TWAS hub - RSBN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.047	0.021	0.0085	0.018	0.004	0.021	0.004	0.013	0.00280	0.089	1.3e-03	0.087	0.00950
2	GTEx	Testis	0.094	0.044	0.0029	0.086	NA	0.089	NA	0.087	0.00012	NA	8.9e-05	NA	0.00011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism (self reported)	56.6	130.0	225.0	5.9	-15.0
Hypothyroidism/myxoedema (self-reported)	48.5	94.6	151.3	6.2	-12.3
Rheumatoid Arthritis	48.3	66.4	114.5	4.3	-10.7
Medication: Levothyroxine sodium	34.5	58.4	97.2	4.4	-9.9
Taking other prescription medications	10.6	16.3	31.5	1.1	-5.6
Long-standing illness, disability or infirmity	10.2	15.6	29.4	1.4	-5.4
Other serious medical condition/disability diagnosed by doctor	9.0	11.7	12.5	3.5	-3.3
Number of treatments/medications taken	7.5	13.5	22.8	-2.1	-4.8
Supplements: Glucosamine	6.3	8.2	13.0	-3.6	1.9
Serious illness, injury or assault to yourself	4.5	5.5	6.7	-2.1	-2.6
Overall health rating	4.4	9.5	18.1	-1.0	-4.3
Alcohol drinker status: Never	4.4	5.3	9.8	0.9	-3.1
Lupus	4.1	6.2	9.0	1.8	-3.0
Ovarian Cancer	3.9	5.1	9.7	-3.1	0.7
Diabetes (self-reported)	3.9	5.9	11.8	-0.2	-3.4
Medication: Cholesterol lowering	3.8	6.0	9.9	-1.4	-3.1
Worry too long after embarrassment	3.7	6.3	11.1	-1.2	3.3
Alcohol intake frequency.	3.7	8.5	9.5	2.7	-3.1
Illness, injury, bereavement, stress in last 2 years	3.7	4.5	8.5	2.9	0.7
Medication for cholesterol, blood pressure or diabetes	3.6	5.9	8.9	1.7	3.0
Wears glasses or contact lenses	3.6	4.1	4.8	1.9	-2.2
Bipolar Disorder (2011)	3.4	3.3	6.1	-0.7	-2.5
Diabetes (father)	3.2	4.0	4.5	-2.1	-1.9
Medication for pain relief, constipation, heartburn	3.2	5.5	6.9	2.6	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	5.4	-2.3	1.4
Mouth/teeth dental problems: Bleeding gums	3.0	3.9	4.8	-2.2	-1.7
Shortness of breath walking on level ground	3.0	3.6	7.1	-0.2	-2.7
Chronic bronchitis/emphysema (father)	2.9	3.4	6.1	-2.5	0.9
Mineral and other dietary supplements	2.9	3.8	7.4	2.7	-0.5
Reaction Time	2.8	5.3	10.5	0.1	3.2
Mouth/teeth dental problems: Loose teeth	2.8	3.3	5.5	2.4	-1.0
Emphysema/chronic bronchitis	2.8	3.2	3.8	-2.0	-1.6
Medication: Metformin	2.5	3.5	7.0	-0.3	-2.6
Hayfever/allergic rhinitis (self-reported)	2.5	3.3	4.6	2.2	1.4
Chest pain or discomfort	2.5	3.7	7.1	0.4	-2.7
Diabetes diagnosed by doctor	2.5	4.2	8.3	0.2	-2.9
Crohns Disease (2017)	2.4	5.3	10.6	0.0	3.3
Pulse wave Arterial Stiffness index	2.4	2.8	5.5	-0.1	2.3
Commuting to job workplace: Car/motor vehicle	2.4	2.7	4.0	1.2	2.0
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	5.0	-2.2	-1.0
Allergy or Eczema	2.3	6.1	11.4	-0.8	3.4
Average weekly spirits intake	2.3	2.8	5.4	-0.5	2.3
Illnesses of siblings	2.3	3.2	4.8	2.2	-1.3
Medication: Aspirin	2.3	3.0	5.9	-0.2	-2.4
Medication: Atorvastatin	2.3	2.9	3.1	1.8	-1.6
Heart attack/myocardial infarction (self-reported)	2.3	3.0	5.2	-0.8	-2.3
Illnesses of mother	2.2	2.8	3.0	-1.7	1.6
Medication: Omeprazole	2.2	2.6	4.0	-2.0	-1.1
Mean time to correctly identify matches	2.2	4.2	8.2	0.4	2.9
Angina	2.1	2.8	4.2	1.2	-2.1
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	4.3	-1.5	-2.1
Length of working week for main job	2.1	2.3	3.9	-0.8	2.0
Pulse wave peak to peak time	2.1	2.5	5.0	0.3	-2.2
Number of self-reported non-cancer illnesses	2.1	3.7	7.1	0.4	-2.7
Bipolar Disorder (2018)	2.0	3.1	5.8	0.6	-2.4
Ever used hormone-replacement therapy (HRT)	2.0	2.5	4.8	-0.4	2.2
Townsend deprivation index at recruitment	2.0	2.8	4.5	-2.1	1.0
Hayfever, allergic rhinitis or eczema	2.0	4.3	8.4	0.4	2.9
Heart attack	2.0	2.5	4.4	-0.8	-2.1
Chronic bronchitis/emphysema (mother)	2.0	2.4	3.2	-1.8	-1.3
Bipolar Disorder or Schizophrenia	1.9	4.5	8.0	1.0	-2.8
LDL Cholesterol	1.9	3.1	6.2	-2.5	-0.1
Pain all over the body in last month	1.9	2.0	3.9	-2.0	-0.4
Medication: Aspirin	1.9	2.4	4.5	-0.6	-2.1
Illnesses of father: Heart disease	1.9	2.6	4.4	-0.9	-2.1
Mother’s age at death	1.9	2.4	3.2	-1.2	1.8
Medication: Atenolol	1.8	2.3	4.3	-0.5	-2.1
Number of incorrect matches in round	1.8	2.9	5.0	0.9	-2.2
Tense / ‘highly strung’	1.8	3.0	5.6	-2.4	-0.6
Birth weight	1.8	4.0	7.7	-0.5	2.8
Medication: Bendroflumethiazide	1.8	2.7	5.4	-2.3	0.3
Alcohol usually taken with meals	1.7	2.8	5.5	-0.1	-2.4
Angina (self-reported)	1.7	2.3	3.2	1.2	-1.8
Supplements: Calcium	1.7	1.9	2.0	-1.4	-1.4
Crohns Disease (2012)	1.6	2.6	5.1	-0.2	2.2
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	3.3	-0.5	-1.8
Age when periods started (menarche)	1.6	3.8	7.6	-0.2	2.8
Diverticular disease/diverticulitis (self-reported)	1.6	2.0	3.8	-2.0	-0.3
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	2.7	-1.6	-1.6
Hair/balding pattern: Pattern 3	1.6	2.4	4.2	0.8	2.1
Depression (self-reported)	1.6	1.9	3.8	-0.2	-2.0
Pulse wave reflection index	1.6	2.0	3.6	-0.6	1.9
High blood pressure (siblings)	1.6	2.3	3.4	-1.8	1.1
Exposure to tobacco smoke outside home	1.6	2.1	4.3	-0.0	2.1
Intelligence (Savage-Jansen 2018)	1.5	4.5	4.8	-2.1	2.2
BMI	1.5	9.0	17.5	0.7	-4.2
Severe depression (siblings)	1.5	1.7	2.5	1.6	-0.9
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	2.6	-0.9	1.6
Ever unenthusiastic/disinterested for a whole week	1.5	1.9	2.5	1.1	-1.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	3.2	-1.8	0.7
Medication: Ventolin 100micrograms inhaler	1.5	2.0	2.6	1.2	1.6
Medication: Blood pressure	1.5	2.7	3.4	-1.4	-1.8
Medication: Allopurinol	1.5	2.0	2.9	1.7	1.1
Loneliness, isolation	1.5	2.1	4.2	0.2	-2.0
Ever taken oral contraceptive pill	1.5	1.7	3.3	0.2	-1.8
Basal cell carcinoma (self-reported)	1.5	1.8	2.0	-1.2	1.4
Breast Cancer	1.4	3.4	6.3	0.7	2.5
Blood White Count	1.4	10.5	15.8	-2.3	4.0
Diabetes (mother)	1.4	1.8	2.8	-0.9	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.1	-1.8	-0.2
Medication: Paracetamol	1.4	2.3	3.8	-0.9	-2.0
Headache pain in last month	1.4	2.4	4.6	-0.5	-2.1
Breast cancer (self-reported)	1.4	1.6	3.2	1.8	0.2
Depression (Nagel 2018)	1.3	1.9	2.0	-1.4	-1.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.4	0.7	-1.6
Medication: Ramipril	1.3	1.6	3.3	-1.8	-0.1
Medication: Simvastatin	1.3	1.9	3.8	-1.9	-0.3
Birth weight of first child	1.3	2.3	4.6	0.3	2.1
Health satisfaction	1.3	1.7	3.3	-0.3	-1.8
Illnesses of father: None of the above (group 1)	1.3	1.6	3.2	1.8	-0.0
Risk taking	1.3	1.9	3.7	0.4	-1.9
Unable to work because of sickness or disability	1.3	1.7	3.3	-0.2	-1.8
Major Depression (MDD)	1.2	1.5	2.8	-0.4	-1.7
Heart disease (mother)	1.2	1.5	3.0	0.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	1.4	-1.2	-1.1
Ever had bowel cancer screening	1.2	1.4	2.6	-1.6	-0.5
Medication: Gliclazide	1.2	1.3	1.7	0.9	-1.3
High cholesterol (Self-reported)	1.2	2.2	2.7	-1.6	-1.3
Ever smoked	1.2	2.2	4.3	0.2	2.1
Prostate Cancer	1.1	1.6	2.2	-1.0	1.5
Relative age of first facial hair	1.1	2.2	3.0	-1.2	1.7
Medication: Co-codamol	1.1	1.3	1.4	1.2	-1.1
High blood pressure (mother)	1.1	1.6	3.1	0.2	-1.8
Body mass index (BMI)	1.1	4.6	9.1	0.2	-3.0
Allergy	1.1	2.5	4.6	0.6	-2.2
Pulse rate	1.1	1.9	3.4	1.8	-0.6
Number of children fathered	1.1	1.2	2.1	1.5	0.5
Medication for cholesterol	1.1	1.7	2.7	0.8	1.6
Leg fat percentage (left)	1.1	3.8	6.3	-1.2	-2.5
Ever depressed for a whole week	1.1	1.3	2.0	-0.8	-1.4
Myopia	1.1	1.6	2.7	0.8	-1.6
Fasting Glucose	1.0	1.2	1.3	1.1	1.1
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.1	-0.8	-1.8
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.4	-1.5	-0.6
Waist circumference	1.0	3.8	7.1	0.7	-2.7
Body fat percentage	1.0	4.1	7.0	-1.1	-2.6
Leg fat percentage (right)	1.0	3.6	6.3	-1.0	-2.5
Comparative body size at age 10	1.0	2.6	4.0	2.0	-1.1
Leg fat mass (right)	1.0	3.9	7.7	-0.2	-2.8
Number of operations (self-reported)	1.0	1.4	2.1	-1.4	0.9
Neuroticism	0.9	2.1	2.9	-1.7	1.1
Pack years adult smoking proportion	0.9	1.3	1.5	-1.2	-1.1
Trunk fat percentage	0.9	3.8	6.3	-1.1	-2.5
Trunk fat mass	0.9	3.7	6.9	-0.7	-2.6
Past tobacco smoking	0.9	1.6	3.3	0.1	-1.8
Arm fat percentage (right)	0.9	3.4	6.7	-0.2	-2.6
Hip circumference	0.9	3.7	7.4	-0.2	-2.7
Father’s age at death	0.9	1.3	2.4	-0.4	1.5
Number of live births	0.9	1.2	2.5	-0.1	1.6
Medication: Amlodipine	0.9	1.3	2.6	-0.0	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.5	1.2	-0.8
Whole body fat mass	0.9	3.6	6.9	-0.5	-2.6
Arm fat percentage (left)	0.9	3.7	7.2	-0.5	-2.7
Hearing aid user	0.9	1.0	1.8	-1.3	-0.5
Commuting to job workplace: Public transport	0.9	1.1	2.2	-0.1	-1.5
Leg fat mass (left)	0.9	3.6	7.2	-0.3	-2.7
Schizophrenia (2018)	0.8	1.7	2.9	0.8	-1.7
Alzheimer’s Disease (in father)	0.8	0.8	1.7	-0.1	-1.3
Sensitivity / hurt feelings	0.8	1.4	1.6	-1.3	1.1
Qualifications: None of the above	0.8	1.7	2.7	-1.6	0.9
Arm fat mass (right)	0.8	3.1	6.2	0.2	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.0	-1.0	0.8
Osteoarthritis (self-reported)	0.8	1.0	1.7	1.3	-0.7
Arm fat mass (left)	0.8	3.2	6.5	-0.1	-2.5
Medication: Paracetamol	0.8	1.2	1.3	-1.1	-1.1
Diastolic blood pressure, automated reading	0.8	2.6	2.9	-1.7	1.5
Pain experienced in last month	0.8	1.3	2.1	1.5	-0.7
Impedance of whole body	0.8	4.0	4.7	-1.8	2.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.2	0.4	1.8
Cardiovascular Disease	0.7	2.2	4.3	-0.2	-2.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	-0.3	1.2
Impedance of leg (left)	0.7	3.4	4.6	-1.5	2.1
Weight	0.7	3.4	6.6	0.4	-2.6
Falls in the last year	0.7	1.0	1.7	-1.3	-0.5
Gout (self-reported)	0.7	1.0	1.8	1.4	0.4
Number of full brothers	0.7	0.9	1.5	-0.5	1.2
Smoking status: Previous	0.7	1.0	2.0	0.1	1.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	-1.3	-0.3
Medication: Lisinopril	0.7	1.0	1.9	-1.4	0.1
Average weekly beer plus cider intake	0.7	0.9	1.4	1.2	0.7
Age at First Birth	0.6	0.9	1.4	1.2	-0.7
Hearing difficulty/problems: Yes	0.6	0.8	1.4	0.6	-1.2
Supplements: Zinc	0.6	0.6	1.1	-1.0	0.4
Impedance of leg (right)	0.6	2.7	3.6	-1.4	1.9
Maternal smoking around birth	0.6	0.9	1.7	-0.0	1.3
Relative age voice broke	0.6	0.8	1.5	-0.4	1.2
Leg predicted mass (left)	0.6	3.1	4.9	1.1	-2.2
Mouth/teeth dental problems	0.6	0.9	1.9	-0.0	1.4
Alcohol intake versus 10 years previously	0.6	1.0	1.9	1.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.0	-1.0	-0.7
Prospective memory result	0.6	0.8	1.3	0.5	-1.1
Lung cancer (father)	0.6	0.7	1.0	-0.6	1.0
Eye problems/disorders: None of the above	0.6	0.7	1.2	1.1	0.3
Pulse rate, automated reading	0.6	2.0	2.3	-1.3	-1.5
Leg pain on walking	0.6	0.7	1.0	-0.6	-1.0
Leg fat-free mass (right)	0.6	3.0	4.5	1.2	-2.1
Qualifications: nursing, teaching	0.6	0.9	1.4	0.7	-1.2
Back pain experienced in last month	0.6	0.8	1.6	-1.3	-0.2
Leg predicted mass (right)	0.6	3.1	4.6	1.2	-2.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.4	-0.1	-1.2
Alcohol drinker status: Previous	0.6	0.7	1.3	0.4	-1.1
Pack years of smoking	0.6	1.0	1.2	-0.8	-1.1
HbA1C	0.5	0.5	1.0	-0.3	-1.0
Systolic Blood Pressure	0.5	2.3	3.7	0.9	1.9
Chronotype (morning person)	0.5	1.0	2.1	-0.2	-1.4
Leg fat-free mass (left)	0.5	2.9	4.5	1.1	-2.1
Average weekly fortified wine intake	0.5	0.6	0.9	0.6	0.9
Financial difficulties in last 2 years	0.5	0.7	1.4	1.2	-0.2
Impedance of arm (right)	0.5	2.2	3.6	-0.9	1.9
Impedance of arm (left)	0.5	2.3	2.9	-1.3	1.7
Exposure to tobacco smoke at home	0.5	0.5	0.8	-0.9	0.5
Breastfed as a baby	0.5	0.6	0.8	-0.6	0.9
Migraine (self-reported)	0.5	0.7	1.0	0.5	-1.0
Medication: Ibuprofen	0.5	0.6	0.8	-0.7	-0.9
Comparative height size at age 10	0.5	2.7	3.3	1.8	-1.4
Mood swings	0.5	0.8	1.2	-1.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.0	-1.1
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.3	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.2	-1.1	0.4
Illnesses of father: High blood pressure	0.5	0.6	0.9	-0.9	0.5
Basal metabolic rate	0.5	2.5	3.6	1.2	-1.9
Heart disease (siblings)	0.5	0.7	1.2	-1.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.4	-0.5	1.2
Blood Platelet Count	0.4	4.8	9.4	-3.1	0.5
Heel T-Score	0.4	3.0	3.5	1.9	-1.6
Hand grip strength (left)	0.4	1.0	1.9	0.3	1.4
Stomach or abdominal pain in last month	0.4	0.5	0.6	0.7	-0.8
Time employed in main current job	0.4	0.4	0.8	-0.9	0.4
Blood clot in the leg (DVT)	0.4	0.5	0.9	-1.0	-0.3
Neck or shoulder pain in last month	0.4	0.6	0.9	-0.6	-1.0
Had major operations	0.4	0.4	0.8	0.9	-0.3
Family relationship satisfaction	0.4	0.5	0.8	0.4	0.9
Knee pain experienced in last month	0.4	0.6	1.3	-0.1	-1.1
Whole body water mass	0.4	2.4	2.7	1.4	-1.6
Miserableness	0.4	0.7	0.7	-0.8	-0.8
Fractured/broken bones in last 5 years	0.4	0.5	0.5	-0.7	-0.7
Commuting to job workplace: Cycle	0.4	0.4	0.9	0.2	0.9
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	-0.8	-0.5
Arm predicted mass (left)	0.4	1.9	2.8	1.0	-1.7
Mean Putamen Volume	0.3	0.3	0.6	0.1	-0.8
HDL Cholesterol	0.3	0.5	1.0	0.2	-1.0
Schizophrenia (2014)	0.3	0.7	0.8	0.9	-0.8
Triglycerides	0.3	0.5	0.9	-0.9	0.2
Smoking Status	0.3	0.6	1.2	0.1	1.1
Lung FEV1/FVC ratio	0.3	1.6	2.8	0.7	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	-0.2
High blood pressure	0.3	0.8	1.4	-1.2	-0.5
Multivitamins +/- minerals	0.3	0.3	0.7	-0.0	-0.8
Sitting height	0.3	2.1	4.0	2.0	-0.5
Had other major operations	0.3	0.4	0.7	-0.8	0.3
Fluid intelligence score	0.3	0.7	1.2	-0.4	1.1
Trunk fat-free mass	0.3	1.7	2.3	1.5	-1.0
Asthma	0.3	0.6	1.1	1.0	0.3
Trunk predicted mass	0.3	1.6	2.3	1.5	-1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.6	-0.1	-1.3
Arm fat-free mass (right)	0.3	1.6	2.3	1.0	-1.5
Arm predicted mass (right)	0.3	1.6	2.3	1.0	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.8	0.2
Hypertension (Self-reported)	0.3	0.8	1.4	-1.2	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.6	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	0.9	-0.7	0.9
Whole body fat-free mass	0.3	2.0	2.2	1.3	-1.5
Osteoporosis (self-reported)	0.3	0.4	0.5	-0.5	0.7
Arm fat-free mass (left)	0.3	1.6	2.0	1.1	-1.4
Vascular/heart problems diagnosed by doctor	0.3	1.0	1.5	0.7	1.2
Depressed Affect (Nagel 2018)	0.2	0.4	0.6	-0.6	-0.8
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	0.4	-0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.2	-0.6
Neuroticism (2016)	0.2	0.3	0.6	-0.1	0.8
Waist Hip Ratio (WHR)	0.2	1.0	2.0	1.4	0.2
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.6	-0.2
Current tobacco smoking	0.2	0.3	0.4	-0.5	0.6
Nervous feelings	0.2	0.3	0.5	-0.5	-0.7
Neuroticism score	0.2	0.4	0.7	-0.9	-0.0
Happiness	0.2	0.2	0.4	-0.0	-0.6
Glaucoma (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	-0.8	0.4
Age at first live birth	0.2	0.4	0.5	0.7	0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.3	-0.6	0.5
Age at last live birth	0.2	0.3	0.6	-0.1	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.1	0.6
Friendships satisfaction	0.2	0.2	0.5	0.0	-0.7
Asthma (self-reported)	0.2	0.4	0.7	0.8	0.3
Smoking status: Current	0.2	0.3	0.4	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.5	-0.9
Guilty feelings	0.2	0.3	0.4	0.7	-0.5
Financial situation satisfaction	0.2	0.3	0.6	-0.1	-0.8
Age started oral contraceptive pill	0.2	0.3	0.4	0.6	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.4	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	0.3	-0.3
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.5	-0.1
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.1	0.4
Ulcerative Colitis	0.1	0.2	0.4	-0.6	0.1
Blood Red Count	0.1	1.2	2.0	1.4	0.7
Height	0.1	1.7	3.2	-0.4	1.8
Lung FVC	0.1	0.4	0.8	-0.0	-0.9
Hair Pigment	0.1	2.4	3.6	-1.1	-1.9
Tanning	0.1	1.3	1.7	1.3	0.9
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.1	0.8
Vitamin and mineral supplements	0.1	0.1	0.1	0.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.3	-0.5	0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.0	-0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.4	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	0.3
Had menopause	0.1	0.2	0.2	0.4	-0.4
Worrier / anxious feelings	0.1	0.2	0.4	0.6	0.1
Noisy workplace	0.1	0.2	0.3	0.0	-0.6
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.6	-0.2
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.4	0.1
Medication: Lansoprazole	0.1	0.1	0.2	0.4	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	0.5	-0.5
Standing height	0.1	0.6	0.8	0.6	0.9
Peak expiratory flow (PEF)	0.1	0.2	0.2	0.4	0.4
Loud music exposure frequency	0.1	0.1	0.2	0.1	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.6	0.1
Qualifications: College or University degree	0.1	0.3	0.5	0.4	-0.7
Number of full sisters	0.1	0.1	0.2	0.2	-0.4
Suffer from ‘nerves’	0.1	0.2	0.3	-0.5	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.4	0.5
Medication: Blood pressure	0.1	0.2	0.5	-0.7	-0.1
Irritability	0.1	0.2	0.2	-0.4	-0.4
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.1
Worry (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	0.2
Blood Eosinophil Count	0.0	0.0	0.0	-0.0	0.2
Respiratory disease	0.0	0.1	0.1	-0.2	-0.4
Hand grip strength (right)	0.0	0.0	0.0	0.0	0.2
Fed-up feelings	0.0	0.0	0.1	-0.2	0.2
Forced vital capacity (FVC)	0.0	0.2	0.4	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.3	-0.0
Supplements: Vitamin C	0.0	0.0	0.0	-0.1	0.0
Average weekly red wine intake	0.0	0.0	0.1	0.3	-0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	0.0	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.2	0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.2	0.2

Hub : Genes

RSBN1

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Trait associations