Hub : Genes

SLC45A3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.077	0.0330	7.4e-03	0.001	NA	-0.001	NA	-0.001	0.270	NA	0.44000	NA	0.36000
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.076	0.0288	2.4e-04	0.004	0.026	0.005	NA	0.008	0.094	5.5e-04	0.08000	NA	0.03400
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.179	0.0545	5.4e-06	0.006	0.060	0.041	NA	0.033	0.060	2.3e-07	0.00002	NA	0.00011

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.7	1.4	-1.2	0.3	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	2.9	-0.2	1.7	-0.8
Depressed Affect (Nagel 2018)	1.8	3.8	7.2	-1.0	1.7	-2.7
Depression (Nagel 2018)	1.7	2.6	2.7	1.7	-1.6	-1.6
Intelligence (Savage-Jansen 2018)	1.5	4.6	7.6	1.0	-2.8	-2.3
Neuroticism (Nagel 2018)	1.0	2.3	2.6	-1.3	1.6	-1.6
Schizophrenia (2018)	0.7	1.5	4.0	0.6	2.0	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.9	0.8	0.3
Worry (Nagel 2018)	1.0	2.1	4.2	-1.4	2.1	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.4	-0.3	-0.4	1.2
Alzheimer’s Disease (in father)	1.2	1.3	1.6	-1.0	1.3	-1.2
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.8	0.4	-0.7
Crohns Disease (2017)	1.7	3.8	4.2	-2.0	2.0	1.8
Irritable Bowel Disease (IBD)	3.2	7.6	16.6	-4.1	2.4	0.7
Ulcerative Colitis (UC)	4.3	8.0	21.3	-4.6	1.6	-0.3
Major Depression (MDD)	0.3	0.4	0.7	-0.6	0.8	-0.4
Reaction Time	3.8	7.2	12.8	-3.6	2.3	1.9
Verbal and Numeric Reasoning (VNR)	1.8	4.4	6.4	1.1	-2.3	-2.5
Breast Cancer	1.1	2.6	7.1	-2.7	0.9	0.1
Ovarian Cancer	0.6	0.8	2.1	0.0	-0.6	1.4
Prostate Cancer	8.2	11.5	20.9	2.9	-4.6	-2.4
Age at First Birth	0.1	0.1	0.2	-0.4	-0.2	0.4
Bipolar Disorder (2011)	0.9	0.9	1.1	-0.8	1.0	-1.0
Body Mass Index (BMI) (2010)	2.4	3.3	5.5	2.4	-2.1	0.1
Coronary Artery Disease (CAD)	1.1	1.3	2.1	1.4	-0.2	1.4
Crohns Disease (2012)	3.9	6.3	8.8	-2.9	3.0	1.4
Mean Putamen Volume	1.1	1.2	2.4	-0.2	1.5	-1.1
Fasting Glucose	1.0	1.1	3.0	1.7	-0.4	-0.5
HbA1C	2.2	2.4	6.0	2.4	-0.9	0.7
HDL Cholesterol	4.6	7.7	10.7	-3.3	2.4	2.6
LDL Cholesterol	0.3	0.5	0.7	0.1	-0.8	0.8
Lupus	1.8	2.7	4.5	-2.1	1.9	0.2
Neuroticism (2016)	0.3	0.4	0.7	-0.2	-0.7	-0.8
Primary Biliary Cirrhosis	1.0	1.4	2.9	1.7	0.5	1.0
Rheumatoid Arthritis	1.2	1.7	2.5	-1.6	0.7	-1.4
Schizophrenia (2014)	0.6	1.3	2.6	0.4	1.6	-1.0
Triglycerides	2.1	3.5	6.8	2.6	-1.7	0.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.4	0.9	-1.6	-0.2
Ulcerative Colitis	2.7	3.9	11.2	-3.4	0.3	-0.6
Blood Eosinophil Count	0.6	4.5	6.0	2.4	-1.4	-2.4
Blood Platelet Count	1.0	11.1	22.1	4.7	-1.9	-2.7
Blood Red Count	0.1	0.8	1.8	-0.2	0.8	1.4
Blood White Count	0.7	5.4	9.9	2.5	-0.6	-3.1
Heel T-Score	0.1	1.1	1.9	0.9	-1.4	0.8
BMI	0.7	4.0	8.5	2.9	-1.5	-1.1
Height	3.5	68.4	102.0	10.1	-9.9	2.3
Waist Hip Ratio (WHR)	0.0	0.1	0.4	0.6	0.1	-0.2
Systolic Blood Pressure	0.2	0.9	1.7	-1.3	0.6	0.8
Smoking Status	2.7	6.4	12.0	-2.7	3.5	-0.1
Allergy or Eczema	0.7	1.8	4.8	0.9	0.1	2.2
Cardiovascular Disease	0.9	3.1	5.8	-1.6	2.4	-0.9
Hypothyroidism (self reported)	1.0	2.4	4.2	-0.2	1.7	2.0
Respiratory disease	0.3	0.7	1.5	0.7	0.1	-1.2
Type 2 Diabetes (T2D) (2018)	0.9	1.7	4.9	2.2	-0.4	-0.3
Lung FEV1/FVC ratio	4.8	24.3	44.6	6.7	-5.3	0.4
Lung FVC	1.9	9.9	21.3	-4.6	2.8	-0.8
Neuroticism	1.9	4.5	6.6	-2.1	2.6	-1.6
Chronotype (morning person)	0.4	1.0	2.9	0.1	-0.2	1.7
Hair Pigment	0.7	20.7	30.4	-5.5	5.5	1.1
Tanning	0.0	0.2	0.3	0.1	-0.6	-0.4
Hand grip strength (left)	6.4	16.7	25.8	4.9	-5.1	-0.0
Number of treatments/medications taken	2.6	4.7	9.4	-2.1	3.1	0.2
Average weekly spirits intake	0.9	1.1	2.8	0.4	0.5	-1.7
Sensitivity / hurt feelings	0.9	1.5	3.3	-1.8	0.1	-1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.4	-0.2	-0.6	-1.2
Hearing difficulty/problems: Yes	2.3	3.5	7.5	2.7	-1.6	0.5
Relative age of first facial hair	0.9	1.8	4.9	-2.2	0.7	0.1
Other serious medical condition/disability diagnosed by doctor	7.0	9.0	17.2	-2.8	4.2	1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-0.4	-0.1	-1.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.6	0.4	-0.8	0.2
Systolic blood pressure, automated reading	0.6	1.7	4.4	-0.4	0.7	2.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.7	0.8	0.6	0.4
Angina	1.6	2.1	5.9	-0.4	2.4	0.5
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.7	0.1	0.1
Vitamin and mineral supplements	2.0	2.7	4.0	2.0	-1.9	-0.7
Supplements: Zinc	0.1	0.1	0.3	-0.5	0.1	0.4
Medication: Co-codamol	0.6	0.7	1.3	-1.1	0.1	-0.9
Medication: Metformin	1.0	1.4	2.7	1.6	-0.4	1.2
Diabetes (father)	0.3	0.3	0.7	0.0	-0.8	0.5
Diabetes (mother)	0.2	0.3	0.6	0.8	0.1	-0.5
Severe depression (siblings)	2.4	2.7	4.8	-1.5	2.2	0.9
Pack years adult smoking proportion	0.8	1.2	1.5	1.0	1.1	-1.2
Impedance of leg (right)	2.6	12.6	19.3	-4.4	4.3	0.7
Leg fat-free mass (left)	5.3	28.1	45.0	6.3	-6.7	-0.3
Trunk fat percentage	0.3	1.1	2.8	1.7	-0.6	0.0
Hand grip strength (right)	6.2	16.9	25.3	5.0	-5.0	1.0
Townsend deprivation index at recruitment	2.2	3.0	5.9	-1.5	2.4	1.0
Current tobacco smoking	2.2	3.6	6.6	-2.0	2.6	-0.2
Average weekly fortified wine intake	1.3	1.5	4.2	-2.0	0.5	0.3
Maternal smoking around birth	0.9	1.2	3.0	-0.3	0.8	-1.7
Fed-up feelings	1.5	2.7	6.6	-0.5	1.1	-2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.2	0.3	-0.8	-1.8
Relative age voice broke	0.1	0.2	0.4	-0.3	-0.2	-0.6
Taking other prescription medications	0.7	1.1	2.9	-0.6	1.7	0.2
Age when periods started (menarche)	2.8	6.8	13.4	-2.3	3.7	-1.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.5	0.4	-1.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.7	6.0	7.7	2.8	-2.5	-2.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.8	0.4	-2.0	-1.3
Qualifications: CSEs or equivalent	1.8	2.3	3.6	-1.9	1.8	-0.6
Serious illness, injury or assault to yourself	3.0	3.7	10.8	-0.4	3.3	0.3
High blood pressure	1.1	3.1	6.0	-1.8	2.4	-0.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	6.2	0.5	0.0	2.5
Multivitamins +/- minerals	4.6	5.8	8.2	-2.5	2.9	1.8
Stomach or abdominal pain in last month	1.7	2.1	3.9	-1.5	2.0	-0.4
Supplements: Glucosamine	0.6	0.8	1.3	-0.9	-0.4	-1.2
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.3	-1.3	1.1	-2.1
Medication: Atenolol	3.3	4.2	8.1	-1.9	2.8	-0.8
Medication: Levothyroxine sodium	1.5	2.5	5.9	-0.6	1.2	2.4
Sitting height	6.3	44.8	76.9	7.5	-8.8	-0.9
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.2	-0.6	-0.5
High blood pressure (mother)	0.6	0.8	1.4	-0.9	1.2	0.5
Body mass index (BMI)	0.5	2.3	4.7	2.2	-1.2	-0.9
Impedance of leg (left)	2.5	12.2	19.2	-4.0	4.4	1.1
Leg predicted mass (left)	5.3	28.0	45.0	6.2	-6.7	-0.3
Trunk fat mass	1.3	5.4	10.6	3.3	-2.3	0.5
Waist circumference	0.6	2.2	5.4	2.3	-1.0	0.2
Number of incorrect matches in round	4.4	7.3	12.2	-3.5	2.9	1.2
Past tobacco smoking	1.7	3.0	4.9	2.2	-2.1	0.1
Alcohol usually taken with meals	1.6	2.6	6.2	-2.5	0.7	1.1
Nervous feelings	0.6	1.1	2.2	-1.5	1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.3	-1.1	1.0	-1.1
Hearing difficulty/problems with background noise	8.3	13.3	28.1	5.3	-3.0	1.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	0.2	-0.3
Had menopause	1.3	1.7	4.2	-0.8	-0.5	2.0
Had other major operations	0.7	0.8	2.3	0.0	-0.4	-1.5
Forced vital capacity (FVC)	0.3	1.0	3.1	0.2	-1.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	3.2	7.4	13.2	2.1	-3.6	-2.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	-0.1	0.4	-0.7
Qualifications: None of the above	1.0	2.1	3.3	-1.7	0.5	-1.8
Financial difficulties in last 2 years	0.6	0.9	2.3	-0.0	0.6	1.5
Mouth/teeth dental problems	0.8	1.3	3.5	1.9	-0.3	-0.4
Heart attack	0.6	0.7	1.2	-0.3	1.1	-0.9
Allergy	0.3	0.8	1.3	-1.2	0.4	-0.9
Pain all over the body in last month	0.9	1.0	2.0	1.0	-0.2	1.4
Diabetes (self-reported)	0.7	1.0	2.4	1.5	-0.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	1.1	-0.0	-0.8
Medication: Ramipril	1.1	1.4	1.9	-1.3	1.4	-0.8
Medication: Simvastatin	0.6	0.9	1.4	-0.2	1.2	1.1
Fluid intelligence score	1.6	3.4	7.5	1.5	-2.7	-0.8
Illnesses of siblings	0.2	0.3	0.7	-0.2	-0.5	-0.8
Neuroticism score	2.2	4.5	8.4	-2.2	2.9	-0.7
Weight	2.9	14.5	22.6	4.7	-4.6	0.2
Impedance of arm (right)	0.9	4.1	6.7	-2.6	2.3	-0.3
Arm fat percentage (right)	0.3	1.2	2.8	1.7	-0.3	-0.8
Trunk fat-free mass	4.6	26.5	43.3	5.9	-6.6	1.1
Hip circumference	1.2	5.2	9.5	3.1	-2.4	0.5
Time employed in main current job	0.4	0.5	0.8	0.3	-0.9	0.8
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.2	-0.9	-0.6
Father’s age at death	0.5	0.7	1.7	-0.5	-0.3	1.3
Worrier / anxious feelings	0.7	1.3	3.1	-0.9	1.8	0.1
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.1	1.7	-1.5	-2.0
Falls in the last year	1.2	1.6	3.2	1.8	-0.8	-0.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.0	0.6	-0.7
Number of live births	1.9	2.7	3.5	-1.3	1.9	-1.7
Forced expiratory volume in 1-second (FEV1)	2.0	6.6	12.9	2.6	-3.6	-0.3
Pulse rate	0.2	0.3	0.8	0.3	-0.9	0.3
Happiness	1.6	1.9	5.1	0.7	-2.3	-0.3
Noisy workplace	0.5	0.6	0.8	-0.8	0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.3	1.3	-1.5	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.5	0.2	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.1	-0.4	-0.7
Asthma	0.6	1.2	3.3	-0.6	-0.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	4.0	-2.0	1.0	-0.1
Medication: Cholesterol lowering	0.3	0.5	1.1	-0.4	1.1	-0.5
Depression (self-reported)	1.0	1.2	1.8	-1.3	0.3	1.3
Medication: Lansoprazole	1.5	1.8	4.9	0.5	0.3	2.2
Prospective memory result	0.1	0.2	0.2	-0.3	0.4	-0.5
Lung cancer (father)	1.1	1.3	2.1	1.0	-1.0	-1.5
Illnesses of mother	0.5	0.7	1.4	0.4	0.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	3.0	1.7	-1.7	-1.5
Pulse wave Arterial Stiffness index	0.6	0.6	1.5	1.2	-0.3	0.6
Impedance of arm (left)	0.7	3.2	6.0	-2.4	1.9	0.1
Arm fat mass (right)	1.3	5.2	9.8	3.1	-2.4	-0.3
Trunk predicted mass	4.7	26.7	43.6	6.0	-6.6	1.0
Standing height	3.5	34.8	60.5	6.2	-7.8	2.3
Length of working week for main job	0.8	0.9	2.2	-0.7	-0.1	-1.5
Exposure to tobacco smoke at home	0.3	0.4	0.9	1.0	-0.3	0.4
Breastfed as a baby	5.3	6.6	9.7	-2.2	3.1	2.3
Tense / ‘highly strung’	4.4	7.2	11.4	-3.1	3.4	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.4	9.7	-1.8	3.1	-0.4
Hair/balding pattern: Pattern 4	0.6	1.5	2.0	1.1	-1.4	1.1
Birth weight of first child	1.4	2.6	6.0	2.5	-1.3	0.4
Peak expiratory flow (PEF)	8.0	18.5	27.8	5.2	-5.3	0.6
Pulse wave reflection index	1.9	2.3	4.9	-0.9	2.2	1.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.6	-0.4	1.0	-1.6
Loud music exposure frequency	0.7	0.8	1.2	1.1	-1.0	-0.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	6.2	1.2	-2.5	-0.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.8	-1.7	-0.6	0.7
Blood clot in the leg (DVT)	1.4	1.9	3.3	1.4	-0.4	1.8
Medication: Paracetamol	2.8	4.7	9.9	-1.9	3.1	-0.9
Headache pain in last month	1.3	2.3	3.5	-1.8	1.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.8	-0.0	-1.1	1.3
Glaucoma (self-reported)	1.3	1.5	4.0	-0.5	2.0	-0.6
Gout (self-reported)	0.3	0.4	0.9	1.0	-0.2	0.3
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	7.3	-0.4	1.3	2.7
Medication: Amlodipine	0.9	1.2	1.5	-0.8	1.2	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.5	-0.8	1.9	-0.3
Birth weight	4.9	10.7	17.6	4.2	-3.3	1.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	0.9	-0.5	-1.1
High blood pressure (siblings)	0.5	0.7	1.9	0.5	-1.4	0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.7	0.1	-0.5	-0.8
Body fat percentage	0.2	0.7	2.0	1.4	-0.1	-0.1
Leg fat percentage (right)	0.2	0.6	1.6	0.3	1.2	-0.2
Arm fat-free mass (right)	4.3	22.0	34.5	5.5	-5.9	0.9
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.2	1.0	0.2
Comparative body size at age 10	5.4	14.9	24.2	4.5	-4.9	-0.2
Number of full brothers	0.7	0.9	2.3	0.3	0.4	-1.5
Worry too long after embarrassment	0.3	0.5	1.0	-0.5	0.3	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.6	4.7	10.4	-3.2	1.9	-0.3
Wheeze or whistling in the chest in last year	1.3	2.4	4.0	0.0	1.8	-2.0
Number of children fathered	2.0	2.2	3.1	-1.5	1.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	0.6	-0.1	-1.4
Age at first live birth	0.2	0.3	0.7	-0.2	-0.3	0.9
Pulse wave peak to peak time	0.2	0.3	0.6	-0.8	-0.3	-0.4
Health satisfaction	0.0	0.1	0.2	-0.1	-0.4	0.0
Shortness of breath walking on level ground	1.8	2.2	6.2	0.6	-0.0	-2.5
Qualifications: College or University degree	0.7	2.3	4.0	1.6	-0.6	2.0
Eye problems/disorders: None of the above	0.4	0.5	1.2	-0.2	-1.1	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	0.2	-0.0	0.7
Emphysema/chronic bronchitis	0.5	0.6	1.5	0.2	0.5	-1.2
Medication for pain relief, constipation, heartburn	4.0	6.8	13.1	2.4	-3.6	-1.1
Neck or shoulder pain in last month	2.9	4.1	5.3	2.0	-1.7	-2.3
Medication: Blood pressure	0.5	0.9	1.7	-0.4	1.3	-1.0
Angina (self-reported)	1.6	2.2	6.0	-0.5	2.4	0.4
Migraine (self-reported)	0.5	0.6	1.3	-0.2	0.6	-1.1
Medication: Ibuprofen	1.7	2.0	3.8	-2.0	1.4	-0.6
Medication: Allopurinol	0.5	0.6	1.3	0.6	1.1	0.5
Medication: Omeprazole	1.3	1.5	2.7	1.6	-1.3	0.5
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.6	-0.2	-0.6
Mean time to correctly identify matches	4.5	8.6	14.5	-3.8	1.9	2.7
Heart disease (mother)	0.4	0.4	1.1	-0.4	0.3	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.8	-0.9	0.7	0.1
Whole body fat mass	1.2	5.0	10.2	3.2	-2.2	0.3
Leg fat mass (right)	1.0	3.9	8.5	2.9	-1.8	-0.2
Arm predicted mass (right)	4.4	22.3	35.4	5.5	-6.0	1.3
Pulse rate, automated reading	1.6	5.1	7.1	2.7	-2.3	1.7
Alcohol intake frequency.	1.2	2.8	7.6	0.8	-0.4	-2.8
Comparative height size at age 10	5.9	32.7	52.1	6.0	-7.2	3.2
Number of full sisters	1.1	1.4	3.4	-0.0	1.8	-0.9
Suffer from ‘nerves’	0.7	1.2	2.7	-0.8	1.6	-0.4
Overall health rating	0.7	1.5	2.5	-0.3	1.6	-1.4
Chest pain or discomfort	1.2	1.7	3.3	0.2	1.8	-1.3
Had major operations	0.9	1.0	2.9	-0.3	1.7	-0.4
Age at last live birth	0.1	0.1	0.2	-0.2	0.4	0.4
Family relationship satisfaction	2.8	3.4	4.7	1.2	-2.0	-2.2
Leg pain on walking	1.5	1.9	2.2	1.5	-1.1	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.7	-0.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.7	1.2	-2.2	-0.5
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.2	0.2	-2.3	-1.0
Medication: Aspirin	3.2	4.2	6.0	-1.1	2.5	2.3
Supplements: Vitamin C	0.6	0.7	1.0	-0.3	1.0	-0.9
Knee pain experienced in last month	1.1	1.6	4.9	0.1	-0.0	-2.2
Hypertension (Self-reported)	1.1	3.2	6.0	-1.8	2.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.2	0.7	1.1
Illnesses of father: Heart disease	3.4	4.7	10.5	-1.4	3.2	1.2
Illnesses of siblings: Diabetes	2.4	2.9	6.9	1.4	-0.2	2.6
Smoking status: Previous	0.6	0.9	1.8	-1.3	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	2.7	1.5	-1.6	1.1
Whole body fat-free mass	5.0	28.7	45.7	6.3	-6.8	0.5
Leg fat-free mass (right)	5.5	29.3	45.4	6.5	-6.7	-0.2
Arm fat percentage (left)	0.3	1.1	2.6	1.6	-0.4	-0.7
Average weekly red wine intake	1.6	2.4	6.1	0.1	2.5	1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.1	-0.7	-0.6
Mood swings	3.2	5.8	11.7	-2.2	3.4	-1.1
Loneliness, isolation	1.1	1.5	3.3	-0.8	0.7	-1.8
Long-standing illness, disability or infirmity	2.0	3.1	6.6	-0.7	2.6	1.5
Ever had bowel cancer screening	1.0	1.1	3.3	0.3	0.2	1.8
Diabetes diagnosed by doctor	0.9	1.5	3.7	1.9	-0.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.9	-2.0	1.7	0.9
Friendships satisfaction	3.3	4.1	4.4	2.1	-2.0	-2.0
Qualifications: nursing, teaching	0.4	0.7	1.7	-0.6	-1.3	0.1
Commuting to job workplace: Walk	0.7	0.7	1.3	0.7	0.6	1.1
Eye problems/disorders: Cataract	2.0	2.4	5.8	0.8	2.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.5	-1.6	0.8	0.2
Medication for cholesterol	0.1	0.1	0.1	0.3	-0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.7	0.4	-1.3	1.2
Back pain experienced in last month	2.9	4.3	7.3	1.8	-1.5	-2.7
Mineral and other dietary supplements	2.5	3.4	9.4	3.1	-0.8	-0.2
Breast cancer (self-reported)	0.5	0.5	1.0	-1.0	0.8	-0.1
Asthma (self-reported)	0.7	1.3	3.5	-0.7	-0.1	-1.9
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.5	0.7	1.1
Osteoarthritis (self-reported)	1.5	1.9	3.6	-0.9	-1.1	-1.9
Medication: Aspirin	2.8	3.6	6.2	-1.3	2.5	1.8
Medication: Gliclazide	0.5	0.6	1.3	1.2	0.5	0.3
Illnesses of father: None of the above (group 1)	1.7	2.1	2.7	1.6	-1.5	-1.2
Smoking status: Current	2.3	3.7	6.5	-2.1	2.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.1	0.2	0.3
Whole body water mass	4.8	27.6	44.2	6.2	-6.7	0.4
Leg predicted mass (right)	5.4	29.1	45.3	6.5	-6.7	-0.2
Arm fat mass (left)	1.2	5.1	10.0	3.2	-2.3	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	2.0	-0.8	1.4	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.5	0.5	0.8
Miserableness	0.6	1.1	2.8	0.6	1.7	0.1
Guilty feelings	0.1	0.1	0.2	-0.4	-0.1	-0.3
Wears glasses or contact lenses	1.2	1.4	3.8	0.4	-0.5	2.0
Ever taken oral contraceptive pill	4.4	4.9	8.1	-2.1	2.8	1.5
Hearing aid user	1.5	1.7	2.2	1.4	-1.5	1.1
Mother’s age at death	1.7	2.2	3.5	1.9	-1.4	-1.1
Financial situation satisfaction	2.2	2.7	4.5	1.6	-2.1	0.9
Tinnitus: Yes, now most or all of the time	3.9	4.5	10.4	1.3	-3.2	-1.3
Commuting to job workplace: Public transport	1.2	1.4	3.0	-0.4	1.0	1.7
Eye problems/disorders: Glaucoma	2.9	3.4	8.5	-1.3	2.9	-0.3
Medication: Blood pressure	0.6	1.2	2.7	-1.6	0.7	-0.6
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.0	0.4	0.4	-2.0
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.8	-1.9	0.2	-0.4
High cholesterol (Self-reported)	0.7	1.2	3.2	-0.4	1.8	-0.4
Medication: Bendroflumethiazide	0.9	1.4	3.4	-1.8	0.8	-0.4
Medication: Paracetamol	3.5	5.4	11.1	-1.9	3.3	-1.2
Medication: Lisinopril	0.3	0.4	1.2	-1.1	0.1	-0.1
Medication: Atorvastatin	0.9	1.1	2.0	1.4	1.1	-0.3
Illnesses of father: High blood pressure	0.8	1.0	1.9	0.5	-0.9	1.4
Alcohol drinker status: Never	1.2	1.5	2.5	-1.1	1.6	0.9
Ever smoked	2.0	3.4	5.7	-2.1	2.4	-0.1
Basal metabolic rate	4.7	26.2	41.3	6.1	-6.4	0.3
Leg fat percentage (left)	0.2	0.8	1.8	0.7	1.3	0.2
Arm fat-free mass (left)	3.8	19.4	31.8	5.1	-5.6	0.6
Number of operations (self-reported)	0.1	0.2	0.4	-0.4	-0.6	-0.2
Average weekly beer plus cider intake	4.6	6.7	10.6	-3.3	3.1	-0.4
Irritability	1.0	1.7	3.1	-0.7	1.3	-1.8
Risk taking	2.8	4.1	6.8	-2.3	2.6	-0.6
Ever had prostate specific antigen (PSA) test	6.6	7.6	11.9	3.5	-2.7	1.9
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.4	-0.4	0.7
Age started oral contraceptive pill	2.3	2.9	6.7	-1.4	0.3	2.6
Diastolic blood pressure, automated reading	0.2	0.6	1.8	0.1	0.1	1.3
Ever depressed for a whole week	0.9	1.1	3.0	0.1	-0.4	-1.7
Unable to work because of sickness or disability	0.8	1.1	2.3	1.0	-0.1	-1.5
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.2	0.9	-0.7
Myopia	0.6	0.9	1.7	0.5	-1.3	0.8
Vascular/heart problems diagnosed by doctor	1.2	3.3	8.0	1.3	-2.8	0.5
Cholesterol lowering medication	0.4	0.6	1.1	0.5	0.6	1.1
Medication: Omeprazole (e.g. Zanprol)	2.0	2.5	4.9	2.2	-1.6	-0.1
Pain experienced in last month	1.2	2.1	4.7	-1.1	0.5	2.2
Supplements: Calcium	1.5	1.6	2.6	-1.6	-0.2	1.5
Basal cell carcinoma (self-reported)	1.7	2.0	3.2	-1.4	1.8	0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-0.2	1.0	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.4	1.6	-0.5	1.8
Heart disease (siblings)	0.6	0.7	1.1	1.1	1.0	-0.2
Alcohol drinker status: Previous	0.3	0.4	1.0	0.5	-0.1	-1.0
Pack years of smoking	0.9	1.4	2.0	1.4	0.8	-1.2
Impedance of whole body	1.5	7.8	11.5	-3.4	3.4	0.6
Leg fat mass (left)	1.1	4.1	9.2	3.0	-1.8	0.0
Arm predicted mass (left)	3.8	19.2	29.3	5.3	-5.4	0.6