5.9e-05 6.5 6.3 2.8e-10 0.58 0.84 0.09 FALSE
11 GTEx Heart Left Ventricle PRICKLE4 0.11 0.05 lasso 4 0.03 9.8e-03 6.3 -6.3 2.1e-10 -0.59 0.26 0.06 FALSE
12 GTEx Heart Left Ventricle MED20 0.22 0.19 enet 8 0.12 5.8e-07 6.7 6.7 2.3e-11 0.61 1.00 0.00 FALSE
13 GTEx Lung BYSL 0.08 0.03 lasso 4 0.02 4.9e-03 8.2 -7.7 1.7e-14 -0.80 0.26 0.57 FALSE
14 GTEx Lung MED20 0.10 0.01 lasso 4 0.00 2.7e-01 -1.0 5.3 1.2e-07 0.52 0.06 0.32 FALSE
15 GTEx Lung USP49 0.09 0.08 lasso 2 0.05 6.2e-05 -6.8 -6.4 1.6e-10 -0.33 0.84 0.01 FALSE
16 GTEx Muscle Skeletal MED20 0.16 0.15 lasso 4 0.16 6.7e-16 6.3 6.4 1.6e-10 0.60 1.00 0.00 FALSE
17 GTEx Nerve Tibial MED20 0.13 0.11 enet 8 0.10 1.5e-07 6.5 6.3 3.5e-10 0.58 1.00 0.00 FALSE
18 GTEx Spleen MED20 0.44 0.13 enet 23 0.07 6.4e-03 6.7 6.2 4.0e-10 0.57 0.11 0.51 FALSE
19 GTEx Testis MED20 0.13 0.03 lasso 6 0.00 2.0e-01 -6.8 7.1 1.1e-12 0.46 0.16 0.17 FALSE
20 GTEx Thyroid MED20 0.05 0.05 lasso 2 0.02 8.1e-03 6.8 6.8 1.5e-11 0.61 0.50 0.36 FALSE
21 GTEx Thyroid FRS3 0.20 0.16 lasso 4 0.16 5.2e-12 7.9 7.3 3.0e-13 0.67 0.98 0.02 FALSE
22 METSIM Adipose MED20 0.13 0.11 enet 27 0.11 2.3e-16 6.6 6.8 9.9e-12 0.61 1.00 0.00 FALSE
23 ROSMAP Brain Pre-frontal Cortex PGC 0.13 0.06 blup 520 0.06 3.2e-08 7.9 -6.2 4.1e-10 -0.58 0.96 0.04 FALSE
24 ROSMAP Brain Pre-frontal Cortex MED20 0.10 0.10 enet 21 0.09 6.0e-12 6.8 6.5 1.0e-10 0.61 1.00 0.00 FALSE
25 YFS Blood CCND3 0.02 0.01 enet 13 0.02 2.3e-06 6.2 -6.2 4.5e-10 -0.55 0.72 0.22 FALSE
26 YFS Blood MED20 0.04 0.03 lasso 5 0.03 3.6e-11 6.3 5.8 5.3e-09 0.61 1.00 0.00 FALSE
27 The Cancer Genome Atlas Bladder Urothelial Carcinoma PRPH2 0.07 0.03 enet 6 0.06 1.9e-05 5.4 -5.3 1.3e-07 0.03 0.00 0.99 TRUE
28 The Cancer Genome Atlas Breast Invasive Carcinoma CCND3 0.04 0.00 blup 99 0.01 1.8e-03 -6.7 6.6 4.1e-11 0.45 0.02 0.10 FALSE
29 The Cancer Genome Atlas Colon Adenocarcinoma MED20 0.05 0.00 blup 50 0.04 2.8e-03 6.3 8.8 1.1e-18 0.70 0.06 0.27 TRUE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED20 0.04 0.03 lasso 3 0.04 7.3e-05 -7.5 7.5 5.0e-14 0.45 0.57 0.02 FALSE
31 The Cancer Genome Atlas Brain Lower Grade Glioma MED20 0.09 0.08 enet 12 0.09 5.5e-10 6.7 7.7 1.1e-14 0.62 1.00 0.00 FALSE
32 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MED20 0.09 0.07 lasso 5 0.07 3.4e-04 -6.8 7.8 4.5e-15 0.51 0.17 0.55 FALSE
33 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UBR2 0.10 0.01 blup 77 0.04 9.1e-03 4.5 -5.3 1.4e-07 0.01 0.01 0.59 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma MED20 0.04 0.06 enet 6 0.05 2.6e-06 6.3 7.2 5.0e-13 0.58 0.91 0.02 FALSE
35 The Cancer Genome Atlas Stomach Adenocarcinoma MED20 0.03 0.05 lasso 2 0.04 1.2e-03 -7.5 7.6 2.5e-14 0.44 0.11 0.06 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma BYSL 0.05 0.06 enet 7 0.06 4.3e-06 6.8 -6.4 1.6e-10 -0.56 0.82 0.09 FALSE