Hub : Genes

CRTC1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.201 0.0760 8.5e-03 0.147 NA 0.074 NA 0.107 4.1e-05 NA 0.00330 NA 4.5e-04
2 GTEx Nerve Tibial 0.110 0.0452 5.5e-03 0.016 NA 0.020 NA 0.034 2.4e-02 NA 0.01300 NA 1.8e-03
3 TCGA Testicular Germ Cell Tumors 0.334 0.1230 4.9e-05 0.076 0.073 0.083 NA 0.125 1.1e-03 0.0015 0.00074 NA 3.5e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.5 2.4 5.2 0.5 -1.3 -2.3
Bipolar Disorder or Schizophrenia 1.0 2.5 4.9 0.9 -1.4 -2.2
Depressed Affect (Nagel 2018) 0.7 1.4 2.2 0.4 -1.4 -1.5
Depression (Nagel 2018) 0.4 0.7 1.1 1.1 -0.7 -0.6
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.5 -0.0 -0.7 -0.2
Neuroticism (Nagel 2018) 0.4 0.8 1.6 -0.1 -0.9 -1.3
Schizophrenia (2018) 0.3 0.7 1.0 0.7 -0.7 -1.0
Schizophrenia vs Biploar Disorder 0.7 1.0 2.5 -0.6 -0.1 1.6
Worry (Nagel 2018) 0.2 0.4 1.2 -0.1 -0.0 -1.1
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 0.1 -0.1 0.1
Alzheimer’s Disease (in father) 1.4 1.6 2.2 -1.2 1.1 1.5
Alzheimer’s Disease (including proxy) 0.5 0.7 0.9 -0.9 0.9 0.7
Crohns Disease (2017) 0.5 1.1 1.9 1.2 -0.2 -1.4
Irritable Bowel Disease (IBD) 0.3 0.7 1.4 0.7 -0.1 -1.2
Ulcerative Colitis (UC) 0.1 0.1 0.4 -0.1 0.0 -0.7
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 5.9 11.2 16.5 3.8 -4.1 -1.5
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.2 0.0 -1.1 -0.4
Breast Cancer 1.1 2.7 5.7 -1.3 2.4 0.9
Ovarian Cancer 0.2 0.3 0.7 0.4 -0.8 0.3
Prostate Cancer 0.9 1.2 3.0 0.6 -0.5 -1.7
Age at First Birth 0.6 0.9 2.4 -1.5 0.6 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 3.9 -1.2 -0.5 -2.0
Coronary Artery Disease (CAD) 1.8 2.1 3.9 -1.5 2.0 -0.2
Crohns Disease (2012) 0.8 1.2 2.1 1.0 -0.9 -1.4
Mean Putamen Volume 0.7 0.8 1.4 1.2 -0.8 -0.5
Fasting Glucose 0.4 0.5 1.3 1.1 0.3 -0.1
HbA1C 0.2 0.3 0.5 0.7 0.1 0.6
HDL Cholesterol 0.8 1.3 1.8 -1.1 0.8 1.4
LDL Cholesterol 0.3 0.5 1.0 -0.6 1.0 -0.1
Lupus 0.6 0.9 2.1 -1.5 0.0 -0.7
Neuroticism (2016) 0.4 0.5 1.2 0.6 -1.1 -0.3
Primary Biliary Cirrhosis 0.0 0.1 0.2 0.1 -0.1 -0.4
Rheumatoid Arthritis 1.0 1.4 2.5 1.1 -1.6 -0.7
Schizophrenia (2014) 0.6 1.3 2.3 0.7 -1.1 -1.5
Triglycerides 0.8 1.4 2.7 -1.1 -0.4 -1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.7 2.1 -0.1 -1.4 0.0
Ulcerative Colitis 0.2 0.2 0.7 -0.3 0.0 -0.8
Blood Eosinophil Count 1.1 8.3 15.1 3.9 -2.2 -2.3
Blood Platelet Count 0.3 3.6 10.7 3.3 0.1 -0.2
Blood Red Count 0.5 4.8 8.6 -2.9 2.2 1.0
Blood White Count 0.8 6.1 15.5 1.6 -0.3 -3.9
Heel T-Score 0.6 4.7 9.7 -1.9 0.9 3.1
BMI 6.3 36.8 53.4 3.8 -6.5 -7.3
Height 0.2 3.4 6.6 -2.6 1.9 0.3
Waist Hip Ratio (WHR) 0.1 0.4 1.2 -0.3 -1.1 -0.0
Systolic Blood Pressure 0.1 0.4 0.9 0.3 -0.9 0.4
Smoking Status 1.0 2.5 6.7 0.9 0.1 -2.6
Allergy or Eczema 1.0 2.5 3.2 1.6 -1.3 1.8
Cardiovascular Disease 5.0 16.6 25.5 3.3 -5.1 -3.7
Hypothyroidism (self reported) 0.8 1.9 3.8 2.0 -1.1 -0.8
Respiratory disease 0.5 1.1 1.7 1.3 0.4 1.2
Type 2 Diabetes (T2D) (2018) 2.7 5.0 12.6 0.6 -1.4 -3.5
Lung FEV1/FVC ratio 0.6 2.9 8.0 0.7 -2.8 0.5
Lung FVC 0.1 0.5 0.9 -1.0 0.7 0.3
Neuroticism 1.3 3.2 5.1 0.7 -2.0 -2.3
Chronotype (morning person) 0.6 1.5 2.3 1.3 -1.5 0.7
Hair Pigment 0.1 2.5 5.5 -1.4 2.3 0.3
Tanning 0.2 2.5 7.2 0.2 0.5 -2.7
Hand grip strength (left) 0.9 2.3 6.6 -0.2 -0.6 2.6
Number of treatments/medications taken 3.8 6.9 8.2 2.8 -2.9 -2.2
Average weekly spirits intake 1.3 1.6 3.9 0.8 -0.5 -2.0
Sensitivity / hurt feelings 1.5 2.6 3.8 1.9 -1.9 -0.8
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.2 0.7 -1.8 -0.9
Hearing difficulty/problems: Yes 0.2 0.3 1.0 0.2 -0.1 -1.0
Relative age of first facial hair 2.4 4.8 9.3 0.7 2.2 3.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.7 -0.7 0.8 1.3
Ever used hormone-replacement therapy (HRT) 0.4 0.6 1.3 -0.6 1.1 -0.0
Ever had hysterectomy (womb removed) 0.7 0.8 2.1 0.3 -0.3 -1.4
Systolic blood pressure, automated reading 1.1 3.1 4.7 1.4 -2.2 -1.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.1 -0.4 -0.7 -1.4
Angina 0.8 1.0 1.6 -1.3 0.1 1.2
Medication for hormone replacement therapy 3.5 3.9 7.5 -2.7 1.8 1.0
Vitamin and mineral supplements 0.4 0.5 1.0 -1.0 0.7 -0.3
Supplements: Zinc 1.2 1.3 2.8 0.8 0.6 1.7
Medication: Co-codamol 0.9 1.1 2.0 0.0 -1.4 -1.1
Medication: Metformin 3.4 4.8 6.7 1.9 -2.1 -2.6
Diabetes (father) 2.7 3.3 4.6 1.2 -2.1 -2.0
Diabetes (mother) 0.9 1.2 2.0 1.0 -1.4 -0.7
Severe depression (siblings) 1.1 1.2 1.5 -1.1 1.2 0.9
Pack years adult smoking proportion 6.6 10.1 13.3 2.8 -3.0 -3.6
Impedance of leg (right) 0.9 4.4 7.0 -1.6 2.6 1.9
Leg fat-free mass (left) 1.0 5.0 7.0 1.1 -2.6 -2.6
Trunk fat percentage 3.3 13.1 32.7 0.1 -2.6 -5.7
Hand grip strength (right) 1.5 4.0 9.9 -1.5 0.1 3.1
Townsend deprivation index at recruitment 0.3 0.4 0.9 -0.0 -0.5 -1.0
Current tobacco smoking 1.5 2.5 4.7 2.2 -1.5 -0.9
Average weekly fortified wine intake 1.4 1.6 2.4 -1.6 1.5 -0.5
Maternal smoking around birth 0.8 1.2 2.5 -0.9 1.6 -0.5
Fed-up feelings 1.1 1.9 3.3 -0.3 -1.8 -1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.5 1.5 -1.9 -0.7
Relative age voice broke 3.5 5.4 8.9 -0.7 2.6 3.0
Taking other prescription medications 1.6 2.5 3.8 1.1 -1.6 -2.0
Age when periods started (menarche) 7.5 18.1 24.2 -3.6 4.9 4.1
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 2.3 1.4 -1.5 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 3.0 6.7 11.0 -2.7 1.3 3.3
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 3.1 0.2 -0.9 1.8
Qualifications: CSEs or equivalent 0.0 0.1 0.1 0.2 -0.0 0.3
Serious illness, injury or assault to yourself 1.4 1.7 2.3 1.1 -1.5 -1.3
High blood pressure 3.0 8.3 10.5 2.1 -3.2 -3.2
Hayfever, allergic rhinitis or eczema 0.8 1.6 2.1 1.4 -1.0 1.4
Multivitamins +/- minerals 0.2 0.2 0.5 0.2 -0.3 0.7
Stomach or abdominal pain in last month 1.5 1.8 4.4 1.0 -2.1 0.4
Supplements: Glucosamine 1.8 2.4 3.0 1.5 -1.7 1.3
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.0 0.2 0.5 1.4
Medication: Atenolol 1.8 2.3 5.3 -0.8 -1.0 -2.3
Medication: Levothyroxine sodium 0.6 1.1 1.8 1.3 -1.2 -0.1
Sitting height 0.4 3.1 5.2 -2.3 1.8 1.0
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 0.4 -0.0 0.9
High blood pressure (mother) 2.7 3.8 5.5 0.9 -2.3 -2.3
Body mass index (BMI) 5.0 21.5 31.0 2.7 -5.1 -5.6
Impedance of leg (left) 1.0 5.0 7.1 -1.7 2.7 2.2
Leg predicted mass (left) 0.9 4.9 6.8 1.1 -2.6 -2.6
Trunk fat mass 3.4 14.7 33.1 0.7 -3.2 -5.8
Waist circumference 3.4 12.6 20.3 1.8 -3.8 -4.5
Number of incorrect matches in round 2.2 3.6 7.9 1.2 -1.2 -2.8
Past tobacco smoking 2.2 4.0 7.7 1.7 -1.2 2.8
Alcohol usually taken with meals 1.0 1.6 3.7 0.9 0.5 1.9
Nervous feelings 0.1 0.2 0.6 -0.4 0.7 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.7 0.2 -0.8 0.1
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.0 0.4 -0.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.4 0.2 0.1 0.6
Had menopause 0.9 1.1 3.2 -0.5 1.8 -0.0
Had other major operations 2.4 2.9 3.4 1.8 -1.4 -1.9
Forced vital capacity (FVC) 0.4 1.6 1.9 -1.3 1.4 1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 8.0 -2.2 0.4 2.8
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 0.5 0.3 0.3
Qualifications: None of the above 0.1 0.3 0.6 -0.7 0.2 -0.6
Financial difficulties in last 2 years 1.3 1.7 2.2 1.3 -1.5 -1.1
Mouth/teeth dental problems 1.1 1.6 3.8 -2.0 1.0 0.2
Heart attack 0.1 0.1 0.3 0.1 -0.0 -0.5
Allergy 0.8 1.9 3.6 -1.9 0.7 -1.3
Pain all over the body in last month 0.1 0.1 0.2 -0.3 0.2 0.4
Diabetes (self-reported) 3.4 5.3 12.8 1.0 -1.5 -3.6
Hayfever/allergic rhinitis (self-reported) 2.4 3.2 6.6 1.5 0.8 2.6
Medication: Ramipril 3.6 4.7 9.0 0.9 -2.0 -3.0
Medication: Simvastatin 1.6 2.3 3.0 1.2 -1.7 -1.6
Fluid intelligence score 0.2 0.5 1.1 0.5 -1.1 -0.3
Illnesses of siblings 1.0 1.4 3.3 -0.3 0.9 1.8
Neuroticism score 0.6 1.3 2.6 0.3 -1.0 -1.6
Weight 3.0 14.8 22.9 1.9 -4.2 -4.8
Impedance of arm (right) 2.9 13.7 24.2 -3.9 4.9 1.4
Arm fat percentage (right) 4.3 17.0 36.7 1.2 -3.6 -6.1
Trunk fat-free mass 1.1 6.3 11.0 2.4 -3.3 -1.5
Hip circumference 2.2 9.7 18.3 1.4 -3.0 -4.3
Time employed in main current job 0.4 0.5 0.7 0.9 -0.8 0.1
Alcohol intake versus 10 years previously 0.8 1.2 2.7 0.7 -0.5 -1.6
Father’s age at death 0.9 1.2 2.5 -0.6 0.9 1.6
Worrier / anxious feelings 0.7 1.4 2.6 -1.2 1.6 -0.4
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 8.9 1.5 -3.0 0.3
Falls in the last year 1.2 1.6 2.1 -1.5 1.0 -1.2
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 0.3 -1.2 -0.4
Number of live births 3.1 4.4 9.9 0.2 -1.8 -3.1
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 3.3 -1.3 1.0 1.8
Pulse rate 1.1 1.8 4.1 1.1 -0.5 -2.0
Happiness 0.5 0.6 1.1 -0.8 0.1 1.0
Noisy workplace 0.6 0.8 1.1 0.8 -1.1 0.7
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 -0.8 -0.1 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 -0.1 -0.6 0.3
Mouth/teeth dental problems: Dentures 1.4 2.3 5.6 2.4 -1.2 0.0
Asthma 0.7 1.4 3.0 0.7 0.8 1.7
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.0 0.0 -0.4 2.0
Medication: Cholesterol lowering 0.6 1.0 2.5 0.3 -0.6 -1.6
Depression (self-reported) 0.2 0.2 0.6 -0.0 -0.8 -0.4
Medication: Lansoprazole 1.4 1.6 4.5 2.1 0.4 -0.4
Prospective memory result 0.4 0.4 1.0 -0.1 -0.5 -1.0
Lung cancer (father) 0.4 0.5 1.3 0.4 -0.2 -1.1
Illnesses of mother 3.4 4.2 6.8 -1.6 1.8 2.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 1.6 -0.7 1.0 1.3
Pulse wave Arterial Stiffness index 1.0 1.1 1.6 -0.5 1.2 -1.3
Impedance of arm (left) 2.7 12.5 23.0 -3.5 4.8 1.5
Arm fat mass (right) 4.2 17.1 32.4 1.7 -4.0 -5.7
Trunk predicted mass 1.1 6.6 11.0 2.5 -3.3 -1.6
Standing height 0.2 1.5 1.9 -1.3 1.4 1.0
Length of working week for main job 4.8 5.3 6.5 2.0 -2.3 -2.5
Exposure to tobacco smoke at home 1.5 1.6 2.5 0.3 -1.5 -1.6
Breastfed as a baby 0.8 1.0 1.5 0.3 1.2 1.2
Tense / ‘highly strung’ 0.4 0.7 2.1 0.1 0.3 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.0 -0.7 -0.4
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 -0.4 0.9 0.1
Birth weight of first child 2.0 3.7 6.0 1.1 -2.5 -2.0
Peak expiratory flow (PEF) 1.0 2.4 3.6 -0.9 1.7 1.9
Pulse wave reflection index 0.6 0.7 1.0 -0.4 1.0 0.9
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.1 -0.5 0.4 1.8
Loud music exposure frequency 0.3 0.3 0.7 0.4 -0.8 0.5
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 1.8 1.4 -1.0 1.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.3 -1.5 0.9 -0.0
Blood clot in the leg (DVT) 0.4 0.6 1.4 1.2 -0.2 -0.5
Medication: Paracetamol 0.2 0.3 0.5 0.6 -0.5 0.7
Headache pain in last month 0.1 0.1 0.3 -0.3 -0.5 -0.2
Medication for cholesterol, blood pressure or diabetes 2.3 3.8 9.0 -0.9 1.2 3.0
Glaucoma (self-reported) 0.3 0.4 1.1 -0.2 -1.0 0.2
Gout (self-reported) 0.4 0.5 1.0 -0.3 -0.6 -1.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.2 1.5 -0.9 -0.7
Medication: Amlodipine 1.1 1.6 2.9 1.1 -0.9 -1.7
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.6 0.8 0.4 0.5
Birth weight 0.8 1.7 3.9 -0.4 -1.0 -2.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.6 1.3 0.2 0.4
High blood pressure (siblings) 0.4 0.6 1.5 0.1 -0.6 -1.2
Forced vital capacity (FVC), Best measure 0.3 1.2 2.6 -0.8 1.6 0.6
Body fat percentage 3.8 15.1 34.8 0.6 -3.2 -5.9
Leg fat percentage (right) 5.9 21.5 37.5 2.2 -4.7 -6.1
Arm fat-free mass (right) 1.3 6.7 11.8 2.2 -3.4 -1.9
Exposure to tobacco smoke outside home 0.8 1.1 1.5 1.1 -0.7 -1.2
Comparative body size at age 10 2.3 6.3 11.2 -0.2 -2.7 -3.4
Number of full brothers 0.6 0.8 1.4 -0.1 -0.9 -1.2
Worry too long after embarrassment 0.2 0.3 0.7 -0.8 -0.2 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.4 -0.5 0.7
Wheeze or whistling in the chest in last year 1.2 2.1 5.9 2.4 -0.7 0.3
Number of children fathered 0.1 0.2 0.2 0.2 0.4 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 1.2 -0.4 -0.3
Age at first live birth 1.0 1.7 4.1 -2.0 0.7 0.8
Pulse wave peak to peak time 1.1 1.2 2.0 0.5 -1.2 1.4
Health satisfaction 1.6 2.1 3.4 1.7 -1.8 0.1
Shortness of breath walking on level ground 0.1 0.1 0.1 -0.3 0.4 0.1
Qualifications: College or University degree 0.1 0.4 0.9 -1.0 0.2 0.4
Eye problems/disorders: None of the above 0.9 1.0 1.5 -0.6 1.2 1.1
Mouth/teeth dental problems: Loose teeth 1.8 2.1 4.5 -1.4 2.1 0.2
Emphysema/chronic bronchitis 1.0 1.2 3.5 1.9 -0.0 -0.1
Medication for pain relief, constipation, heartburn 0.5 0.8 1.4 -1.0 1.2 0.4
Neck or shoulder pain in last month 0.1 0.2 0.2 0.5 -0.5 -0.1
Medication: Blood pressure 1.8 3.1 6.5 1.2 -1.2 -2.5
Angina (self-reported) 1.1 1.4 2.7 -1.6 0.4 1.2
Migraine (self-reported) 0.6 0.7 0.8 -0.7 0.8 0.9
Medication: Ibuprofen 1.4 1.6 4.2 0.4 -0.7 2.0
Medication: Allopurinol 0.8 1.1 2.7 -1.6 0.1 -0.7
Medication: Omeprazole 7.4 8.9 10.4 2.8 -2.9 -3.2
Medication: Seretide 50 evohaler 0.4 0.5 1.0 0.2 -0.6 -1.0
Mean time to correctly identify matches 4.8 9.1 12.9 3.6 -3.6 -1.3
Heart disease (mother) 1.0 1.2 3.0 -0.3 -0.7 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.3 4.0 10.0 -0.6 1.2 3.2
Whole body fat mass 4.0 16.8 34.6 1.2 -3.8 -5.9
Leg fat mass (right) 4.9 18.9 32.3 1.9 -4.6 -5.7
Arm predicted mass (right) 1.4 7.1 11.8 2.4 -3.4 -2.0
Pulse rate, automated reading 0.4 1.4 4.0 0.4 0.3 -2.0
Alcohol intake frequency. 2.3 5.3 8.0 2.8 -2.7 -0.7
Comparative height size at age 10 0.2 1.0 2.8 0.1 -0.5 -1.7
Number of full sisters 2.0 2.4 3.8 2.0 -1.6 -0.8
Suffer from ‘nerves’ 0.0 0.0 0.0 0.1 0.1 0.0
Overall health rating 0.7 1.5 3.0 1.7 -1.2 -0.3
Chest pain or discomfort 1.3 1.9 2.5 1.6 -1.2 -1.3
Had major operations 0.7 0.9 1.1 -1.0 -1.0 -0.7
Age at last live birth 1.7 2.5 3.0 -1.7 1.4 1.6
Family relationship satisfaction 1.8 2.2 2.9 1.7 -1.6 -1.1
Leg pain on walking 1.1 1.4 3.0 -0.5 0.9 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 1.3 -0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.0 0.5 -1.4 -0.5
Illness, injury, bereavement, stress in last 2 years 1.5 1.8 3.2 -1.4 1.8 0.6
Medication: Aspirin 0.1 0.2 0.4 0.4 -0.0 -0.6
Supplements: Vitamin C 0.2 0.2 0.3 0.5 -0.6 0.2
Knee pain experienced in last month 0.6 1.0 2.6 1.6 0.4 0.4
Hypertension (Self-reported) 3.1 8.6 10.2 2.4 -3.2 -3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 1.9 0.6 -1.4 -1.2
Illnesses of father: Heart disease 0.3 0.4 1.2 0.3 -0.3 1.1
Illnesses of siblings: Diabetes 1.0 1.2 2.0 -1.4 -0.5 -1.2
Smoking status: Previous 3.9 5.9 7.4 -2.7 1.9 -2.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.8 0.3 0.2 0.9
Whole body fat-free mass 1.0 5.7 9.5 1.9 -3.1 -1.9
Leg fat-free mass (right) 0.6 3.4 5.3 1.0 -2.3 -2.0
Arm fat percentage (left) 4.0 15.8 34.2 1.2 -3.4 -5.8
Average weekly red wine intake 0.5 0.7 1.0 0.5 1.0 0.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.0 -0.1 0.5
Mood swings 1.1 2.0 3.0 0.6 -1.7 -1.7
Loneliness, isolation 1.3 1.8 2.9 1.4 -0.6 -1.7
Long-standing illness, disability or infirmity 1.2 1.8 3.7 1.9 -1.3 -0.2
Ever had bowel cancer screening 2.3 2.7 3.6 -1.8 1.9 1.1
Diabetes diagnosed by doctor 4.8 7.8 16.3 1.6 -2.1 -4.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.9 -0.2 -1.4 -0.8
Friendships satisfaction 0.2 0.3 0.8 0.2 0.1 0.9
Qualifications: nursing, teaching 0.8 1.3 2.0 1.1 -1.4 -0.7
Commuting to job workplace: Walk 3.0 3.3 4.4 -1.1 2.0 2.1
Eye problems/disorders: Cataract 0.8 0.9 1.8 -1.3 0.1 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.6 0.8 -0.8 0.6
Medication for cholesterol 0.3 0.4 0.8 -0.4 0.5 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.8 3.3 9.2 -0.4 0.6 3.0
Back pain experienced in last month 2.3 3.3 5.1 2.2 -1.6 1.6
Mineral and other dietary supplements 0.5 0.7 2.0 0.1 -0.1 -1.4
Breast cancer (self-reported) 0.8 0.9 1.9 0.1 -0.9 -1.4
Asthma (self-reported) 0.8 1.6 3.3 1.1 0.5 1.8
Osteoporosis (self-reported) 0.3 0.4 0.9 0.1 -0.4 -1.0
Osteoarthritis (self-reported) 1.5 1.9 3.2 1.6 -0.2 1.8
Medication: Aspirin 0.2 0.3 0.4 0.5 -0.4 -0.6
Medication: Gliclazide 0.3 0.4 0.7 0.1 -0.8 0.6
Illnesses of father: None of the above (group 1) 1.8 2.2 4.8 -2.2 1.4 0.0
Smoking status: Current 1.5 2.3 4.9 2.2 -1.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 1.8 -0.6 0.7 1.4
Whole body water mass 1.1 6.1 10.0 2.0 -3.2 -2.0
Leg predicted mass (right) 0.7 3.5 5.2 1.0 -2.3 -2.0
Arm fat mass (left) 4.1 17.0 31.4 1.8 -4.1 -5.6
Number of self-reported non-cancer illnesses 2.7 4.7 9.7 3.1 -1.9 -0.8
Average weekly champagne plus white wine intake 4.3 6.0 7.6 -2.4 2.8 2.1
Miserableness 0.9 1.6 3.4 1.1 -1.9 -0.6
Guilty feelings 1.1 1.7 4.9 0.5 -0.2 -2.2
Wears glasses or contact lenses 1.1 1.3 3.1 0.4 -0.7 -1.8
Ever taken oral contraceptive pill 0.3 0.4 1.1 0.1 -1.0 0.3
Hearing aid user 0.0 0.0 0.0 0.0 0.1 0.2
Mother’s age at death 0.5 0.6 1.1 0.2 0.8 1.1
Financial situation satisfaction 0.8 1.0 1.7 1.3 -0.7 0.8
Tinnitus: Yes, now most or all of the time 2.3 2.7 3.7 -1.1 1.9 1.8
Commuting to job workplace: Public transport 1.1 1.3 2.1 -1.3 1.4 0.4
Eye problems/disorders: Glaucoma 1.1 1.3 2.5 1.2 -1.6 -0.1
Medication: Blood pressure 1.7 3.2 3.4 1.8 -1.8 -1.7
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.3 1.8 -0.9 -1.4
Supplements: Fish oil (including cod liver oil) 1.0 1.3 3.7 -0.2 0.5 1.9
High cholesterol (Self-reported) 0.8 1.4 2.3 0.8 -1.5 -1.1
Medication: Bendroflumethiazide 0.3 0.5 0.6 0.8 -0.6 -0.8
Medication: Paracetamol 0.5 0.7 1.3 0.9 -1.1 0.3
Medication: Lisinopril 1.0 1.3 2.5 1.6 -1.2 -0.1
Medication: Atorvastatin 0.6 0.7 2.0 -0.4 0.0 -1.4
Illnesses of father: High blood pressure 2.0 2.4 4.3 1.6 -2.1 0.6
Alcohol drinker status: Never 0.7 0.9 1.7 0.9 -1.3 0.3
Ever smoked 1.6 2.8 7.1 -0.8 0.7 -2.7
Basal metabolic rate 1.3 7.3 11.2 1.9 -3.3 -2.6
Leg fat percentage (left) 5.8 21.0 35.5 2.1 -4.8 -6.0
Arm fat-free mass (left) 1.7 8.7 13.8 2.4 -3.7 -2.6
Number of operations (self-reported) 1.2 1.8 5.1 -0.5 0.0 -2.3
Average weekly beer plus cider intake 0.5 0.7 1.7 -0.4 -0.4 -1.3
Irritability 0.1 0.1 0.2 -0.3 0.0 -0.4
Risk taking 0.6 0.8 1.5 1.0 0.1 -1.2
Ever had prostate specific antigen (PSA) test 0.0 0.1 0.2 -0.0 -0.4 0.1
Fractured/broken bones in last 5 years 4.4 5.7 8.5 1.1 -2.7 -2.9
Age started oral contraceptive pill 4.2 5.3 8.0 -2.8 2.5 1.3
Diastolic blood pressure, automated reading 2.1 6.4 7.0 2.5 -2.6 -2.5
Ever depressed for a whole week 2.0 2.4 4.9 2.2 -0.7 1.4
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.0 -0.5 -0.3
Commuting to job workplace: Cycle 2.3 2.8 3.5 -1.8 1.9 1.3
Myopia 3.0 4.3 7.6 -1.6 1.7 2.8
Vascular/heart problems diagnosed by doctor 2.3 6.3 8.5 -1.6 2.9 2.8
Cholesterol lowering medication 0.6 0.8 1.4 0.2 -1.1 -1.2
Medication: Omeprazole (e.g. Zanprol) 4.6 5.6 7.4 2.7 -2.2 -2.2
Pain experienced in last month 0.4 0.6 1.6 -0.4 0.4 -1.3
Supplements: Calcium 1.5 1.7 2.3 1.4 -1.5 -0.8
Basal cell carcinoma (self-reported) 1.3 1.5 2.9 0.4 -1.3 -1.7
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 0.4 -0.2 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.2 1.5 -0.3 0.0
Heart disease (siblings) 1.0 1.2 2.2 -0.5 1.1 -1.5
Alcohol drinker status: Previous 0.5 0.6 1.0 0.4 1.0 0.7
Pack years of smoking 6.2 9.0 13.4 2.5 -2.8 -3.7
Impedance of whole body 2.4 12.0 20.7 -3.3 4.5 2.1
Leg fat mass (left) 4.7 18.2 30.5 1.9 -4.5 -5.5
Arm predicted mass (left) 1.6 8.4 13.2 2.4 -3.6 -2.5