TWAS hub - CRTC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.201	0.0760	8.5e-03	0.147	NA	0.074	NA	0.107	4.1e-05	NA	0.00330	NA	4.5e-04
2	GTEx	Nerve Tibial	0.110	0.0452	5.5e-03	0.016	NA	0.020	NA	0.034	2.4e-02	NA	0.01300	NA	1.8e-03
3	TCGA	Testicular Germ Cell Tumors	0.334	0.1230	4.9e-05	0.076	0.073	0.083	NA	0.125	1.1e-03	0.0015	0.00074	NA	3.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age when periods started (menarche)	7.5	18.1	24.2	-3.6	4.9	4.1
Medication: Omeprazole	7.4	8.9	10.4	2.8	-2.9	-3.2
Pack years adult smoking proportion	6.6	10.1	13.3	2.8	-3.0	-3.6
BMI	6.3	36.8	53.4	3.8	-6.5	-7.3
Pack years of smoking	6.2	9.0	13.4	2.5	-2.8	-3.7
Reaction Time	5.9	11.2	16.5	3.8	-4.1	-1.5
Leg fat percentage (right)	5.9	21.5	37.5	2.2	-4.7	-6.1
Leg fat percentage (left)	5.8	21.0	35.5	2.1	-4.8	-6.0
Cardiovascular Disease	5.0	16.6	25.5	3.3	-5.1	-3.7
Body mass index (BMI)	5.0	21.5	31.0	2.7	-5.1	-5.6
Leg fat mass (right)	4.9	18.9	32.3	1.9	-4.6	-5.7
Length of working week for main job	4.8	5.3	6.5	2.0	-2.3	-2.5
Mean time to correctly identify matches	4.8	9.1	12.9	3.6	-3.6	-1.3
Diabetes diagnosed by doctor	4.8	7.8	16.3	1.6	-2.1	-4.0
Leg fat mass (left)	4.7	18.2	30.5	1.9	-4.5	-5.5
Medication: Omeprazole (e.g. Zanprol)	4.6	5.6	7.4	2.7	-2.2	-2.2
Fractured/broken bones in last 5 years	4.4	5.7	8.5	1.1	-2.7	-2.9
Arm fat percentage (right)	4.3	17.0	36.7	1.2	-3.6	-6.1
Average weekly champagne plus white wine intake	4.3	6.0	7.6	-2.4	2.8	2.1
Arm fat mass (right)	4.2	17.1	32.4	1.7	-4.0	-5.7
Age started oral contraceptive pill	4.2	5.3	8.0	-2.8	2.5	1.3
Arm fat mass (left)	4.1	17.0	31.4	1.8	-4.1	-5.6
Whole body fat mass	4.0	16.8	34.6	1.2	-3.8	-5.9
Arm fat percentage (left)	4.0	15.8	34.2	1.2	-3.4	-5.8
Smoking status: Previous	3.9	5.9	7.4	-2.7	1.9	-2.6
Number of treatments/medications taken	3.8	6.9	8.2	2.8	-2.9	-2.2
Body fat percentage	3.8	15.1	34.8	0.6	-3.2	-5.9
Medication: Ramipril	3.6	4.7	9.0	0.9	-2.0	-3.0
Medication for hormone replacement therapy	3.5	3.9	7.5	-2.7	1.8	1.0
Relative age voice broke	3.5	5.4	8.9	-0.7	2.6	3.0
Medication: Metformin	3.4	4.8	6.7	1.9	-2.1	-2.6
Trunk fat mass	3.4	14.7	33.1	0.7	-3.2	-5.8
Waist circumference	3.4	12.6	20.3	1.8	-3.8	-4.5
Diabetes (self-reported)	3.4	5.3	12.8	1.0	-1.5	-3.6
Illnesses of mother	3.4	4.2	6.8	-1.6	1.8	2.6
Trunk fat percentage	3.3	13.1	32.7	0.1	-2.6	-5.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	4.0	10.0	-0.6	1.2	3.2
Number of live births	3.1	4.4	9.9	0.2	-1.8	-3.1
Hypertension (Self-reported)	3.1	8.6	10.2	2.4	-3.2	-3.2
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.7	11.0	-2.7	1.3	3.3
High blood pressure	3.0	8.3	10.5	2.1	-3.2	-3.2
Weight	3.0	14.8	22.9	1.9	-4.2	-4.8
Commuting to job workplace: Walk	3.0	3.3	4.4	-1.1	2.0	2.1
Myopia	3.0	4.3	7.6	-1.6	1.7	2.8
Impedance of arm (right)	2.9	13.7	24.2	-3.9	4.9	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	9.2	-0.4	0.6	3.0
Type 2 Diabetes (T2D) (2018)	2.7	5.0	12.6	0.6	-1.4	-3.5
Diabetes (father)	2.7	3.3	4.6	1.2	-2.1	-2.0
High blood pressure (mother)	2.7	3.8	5.5	0.9	-2.3	-2.3
Impedance of arm (left)	2.7	12.5	23.0	-3.5	4.8	1.5
Number of self-reported non-cancer illnesses	2.7	4.7	9.7	3.1	-1.9	-0.8
Relative age of first facial hair	2.4	4.8	9.3	0.7	2.2	3.1
Had other major operations	2.4	2.9	3.4	1.8	-1.4	-1.9
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	6.6	1.5	0.8	2.6
Impedance of whole body	2.4	12.0	20.7	-3.3	4.5	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	8.9	1.5	-3.0	0.3
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	9.0	-0.9	1.2	3.0
Comparative body size at age 10	2.3	6.3	11.2	-0.2	-2.7	-3.4
Alcohol intake frequency.	2.3	5.3	8.0	2.8	-2.7	-0.7
Ever had bowel cancer screening	2.3	2.7	3.6	-1.8	1.9	1.1
Back pain experienced in last month	2.3	3.3	5.1	2.2	-1.6	1.6
Tinnitus: Yes, now most or all of the time	2.3	2.7	3.7	-1.1	1.9	1.8
Commuting to job workplace: Cycle	2.3	2.8	3.5	-1.8	1.9	1.3
Vascular/heart problems diagnosed by doctor	2.3	6.3	8.5	-1.6	2.9	2.8
Number of incorrect matches in round	2.2	3.6	7.9	1.2	-1.2	-2.8
Past tobacco smoking	2.2	4.0	7.7	1.7	-1.2	2.8
Hip circumference	2.2	9.7	18.3	1.4	-3.0	-4.3
Diastolic blood pressure, automated reading	2.1	6.4	7.0	2.5	-2.6	-2.5
Birth weight of first child	2.0	3.7	6.0	1.1	-2.5	-2.0
Number of full sisters	2.0	2.4	3.8	2.0	-1.6	-0.8
Illnesses of father: High blood pressure	2.0	2.4	4.3	1.6	-2.1	0.6
Ever depressed for a whole week	2.0	2.4	4.9	2.2	-0.7	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	8.0	-2.2	0.4	2.8
Coronary Artery Disease (CAD)	1.8	2.1	3.9	-1.5	2.0	-0.2
Supplements: Glucosamine	1.8	2.4	3.0	1.5	-1.7	1.3
Medication: Atenolol	1.8	2.3	5.3	-0.8	-1.0	-2.3
Mouth/teeth dental problems: Loose teeth	1.8	2.1	4.5	-1.4	2.1	0.2
Medication: Blood pressure	1.8	3.1	6.5	1.2	-1.2	-2.5
Family relationship satisfaction	1.8	2.2	2.9	1.7	-1.6	-1.1
Illnesses of father: None of the above (group 1)	1.8	2.2	4.8	-2.2	1.4	0.0
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	2.3	1.4	-1.5	-1.2
Age at last live birth	1.7	2.5	3.0	-1.7	1.4	1.6
Medication: Blood pressure	1.7	3.2	3.4	1.8	-1.8	-1.7
Arm fat-free mass (left)	1.7	8.7	13.8	2.4	-3.7	-2.6
Taking other prescription medications	1.6	2.5	3.8	1.1	-1.6	-2.0
Medication: Simvastatin	1.6	2.3	3.0	1.2	-1.7	-1.6
Health satisfaction	1.6	2.1	3.4	1.7	-1.8	0.1
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.3	1.8	-0.9	-1.4
Ever smoked	1.6	2.8	7.1	-0.8	0.7	-2.7
Arm predicted mass (left)	1.6	8.4	13.2	2.4	-3.6	-2.5
Bipolar Disorder (2018)	1.5	2.4	5.2	0.5	-1.3	-2.3
Sensitivity / hurt feelings	1.5	2.6	3.8	1.9	-1.9	-0.8
Hand grip strength (right)	1.5	4.0	9.9	-1.5	0.1	3.1
Current tobacco smoking	1.5	2.5	4.7	2.2	-1.5	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.5	1.5	-1.9	-0.7
Stomach or abdominal pain in last month	1.5	1.8	4.4	1.0	-2.1	0.4
Exposure to tobacco smoke at home	1.5	1.6	2.5	0.3	-1.5	-1.6
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.2	-1.4	1.8	0.6
Osteoarthritis (self-reported)	1.5	1.9	3.2	1.6	-0.2	1.8
Smoking status: Current	1.5	2.3	4.9	2.2	-1.3	-0.6
Supplements: Calcium	1.5	1.7	2.3	1.4	-1.5	-0.8
Alzheimer’s Disease (in father)	1.4	1.6	2.2	-1.2	1.1	1.5
Average weekly fortified wine intake	1.4	1.6	2.4	-1.6	1.5	-0.5
Serious illness, injury or assault to yourself	1.4	1.7	2.3	1.1	-1.5	-1.3
Mouth/teeth dental problems: Dentures	1.4	2.3	5.6	2.4	-1.2	0.0
Medication: Lansoprazole	1.4	1.6	4.5	2.1	0.4	-0.4
Medication: Ibuprofen	1.4	1.6	4.2	0.4	-0.7	2.0
Arm predicted mass (right)	1.4	7.1	11.8	2.4	-3.4	-2.0
Body Mass Index (BMI) (2010)	1.3	1.8	3.9	-1.2	-0.5	-2.0
Neuroticism	1.3	3.2	5.1	0.7	-2.0	-2.3
Average weekly spirits intake	1.3	1.6	3.9	0.8	-0.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.3	3.1	0.2	-0.9	1.8
Financial difficulties in last 2 years	1.3	1.7	2.2	1.3	-1.5	-1.1
Arm fat-free mass (right)	1.3	6.7	11.8	2.2	-3.4	-1.9
Chest pain or discomfort	1.3	1.9	2.5	1.6	-1.2	-1.3
Loneliness, isolation	1.3	1.8	2.9	1.4	-0.6	-1.7
Basal metabolic rate	1.3	7.3	11.2	1.9	-3.3	-2.6
Basal cell carcinoma (self-reported)	1.3	1.5	2.9	0.4	-1.3	-1.7
Supplements: Zinc	1.2	1.3	2.8	0.8	0.6	1.7
Falls in the last year	1.2	1.6	2.1	-1.5	1.0	-1.2
Wheeze or whistling in the chest in last year	1.2	2.1	5.9	2.4	-0.7	0.3
Long-standing illness, disability or infirmity	1.2	1.8	3.7	1.9	-1.3	-0.2
Number of operations (self-reported)	1.2	1.8	5.1	-0.5	0.0	-2.3
Breast Cancer	1.1	2.7	5.7	-1.3	2.4	0.9
Blood Eosinophil Count	1.1	8.3	15.1	3.9	-2.2	-2.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.2	0.7	-1.8	-0.9
Systolic blood pressure, automated reading	1.1	3.1	4.7	1.4	-2.2	-1.6
Severe depression (siblings)	1.1	1.2	1.5	-1.1	1.2	0.9
Fed-up feelings	1.1	1.9	3.3	-0.3	-1.8	-1.5
Mouth/teeth dental problems	1.1	1.6	3.8	-2.0	1.0	0.2
Trunk fat-free mass	1.1	6.3	11.0	2.4	-3.3	-1.5
Pulse rate	1.1	1.8	4.1	1.1	-0.5	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.0	0.0	-0.4	2.0
Trunk predicted mass	1.1	6.6	11.0	2.5	-3.3	-1.6
Medication: Amlodipine	1.1	1.6	2.9	1.1	-0.9	-1.7
Pulse wave peak to peak time	1.1	1.2	2.0	0.5	-1.2	1.4
Angina (self-reported)	1.1	1.4	2.7	-1.6	0.4	1.2
Leg pain on walking	1.1	1.4	3.0	-0.5	0.9	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.9	0.6	-1.4	-1.2
Mood swings	1.1	2.0	3.0	0.6	-1.7	-1.7
Whole body water mass	1.1	6.1	10.0	2.0	-3.2	-2.0
Guilty feelings	1.1	1.7	4.9	0.5	-0.2	-2.2
Wears glasses or contact lenses	1.1	1.3	3.1	0.4	-0.7	-1.8
Commuting to job workplace: Public transport	1.1	1.3	2.1	-1.3	1.4	0.4
Eye problems/disorders: Glaucoma	1.1	1.3	2.5	1.2	-1.6	-0.1
Bipolar Disorder or Schizophrenia	1.0	2.5	4.9	0.9	-1.4	-2.2
Rheumatoid Arthritis	1.0	1.4	2.5	1.1	-1.6	-0.7
Smoking Status	1.0	2.5	6.7	0.9	0.1	-2.6
Allergy or Eczema	1.0	2.5	3.2	1.6	-1.3	1.8
Leg fat-free mass (left)	1.0	5.0	7.0	1.1	-2.6	-2.6
Impedance of leg (left)	1.0	5.0	7.1	-1.7	2.7	2.2
Alcohol usually taken with meals	1.0	1.6	3.7	0.9	0.5	1.9
Illnesses of siblings	1.0	1.4	3.3	-0.3	0.9	1.8
Pulse wave Arterial Stiffness index	1.0	1.1	1.6	-0.5	1.2	-1.3
Peak expiratory flow (PEF)	1.0	2.4	3.6	-0.9	1.7	1.9
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.1	-0.5	0.4	1.8
Age at first live birth	1.0	1.7	4.1	-2.0	0.7	0.8
Emphysema/chronic bronchitis	1.0	1.2	3.5	1.9	-0.0	-0.1
Heart disease (mother)	1.0	1.2	3.0	-0.3	-0.7	-1.7
Illnesses of siblings: Diabetes	1.0	1.2	2.0	-1.4	-0.5	-1.2
Whole body fat-free mass	1.0	5.7	9.5	1.9	-3.1	-1.9
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.7	-0.2	0.5	1.9
Medication: Lisinopril	1.0	1.3	2.5	1.6	-1.2	-0.1
Heart disease (siblings)	1.0	1.2	2.2	-0.5	1.1	-1.5
Prostate Cancer	0.9	1.2	3.0	0.6	-0.5	-1.7
Hand grip strength (left)	0.9	2.3	6.6	-0.2	-0.6	2.6
Medication: Co-codamol	0.9	1.1	2.0	0.0	-1.4	-1.1
Diabetes (mother)	0.9	1.2	2.0	1.0	-1.4	-0.7
Impedance of leg (right)	0.9	4.4	7.0	-1.6	2.6	1.9
Leg predicted mass (left)	0.9	4.9	6.8	1.1	-2.6	-2.6
Had menopause	0.9	1.1	3.2	-0.5	1.8	-0.0
Father’s age at death	0.9	1.2	2.5	-0.6	0.9	1.6
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	1.8	1.4	-1.0	1.3
Eye problems/disorders: None of the above	0.9	1.0	1.5	-0.6	1.2	1.1
Miserableness	0.9	1.6	3.4	1.1	-1.9	-0.6
Crohns Disease (2012)	0.8	1.2	2.1	1.0	-0.9	-1.4
HDL Cholesterol	0.8	1.3	1.8	-1.1	0.8	1.4
Triglycerides	0.8	1.4	2.7	-1.1	-0.4	-1.6
Blood White Count	0.8	6.1	15.5	1.6	-0.3	-3.9
Hypothyroidism (self reported)	0.8	1.9	3.8	2.0	-1.1	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.1	-0.4	-0.7	-1.4
Angina	0.8	1.0	1.6	-1.3	0.1	1.2
Maternal smoking around birth	0.8	1.2	2.5	-0.9	1.6	-0.5
Hayfever, allergic rhinitis or eczema	0.8	1.6	2.1	1.4	-1.0	1.4
Allergy	0.8	1.9	3.6	-1.9	0.7	-1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.7	0.7	-0.5	-1.6
Breastfed as a baby	0.8	1.0	1.5	0.3	1.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.3	-1.5	0.9	-0.0
Birth weight	0.8	1.7	3.9	-0.4	-1.0	-2.0
Exposure to tobacco smoke outside home	0.8	1.1	1.5	1.1	-0.7	-1.2
Medication: Allopurinol	0.8	1.1	2.7	-1.6	0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.9	-0.2	-1.4	-0.8
Qualifications: nursing, teaching	0.8	1.3	2.0	1.1	-1.4	-0.7
Eye problems/disorders: Cataract	0.8	0.9	1.8	-1.3	0.1	-0.9
Breast cancer (self-reported)	0.8	0.9	1.9	0.1	-0.9	-1.4
Asthma (self-reported)	0.8	1.6	3.3	1.1	0.5	1.8
Financial situation satisfaction	0.8	1.0	1.7	1.3	-0.7	0.8
High cholesterol (Self-reported)	0.8	1.4	2.3	0.8	-1.5	-1.1
Depressed Affect (Nagel 2018)	0.7	1.4	2.2	0.4	-1.4	-1.5
Schizophrenia vs Biploar Disorder	0.7	1.0	2.5	-0.6	-0.1	1.6
Mean Putamen Volume	0.7	0.8	1.4	1.2	-0.8	-0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	-0.7	0.8	1.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.1	0.3	-0.3	-1.4
Worrier / anxious feelings	0.7	1.4	2.6	-1.2	1.6	-0.4
Asthma	0.7	1.4	3.0	0.7	0.8	1.7
Overall health rating	0.7	1.5	3.0	1.7	-1.2	-0.3
Had major operations	0.7	0.9	1.1	-1.0	-1.0	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.0	0.5	-1.4	-0.5
Leg predicted mass (right)	0.7	3.5	5.2	1.0	-2.3	-2.0
Alcohol drinker status: Never	0.7	0.9	1.7	0.9	-1.3	0.3
Age at First Birth	0.6	0.9	2.4	-1.5	0.6	0.2
Lupus	0.6	0.9	2.1	-1.5	0.0	-0.7
Schizophrenia (2014)	0.6	1.3	2.3	0.7	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	-0.1	-1.4	0.0
Heel T-Score	0.6	4.7	9.7	-1.9	0.9	3.1
Lung FEV1/FVC ratio	0.6	2.9	8.0	0.7	-2.8	0.5
Chronotype (morning person)	0.6	1.5	2.3	1.3	-1.5	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	0.2	0.5	1.4
Medication: Levothyroxine sodium	0.6	1.1	1.8	1.3	-1.2	-0.1
Neuroticism score	0.6	1.3	2.6	0.3	-1.0	-1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	3.3	-1.3	1.0	1.8
Noisy workplace	0.6	0.8	1.1	0.8	-1.1	0.7
Medication: Cholesterol lowering	0.6	1.0	2.5	0.3	-0.6	-1.6
Pulse wave reflection index	0.6	0.7	1.0	-0.4	1.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.2	1.5	-0.9	-0.7
Number of full brothers	0.6	0.8	1.4	-0.1	-0.9	-1.2
Migraine (self-reported)	0.6	0.7	0.8	-0.7	0.8	0.9
Knee pain experienced in last month	0.6	1.0	2.6	1.6	0.4	0.4
Leg fat-free mass (right)	0.6	3.4	5.3	1.0	-2.3	-2.0
Medication: Atorvastatin	0.6	0.7	2.0	-0.4	0.0	-1.4
Risk taking	0.6	0.8	1.5	1.0	0.1	-1.2
Cholesterol lowering medication	0.6	0.8	1.4	0.2	-1.1	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.2	1.5	-0.3	0.0
Alzheimer’s Disease (including proxy)	0.5	0.7	0.9	-0.9	0.9	0.7
Crohns Disease (2017)	0.5	1.1	1.9	1.2	-0.2	-1.4
Blood Red Count	0.5	4.8	8.6	-2.9	2.2	1.0
Respiratory disease	0.5	1.1	1.7	1.3	0.4	1.2
Happiness	0.5	0.6	1.1	-0.8	0.1	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	1.3	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	1.2	-0.4	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	-1.0	1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	1.3	-0.2	-0.3
Average weekly red wine intake	0.5	0.7	1.0	0.5	1.0	0.9
Mineral and other dietary supplements	0.5	0.7	2.0	0.1	-0.1	-1.4
Mother’s age at death	0.5	0.6	1.1	0.2	0.8	1.1
Medication: Paracetamol	0.5	0.7	1.3	0.9	-1.1	0.3
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.4	-0.4	-1.3
Alcohol drinker status: Previous	0.5	0.6	1.0	0.4	1.0	0.7
Depression (Nagel 2018)	0.4	0.7	1.1	1.1	-0.7	-0.6
Neuroticism (Nagel 2018)	0.4	0.8	1.6	-0.1	-0.9	-1.3
Fasting Glucose	0.4	0.5	1.3	1.1	0.3	-0.1
Neuroticism (2016)	0.4	0.5	1.2	0.6	-1.1	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	1.3	-0.6	1.1	-0.0
Vitamin and mineral supplements	0.4	0.5	1.0	-1.0	0.7	-0.3
Sitting height	0.4	3.1	5.2	-2.3	1.8	1.0
Forced vital capacity (FVC)	0.4	1.6	1.9	-1.3	1.4	1.1
Time employed in main current job	0.4	0.5	0.7	0.9	-0.8	0.1
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	0.3	-1.2	-0.4
Prospective memory result	0.4	0.4	1.0	-0.1	-0.5	-1.0
Lung cancer (father)	0.4	0.5	1.3	0.4	-0.2	-1.1
Tense / ‘highly strung’	0.4	0.7	2.1	0.1	0.3	-1.4
Blood clot in the leg (DVT)	0.4	0.6	1.4	1.2	-0.2	-0.5
Gout (self-reported)	0.4	0.5	1.0	-0.3	-0.6	-1.0
High blood pressure (siblings)	0.4	0.6	1.5	0.1	-0.6	-1.2
Medication: Seretide 50 evohaler	0.4	0.5	1.0	0.2	-0.6	-1.0
Pulse rate, automated reading	0.4	1.4	4.0	0.4	0.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	-0.6	0.7	1.4
Pain experienced in last month	0.4	0.6	1.6	-0.4	0.4	-1.3
Schizophrenia (2018)	0.3	0.7	1.0	0.7	-0.7	-1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	0.7	-0.1	-1.2
LDL Cholesterol	0.3	0.5	1.0	-0.6	1.0	-0.1
Blood Platelet Count	0.3	3.6	10.7	3.3	0.1	-0.2
Townsend deprivation index at recruitment	0.3	0.4	0.9	-0.0	-0.5	-1.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.4	-0.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	1.6	-0.7	1.0	1.3
Loud music exposure frequency	0.3	0.3	0.7	0.4	-0.8	0.5
Glaucoma (self-reported)	0.3	0.4	1.1	-0.2	-1.0	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.6	0.8	0.4	0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	2.6	-0.8	1.6	0.6
Illnesses of father: Heart disease	0.3	0.4	1.2	0.3	-0.3	1.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.6	0.8	-0.8	0.6
Medication for cholesterol	0.3	0.4	0.8	-0.4	0.5	0.9
Osteoporosis (self-reported)	0.3	0.4	0.9	0.1	-0.4	-1.0
Medication: Gliclazide	0.3	0.4	0.7	0.1	-0.8	0.6
Ever taken oral contraceptive pill	0.3	0.4	1.1	0.1	-1.0	0.3
Medication: Bendroflumethiazide	0.3	0.5	0.6	0.8	-0.6	-0.8
Worry (Nagel 2018)	0.2	0.4	1.2	-0.1	-0.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	0.0	-1.1	-0.4
Ovarian Cancer	0.2	0.3	0.7	0.4	-0.8	0.3
HbA1C	0.2	0.3	0.5	0.7	0.1	0.6
Ulcerative Colitis	0.2	0.2	0.7	-0.3	0.0	-0.8
Height	0.2	3.4	6.6	-2.6	1.9	0.3
Tanning	0.2	2.5	7.2	0.2	0.5	-2.7
Hearing difficulty/problems: Yes	0.2	0.3	1.0	0.2	-0.1	-1.0
Multivitamins +/- minerals	0.2	0.2	0.5	0.2	-0.3	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.2	-0.8	0.1
Fluid intelligence score	0.2	0.5	1.1	0.5	-1.1	-0.3
Depression (self-reported)	0.2	0.2	0.6	-0.0	-0.8	-0.4
Standing height	0.2	1.5	1.9	-1.3	1.4	1.0
Medication: Paracetamol	0.2	0.3	0.5	0.6	-0.5	0.7
Worry too long after embarrassment	0.2	0.3	0.7	-0.8	-0.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.4	-0.5	0.7
Comparative height size at age 10	0.2	1.0	2.8	0.1	-0.5	-1.7
Supplements: Vitamin C	0.2	0.2	0.3	0.5	-0.6	0.2
Friendships satisfaction	0.2	0.3	0.8	0.2	0.1	0.9
Medication: Aspirin	0.2	0.3	0.4	0.5	-0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	-0.0	-0.7	-0.2
Ulcerative Colitis (UC)	0.1	0.1	0.4	-0.1	0.0	-0.7
Waist Hip Ratio (WHR)	0.1	0.4	1.2	-0.3	-1.1	-0.0
Systolic Blood Pressure	0.1	0.4	0.9	0.3	-0.9	0.4
Lung FVC	0.1	0.5	0.9	-1.0	0.7	0.3
Hair Pigment	0.1	2.5	5.5	-1.4	2.3	0.3
Nervous feelings	0.1	0.2	0.6	-0.4	0.7	0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.0	0.4	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	0.2	0.1	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.5	0.3	0.3
Qualifications: None of the above	0.1	0.3	0.6	-0.7	0.2	-0.6
Heart attack	0.1	0.1	0.3	0.1	-0.0	-0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.3	0.2	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.8	-0.1	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.1	-0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.0	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	-0.4	0.9	0.1
Headache pain in last month	0.1	0.1	0.3	-0.3	-0.5	-0.2
Number of children fathered	0.1	0.2	0.2	0.2	0.4	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.1	-0.3	0.4	0.1
Qualifications: College or University degree	0.1	0.4	0.9	-1.0	0.2	0.4
Neck or shoulder pain in last month	0.1	0.2	0.2	0.5	-0.5	-0.1
Medication: Aspirin	0.1	0.2	0.4	0.4	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.8	0.3	0.2	0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.0	-0.1	0.5
Irritability	0.1	0.1	0.2	-0.3	0.0	-0.4
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.0	-0.5	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.4	-0.2	-0.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.1	-0.1	0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.1	0.2	0.1	-0.1	-0.4
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.2	-0.0	0.3
Suffer from ‘nerves’	0.0	0.0	0.0	0.1	0.1	0.0
Hearing aid user	0.0	0.0	0.0	0.0	0.1	0.2
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.2	-0.0	-0.4	0.1

Hub : Genes

CRTC1

Models

Trait associations