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chr7:75,913,086-78,122,616

Best TWAS P=1.74e-15 · Best GWAS P=4.33e-12 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DTX2P1-UPK3BP1-PMS2P11	0.18	0.09	enet	21	0.12	6.1e-15	6.3	8.0	1.7e-15	0.82	0.00	1.00	TRUE
40	ROSMAP	Brain Pre-frontal Cortex	RSBN1L	0.09	0.07	enet	42	0.08	9.9e-11	-5.5	-7.4	1.8e-13	-0.03	0.06	0.94	TRUE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-6.4	6.7	2.0e-11	0.01	0.02	0.86	TRUE
12	GTEx	Brain Frontal Cortex BA9	GSAP	0.38	0.22	lasso	6	0.21	3.0e-06	5.8	-6.5	5.7e-11	-0.13	0.14	0.22	TRUE
6	GTEx	Artery Aorta	GSAP	0.19	0.07	lasso	2	0.04	2.8e-03	5.8	-6.3	3.3e-10	-0.03	0.24	0.13	TRUE
4	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-6.5	-6.2	4.4e-10	-0.01	0.05	0.95	TRUE
19	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-6.5	-6.2	6.2e-10	-0.03	0.03	0.97	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	GSAP	0.36	0.27	lasso	7	0.28	1.5e-35	5.8	-5.7	9.3e-09	-0.02	0.64	0.36	TRUE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	PION	0.08	0.05	lasso	3	0.05	8.5e-07	5.8	-5.6	2.0e-08	-0.06	0.00	1.00	TRUE
36	GTEx	Thyroid	AC007000.12	0.13	0.08	enet	24	0.07	2.6e-06	-4.5	-5.5	4.1e-08	-0.18	0.66	0.02	TRUE
23	GTEx	Heart Left Ventricle	GSAP	0.21	0.02	lasso	5	0.03	9.3e-03	3.1	-5.3	1.4e-07	-0.01	0.12	0.05	TRUE
24	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-6.4	6.6	3.7e-11	0.02	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	6.6	-6.6	5.5e-11	0.00	0.00	1.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-6.4	-6.4	1.2e-10	-0.01	0.01	0.99	FALSE
26	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-6.4	-6.4	1.5e-10	-0.02	0.03	0.97	FALSE
14	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-6.4	-6.4	1.8e-10	-0.02	0.01	0.99	FALSE
38	METSIM	Adipose	TMEM60	0.10	0.07	enet	9	0.08	2.1e-12	6.3	-6.4	2.0e-10	-0.02	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	6.6	-6.3	2.5e-10	-0.01	0.01	0.91	FALSE
20	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-6.4	-6.3	2.7e-10	-0.02	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	PHTF2	0.06	0.04	blup	72	0.04	2.0e-03	6.0	-6.3	3.4e-10	-0.01	0.04	0.70	FALSE
37	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-6.1	-6.2	4.2e-10	-0.02	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-6.1	-6.2	5.1e-10	-0.03	0.06	0.94	FALSE
29	GTEx	Pituitary	TMEM60	0.19	0.06	lasso	6	0.04	2.8e-02	5.4	-6.2	6.9e-10	-0.02	0.05	0.87	FALSE
33	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.9	-6.1	8.6e-10	0.00	0.10	0.90	FALSE
9	GTEx	Artery Tibial	FAM185BP	0.11	0.02	enet	22	0.02	1.1e-02	5.7	6.0	1.6e-09	0.44	0.06	0.42	FALSE
3	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-6.2	-6.0	1.7e-09	-0.03	0.03	0.97	FALSE
15	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-6.0	-6.0	2.2e-09	-0.03	0.06	0.79	FALSE
8	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	-6.4	-6.0	2.5e-09	0.00	0.02	0.96	FALSE
11	GTEx	Brain Cerebellum	RSBN1L	0.14	0.12	lasso	2	0.13	1.3e-04	5.7	6.0	2.7e-09	0.05	0.05	0.89	FALSE
7	GTEx	Artery Tibial	PTPN12	0.25	0.13	lasso	8	0.12	1.8e-09	5.9	-5.9	3.2e-09	0.05	0.27	0.73	FALSE
10	GTEx	Brain Cerebellum	GSAP	0.38	0.30	lasso	4	0.31	6.4e-10	5.7	-5.9	4.2e-09	-0.01	0.65	0.30	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF2	0.02	0.03	lasso	1	0.02	8.0e-04	5.9	-5.9	4.3e-09	0.04	0.09	0.74	FALSE
28	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	-5.5	-5.9	4.5e-09	0.00	0.04	0.87	FALSE
41	YFS	Blood	TMEM60	0.14	0.16	lasso	4	0.18	1.8e-55	-6.4	-5.9	4.6e-09	-0.02	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF2	0.02	0.01	lasso	1	0.01	3.0e-03	5.8	-5.8	5.4e-09	0.04	0.16	0.73	FALSE
25	GTEx	Muscle Skeletal	GSAP	0.20	0.12	lasso	2	0.12	1.8e-11	5.8	-5.8	5.5e-09	-0.04	0.65	0.35	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	TMEM60	0.14	0.08	lasso	4	0.03	1.4e-02	-6.4	-5.8	5.9e-09	-0.01	0.02	0.97	FALSE
35	GTEx	Thyroid	GSAP	0.19	0.08	lasso	3	0.07	3.3e-06	5.8	-5.8	6.3e-09	-0.02	0.60	0.34	FALSE
16	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	-5.5	-5.8	7.7e-09	-0.01	0.10	0.90	FALSE
22	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	-5.5	-5.7	9.3e-09	0.00	0.31	0.69	FALSE
18	GTEx	Colon Transverse	RSBN1L-AS1	0.32	0.24	lasso	9	0.22	5.7e-11	-5.5	-5.7	1.2e-08	-0.03	0.05	0.95	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	PTPN12	0.04	0.04	enet	4	0.04	1.0e-04	5.4	-5.6	2.4e-08	0.06	0.01	0.98	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	PION	0.13	0.07	enet	9	0.08	3.4e-09	5.8	-5.5	3.1e-08	-0.03	0.00	1.00	FALSE
34	GTEx	Thyroid	TMEM60	0.06	0.04	lasso	8	0.04	8.2e-04	-5.1	-5.4	5.2e-08	-0.01	0.07	0.92	FALSE
27	GTEx	Ovary	TMEM60	0.23	0.19	enet	7	0.13	5.2e-04	-5.1	-5.4	6.0e-08	0.01	0.11	0.48	FALSE
44	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM60	0.10	0.10	blup	29	0.09	1.4e-03	6.0	-5.4	7.4e-08	-0.05	0.01	0.72	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM60	0.05	0.02	blup	29	0.03	7.9e-03	6.6	-5.3	1.5e-07	0.00	0.01	0.73	FALSE
13	GTEx	Brain Putamen basal ganglia	GSAP	0.48	0.20	lasso	12	0.15	2.2e-04	5.8	-5.2	1.8e-07	-0.11	0.14	0.20	FALSE
32	GTEx	Skin Sun Exposed Lower leg	RSBN1L-AS1	0.25	0.18	enet	22	0.28	4.1e-23	6.3	-5.2	1.8e-07	-0.05	0.02	0.98	FALSE
17	GTEx	Colon Transverse	PTPN12	0.17	0.12	lasso	6	0.10	1.8e-05	5.4	-5.2	2.2e-07	0.06	0.33	0.50	FALSE
5	GTEx	Adrenal Gland	PTPN12	0.16	0.10	lasso	4	0.04	1.0e-02	5.4	-5.1	2.8e-07	0.04	0.31	0.36	FALSE
21	GTEx	Esophagus Muscularis	RSBN1L	0.07	0.03	lasso	3	0.01	4.3e-02	-5.1	-5.1	2.9e-07	-0.01	0.19	0.58	FALSE