Best TWAS P=2.17e-12 · Best GWAS P=1.47e-11 conditioned to 0.365
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHRS11 | 0.22 | 0.24 | bslmm | 311 | 0.25 | 1.6e-30 | -6.7 | 5.6 | 1.9e-08 | -0.92 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | MYO19 | 0.05 | 0.05 | lasso | 2 | 0.05 | 8.4e-07 | -5.6 | 5.8 | 6.7e-09 | -0.84 | 0.26 | 0.74 | FALSE |
3 | GTEx | Adipose Subcutaneous | GGNBP2 | 0.10 | 0.11 | enet | 9 | 0.11 | 3.5e-09 | 6.3 | -6.7 | 1.8e-11 | 0.87 | 0.06 | 0.94 | FALSE |
4 | GTEx | Adipose Subcutaneous | MYO19 | 0.07 | 0.05 | enet | 10 | 0.03 | 1.3e-03 | 6.4 | 6.5 | 1.0e-10 | -0.81 | 0.04 | 0.94 | FALSE |
5 | GTEx | Adipose Visceral Omentum | GGNBP2 | 0.13 | 0.12 | enet | 11 | 0.13 | 1.9e-07 | -5.9 | -6.4 | 1.8e-10 | 0.84 | 0.08 | 0.92 | FALSE |
6 | GTEx | Artery Aorta | GGNBP2 | 0.13 | 0.12 | lasso | 4 | 0.12 | 2.4e-07 | -6.8 | -6.5 | 7.5e-11 | 0.96 | 0.02 | 0.98 | FALSE |
7 | GTEx | Artery Aorta | DHRS11 | 0.10 | 0.07 | lasso | 5 | 0.06 | 2.7e-04 | -6.7 | 6.8 | 1.2e-11 | -1.00 | 0.02 | 0.98 | FALSE |
8 | GTEx | Artery Aorta | MYO19 | 0.20 | 0.16 | enet | 9 | 0.15 | 1.6e-08 | -5.6 | 5.3 | 1.4e-07 | -0.78 | 0.17 | 0.83 | FALSE |
9 | GTEx | Artery Tibial | GGNBP2 | 0.12 | 0.12 | enet | 15 | 0.12 | 1.2e-09 | -6.7 | -6.7 | 2.6e-11 | 0.98 | 0.01 | 0.99 | FALSE |
10 | GTEx | Artery Tibial | DHRS11 | 0.14 | 0.08 | enet | 11 | 0.11 | 7.1e-09 | -6.5 | 6.2 | 4.2e-10 | -0.90 | 0.04 | 0.96 | FALSE |
11 | GTEx | Artery Tibial | MYO19 | 0.12 | 0.11 | lasso | 6 | 0.13 | 4.1e-10 | 6.3 | 6.8 | 8.4e-12 | -0.90 | 0.04 | 0.96 | FALSE |
12 | GTEx | Brain Caudate basal ganglia | DHRS11 | 0.18 | 0.12 | lasso | 4 | 0.02 | 9.2e-02 | -6.5 | 6.7 | 2.4e-11 | -0.99 | 0.02 | 0.87 | FALSE |
13 | GTEx | Brain Cerebellar Hemisphere | CTB-75G16.3 | 0.27 | 0.14 | lasso | 4 | 0.05 | 1.8e-02 | -6.5 | -6.7 | 1.9e-11 | 0.97 | 0.02 | 0.82 | FALSE |
14 | GTEx | Brain Cerebellum | DHRS11 | 0.33 | 0.23 | lasso | 4 | 0.20 | 1.9e-06 | -6.7 | 6.8 | 1.4e-11 | -1.00 | 0.01 | 0.99 | FALSE |
15 | GTEx | Brain Cortex | DHRS11 | 0.23 | 0.18 | enet | 24 | 0.18 | 8.5e-06 | -6.7 | 6.7 | 1.9e-11 | -0.94 | 0.02 | 0.98 | FALSE |
16 | GTEx | Brain Frontal Cortex BA9 | DHRS11 | 0.34 | 0.26 | enet | 19 | 0.25 | 2.5e-07 | -6.7 | 6.8 | 1.4e-11 | -0.92 | 0.02 | 0.98 | FALSE |
17 | GTEx | Brain Hypothalamus | DHRS11 | 0.24 | 0.12 | lasso | 2 | 0.12 | 1.1e-03 | -6.2 | 6.1 | 1.4e-09 | -0.92 | 0.03 | 0.89 | FALSE |
18 | GTEx | Brain Nucleus accumbens basal ganglia | DHRS11 | 0.18 | 0.20 | lasso | 3 | 0.15 | 8.8e-05 | -6.6 | 6.6 | 4.0e-11 | -0.99 | 0.02 | 0.96 | FALSE |
19 | GTEx | Breast Mammary Tissue | GGNBP2 | 0.08 | 0.06 | lasso | 2 | 0.03 | 7.8e-03 | -5.6 | -6.5 | 9.6e-11 | 0.78 | 0.04 | 0.82 | FALSE |
20 | GTEx | Cells EBV-transformed lymphocytes | GGNBP2 | 0.13 | 0.15 | lasso | 2 | 0.13 | 5.5e-05 | -6.2 | -6.2 | 4.5e-10 | 0.92 | 0.03 | 0.92 | FALSE |
21 | GTEx | Cells EBV-transformed lymphocytes | DHRS11 | 0.14 | 0.08 | enet | 3 | 0.07 | 3.2e-03 | -6.3 | 6.2 | 4.0e-10 | -0.92 | 0.04 | 0.81 | FALSE |
22 | GTEx | Cells EBV-transformed lymphocytes | ZNHIT3 | 0.31 | 0.32 | enet | 9 | 0.22 | 1.1e-07 | 6.4 | 6.6 | 3.2e-11 | -0.79 | 0.10 | 0.90 | FALSE |
23 | GTEx | Cells Transformed fibroblasts | DHRS11 | 0.11 | 0.08 | lasso | 2 | 0.08 | 2.7e-06 | -6.7 | 6.2 | 4.5e-10 | -0.98 | 0.01 | 0.99 | FALSE |
24 | GTEx | Cells Transformed fibroblasts | ZNHIT3 | 0.15 | 0.07 | lasso | 7 | 0.05 | 1.7e-04 | 6.3 | 6.0 | 2.6e-09 | -0.73 | 0.09 | 0.86 | FALSE |
25 | GTEx | Colon Transverse | GGNBP2 | 0.15 | 0.15 | enet | 13 | 0.11 | 4.8e-06 | -6.8 | -6.1 | 1.4e-09 | 0.98 | 0.01 | 0.99 | FALSE |
26 | GTEx | Colon Transverse | MYO19 | 0.13 | 0.12 | lasso | 2 | 0.11 | 8.0e-06 | 6.6 | 6.4 | 1.3e-10 | -0.75 | 0.04 | 0.95 | FALSE |
27 | GTEx | Esophagus Gastroesophageal Junction | GGNBP2 | 0.12 | 0.12 | lasso | 2 | 0.09 | 4.9e-04 | -6.7 | -6.8 | 1.3e-11 | 1.00 | 0.01 | 0.96 | FALSE |
28 | GTEx | Esophagus Mucosa | GGNBP2 | 0.16 | 0.16 | enet | 15 | 0.18 | 3.1e-12 | -5.5 | -6.7 | 1.5e-11 | 0.92 | 0.07 | 0.93 | FALSE |
29 | GTEx | Esophagus Mucosa | DHRS11 | 0.12 | 0.08 | lasso | 2 | 0.06 | 5.1e-05 | 6.6 | 7.0 | 3.1e-12 | -0.90 | 0.02 | 0.98 | FALSE |
30 | GTEx | Esophagus Mucosa | ZNHIT3 | 0.22 | 0.13 | enet | 15 | 0.08 | 8.1e-06 | 6.4 | 5.4 | 5.6e-08 | -0.73 | 0.08 | 0.92 | FALSE |
31 | GTEx | Esophagus Mucosa | MYO19 | 0.11 | 0.08 | enet | 12 | 0.04 | 1.2e-03 | 6.4 | 6.0 | 2.7e-09 | -0.72 | 0.08 | 0.91 | FALSE |
32 | GTEx | Esophagus Muscularis | GGNBP2 | 0.15 | 0.11 | enet | 13 | 0.14 | 1.4e-08 | 6.3 | -5.9 | 4.6e-09 | 0.75 | 0.04 | 0.96 | FALSE |
33 | GTEx | Esophagus Muscularis | DHRS11 | 0.14 | 0.08 | lasso | 5 | 0.08 | 8.2e-06 | -6.1 | 6.6 | 5.2e-11 | -0.88 | 0.06 | 0.94 | FALSE |
34 | GTEx | Esophagus Muscularis | MYO19 | 0.14 | 0.14 | enet | 8 | 0.15 | 2.8e-09 | 6.6 | 6.5 | 8.0e-11 | -0.82 | 0.06 | 0.94 | FALSE |
35 | GTEx | Heart Atrial Appendage | MYO19 | 0.13 | 0.12 | lasso | 1 | 0.11 | 1.1e-05 | -6.1 | 6.1 | 1.3e-09 | -0.90 | 0.04 | 0.95 | FALSE |
36 | GTEx | Heart Left Ventricle | DHRS11 | 0.13 | 0.10 | lasso | 1 | 0.08 | 3.3e-05 | -6.2 | 6.2 | 6.0e-10 | -0.98 | 0.01 | 0.99 | FALSE |
37 | GTEx | Heart Left Ventricle | MYO19 | 0.10 | 0.06 | lasso | 3 | 0.04 | 5.4e-03 | 6.6 | 6.3 | 3.5e-10 | -0.85 | 0.03 | 0.91 | FALSE |
38 | GTEx | Lung | GGNBP2 | 0.08 | 0.01 | enet | 8 | 0.01 | 3.3e-02 | 6.6 | -6.8 | 1.2e-11 | 0.89 | 0.02 | 0.97 | FALSE |
39 | GTEx | Lung | DHRS11 | 0.09 | 0.08 | lasso | 5 | 0.10 | 3.7e-08 | -6.5 | 6.8 | 9.2e-12 | -0.98 | 0.01 | 0.99 | FALSE |
40 | GTEx | Lung | MYO19 | 0.15 | 0.14 | enet | 8 | 0.13 | 2.1e-10 | 6.4 | 6.2 | 7.2e-10 | -0.74 | 0.13 | 0.87 | FALSE |
41 | GTEx | Muscle Skeletal | GGNBP2 | 0.08 | 0.06 | enet | 14 | 0.05 | 2.5e-05 | -5.5 | -5.8 | 6.3e-09 | 0.83 | 0.08 | 0.92 | FALSE |
42 | GTEx | Muscle Skeletal | DHRS11 | 0.09 | 0.08 | lasso | 3 | 0.09 | 9.3e-09 | -6.5 | 6.5 | 8.5e-11 | -0.98 | 0.03 | 0.97 | FALSE |
43 | GTEx | Muscle Skeletal | MYO19 | 0.04 | 0.05 | enet | 14 | 0.03 | 6.4e-04 | -5.6 | 5.6 | 1.7e-08 | -0.80 | 0.08 | 0.88 | FALSE |
44 | GTEx | Nerve Tibial | GGNBP2 | 0.10 | 0.04 | lasso | 3 | 0.05 | 2.4e-04 | 6.3 | -6.6 | 5.1e-11 | 0.85 | 0.05 | 0.95 | FALSE |
45 | GTEx | Nerve Tibial | MYO19 | 0.11 | 0.11 | enet | 8 | 0.08 | 1.4e-06 | 6.3 | 6.2 | 5.4e-10 | -0.74 | 0.16 | 0.84 | FALSE |
46 | GTEx | Pancreas | GGNBP2 | 0.15 | 0.09 | lasso | 2 | 0.07 | 5.1e-04 | -6.5 | -6.3 | 3.0e-10 | 0.94 | 0.02 | 0.98 | FALSE |
47 | GTEx | Skin Sun Exposed Lower leg | GGNBP2 | 0.11 | 0.06 | enet | 11 | 0.10 | 1.3e-08 | -5.5 | -6.4 | 1.8e-10 | 0.91 | 0.05 | 0.95 | FALSE |
48 | GTEx | Skin Sun Exposed Lower leg | MYO19 | 0.07 | 0.01 | enet | 7 | 0.03 | 1.8e-03 | 6.3 | 5.8 | 8.3e-09 | -0.73 | 0.16 | 0.81 | FALSE |
49 | GTEx | Stomach | GGNBP2 | 0.13 | 0.06 | lasso | 3 | 0.06 | 5.9e-04 | -5.6 | -6.1 | 9.7e-10 | 0.91 | 0.03 | 0.94 | FALSE |
50 | GTEx | Testis | GGNBP2 | 0.19 | 0.19 | lasso | 1 | 0.15 | 3.8e-07 | -6.2 | -6.2 | 6.0e-10 | 0.98 | 0.02 | 0.98 | FALSE |
51 | GTEx | Testis | ZNHIT3 | 0.27 | 0.33 | lasso | 2 | 0.32 | 8.0e-15 | 6.4 | -6.3 | 3.0e-10 | 0.73 | 0.11 | 0.89 | FALSE |
52 | GTEx | Thyroid | GGNBP2 | 0.07 | 0.06 | lasso | 2 | 0.04 | 2.8e-04 | -6.8 | -6.9 | 5.4e-12 | 1.00 | 0.01 | 0.98 | FALSE |
53 | GTEx | Thyroid | MYO19 | 0.11 | 0.05 | lasso | 3 | 0.04 | 7.1e-04 | -5.6 | 5.4 | 6.7e-08 | -0.81 | 0.12 | 0.71 | FALSE |
54 | GTEx | Whole Blood | GGNBP2 | 0.08 | 0.01 | lasso | 4 | 0.01 | 3.6e-02 | -6.1 | -6.0 | 1.8e-09 | 0.89 | 0.06 | 0.72 | FALSE |
55 | METSIM | Adipose | GGNBP2 | 0.16 | 0.14 | lasso | 5 | 0.14 | 6.2e-21 | 6.4 | -6.4 | 1.5e-10 | 0.80 | 0.15 | 0.85 | FALSE |
56 | METSIM | Adipose | MYO19 | 0.10 | 0.10 | lasso | 4 | 0.10 | 1.6e-14 | 6.3 | 6.5 | 7.5e-11 | -0.73 | 0.14 | 0.86 | FALSE |
57 | NTR | Blood | GGNBP2 | 0.03 | 0.02 | bslmm | 331 | 0.02 | 7.7e-07 | -5.5 | -6.5 | 9.1e-11 | 0.77 | 0.09 | 0.91 | FALSE |
58 | YFS | Blood | DHRS11 | 0.05 | 0.06 | lasso | 7 | 0.06 | 2.5e-18 | -5.9 | 6.2 | 6.2e-10 | -0.87 | 0.66 | 0.34 | FALSE |
59 | YFS | Blood | GGNBP2 | 0.07 | 0.09 | enet | 21 | 0.10 | 4.7e-31 | 6.3 | -5.7 | 1.2e-08 | 0.74 | 0.15 | 0.85 | FALSE |
60 | YFS | Blood | MYO19 | 0.12 | 0.14 | enet | 14 | 0.14 | 4.0e-45 | 6.2 | 6.0 | 2.2e-09 | -0.67 | 0.18 | 0.82 | FALSE |
61 | The Cancer Genome Atlas | Colon Adenocarcinoma | GGNBP2 | 0.10 | 0.05 | lasso | 3 | 0.06 | 2.5e-04 | -5.5 | -5.5 | 4.6e-08 | 0.78 | 0.03 | 0.78 | FALSE |
62 | The Cancer Genome Atlas | Colon Adenocarcinoma | MRM1 | 0.06 | 0.06 | enet | 4 | 0.05 | 9.4e-04 | -6.7 | -6.7 | 1.8e-11 | 1.00 | 0.00 | 0.95 | FALSE |
63 | The Cancer Genome Atlas | Esophageal Carcinoma | DHRS11 | 0.12 | 0.12 | blup | 13 | 0.12 | 1.5e-04 | -6.7 | 6.2 | 6.0e-10 | -0.89 | 0.00 | 0.94 | FALSE |
64 | The Cancer Genome Atlas | Esophageal Carcinoma | ZNHIT3 | 0.11 | 0.11 | lasso | 4 | 0.09 | 6.2e-04 | -6.5 | 6.5 | 5.9e-11 | -0.99 | 0.01 | 0.84 | FALSE |
65 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNHIT3 | 0.05 | 0.03 | enet | 4 | 0.04 | 4.7e-05 | 6.6 | 7.0 | 2.2e-12 | -0.91 | 0.00 | 1.00 | TRUE |
66 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DHRS11 | 0.04 | 0.04 | lasso | 2 | 0.04 | 3.1e-05 | -6.7 | 6.7 | 1.7e-11 | -1.00 | 0.00 | 1.00 | FALSE |
67 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GGNBP2 | 0.04 | 0.04 | enet | 3 | 0.04 | 6.3e-05 | 6.3 | -7.0 | 3.7e-12 | 0.93 | 0.01 | 0.99 | FALSE |
68 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHRS11 | 0.05 | 0.11 | enet | 6 | 0.10 | 7.4e-12 | -6.2 | 6.6 | 5.1e-11 | -0.99 | 0.00 | 1.00 | FALSE |
69 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | GGNBP2 | 0.05 | 0.04 | lasso | 2 | 0.01 | 8.1e-02 | -6.5 | -6.5 | 8.7e-11 | 0.98 | 0.01 | 0.83 | FALSE |
70 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNHIT3 | 0.03 | 0.03 | enet | 4 | 0.03 | 1.8e-04 | -6.5 | 6.8 | 1.2e-11 | -0.99 | 0.01 | 0.95 | FALSE |
71 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGNBP2 | 0.02 | 0.02 | enet | 4 | 0.02 | 6.0e-03 | -5.5 | -6.0 | 1.5e-09 | 0.84 | 0.02 | 0.69 | FALSE |
72 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ZNHIT3 | 0.06 | 0.03 | enet | 2 | 0.04 | 1.3e-03 | -6.1 | 6.3 | 2.4e-10 | -0.94 | 0.01 | 0.93 | FALSE |
73 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DHRS11 | 0.06 | 0.06 | blup | 12 | 0.04 | 2.0e-02 | -6.2 | 6.5 | 7.9e-11 | -0.97 | 0.00 | 0.68 | FALSE |
74 | The Cancer Genome Atlas | Thyroid Carcinoma | GGNBP2 | 0.04 | 0.04 | enet | 6 | 0.05 | 1.4e-05 | -6.4 | -6.5 | 6.1e-11 | 0.90 | 0.01 | 0.98 | FALSE |