Hub : Traits :

Long-standing illness, disability or infirmity

11 significantly associated models · 9 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	113608257	115152814	4	1	8.5e-09	1.4e-14	4.7e-08	50	DCLRE1B
2	2	241922182	242502642	1	1	1.7e-07	1.2e-06	3.6e-01	96	HDLBP
3	9	14857740	16758776	1	1	2.8e-07	3.7e-07	3.0e-01	96	CCDC171
4	11	82478824	86036955	2	1	3.8e-08	1.4e-09	1.0e+00	100	AP003026.1
5	15	67301451	68034150	1	1	7.6e-08	8.4e-07	3.8e-02	82	IQCH

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Rheumatoid Arthritis	29.45	2	1	2.2	0.00	1.000	CCDC171 DCLRE1B
Hypothyroidism (self reported)	24.58	2	1	2.2	0.00	1.000	DCLRE1B HDLBP
Hypothyroidism/myxoedema (self-reported)	18.16	2	1	2.2	0.00	1.000	DCLRE1B HDLBP
Medication: Levothyroxine sodium	13.36	1	1	2.2	0.00	1.000	DCLRE1B
Body fat percentage	11.30	2	2	4.4	0.00	1.000	CCDC171 IQCH
Trunk fat percentage	10.85	2	2	4.4	0.00	1.000	CCDC171 IQCH
Leg fat percentage (left)	10.49	2	2	4.4	0.00	1.000	CCDC171 IQCH
Leg fat percentage (right)	10.35	2	2	4.4	0.00	1.000	CCDC171 IQCH
Taking other prescription medications	10.21	4	1	2.2	0.99	0.011	AP003026.1 CCDC171 DCLRE1B IQCH
Arm fat percentage (left)	9.92	2	2	4.4	0.00	1.000	CCDC171 IQCH
Arm fat percentage (right)	9.84	2	2	4.4	0.00	1.000	CCDC171 IQCH
Trunk fat mass	8.79	2	2	4.4	0.00	1.000	CCDC171 IQCH
Whole body fat mass	8.61	2	2	4.4	0.00	1.000	CCDC171 IQCH
Leg fat mass (right)	8.02	2	2	4.4	0.00	1.000	CCDC171 IQCH
Leg fat mass (left)	7.91	2	2	4.4	0.00	1.000	CCDC171 IQCH
Arm fat mass (left)	7.59	2	2	4.4	0.00	1.000	CCDC171 IQCH
Arm fat mass (right)	7.34	2	2	4.4	0.00	1.000	CCDC171 IQCH
Respiratory disease	6.61	2	1	2.2	0.00	1.000	CCDC171 IQCH
Number of self-reported non-cancer illnesses	6.56	2	1	2.2	0.00	1.000	DCLRE1B IQCH
Waist circumference	6.44	2	2	4.4	0.00	1.000	CCDC171 IQCH
Overall health rating	6.15	3	0	0.0	0.00	1.000	AP003026.1 DCLRE1B IQCH
Number of treatments/medications taken	6.07	3	1	2.2	0.00	1.000	CCDC171 DCLRE1B IQCH
Other serious medical condition/disability diagnosed by doctor	5.97	2	0	0.0	0.00	1.000	DCLRE1B HDLBP
Wheeze or whistling in the chest in last year	5.58	3	0	0.0	0.00	1.000	AP003026.1 CCDC171 IQCH
Body mass index (BMI)	5.54	2	1	2.2	0.00	1.000	CCDC171 IQCH
Mean Putamen Volume	5.47	1	1	2.2	0.00	1.000	AP003026.1
BMI	5.43	2	2	4.4	0.00	1.000	CCDC171 IQCH
Serious illness, injury or assault to yourself	5.35	2	0	0.0	0.00	1.000	DCLRE1B IQCH
Worry too long after embarrassment	4.88	2	0	0.0	0.00	1.000	DCLRE1B IQCH
Fractured/broken bones in last 5 years	4.81	2	0	0.0	0.00	1.000	HDLBP IQCH
Lung FVC	4.67	3	2	4.4	0.00	1.000	CCDC171 DCLRE1B IQCH
Number of operations (self-reported)	4.60	2	0	0.0	0.00	1.000	HDLBP IQCH
Bilateral oophorectomy (both ovaries removed)	4.52	1	0	0.0	0.00	1.000	CCDC171
Unable to work because of sickness or disability	4.50	1	0	0.0	0.00	1.000	AP003026.1
Hip circumference	4.35	2	2	4.4	0.00	1.000	CCDC171 IQCH
Risk taking	4.31	1	0	0.0	0.00	1.000	CCDC171
Asthma	4.25	1	1	2.2	0.00	1.000	IQCH
Asthma (self-reported)	4.24	1	1	2.2	0.00	1.000	IQCH
Chronic bronchitis/emphysema (father)	4.12	1	0	0.0	0.00	1.000	IQCH
Forced vital capacity (FVC)	4.09	2	1	2.2	0.00	1.000	CCDC171 IQCH
Past tobacco smoking	3.98	1	0	0.0	0.00	1.000	IQCH
Had major operations	3.95	1	0	0.0	0.00	1.000	IQCH
Weight	3.89	2	2	4.4	0.00	1.000	CCDC171 IQCH
Medication: Omeprazole	3.80	2	0	0.0	0.00	1.000	AP003026.1 CCDC171
Medication: Ventolin 100micrograms inhaler	3.70	1	0	0.0	0.00	1.000	IQCH
Smoking status: Previous	3.61	1	0	0.0	0.00	1.000	IQCH
Pulse wave Arterial Stiffness index	3.50	1	0	0.0	0.00	1.000	IQCH
Chest pain or discomfort	3.50	2	0	0.0	0.00	1.000	DCLRE1B HDLBP
Health satisfaction	3.44	1	0	0.0	0.00	1.000	AP003026.1
Ever smoked	3.44	2	0	0.0	0.00	1.000	CCDC171 IQCH
Headache pain in last month	3.39	1	0	0.0	0.00	1.000	IQCH
Myopia	3.38	2	0	0.0	0.00	1.000	CCDC171 DCLRE1B
Pain type(s) experienced in last month: Hip pain	3.36	1	0	0.0	0.00	1.000	CCDC171
Osteoarthritis (self-reported)	3.31	1	0	0.0	0.00	1.000	CCDC171
Mother's age at death	3.26	1	0	0.0	0.00	1.000	AP003026.1
Maternal smoking around birth	3.21	2	0	0.0	0.00	1.000	CCDC171 IQCH
Allergy	3.19	1	0	0.0	0.00	1.000	IQCH
Forced vital capacity (FVC), Best measure	3.13	2	1	2.2	0.00	1.000	CCDC171 IQCH
Age when periods started (menarche)	3.12	2	0	0.0	0.00	1.000	DCLRE1B IQCH
Birth weight of first child	2.96	1	0	0.0	0.00	1.000	DCLRE1B
Medication: Cholesterol lowering	2.91	1	0	0.0	0.00	1.000	DCLRE1B
Breast Cancer	2.87	2	0	0.0	0.00	1.000	DCLRE1B IQCH
Shortness of breath walking on level ground	2.84	1	0	0.0	0.00	1.000	AP003026.1
Heart attack/myocardial infarction (self-reported)	2.81	1	0	0.0	0.00	1.000	DCLRE1B
Medication for cholesterol, blood pressure or diabetes	2.76	1	0	0.0	0.00	1.000	DCLRE1B
Commuting to job workplace: Car/motor vehicle	2.73	1	0	0.0	0.00	1.000	DCLRE1B
Comparative body size at age 10	2.58	1	1	2.2	0.00	1.000	HDLBP
Frequency of tiredness / lethargy in last 2 weeks	2.57	1	0	0.0	0.00	1.000	DCLRE1B
Forced expiratory volume in 1-second (FEV1)	2.57	2	1	2.2	0.00	1.000	CCDC171 IQCH
Mineral and other dietary supplements	2.55	1	0	0.0	0.00	1.000	CCDC171
Nervous feelings	2.53	1	0	0.0	0.00	1.000	IQCH
Heel T-Score	2.49	4	1	2.2	-0.78	0.218	AP003026.1 CCDC171 HDLBP IQCH
Vascular/heart problems diagnosed by doctor	2.49	2	0	0.0	0.00	1.000	AP003026.1 IQCH
Sensitivity / hurt feelings	2.48	1	0	0.0	0.00	1.000	IQCH
Commuting to job workplace: Public transport	2.48	1	0	0.0	0.00	1.000	DCLRE1B
Neuroticism	2.44	2	0	0.0	0.00	1.000	AP003026.1 IQCH
Neuroticism score	2.37	2	0	0.0	0.00	1.000	AP003026.1 IQCH
Depression (Nagel 2018)	2.36	1	0	0.0	0.00	1.000	AP003026.1
Diabetes diagnosed by doctor	2.35	1	0	0.0	0.00	1.000	DCLRE1B
Alcohol drinker status: Never	2.35	1	0	0.0	0.00	1.000	DCLRE1B
Blood White Count	2.31	3	1	2.2	0.00	1.000	AP003026.1 CCDC171 DCLRE1B
Worrier / anxious feelings	2.30	1	0	0.0	0.00	1.000	AP003026.1
Diastolic blood pressure, automated reading	2.30	3	0	0.0	0.00	1.000	AP003026.1 CCDC171 IQCH
Lupus	2.25	1	0	0.0	0.00	1.000	DCLRE1B
Crohns Disease (2017)	2.24	1	0	0.0	0.00	1.000	DCLRE1B
Diabetes (self-reported)	2.24	1	0	0.0	0.00	1.000	DCLRE1B
Medication: Ramipril	2.22	1	0	0.0	0.00	1.000	IQCH
Lung FEV1/FVC ratio	2.19	2	1	2.2	0.00	1.000	CCDC171 IQCH
Illnesses of father: None of the above (group 1)	2.18	1	0	0.0	0.00	1.000	AP003026.1
Allergy or Eczema	2.16	2	0	0.0	0.00	1.000	DCLRE1B IQCH
Body Mass Index (BMI) (2010)	2.13	1	0	0.0	0.00	1.000	CCDC171
Loneliness, isolation	2.13	1	0	0.0	0.00	1.000	AP003026.1
Financial situation satisfaction	2.06	1	0	0.0	0.00	1.000	CCDC171
Fed-up feelings	2.04	1	0	0.0	0.00	1.000	AP003026.1
Suffer from 'nerves'	2.01	1	0	0.0	0.00	1.000	IQCH
Depressed Affect (Nagel 2018)	1.95	1	0	0.0	0.00	1.000	AP003026.1
Age at first live birth	1.88	1	0	0.0	0.00	1.000	CCDC171
Bipolar Disorder or Schizophrenia	1.85	1	0	0.0	0.00	1.000	AP003026.1
Comparative height size at age 10	1.84	1	1	2.2	0.00	1.000	IQCH
Medication: Paracetamol	1.82	1	0	0.0	0.00	1.000	CCDC171
Hypertension (Self-reported)	1.81	1	0	0.0	0.00	1.000	IQCH
High blood pressure	1.80	1	0	0.0	0.00	1.000	IQCH
Medication for pain relief, constipation, heartburn	1.77	1	0	0.0	0.00	1.000	CCDC171
Alcohol intake frequency.	1.76	1	0	0.0	0.00	1.000	DCLRE1B
Hayfever, allergic rhinitis or eczema	1.73	1	0	0.0	0.00	1.000	DCLRE1B
Hair/balding pattern: Pattern 4	1.73	1	0	0.0	0.00	1.000	IQCH
Worry (Nagel 2018)	1.70	1	0	0.0	0.00	1.000	IQCH
Blood Eosinophil Count	1.69	2	1	2.2	0.00	1.000	HDLBP IQCH
Heel bone mineral density (BMD) T-score, automated (right)	1.69	1	0	0.0	0.00	1.000	IQCH
Cholesterol lowering medication	1.68	1	0	0.0	0.00	1.000	CCDC171
Townsend deprivation index at recruitment	1.67	1	0	0.0	0.00	1.000	IQCH
Hearing difficulty/problems: Yes	1.65	1	0	0.0	0.00	1.000	IQCH
Frequency of depressed mood in last 2 weeks	1.62	1	0	0.0	0.00	1.000	AP003026.1
Impedance of arm (right)	1.61	2	0	0.0	0.00	1.000	HDLBP IQCH
Forced expiratory volume in 1-second (FEV1), Best measure	1.60	1	0	0.0	0.00	1.000	CCDC171
Reaction Time	1.59	1	0	0.0	0.00	1.000	AP003026.1
Waist Hip Ratio (WHR)	1.59	1	1	2.2	0.00	1.000	IQCH
Cardiovascular Disease	1.58	1	0	0.0	0.00	1.000	IQCH
Medication: Paracetamol	1.55	1	0	0.0	0.00	1.000	CCDC171
Qualifications: A levels/AS levels or equivalent	1.54	1	0	0.0	0.00	1.000	CCDC171
Schizophrenia (2018)	1.53	1	0	0.0	0.00	1.000	AP003026.1
Pack years adult smoking proportion	1.50	1	0	0.0	0.00	1.000	CCDC171
Intelligence (Savage-Jansen 2018)	1.45	1	0	0.0	0.00	1.000	CCDC171
Impedance of arm (left)	1.45	2	0	0.0	0.00	1.000	HDLBP IQCH
Mood swings	1.45	1	0	0.0	0.00	1.000	AP003026.1
Smoking Status	1.42	1	0	0.0	0.00	1.000	IQCH
Sitting height	1.40	1	1	2.2	0.00	1.000	CCDC171
Neuroticism (Nagel 2018)	1.35	1	0	0.0	0.00	1.000	AP003026.1
Pulse rate, automated reading	1.27	1	0	0.0	0.00	1.000	CCDC171
Height	1.24	3	2	4.4	0.00	1.000	CCDC171 HDLBP IQCH
Schizophrenia (2014)	1.10	1	0	0.0	0.00	1.000	AP003026.1
Birth weight	1.08	1	0	0.0	0.00	1.000	DCLRE1B
Standing height	1.05	2	0	0.0	0.00	1.000	CCDC171 IQCH
Impedance of whole body	1.03	1	0	0.0	0.00	1.000	HDLBP
Leg predicted mass (left)	0.93	1	0	0.0	0.00	1.000	IQCH
Basal metabolic rate	0.89	1	0	0.0	0.00	1.000	IQCH
Leg fat-free mass (left)	0.88	1	0	0.0	0.00	1.000	IQCH
Leg predicted mass (right)	0.70	1	0	0.0	0.00	1.000	IQCH
Leg fat-free mass (right)	0.69	1	0	0.0	0.00	1.000	IQCH
Arm fat-free mass (left)	0.69	1	0	0.0	0.00	1.000	IQCH
Whole body fat-free mass	0.43	1	0	0.0	0.00	1.000	IQCH
Whole body water mass	0.42	1	0	0.0	0.00	1.000	IQCH
Blood Platelet Count	0.35	1	0	0.0	0.00	1.000	AP003026.1
Tanning	0.33	1	0	0.0	0.00	1.000	HDLBP

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.7
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.7
GTEx	Ovary	0	0.000	1.7
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.7
GTEx	Adipose Subcutaneous	0	0.000	1.6
GTEx	Artery Aorta	0	0.000	1.6
GTEx	Artery Tibial	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.6
GTEx	Brain Cerebellum	0	0.000	1.6
GTEx	Brain Frontal Cortex BA9	0	0.000	1.6
GTEx	Brain Hypothalamus	0	0.000	1.6
GTEx	Brain Putamen basal ganglia	0	0.000	1.6
GTEx	Breast Mammary Tissue	1	0.051	1.6
GTEx	Cells Transformed fibroblasts	0	0.000	1.6
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Colon Transverse	0	0.000	1.6
GTEx	Esophagus Mucosa	0	0.000	1.6
GTEx	Heart Atrial Appendage	0	0.000	1.6
GTEx	Heart Left Ventricle	0	0.000	1.6
GTEx	Muscle Skeletal	0	0.000	1.6
GTEx	Nerve Tibial	0	0.000	1.6
GTEx	Pituitary	0	0.000	1.6
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.6
GTEx	Spleen	0	0.000	1.6
GTEx	Stomach	0	0.000	1.6
GTEx	Testis	1	0.032	1.6
GTEx	Thyroid	0	0.000	1.6
GTEx	Whole Blood	0	0.000	1.6
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.6
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
METSIM	Adipose	0	0.000	1.5
NTR	Blood	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
YFS	Blood	0	0.000	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5
GTEx	Uterus	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.196	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4