Best TWAS P=8.49e-09 · Best GWAS P=1.36e-14 conditioned to 4.66e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | DCLRE1B | 0.19 | 0.02 | lasso | 5 | 0.03 | 9.1e-03 | 5.7 | -5.2 | 2.0e-07 | -0.39 | 0.28 | 0.36 | FALSE |
| 2 | GTEx | Testis | RSBN1 | 0.09 | 0.09 | enet | 6 | 0.09 | 8.9e-05 | 5.6 | -5.4 | 6.0e-08 | -0.37 | 0.51 | 0.07 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PTPN22 | 0.02 | 0.01 | blup | 67 | 0.01 | 9.6e-03 | 4.9 | 5.5 | 3.6e-08 | 0.57 | 0.11 | 0.37 | FALSE |
| 4 | The Cancer Genome Atlas | Glioblastoma Multiforme | DCLRE1B | 0.20 | -0.01 | blup | 39 | 0.04 | 3.0e-02 | 5.0 | -5.8 | 8.5e-09 | -0.54 | 0.01 | 0.28 | TRUE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BCL2L15 | 0.09 | 0.00 | blup | 42 | 0.04 | 1.1e-02 | 4.5 | 5.4 | 6.9e-08 | 0.37 | 0.02 | 0.05 | FALSE |