Best TWAS P=1.71e-16 · Best GWAS P=1.61e-15 conditioned to 0.639
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POM121C | 0.08 | 0.05 | lasso | 2 | 0.04 | 1.1e-05 | -8.0 | -7.8 | 8.0e-15 | 0.99 | 0.00 | 1.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | STAG3L1 | 0.23 | 0.14 | enet | 13 | 0.17 | 1.0e-19 | -8.0 | -7.8 | 9.0e-15 | 0.91 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | PMS2P3 | 0.15 | 0.12 | lasso | 3 | 0.10 | 9.8e-09 | -6.8 | -7.1 | 1.0e-12 | 0.96 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | POM121C | 0.20 | 0.11 | enet | 18 | 0.12 | 1.2e-09 | -8.0 | -6.8 | 8.7e-12 | 0.80 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | TRIM73 | 0.20 | 0.12 | enet | 26 | 0.12 | 2.0e-10 | -8.0 | -6.8 | 1.4e-11 | 0.82 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Adipose Subcutaneous | STAG3L1 | 0.30 | 0.24 | enet | 24 | 0.27 | 2.4e-22 | -8.0 | -8.0 | 1.9e-15 | 0.92 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Adipose Visceral Omentum | POM121C | 0.16 | 0.10 | lasso | 5 | 0.12 | 7.2e-07 | 5.3 | -6.6 | 4.5e-11 | 0.80 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Adipose Visceral Omentum | TRIM73 | 0.17 | 0.19 | lasso | 3 | 0.22 | 1.4e-11 | -6.8 | -6.0 | 1.6e-09 | 0.92 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Adipose Visceral Omentum | STAG3L1 | 0.20 | 0.19 | lasso | 3 | 0.17 | 2.3e-09 | -8.0 | -7.9 | 2.4e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Artery Aorta | STAG3L1 | 0.18 | 0.03 | lasso | 4 | 0.08 | 3.9e-05 | -8.0 | -7.7 | 1.1e-14 | 1.00 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Artery Coronary | STAG3L1 | 0.28 | 0.13 | lasso | 4 | 0.17 | 1.8e-06 | -7.4 | -7.6 | 2.5e-14 | 0.86 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Artery Tibial | POM121C | 0.12 | 0.10 | lasso | 1 | 0.10 | 6.8e-08 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Artery Tibial | TRIM73 | 0.10 | 0.00 | lasso | 7 | 0.02 | 5.5e-03 | -8.0 | -5.5 | 4.6e-08 | 0.82 | 0.00 | 0.96 | FALSE |
| 14 | GTEx | Artery Tibial | STAG3L1 | 0.25 | 0.19 | lasso | 4 | 0.19 | 8.3e-15 | -8.0 | -8.0 | 1.1e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 15 | GTEx | Brain Cerebellar Hemisphere | POM121C | 0.33 | 0.32 | lasso | 3 | 0.30 | 1.4e-08 | -8.0 | -7.9 | 3.8e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Brain Cerebellar Hemisphere | TRIM73 | 0.35 | 0.28 | enet | 25 | 0.25 | 3.6e-07 | -8.0 | -5.9 | 4.6e-09 | 0.84 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Brain Cerebellum | POM121C | 0.30 | 0.15 | lasso | 8 | 0.08 | 2.4e-03 | -8.0 | -7.3 | 2.0e-13 | 0.90 | 0.00 | 0.97 | FALSE |
| 18 | GTEx | Brain Cerebellum | TRIM73 | 0.24 | 0.06 | enet | 12 | 0.14 | 8.2e-05 | -6.8 | -5.1 | 2.7e-07 | 0.83 | 0.00 | 0.98 | FALSE |
| 19 | GTEx | Brain Frontal Cortex BA9 | POM121C | 0.43 | 0.16 | enet | 24 | 0.17 | 3.4e-05 | -8.0 | -5.7 | 1.2e-08 | 0.81 | 0.00 | 0.98 | FALSE |
| 20 | GTEx | Brain Nucleus accumbens basal ganglia | POM121C | 0.33 | 0.27 | enet | 11 | 0.25 | 2.7e-07 | 5.3 | -5.9 | 3.2e-09 | 0.59 | 0.04 | 0.86 | FALSE |
| 21 | GTEx | Brain Nucleus accumbens basal ganglia | TRIM73 | 0.34 | 0.16 | enet | 11 | 0.29 | 1.5e-08 | 5.3 | -6.6 | 4.3e-11 | 0.82 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Brain Nucleus accumbens basal ganglia | STAG3L1 | 0.29 | 0.09 | enet | 13 | 0.18 | 1.9e-05 | -8.0 | -6.6 | 4.4e-11 | 0.79 | 0.00 | 0.97 | FALSE |
| 23 | GTEx | Brain Putamen basal ganglia | PMS2P3 | 0.37 | 0.13 | lasso | 6 | 0.18 | 6.0e-05 | -7.4 | -6.3 | 2.4e-10 | 0.73 | 0.01 | 0.85 | FALSE |
| 24 | GTEx | Breast Mammary Tissue | PMS2P3 | 0.19 | 0.14 | lasso | 4 | 0.19 | 3.5e-10 | -6.8 | -6.8 | 1.0e-11 | 0.88 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Breast Mammary Tissue | STAG3L1 | 0.16 | 0.15 | lasso | 2 | 0.14 | 8.7e-08 | -8.0 | -8.1 | 7.9e-16 | 0.98 | 0.00 | 1.00 | FALSE |
| 26 | GTEx | Breast Mammary Tissue (Female) | PMS2P3 | 0.31 | 0.05 | enet | 8 | 0.10 | 6.2e-04 | -7.4 | -5.4 | 5.3e-08 | 0.69 | 0.01 | 0.80 | FALSE |
| 27 | GTEx | Breast Mammary Tissue (Female) | POM121C | 0.17 | -0.01 | lasso | 3 | 0.02 | 6.3e-02 | -8.0 | -7.0 | 1.7e-12 | 0.90 | 0.01 | 0.62 | FALSE |
| 28 | GTEx | Breast Mammary Tissue (Female) | STAG3L1 | 0.04 | 0.12 | lasso | 1 | 0.04 | 2.9e-02 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 0.96 | FALSE |
| 29 | GTEx | Cells EBV-transformed lymphocytes | STAG3L1 | 0.43 | 0.21 | enet | 21 | 0.23 | 3.8e-08 | -8.0 | -8.2 | 1.7e-16 | 0.86 | 0.00 | 1.00 | TRUE |
| 30 | GTEx | Cells Transformed fibroblasts | PMS2P3 | 0.23 | 0.15 | lasso | 6 | 0.15 | 1.4e-11 | -6.8 | -7.2 | 6.3e-13 | 0.94 | 0.00 | 1.00 | FALSE |
| 31 | GTEx | Cells Transformed fibroblasts | POM121C | 0.15 | 0.06 | lasso | 5 | 0.07 | 1.2e-05 | -8.0 | -8.1 | 5.3e-16 | 0.99 | 0.00 | 1.00 | FALSE |
| 32 | GTEx | Cells Transformed fibroblasts | STAG3L1 | 0.22 | 0.17 | lasso | 4 | 0.18 | 2.6e-13 | -8.0 | -8.1 | 4.5e-16 | 0.96 | 0.00 | 1.00 | FALSE |
| 33 | GTEx | Colon Sigmoid | STAG3L1 | 0.30 | 0.18 | lasso | 4 | 0.18 | 8.5e-07 | -8.0 | -7.8 | 6.9e-15 | 0.97 | 0.00 | 1.00 | FALSE |
| 34 | GTEx | Colon Transverse | STAG3L1 | 0.22 | 0.18 | lasso | 1 | 0.16 | 4.0e-08 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 35 | GTEx | Esophagus Gastroesophageal Junction | STAG3L1 | 0.36 | 0.16 | lasso | 5 | 0.16 | 1.7e-06 | -8.0 | -7.3 | 2.1e-13 | 0.93 | 0.00 | 1.00 | FALSE |
| 36 | GTEx | Esophagus Mucosa | PMS2P3 | 0.14 | 0.15 | lasso | 2 | 0.14 | 9.7e-10 | -8.0 | -8.1 | 5.2e-16 | 1.00 | 0.00 | 1.00 | FALSE |
| 37 | GTEx | Esophagus Mucosa | POM121C | 0.13 | 0.10 | lasso | 1 | 0.07 | 1.0e-05 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 38 | GTEx | Esophagus Mucosa | STAG3L1 | 0.19 | 0.19 | lasso | 1 | 0.18 | 2.4e-12 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 39 | GTEx | Esophagus Muscularis | TRIM73 | 0.12 | 0.07 | lasso | 2 | 0.05 | 3.5e-04 | -6.8 | -6.8 | 1.2e-11 | 0.96 | 0.00 | 0.98 | FALSE |
| 40 | GTEx | Esophagus Muscularis | STAG3L1 | 0.30 | 0.15 | lasso | 4 | 0.16 | 4.3e-10 | -8.0 | -7.4 | 1.8e-13 | 0.94 | 0.00 | 1.00 | FALSE |
| 41 | GTEx | Heart Atrial Appendage | STAG3L1 | 0.14 | 0.04 | enet | 12 | 0.04 | 5.0e-03 | -6.8 | -7.3 | 2.1e-13 | 0.76 | 0.00 | 0.95 | FALSE |
| 42 | GTEx | Heart Left Ventricle | POM121C | 0.13 | 0.12 | lasso | 1 | 0.09 | 2.2e-05 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 43 | GTEx | Lung | POM121C | 0.13 | 0.10 | lasso | 3 | 0.10 | 7.8e-08 | -8.0 | -8.0 | 1.7e-15 | 0.98 | 0.00 | 1.00 | FALSE |
| 44 | GTEx | Lung | TRIM73 | 0.14 | 0.03 | enet | 8 | 0.06 | 2.9e-05 | -6.8 | -6.0 | 1.8e-09 | 0.79 | 0.00 | 0.99 | FALSE |
| 45 | GTEx | Lung | STAG3L1 | 0.28 | 0.12 | enet | 35 | 0.16 | 3.3e-12 | -8.0 | -6.6 | 4.5e-11 | 0.79 | 0.00 | 1.00 | FALSE |
| 46 | GTEx | Muscle Skeletal | PMS2P3 | 0.07 | 0.07 | lasso | 2 | 0.06 | 3.8e-06 | -8.0 | -8.0 | 1.9e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 47 | GTEx | Muscle Skeletal | TRIM73 | 0.08 | 0.05 | enet | 11 | 0.06 | 3.4e-06 | -8.0 | -7.6 | 2.3e-14 | 0.88 | 0.00 | 1.00 | FALSE |
| 48 | GTEx | Muscle Skeletal | STAG3L1 | 0.16 | 0.10 | enet | 24 | 0.10 | 3.7e-10 | -8.0 | -6.9 | 6.6e-12 | 0.85 | 0.00 | 1.00 | FALSE |
| 49 | GTEx | Nerve Tibial | PMS2P5 | 0.16 | 0.04 | enet | 34 | 0.08 | 3.5e-06 | 3.4 | -5.2 | 2.4e-07 | 0.22 | 0.02 | 0.81 | FALSE |
| 50 | GTEx | Nerve Tibial | PMS2P3 | 0.29 | 0.13 | enet | 4 | 0.18 | 1.1e-12 | -7.4 | -6.8 | 1.2e-11 | 0.87 | 0.02 | 0.98 | FALSE |
| 51 | GTEx | Nerve Tibial | POM121C | 0.22 | 0.14 | lasso | 5 | 0.14 | 6.9e-10 | -8.0 | -8.0 | 1.2e-15 | 0.97 | 0.00 | 1.00 | FALSE |
| 52 | GTEx | Nerve Tibial | STAG3L2 | 0.36 | 0.09 | enet | 13 | 0.24 | 9.5e-17 | 3.4 | -5.4 | 5.2e-08 | 0.25 | 0.03 | 0.78 | FALSE |
| 53 | GTEx | Nerve Tibial | TRIM73 | 0.19 | 0.20 | enet | 6 | 0.20 | 6.3e-14 | -8.0 | -7.0 | 2.7e-12 | 0.96 | 0.00 | 1.00 | FALSE |
| 54 | GTEx | Nerve Tibial | STAG3L1 | 0.37 | 0.21 | enet | 34 | 0.22 | 1.2e-15 | -8.0 | -6.3 | 2.9e-10 | 0.83 | 0.00 | 1.00 | FALSE |
| 55 | GTEx | Skin Not Sun Exposed Suprapubic | PMS2P3 | 0.26 | 0.19 | lasso | 3 | 0.17 | 1.3e-09 | -8.0 | -7.7 | 1.2e-14 | 0.99 | 0.00 | 1.00 | FALSE |
| 56 | GTEx | Skin Not Sun Exposed Suprapubic | STAG3L1 | 0.13 | 0.19 | lasso | 1 | 0.18 | 2.6e-10 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 57 | GTEx | Skin Sun Exposed Lower leg | PMS2P3 | 0.38 | 0.30 | lasso | 3 | 0.29 | 1.9e-24 | -8.0 | -8.1 | 8.6e-16 | 1.00 | 0.00 | 1.00 | FALSE |
| 58 | GTEx | Skin Sun Exposed Lower leg | TRIM73 | 0.13 | 0.08 | enet | 10 | 0.14 | 1.6e-11 | -6.8 | -5.6 | 1.7e-08 | 0.85 | 0.01 | 0.99 | FALSE |
| 59 | GTEx | Skin Sun Exposed Lower leg | STAG3L1 | 0.27 | 0.15 | lasso | 5 | 0.15 | 1.3e-12 | -8.0 | -8.2 | 2.5e-16 | 0.98 | 0.00 | 1.00 | FALSE |
| 60 | GTEx | Stomach | PMS2P3 | 0.16 | 0.07 | lasso | 5 | 0.09 | 3.7e-05 | -7.4 | -7.4 | 1.2e-13 | 0.91 | 0.00 | 0.99 | FALSE |
| 61 | GTEx | Stomach | TRIM73 | 0.23 | 0.09 | lasso | 5 | 0.09 | 3.2e-05 | -8.0 | -7.7 | 1.2e-14 | 0.96 | 0.00 | 0.99 | FALSE |
| 62 | GTEx | Stomach | STAG3L1 | 0.35 | 0.20 | lasso | 5 | 0.18 | 4.2e-09 | -7.4 | -7.5 | 8.0e-14 | 0.86 | 0.01 | 0.99 | FALSE |
| 63 | GTEx | Testis | TRIM73 | 0.20 | 0.21 | lasso | 2 | 0.19 | 6.2e-09 | -8.0 | -7.9 | 2.0e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 64 | GTEx | Testis | STAG3L1 | 0.24 | 0.24 | enet | 14 | 0.27 | 1.4e-12 | -8.0 | -7.8 | 7.4e-15 | 0.88 | 0.00 | 1.00 | FALSE |
| 65 | GTEx | Thyroid | POM121C | 0.14 | 0.08 | lasso | 3 | 0.07 | 3.4e-06 | -8.0 | -7.9 | 2.3e-15 | 0.96 | 0.00 | 1.00 | FALSE |
| 66 | GTEx | Thyroid | TRIM73 | 0.21 | 0.17 | lasso | 4 | 0.18 | 1.6e-13 | -8.0 | -7.1 | 1.3e-12 | 0.97 | 0.00 | 1.00 | FALSE |
| 67 | GTEx | Thyroid | STAG3L1 | 0.36 | 0.24 | enet | 17 | 0.27 | 8.0e-21 | -8.0 | -7.6 | 3.0e-14 | 0.92 | 0.00 | 1.00 | FALSE |
| 68 | GTEx | Whole Blood | STAG3L1 | 0.08 | 0.06 | lasso | 3 | 0.07 | 2.8e-07 | -8.0 | -8.0 | 1.5e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 69 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 5.1 | 5.3 | 1.2e-07 | 0.03 | 0.01 | 0.99 | TRUE |
| 70 | METSIM | Adipose | NCF1 | 0.05 | 0.03 | blup | 130 | 0.04 | 3.9e-07 | 4.2 | 5.5 | 3.4e-08 | -0.22 | 0.02 | 0.89 | TRUE |
| 71 | METSIM | Adipose | POM121C | 0.11 | 0.08 | lasso | 1 | 0.08 | 1.6e-11 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 72 | METSIM | Adipose | TRIM73 | 0.11 | 0.11 | lasso | 5 | 0.12 | 8.6e-18 | -6.8 | -6.8 | 1.1e-11 | 0.95 | 0.01 | 0.99 | FALSE |
| 73 | ROSMAP | Brain Pre-frontal Cortex | PMS2P3 | 0.05 | 0.04 | lasso | 1 | 0.03 | 4.6e-05 | -8.0 | -8.0 | 1.6e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 74 | ROSMAP | Brain Pre-frontal Cortex | POM121C | 0.36 | 0.26 | lasso | 7 | 0.27 | 2.8e-34 | -8.0 | -8.0 | 1.9e-15 | 0.99 | 0.00 | 1.00 | FALSE |
| 75 | ROSMAP | Brain Pre-frontal Cortex | PMS2P2 | 0.17 | 0.08 | enet | 8 | 0.08 | 6.0e-10 | -8.0 | -7.2 | 8.8e-13 | 0.90 | 0.00 | 1.00 | FALSE |
| 76 | ROSMAP | Brain Pre-frontal Cortex | STAG3L1 | 0.46 | 0.32 | lasso | 4 | 0.32 | 2.2e-42 | -8.0 | -8.0 | 1.5e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 77 | ROSMAP | Brain Pre-frontal Cortex | GTF2IP1 | 0.09 | 0.06 | lasso | 3 | 0.05 | 1.7e-07 | -8.0 | -8.0 | 1.4e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 78 | The Cancer Genome Atlas | Breast Invasive Carcinoma | POM121C | 0.04 | 0.04 | lasso | 2 | 0.03 | 1.2e-07 | -8.0 | -7.9 | 2.5e-15 | 1.00 | 0.00 | 1.00 | FALSE |
| 79 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 5.2 | 5.2 | 2.3e-07 | 0.01 | 0.00 | 0.95 | FALSE |
| 80 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | POM121C | 0.07 | 0.02 | enet | 3 | 0.04 | 5.8e-03 | -8.0 | -5.9 | 2.8e-09 | 0.85 | 0.00 | 0.67 | FALSE |
| 81 | The Cancer Genome Atlas | Thyroid Carcinoma | POM121C | 0.08 | 0.07 | lasso | 3 | 0.07 | 3.6e-07 | -8.0 | -8.0 | 9.4e-16 | 0.99 | 0.00 | 1.00 | FALSE |
| 82 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | PMS2L3 | 0.23 | 0.14 | lasso | 2 | 0.14 | 1.3e-04 | -8.0 | -8.1 | 4.6e-16 | 0.98 | 0.00 | 0.92 | FALSE |