Hub : Genes

BCL2L15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1087	0.0308	2.8e-05	0.018	0.041	0.016	0.044	0.026	2.0e-03	5.1e-06	2.8e-03	2e-06	2.2e-04
2	TCGA	Brain Lower Grade Glioma	0.0786	0.0307	1.2e-07	0.044	0.060	0.067	NA	0.064	8.1e-06	2.1e-07	4.9e-08	NA	9.2e-08
3	TCGA	Pheochromocytoma and Paraganglioma	0.0910	0.0580	8.0e-03	0.002	0.039	0.001	NA	0.007	2.7e-01	1.1e-02	2.8e-01	NA	1.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.0	2.5	-1.4	-1.2	1.6
Bipolar Disorder or Schizophrenia	1.0	2.6	7.6	-0.0	0.1	2.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.0	-1.4	0.1	0.6
Depression (Nagel 2018)	0.6	0.9	2.6	0.1	0.3	1.6
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.9	0.4	-0.7	-2.2
Neuroticism (Nagel 2018)	0.1	0.3	0.8	-0.9	0.4	-0.3
Schizophrenia (2018)	1.3	2.7	5.6	1.1	1.1	2.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	-1.5	-0.2	-0.3
Worry (Nagel 2018)	0.3	0.7	2.0	-0.1	1.4	0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.3	-0.3	0.5
Alzheimer’s Disease (in father)	1.2	1.3	3.1	0.3	-1.8	0.9
Alzheimer’s Disease (including proxy)	0.8	1.2	2.6	-0.9	-1.6	-0.1
Crohns Disease (2017)	3.9	8.6	19.4	-1.2	-2.2	-4.4
Irritable Bowel Disease (IBD)	1.5	3.5	5.9	-1.3	-1.8	-2.4
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.9	-0.3	0.3
Major Depression (MDD)	0.6	0.8	1.0	-0.7	-0.9	1.0
Reaction Time	1.7	3.3	9.5	0.4	0.2	-3.1
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.6	-0.7	-1.2	-1.9
Breast Cancer	2.9	7.0	18.6	-1.1	-1.1	-4.3
Ovarian Cancer	0.7	0.9	2.2	0.6	1.5	0.1
Prostate Cancer	0.7	1.0	1.1	1.0	-1.1	-0.9
Age at First Birth	0.3	0.5	1.2	0.5	-0.2	1.1
Bipolar Disorder (2011)	3.2	3.1	8.8	0.6	0.5	3.0
Body Mass Index (BMI) (2010)	2.6	3.5	5.3	-2.3	-2.2	-0.6
Coronary Artery Disease (CAD)	0.6	0.7	1.0	0.5	-0.9	1.0
Crohns Disease (2012)	2.6	4.3	8.5	-1.3	-1.6	-2.9
Mean Putamen Volume	0.2	0.2	0.5	-0.7	-0.1	0.2
Fasting Glucose	0.7	0.9	1.6	0.3	0.9	-1.3
HbA1C	0.3	0.3	0.8	-0.3	-0.2	0.9
HDL Cholesterol	0.1	0.2	0.3	0.5	-0.1	0.6
LDL Cholesterol	0.7	1.1	1.6	-1.3	-0.9	0.9
Lupus	3.2	4.9	11.4	-1.0	1.5	3.4
Neuroticism (2016)	0.3	0.5	1.4	0.1	0.1	-1.2
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.3	0.1	-0.4
Rheumatoid Arthritis	33.2	45.6	130.0	-2.6	-0.4	11.4
Schizophrenia (2014)	0.1	0.3	0.9	0.2	0.2	0.9
Triglycerides	0.8	1.3	1.9	-1.3	1.4	0.4
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	-0.9	-0.4	-0.6
Ulcerative Colitis	1.1	1.6	3.0	-1.7	-1.4	0.1
Blood Eosinophil Count	0.1	0.7	1.4	-0.8	0.5	-1.2
Blood Platelet Count	0.7	7.9	17.1	2.1	4.1	1.4
Blood Red Count	0.1	1.1	2.4	-1.6	-0.6	-0.6
Blood White Count	1.6	11.9	18.7	3.1	2.6	-4.3
Heel T-Score	0.9	7.0	14.1	3.8	1.1	2.4
BMI	0.9	5.3	7.5	-1.2	-2.7	2.7
Height	0.1	1.9	3.8	0.3	1.3	-1.9
Waist Hip Ratio (WHR)	0.8	3.6	4.9	-2.2	-2.0	-1.4
Systolic Blood Pressure	0.1	0.4	0.9	-0.3	0.5	-1.0
Smoking Status	0.5	1.1	3.0	0.2	0.6	-1.7
Allergy or Eczema	1.4	3.6	8.4	0.9	1.3	-2.9
Cardiovascular Disease	0.5	1.8	4.5	-0.6	0.7	2.1
Hypothyroidism (self reported)	33.3	76.6	216.1	-3.6	1.0	14.7
Respiratory disease	0.3	0.8	0.9	-1.0	1.0	0.7
Type 2 Diabetes (T2D) (2018)	1.6	3.0	5.3	-2.3	0.8	1.7
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.5	-0.2	0.5
Lung FVC	0.2	1.2	3.0	-0.6	-0.6	1.7
Neuroticism	0.4	0.9	1.3	-1.2	-0.6	-1.0
Chronotype (morning person)	0.5	1.2	3.5	-0.1	0.3	1.9
Hair Pigment	0.1	3.0	8.2	-0.4	0.8	2.9
Tanning	0.1	1.2	3.2	0.1	-0.6	-1.8
Hand grip strength (left)	0.9	2.3	4.5	0.0	-1.5	-2.1
Number of treatments/medications taken	4.9	8.9	26.1	-0.6	0.4	5.1
Average weekly spirits intake	1.4	1.7	4.1	0.7	0.8	-2.0
Sensitivity / hurt feelings	0.6	1.1	3.0	-0.4	-0.3	-1.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.0	-0.5	1.4	0.9
Hearing difficulty/problems: Yes	0.9	1.4	3.6	-1.9	-0.8	0.0
Relative age of first facial hair	0.7	1.4	2.1	0.3	1.5	-1.4
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	5.8	-0.7	-1.6	2.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.5	1.0	0.3	-1.6
Ever had hysterectomy (womb removed)	1.6	1.8	3.4	-1.3	-0.5	-1.8
Systolic blood pressure, automated reading	0.1	0.2	0.3	0.3	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.2	0.2	-0.2	2.0
Angina	1.5	1.9	2.7	-1.7	-1.3	1.2
Medication for hormone replacement therapy	0.5	0.5	1.6	0.1	1.3	-0.0
Vitamin and mineral supplements	0.4	0.6	0.8	0.7	0.9	0.7
Supplements: Zinc	0.3	0.3	0.6	-0.5	0.7	-0.3
Medication: Co-codamol	0.2	0.2	0.4	-0.2	-0.6	0.3
Medication: Metformin	2.0	2.8	7.4	-0.9	0.6	2.7
Diabetes (father)	0.7	0.9	1.6	-1.1	-0.0	1.3
Diabetes (mother)	1.9	2.4	4.2	-1.6	-0.7	-2.0
Severe depression (siblings)	2.0	2.3	5.1	-1.3	-2.3	0.0
Pack years adult smoking proportion	0.8	1.3	3.2	0.7	0.5	1.8
Impedance of leg (right)	0.6	2.9	4.1	1.4	2.0	-1.6
Leg fat-free mass (left)	0.2	1.0	1.5	-1.2	-0.8	0.9
Trunk fat percentage	0.4	1.6	3.5	1.1	0.3	1.9
Hand grip strength (right)	0.1	0.3	0.7	-0.0	-0.8	-0.4
Townsend deprivation index at recruitment	0.4	0.6	1.1	1.0	0.8	-0.3
Current tobacco smoking	0.3	0.6	1.4	0.3	0.4	-1.2
Average weekly fortified wine intake	0.8	1.0	2.8	-0.4	0.0	-1.7
Maternal smoking around birth	1.1	1.6	2.9	-0.2	-1.3	-1.7
Fed-up feelings	0.2	0.4	0.6	-0.7	0.7	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.6	-0.3	0.2
Relative age voice broke	0.3	0.4	0.6	0.8	0.4	-0.7
Taking other prescription medications	7.7	11.8	34.5	-0.7	0.8	5.9
Age when periods started (menarche)	1.6	3.9	9.1	1.2	1.0	-3.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	0.6	-0.2	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.3	1.8	0.8	0.1
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	2.8	-1.7	-1.3	1.0
Qualifications: CSEs or equivalent	1.3	1.7	4.3	-2.1	-0.9	-0.3
Serious illness, injury or assault to yourself	3.3	4.0	9.1	-0.7	-1.6	3.0
High blood pressure	0.9	2.4	6.2	0.1	2.5	1.0
Hayfever, allergic rhinitis or eczema	1.7	3.8	7.8	0.9	1.6	-2.8
Multivitamins +/- minerals	0.1	0.2	0.4	-0.6	0.3	0.1
Stomach or abdominal pain in last month	0.4	0.4	1.0	-0.4	-1.0	0.4
Supplements: Glucosamine	1.2	1.6	3.6	1.9	0.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.1	-0.3	0.1
Medication: Atenolol	0.9	1.1	3.1	-0.2	-0.2	1.8
Medication: Levothyroxine sodium	18.9	32.0	88.0	-2.6	1.1	9.4
Sitting height	0.1	1.0	3.0	-1.7	-0.1	-0.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.3	-0.3	-1.2	-1.5
High blood pressure (mother)	1.1	1.5	3.3	-1.8	-0.2	1.0
Body mass index (BMI)	0.4	1.8	4.8	-0.1	-0.8	2.2
Impedance of leg (left)	0.6	3.0	3.9	1.5	2.0	-1.6
Leg predicted mass (left)	0.2	1.1	1.5	-1.2	-0.8	1.0
Trunk fat mass	0.2	1.1	2.8	0.6	0.0	1.7
Waist circumference	0.3	1.1	1.6	-0.4	-1.3	1.2
Number of incorrect matches in round	1.3	2.2	3.6	-0.1	-1.9	1.7
Past tobacco smoking	1.6	2.9	7.5	1.0	-0.6	2.7
Alcohol usually taken with meals	2.9	4.7	11.1	0.6	1.6	3.3
Nervous feelings	0.6	1.1	2.2	-0.5	1.5	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.2	-1.0	-0.7	1.8
Hearing difficulty/problems with background noise	1.4	2.3	4.5	-2.1	-0.7	-1.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	0.6	-0.1	-0.3
Had menopause	1.1	1.4	3.8	1.9	0.3	0.4
Had other major operations	0.1	0.1	0.2	-0.4	0.4	-0.1
Forced vital capacity (FVC)	0.6	2.3	3.8	-1.6	-2.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.6	1.6	1.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	-1.1	-0.5	1.3
Qualifications: None of the above	0.2	0.4	0.6	-0.8	-0.3	-0.8
Financial difficulties in last 2 years	0.8	1.1	2.9	-0.6	-1.7	-0.4
Mouth/teeth dental problems	1.7	2.7	3.8	2.0	1.7	-1.1
Heart attack	2.2	2.8	7.9	0.6	-0.1	2.8
Allergy	1.6	3.8	5.8	-1.6	-2.4	1.7
Pain all over the body in last month	1.3	1.4	2.3	-0.0	1.5	1.4
Diabetes (self-reported)	3.4	5.2	13.0	-1.3	0.9	3.6
Hayfever/allergic rhinitis (self-reported)	2.2	2.8	6.3	-1.4	0.6	-2.5
Medication: Ramipril	1.1	1.4	2.4	-1.6	1.2	0.6
Medication: Simvastatin	0.1	0.2	0.3	-0.5	0.1	0.5
Fluid intelligence score	0.3	0.7	1.2	-0.6	-0.6	-1.1
Illnesses of siblings	1.7	2.4	5.7	-1.2	-2.4	-0.2
Neuroticism score	0.2	0.5	1.2	-1.1	0.4	0.1
Weight	0.2	0.9	1.7	-0.5	-0.8	1.3
Impedance of arm (right)	0.3	1.4	2.9	0.8	0.9	-1.7
Arm fat percentage (right)	0.3	1.1	2.9	0.1	-0.5	1.7
Trunk fat-free mass	0.1	0.8	2.0	-1.4	-0.5	-0.3
Hip circumference	0.2	1.0	2.7	0.4	-0.3	1.6
Time employed in main current job	0.4	0.5	1.0	-0.3	-0.7	-1.0
Alcohol intake versus 10 years previously	0.0	0.1	0.1	-0.3	-0.2	-0.2
Father’s age at death	1.0	1.3	2.3	1.2	0.4	-1.5
Worrier / anxious feelings	0.2	0.4	0.7	0.8	0.7	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	4.5	-1.0	0.0	2.1
Falls in the last year	0.0	0.0	0.0	0.2	-0.1	0.2
Hair/balding pattern: Pattern 3	1.4	2.0	3.3	0.3	-1.6	-1.8
Number of live births	1.1	1.5	2.5	0.9	1.0	-1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	3.8	-1.6	-1.9	-0.3
Pulse rate	0.1	0.3	0.3	0.6	-0.5	0.3
Happiness	0.2	0.2	0.6	-0.8	0.0	0.0
Noisy workplace	0.7	0.8	2.0	-0.4	-1.4	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	0.3	0.4	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	-0.3	-0.3	-0.1
Mouth/teeth dental problems: Dentures	0.9	1.5	2.8	-1.7	-1.3	-0.4
Asthma	0.4	0.8	1.7	0.7	1.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.4	-0.2	0.5
Medication: Cholesterol lowering	2.9	4.6	13.0	-0.6	0.5	3.6
Depression (self-reported)	1.4	1.7	4.2	-2.1	-0.1	0.9
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	0.4	0.5
Prospective memory result	0.0	0.0	0.1	0.0	-0.2	0.3
Lung cancer (father)	1.0	1.2	2.7	-0.7	-0.7	-1.6
Illnesses of mother	1.0	1.2	2.9	1.7	0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.8	-1.7	-1.4	0.1
Pulse wave Arterial Stiffness index	1.6	1.9	5.5	0.2	-0.0	-2.3
Impedance of arm (left)	0.3	1.2	1.6	0.7	1.2	-1.3
Arm fat mass (right)	0.2	0.8	1.9	-0.2	-0.8	1.4
Trunk predicted mass	0.1	0.8	2.0	-1.4	-0.5	-0.3
Standing height	0.2	1.6	4.0	-0.8	-0.1	-2.0
Length of working week for main job	1.8	2.0	5.2	-0.8	0.4	-2.3
Exposure to tobacco smoke at home	0.5	0.6	0.8	0.9	-0.6	-0.8
Breastfed as a baby	0.9	1.2	3.1	1.7	0.2	-0.7
Tense / ‘highly strung’	1.5	2.5	4.4	0.7	2.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	-0.3	-1.0	-0.8
Hair/balding pattern: Pattern 4	0.4	1.1	2.9	-0.1	0.5	1.7
Birth weight of first child	1.4	2.5	7.6	-0.2	-0.2	-2.8
Peak expiratory flow (PEF)	0.5	1.1	2.6	-0.4	-0.8	-1.6
Pulse wave reflection index	0.9	1.1	3.2	-0.2	0.3	-1.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.4	1.2	0.2
Loud music exposure frequency	0.3	0.3	0.6	-0.8	-0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	0.1	-0.7	-0.1
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	7.4	0.1	1.1	2.7
Blood clot in the leg (DVT)	2.3	2.9	4.8	2.2	1.8	0.9
Medication: Paracetamol	0.6	1.0	3.1	-0.0	-0.2	1.8
Headache pain in last month	1.1	1.9	4.1	-1.0	-0.7	2.0
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	10.8	1.4	-0.7	-3.3
Glaucoma (self-reported)	1.7	2.0	5.4	-2.3	-0.8	-0.1
Gout (self-reported)	0.2	0.2	0.3	0.2	-0.5	-0.6
Hypothyroidism/myxoedema (self-reported)	26.1	51.0	146.4	-2.1	1.4	12.1
Medication: Amlodipine	1.8	2.5	5.5	-2.4	-0.7	1.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.4	-1.1	-0.4	-1.6
Birth weight	2.1	4.6	12.7	-0.8	0.6	-3.6
Chronic bronchitis/emphysema (mother)	2.2	2.5	4.3	0.7	2.1	1.6
High blood pressure (siblings)	1.8	2.5	6.4	1.1	2.5	0.0
Forced vital capacity (FVC), Best measure	0.5	1.9	3.3	-1.8	-1.5	-0.2
Body fat percentage	0.5	1.9	4.2	1.1	0.4	2.1
Leg fat percentage (right)	0.6	2.2	4.4	1.3	0.8	2.1
Arm fat-free mass (right)	0.1	0.4	0.8	-0.9	-0.2	0.4
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-0.1	0.8	-1.4
Comparative body size at age 10	0.3	0.8	2.1	-0.6	-1.4	0.1
Number of full brothers	2.7	3.4	7.2	2.7	1.6	0.5
Worry too long after embarrassment	2.3	3.9	11.1	0.5	0.7	-3.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	2.3	-1.5	-1.5	-1.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.4	0.4	-0.8
Number of children fathered	1.4	1.6	3.1	-1.7	-0.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.1	-0.3	-1.8	0.8
Age at first live birth	0.3	0.5	1.4	1.2	0.3	0.0
Pulse wave peak to peak time	1.3	1.5	4.0	-0.6	-0.4	2.0
Health satisfaction	1.9	2.4	5.6	-2.4	-0.8	1.0
Shortness of breath walking on level ground	1.6	1.9	4.5	-0.5	-1.0	2.1
Qualifications: College or University degree	0.1	0.3	0.5	-0.6	0.1	0.7
Eye problems/disorders: None of the above	0.8	0.9	2.1	-0.7	-1.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.8	-1.0	1.4	0.9
Emphysema/chronic bronchitis	0.3	0.4	0.9	-0.2	-0.4	1.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.4	-0.0	-0.3	-1.8
Neck or shoulder pain in last month	0.8	1.1	2.6	-1.6	-0.8	0.3
Medication: Blood pressure	1.3	2.3	5.2	-1.0	0.9	2.3
Angina (self-reported)	1.6	2.1	3.6	-1.9	-1.4	0.8
Migraine (self-reported)	0.6	0.7	1.2	0.1	1.1	1.0
Medication: Ibuprofen	0.3	0.4	0.9	-0.3	-0.3	0.9
Medication: Allopurinol	0.9	1.3	2.0	0.4	-1.4	-1.3
Medication: Omeprazole	1.0	1.2	1.9	-1.1	-0.6	1.4
Medication: Seretide 50 evohaler	1.9	2.2	6.5	-0.0	2.5	0.1
Mean time to correctly identify matches	1.6	3.0	7.1	1.3	0.5	-2.7
Heart disease (mother)	1.3	1.6	4.5	-0.6	-0.2	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.3	1.2	1.5	-0.5
Whole body fat mass	0.2	1.0	2.7	0.5	0.1	1.6
Leg fat mass (right)	0.3	1.0	2.9	0.2	-0.0	1.7
Arm predicted mass (right)	0.1	0.3	0.7	-0.8	-0.5	0.4
Pulse rate, automated reading	1.2	3.8	4.9	1.9	2.2	1.7
Alcohol intake frequency.	2.2	5.2	6.3	-2.0	-2.5	2.3
Comparative height size at age 10	1.0	5.5	8.4	-2.9	-2.8	-0.8
Number of full sisters	0.8	1.0	2.0	-0.9	-1.4	0.3
Suffer from ‘nerves’	0.4	0.7	1.7	-1.3	0.2	-0.5
Overall health rating	2.9	6.3	16.7	-1.4	-0.6	4.1
Chest pain or discomfort	2.6	3.8	9.6	0.9	1.0	3.1
Had major operations	0.3	0.4	0.9	0.1	0.3	1.0
Age at last live birth	1.3	1.9	3.2	1.8	1.6	-0.0
Family relationship satisfaction	0.1	0.1	0.4	-0.1	-0.2	-0.6
Leg pain on walking	1.1	1.4	1.8	-1.3	-1.3	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.7	0.7	-0.8	-0.8
Commuting to job workplace: Car/motor vehicle	2.2	2.6	7.3	-0.2	0.5	-2.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	0.5	-0.4	-1.1
Medication: Aspirin	1.7	2.2	5.1	0.6	1.1	2.2
Supplements: Vitamin C	0.2	0.3	0.3	0.6	-0.6	-0.4
Knee pain experienced in last month	1.1	1.6	2.6	-1.0	-1.6	1.1
Hypertension (Self-reported)	0.9	2.4	6.2	-0.1	2.5	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	2.2	-1.4	-1.5	1.2
Illnesses of father: Heart disease	2.7	3.8	8.4	0.5	1.7	2.9
Illnesses of siblings: Diabetes	3.0	3.7	6.7	1.1	2.6	1.8
Smoking status: Previous	1.1	1.7	4.4	-0.7	0.2	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.1	-1.1	0.5	-1.0
Whole body fat-free mass	0.1	0.7	1.7	-1.3	-0.6	0.3
Leg fat-free mass (right)	0.3	1.4	1.9	-1.4	-1.1	1.1
Arm fat percentage (left)	0.3	1.3	3.8	0.2	-0.1	2.0
Average weekly red wine intake	0.4	0.6	1.0	0.8	0.4	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.1	-0.0	-0.7	-1.1
Mood swings	0.3	0.5	0.8	-0.3	0.8	0.9
Loneliness, isolation	1.6	2.1	4.7	-0.6	1.2	2.2
Long-standing illness, disability or infirmity	6.5	10.0	29.1	-1.0	-0.1	5.4
Ever had bowel cancer screening	1.6	1.8	2.1	1.4	1.5	1.2
Diabetes diagnosed by doctor	2.6	4.2	8.9	-1.8	0.7	3.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.3	-1.0	0.4	-1.2
Friendships satisfaction	0.4	0.5	1.4	-0.3	-0.1	1.2
Qualifications: nursing, teaching	0.6	1.0	2.2	-0.8	-0.1	1.5
Commuting to job workplace: Walk	2.1	2.2	3.8	-1.6	-1.9	-0.6
Eye problems/disorders: Cataract	0.7	0.8	2.0	1.4	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	5.2	-1.6	-2.3	-1.5
Medication for cholesterol	1.1	1.7	3.5	-1.0	-0.8	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.4	0.4	1.1
Back pain experienced in last month	0.2	0.2	0.6	0.1	-0.3	0.8
Mineral and other dietary supplements	0.9	1.2	3.5	-1.9	-0.3	-0.0
Breast cancer (self-reported)	0.6	0.8	1.2	-0.5	-1.1	-0.9
Asthma (self-reported)	0.2	0.5	1.2	0.4	1.1	0.2
Osteoporosis (self-reported)	0.5	0.6	1.4	1.2	0.5	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.5	0.0	0.1
Medication: Aspirin	1.4	1.9	5.3	0.0	0.6	2.3
Medication: Gliclazide	0.6	0.7	1.5	-0.8	0.2	1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.3	-1.1	-1.2	-0.6
Smoking status: Current	0.3	0.5	1.0	0.4	0.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	-1.3	-0.2	1.0
Whole body water mass	0.1	0.8	1.9	-1.4	-0.7	0.4
Leg predicted mass (right)	0.3	1.4	1.8	-1.3	-1.1	1.1
Arm fat mass (left)	0.2	0.9	2.3	-0.3	-0.5	1.5
Number of self-reported non-cancer illnesses	2.3	3.9	8.2	-1.4	1.3	2.9
Average weekly champagne plus white wine intake	0.8	1.1	2.7	-0.0	1.6	-0.7
Miserableness	0.6	1.1	1.6	-1.3	1.0	0.8
Guilty feelings	0.4	0.7	1.4	-0.8	-1.2	0.1
Wears glasses or contact lenses	2.8	3.3	7.2	-0.1	-2.7	1.6
Ever taken oral contraceptive pill	1.2	1.4	4.1	0.1	0.0	2.0
Hearing aid user	0.0	0.0	0.1	-0.1	-0.3	0.1
Mother’s age at death	1.1	1.4	1.8	1.0	1.1	-1.3
Financial situation satisfaction	0.8	1.0	2.2	-1.5	-0.8	0.2
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.4	0.2	-1.1	-1.2
Commuting to job workplace: Public transport	1.6	1.9	5.0	-0.6	-0.5	2.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	-0.7	0.6	0.1
Medication: Blood pressure	0.6	1.1	2.8	0.6	1.7	0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.6	-0.8	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.6	-0.0	-0.4
High cholesterol (Self-reported)	0.3	0.6	1.6	-0.3	0.3	1.2
Medication: Bendroflumethiazide	3.8	5.8	11.0	2.3	3.3	0.9
Medication: Paracetamol	0.3	0.5	1.1	0.3	-0.4	1.1
Medication: Lisinopril	0.4	0.5	1.0	0.6	1.0	0.2
Medication: Atorvastatin	0.9	1.1	2.7	0.6	0.6	1.6
Illnesses of father: High blood pressure	0.5	0.6	1.1	-1.0	0.6	-0.5
Alcohol drinker status: Never	4.2	5.0	7.6	-2.8	-1.9	2.0
Ever smoked	1.9	3.4	9.2	-0.9	0.2	-3.0
Basal metabolic rate	0.2	1.0	1.8	-1.4	-0.9	0.5
Leg fat percentage (left)	0.7	2.6	5.1	1.4	0.7	2.3
Arm fat-free mass (left)	0.1	0.4	0.7	-0.8	-0.6	0.4
Number of operations (self-reported)	0.5	0.7	1.4	-1.2	0.1	-0.8
Average weekly beer plus cider intake	0.8	1.1	2.0	-0.6	-1.0	-1.4
Irritability	1.3	2.2	3.8	0.1	2.0	1.7
Risk taking	1.6	2.3	5.1	1.4	0.2	2.3
Ever had prostate specific antigen (PSA) test	3.0	3.5	5.8	2.4	0.9	1.9
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.0	0.6	0.6
Age started oral contraceptive pill	0.2	0.3	0.3	0.6	0.4	0.5
Diastolic blood pressure, automated reading	0.3	1.1	2.0	1.4	0.4	-1.0
Ever depressed for a whole week	0.6	0.7	1.4	-1.2	-0.7	0.6
Unable to work because of sickness or disability	0.7	0.9	2.8	0.3	0.1	1.7
Commuting to job workplace: Cycle	1.8	2.1	3.0	-1.4	-1.2	-1.7
Myopia	3.5	5.0	8.6	-2.1	-2.9	1.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.7	0.0	-1.6	-1.5
Cholesterol lowering medication	0.4	0.6	1.0	1.0	0.9	0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.6	-0.1	-0.3	1.3
Pain experienced in last month	0.0	0.1	0.1	0.3	0.3	0.0
Supplements: Calcium	0.6	0.7	1.3	0.7	-0.5	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.7	0.4	0.6	-1.3
Heart attack/myocardial infarction (self-reported)	2.3	3.0	8.8	0.4	-0.3	3.0
Deep venous thrombosis (DVT) (self-reported)	2.1	2.8	3.7	1.9	1.9	0.9
Heart disease (siblings)	0.2	0.2	0.4	-0.4	-0.2	0.6
Alcohol drinker status: Previous	1.2	1.4	2.8	-0.2	-1.1	1.7
Pack years of smoking	1.0	1.4	3.1	1.0	0.6	1.8
Impedance of whole body	0.5	2.3	3.0	1.3	1.7	-1.6
Leg fat mass (left)	0.3	1.0	3.0	0.2	-0.0	1.7
Arm predicted mass (left)	0.1	0.4	0.7	-0.8	-0.6	0.5