Best TWAS P=7.18e-10 · Best GWAS P=2.53e-10 conditioned to 0.0369
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EFCAB5 | 0.11 | 0.18 | blup | 392 | 0.17 | 1.7e-20 | -5.4 | -5.8 | 6.9e-09 | 0.91 | 0.15 | 0.85 | FALSE |
2 | GTEx | Brain Nucleus accumbens basal ganglia | CORO6 | 0.11 | 0.10 | lasso | 2 | 0.05 | 2.2e-02 | -5.1 | 5.2 | 2.2e-07 | -0.89 | 0.06 | 0.74 | FALSE |
3 | GTEx | Esophagus Muscularis | SSH2 | 0.04 | 0.01 | enet | 10 | 0.00 | 3.3e-01 | -4.6 | -5.5 | 4.3e-08 | 0.83 | 0.35 | 0.38 | FALSE |
4 | GTEx | Lung | SSH2 | 0.08 | 0.05 | lasso | 6 | 0.06 | 2.7e-05 | -4.3 | -5.3 | 1.3e-07 | 0.87 | 0.55 | 0.45 | FALSE |
5 | GTEx | Thyroid | ANKRD13B | 0.23 | 0.12 | lasso | 6 | 0.18 | 2.3e-13 | -4.0 | -5.3 | 9.6e-08 | 0.67 | 0.90 | 0.10 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFCAB5 | 0.02 | 0.04 | lasso | 4 | 0.04 | 1.9e-08 | -5.4 | -5.2 | 2.5e-07 | 0.92 | 0.05 | 0.95 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC55 | 0.15 | 0.01 | blup | 64 | 0.04 | 1.9e-03 | -5.6 | 6.2 | 7.2e-10 | -0.85 | 0.02 | 0.55 | TRUE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | EFCAB5 | 0.06 | 0.05 | blup | 79 | 0.03 | 5.7e-03 | -5.4 | -5.3 | 9.6e-08 | 0.92 | 0.04 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC55 | 0.27 | 0.00 | blup | 64 | 0.00 | 3.5e-01 | -1.0 | 5.4 | 7.7e-08 | -0.61 | 0.01 | 0.39 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EFCAB5 | 0.04 | 0.03 | enet | 10 | 0.02 | 6.0e-03 | -5.3 | -5.9 | 4.3e-09 | 0.85 | 0.04 | 0.92 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | EFCAB5 | 0.06 | 0.07 | lasso | 2 | 0.05 | 8.2e-04 | -5.4 | -5.2 | 2.1e-07 | 0.92 | 0.04 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | EFCAB5 | 0.11 | 0.18 | enet | 13 | 0.20 | 5.8e-19 | -5.4 | -5.3 | 1.2e-07 | 0.92 | 0.10 | 0.90 | FALSE |