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chr7:72,674,074-75,842,792

Best TWAS P=1.71e-16 · Best GWAS P=1.61e-15 conditioned to 0.639

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
29	GTEx	Cells EBV-transformed lymphocytes	STAG3L1	0.43	0.21	enet	21	0.23	3.8e-08	-8.0	-8.2	1.7e-16	0.86	0.00	1.00	TRUE
70	METSIM	Adipose	NCF1	0.05	0.03	blup	130	0.04	3.9e-07	4.2	5.5	3.4e-08	-0.22	0.02	0.89	TRUE
69	METSIM	Adipose	MLXIPL	0.12	0.14	lasso	4	0.13	1.8e-19	5.1	5.3	1.2e-07	0.03	0.01	0.99	TRUE
59	GTEx	Skin Sun Exposed Lower leg	STAG3L1	0.27	0.15	lasso	5	0.15	1.3e-12	-8.0	-8.2	2.5e-16	0.98	0.00	1.00	FALSE
32	GTEx	Cells Transformed fibroblasts	STAG3L1	0.22	0.17	lasso	4	0.18	2.6e-13	-8.0	-8.1	4.5e-16	0.96	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	PMS2L3	0.23	0.14	lasso	2	0.14	1.3e-04	-8.0	-8.1	4.6e-16	0.98	0.00	0.92	FALSE
36	GTEx	Esophagus Mucosa	PMS2P3	0.14	0.15	lasso	2	0.14	9.7e-10	-8.0	-8.1	5.2e-16	1.00	0.00	1.00	FALSE
31	GTEx	Cells Transformed fibroblasts	POM121C	0.15	0.06	lasso	5	0.07	1.2e-05	-8.0	-8.1	5.3e-16	0.99	0.00	1.00	FALSE
25	GTEx	Breast Mammary Tissue	STAG3L1	0.16	0.15	lasso	2	0.14	8.7e-08	-8.0	-8.1	7.9e-16	0.98	0.00	1.00	FALSE
57	GTEx	Skin Sun Exposed Lower leg	PMS2P3	0.38	0.30	lasso	3	0.29	1.9e-24	-8.0	-8.1	8.6e-16	1.00	0.00	1.00	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	POM121C	0.08	0.07	lasso	3	0.07	3.6e-07	-8.0	-8.0	9.4e-16	0.99	0.00	1.00	FALSE
14	GTEx	Artery Tibial	STAG3L1	0.25	0.19	lasso	4	0.19	8.3e-15	-8.0	-8.0	1.1e-15	1.00	0.00	1.00	FALSE
51	GTEx	Nerve Tibial	POM121C	0.22	0.14	lasso	5	0.14	6.9e-10	-8.0	-8.0	1.2e-15	0.97	0.00	1.00	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	GTF2IP1	0.09	0.06	lasso	3	0.05	1.7e-07	-8.0	-8.0	1.4e-15	1.00	0.00	1.00	FALSE
68	GTEx	Whole Blood	STAG3L1	0.08	0.06	lasso	3	0.07	2.8e-07	-8.0	-8.0	1.5e-15	1.00	0.00	1.00	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	STAG3L1	0.46	0.32	lasso	4	0.32	2.2e-42	-8.0	-8.0	1.5e-15	1.00	0.00	1.00	FALSE
12	GTEx	Artery Tibial	POM121C	0.12	0.10	lasso	1	0.10	6.8e-08	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
28	GTEx	Breast Mammary Tissue (Female)	STAG3L1	0.04	0.12	lasso	1	0.04	2.9e-02	-8.0	-8.0	1.6e-15	1.00	0.00	0.96	FALSE
34	GTEx	Colon Transverse	STAG3L1	0.22	0.18	lasso	1	0.16	4.0e-08	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
37	GTEx	Esophagus Mucosa	POM121C	0.13	0.10	lasso	1	0.07	1.0e-05	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
38	GTEx	Esophagus Mucosa	STAG3L1	0.19	0.19	lasso	1	0.18	2.4e-12	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
42	GTEx	Heart Left Ventricle	POM121C	0.13	0.12	lasso	1	0.09	2.2e-05	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	STAG3L1	0.13	0.19	lasso	1	0.18	2.6e-10	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
71	METSIM	Adipose	POM121C	0.11	0.08	lasso	1	0.08	1.6e-11	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	PMS2P3	0.05	0.04	lasso	1	0.03	4.6e-05	-8.0	-8.0	1.6e-15	1.00	0.00	1.00	FALSE
43	GTEx	Lung	POM121C	0.13	0.10	lasso	3	0.10	7.8e-08	-8.0	-8.0	1.7e-15	0.98	0.00	1.00	FALSE
6	GTEx	Adipose Subcutaneous	STAG3L1	0.30	0.24	enet	24	0.27	2.4e-22	-8.0	-8.0	1.9e-15	0.92	0.00	1.00	FALSE
46	GTEx	Muscle Skeletal	PMS2P3	0.07	0.07	lasso	2	0.06	3.8e-06	-8.0	-8.0	1.9e-15	1.00	0.00	1.00	FALSE
74	ROSMAP	Brain Pre-frontal Cortex	POM121C	0.36	0.26	lasso	7	0.27	2.8e-34	-8.0	-8.0	1.9e-15	0.99	0.00	1.00	FALSE
63	GTEx	Testis	TRIM73	0.20	0.21	lasso	2	0.19	6.2e-09	-8.0	-7.9	2.0e-15	1.00	0.00	1.00	FALSE
65	GTEx	Thyroid	POM121C	0.14	0.08	lasso	3	0.07	3.4e-06	-8.0	-7.9	2.3e-15	0.96	0.00	1.00	FALSE
9	GTEx	Adipose Visceral Omentum	STAG3L1	0.20	0.19	lasso	3	0.17	2.3e-09	-8.0	-7.9	2.4e-15	1.00	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	POM121C	0.04	0.04	lasso	2	0.03	1.2e-07	-8.0	-7.9	2.5e-15	1.00	0.00	1.00	FALSE
15	GTEx	Brain Cerebellar Hemisphere	POM121C	0.33	0.32	lasso	3	0.30	1.4e-08	-8.0	-7.9	3.8e-15	1.00	0.00	1.00	FALSE
33	GTEx	Colon Sigmoid	STAG3L1	0.30	0.18	lasso	4	0.18	8.5e-07	-8.0	-7.8	6.9e-15	0.97	0.00	1.00	FALSE
64	GTEx	Testis	STAG3L1	0.24	0.24	enet	14	0.27	1.4e-12	-8.0	-7.8	7.4e-15	0.88	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	POM121C	0.08	0.05	lasso	2	0.04	1.1e-05	-8.0	-7.8	8.0e-15	0.99	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STAG3L1	0.23	0.14	enet	13	0.17	1.0e-19	-8.0	-7.8	9.0e-15	0.91	0.00	1.00	FALSE
10	GTEx	Artery Aorta	STAG3L1	0.18	0.03	lasso	4	0.08	3.9e-05	-8.0	-7.7	1.1e-14	1.00	0.00	1.00	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	PMS2P3	0.26	0.19	lasso	3	0.17	1.3e-09	-8.0	-7.7	1.2e-14	0.99	0.00	1.00	FALSE
61	GTEx	Stomach	TRIM73	0.23	0.09	lasso	5	0.09	3.2e-05	-8.0	-7.7	1.2e-14	0.96	0.00	0.99	FALSE
47	GTEx	Muscle Skeletal	TRIM73	0.08	0.05	enet	11	0.06	3.4e-06	-8.0	-7.6	2.3e-14	0.88	0.00	1.00	FALSE
11	GTEx	Artery Coronary	STAG3L1	0.28	0.13	lasso	4	0.17	1.8e-06	-7.4	-7.6	2.5e-14	0.86	0.01	0.99	FALSE
67	GTEx	Thyroid	STAG3L1	0.36	0.24	enet	17	0.27	8.0e-21	-8.0	-7.6	3.0e-14	0.92	0.00	1.00	FALSE
62	GTEx	Stomach	STAG3L1	0.35	0.20	lasso	5	0.18	4.2e-09	-7.4	-7.5	8.0e-14	0.86	0.01	0.99	FALSE
60	GTEx	Stomach	PMS2P3	0.16	0.07	lasso	5	0.09	3.7e-05	-7.4	-7.4	1.2e-13	0.91	0.00	0.99	FALSE
40	GTEx	Esophagus Muscularis	STAG3L1	0.30	0.15	lasso	4	0.16	4.3e-10	-8.0	-7.4	1.8e-13	0.94	0.00	1.00	FALSE
17	GTEx	Brain Cerebellum	POM121C	0.30	0.15	lasso	8	0.08	2.4e-03	-8.0	-7.3	2.0e-13	0.90	0.00	0.97	FALSE
35	GTEx	Esophagus Gastroesophageal Junction	STAG3L1	0.36	0.16	lasso	5	0.16	1.7e-06	-8.0	-7.3	2.1e-13	0.93	0.00	1.00	FALSE
41	GTEx	Heart Atrial Appendage	STAG3L1	0.14	0.04	enet	12	0.04	5.0e-03	-6.8	-7.3	2.1e-13	0.76	0.00	0.95	FALSE
30	GTEx	Cells Transformed fibroblasts	PMS2P3	0.23	0.15	lasso	6	0.15	1.4e-11	-6.8	-7.2	6.3e-13	0.94	0.00	1.00	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	PMS2P2	0.17	0.08	enet	8	0.08	6.0e-10	-8.0	-7.2	8.8e-13	0.90	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	PMS2P3	0.15	0.12	lasso	3	0.10	9.8e-09	-6.8	-7.1	1.0e-12	0.96	0.00	1.00	FALSE
66	GTEx	Thyroid	TRIM73	0.21	0.17	lasso	4	0.18	1.6e-13	-8.0	-7.1	1.3e-12	0.97	0.00	1.00	FALSE
27	GTEx	Breast Mammary Tissue (Female)	POM121C	0.17	-0.01	lasso	3	0.02	6.3e-02	-8.0	-7.0	1.7e-12	0.90	0.01	0.62	FALSE
53	GTEx	Nerve Tibial	TRIM73	0.19	0.20	enet	6	0.20	6.3e-14	-8.0	-7.0	2.7e-12	0.96	0.00	1.00	FALSE
48	GTEx	Muscle Skeletal	STAG3L1	0.16	0.10	enet	24	0.10	3.7e-10	-8.0	-6.9	6.6e-12	0.85	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	POM121C	0.20	0.11	enet	18	0.12	1.2e-09	-8.0	-6.8	8.7e-12	0.80	0.00	1.00	FALSE
24	GTEx	Breast Mammary Tissue	PMS2P3	0.19	0.14	lasso	4	0.19	3.5e-10	-6.8	-6.8	1.0e-11	0.88	0.00	1.00	FALSE
72	METSIM	Adipose	TRIM73	0.11	0.11	lasso	5	0.12	8.6e-18	-6.8	-6.8	1.1e-11	0.95	0.01	0.99	FALSE
39	GTEx	Esophagus Muscularis	TRIM73	0.12	0.07	lasso	2	0.05	3.5e-04	-6.8	-6.8	1.2e-11	0.96	0.00	0.98	FALSE
50	GTEx	Nerve Tibial	PMS2P3	0.29	0.13	enet	4	0.18	1.1e-12	-7.4	-6.8	1.2e-11	0.87	0.02	0.98	FALSE
5	GTEx	Adipose Subcutaneous	TRIM73	0.20	0.12	enet	26	0.12	2.0e-10	-8.0	-6.8	1.4e-11	0.82	0.00	1.00	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	TRIM73	0.34	0.16	enet	11	0.29	1.5e-08	5.3	-6.6	4.3e-11	0.82	0.00	1.00	FALSE
22	GTEx	Brain Nucleus accumbens basal ganglia	STAG3L1	0.29	0.09	enet	13	0.18	1.9e-05	-8.0	-6.6	4.4e-11	0.79	0.00	0.97	FALSE
7	GTEx	Adipose Visceral Omentum	POM121C	0.16	0.10	lasso	5	0.12	7.2e-07	5.3	-6.6	4.5e-11	0.80	0.02	0.98	FALSE
45	GTEx	Lung	STAG3L1	0.28	0.12	enet	35	0.16	3.3e-12	-8.0	-6.6	4.5e-11	0.79	0.00	1.00	FALSE
23	GTEx	Brain Putamen basal ganglia	PMS2P3	0.37	0.13	lasso	6	0.18	6.0e-05	-7.4	-6.3	2.4e-10	0.73	0.01	0.85	FALSE
54	GTEx	Nerve Tibial	STAG3L1	0.37	0.21	enet	34	0.22	1.2e-15	-8.0	-6.3	2.9e-10	0.83	0.00	1.00	FALSE
8	GTEx	Adipose Visceral Omentum	TRIM73	0.17	0.19	lasso	3	0.22	1.4e-11	-6.8	-6.0	1.6e-09	0.92	0.00	1.00	FALSE
44	GTEx	Lung	TRIM73	0.14	0.03	enet	8	0.06	2.9e-05	-6.8	-6.0	1.8e-09	0.79	0.00	0.99	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POM121C	0.07	0.02	enet	3	0.04	5.8e-03	-8.0	-5.9	2.8e-09	0.85	0.00	0.67	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	POM121C	0.33	0.27	enet	11	0.25	2.7e-07	5.3	-5.9	3.2e-09	0.59	0.04	0.86	FALSE
16	GTEx	Brain Cerebellar Hemisphere	TRIM73	0.35	0.28	enet	25	0.25	3.6e-07	-8.0	-5.9	4.6e-09	0.84	0.00	1.00	FALSE
19	GTEx	Brain Frontal Cortex BA9	POM121C	0.43	0.16	enet	24	0.17	3.4e-05	-8.0	-5.7	1.2e-08	0.81	0.00	0.98	FALSE
58	GTEx	Skin Sun Exposed Lower leg	TRIM73	0.13	0.08	enet	10	0.14	1.6e-11	-6.8	-5.6	1.7e-08	0.85	0.01	0.99	FALSE
13	GTEx	Artery Tibial	TRIM73	0.10	0.00	lasso	7	0.02	5.5e-03	-8.0	-5.5	4.6e-08	0.82	0.00	0.96	FALSE
52	GTEx	Nerve Tibial	STAG3L2	0.36	0.09	enet	13	0.24	9.5e-17	3.4	-5.4	5.2e-08	0.25	0.03	0.78	FALSE
26	GTEx	Breast Mammary Tissue (Female)	PMS2P3	0.31	0.05	enet	8	0.10	6.2e-04	-7.4	-5.4	5.3e-08	0.69	0.01	0.80	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	MLXIPL	0.04	0.03	lasso	1	0.02	2.3e-03	5.2	5.2	2.3e-07	0.01	0.00	0.95	FALSE
49	GTEx	Nerve Tibial	PMS2P5	0.16	0.04	enet	34	0.08	3.5e-06	3.4	-5.2	2.4e-07	0.22	0.02	0.81	FALSE
18	GTEx	Brain Cerebellum	TRIM73	0.24	0.06	enet	12	0.14	8.2e-05	-6.8	-5.1	2.7e-07	0.83	0.00	0.98	FALSE