Best TWAS P=6.86e-09 · Best GWAS P=3.51e-08 conditioned to 0.225
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DDHD2 | 0.04 | 0.04 | bslmm | 286 | 0.04 | 2.0e-05 | -5.2 | -5.1 | 3.0e-07 | 0.94 | 0.04 | 0.96 | FALSE |
2 | GTEx | Adrenal Gland | DDHD2 | 0.25 | 0.21 | lasso | 2 | 0.19 | 1.7e-07 | -5.4 | -5.3 | 1.1e-07 | 0.99 | 0.04 | 0.96 | FALSE |
3 | GTEx | Artery Tibial | DDHD2 | 0.07 | 0.07 | lasso | 2 | 0.05 | 7.3e-05 | -5.4 | -5.4 | 7.1e-08 | 1.00 | 0.03 | 0.96 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | RP11-350N15.5 | 0.12 | 0.10 | lasso | 2 | 0.07 | 3.9e-03 | -5.5 | 5.5 | 4.5e-08 | -0.99 | 0.03 | 0.84 | FALSE |
5 | GTEx | Colon Sigmoid | DDHD2 | 0.15 | 0.15 | lasso | 3 | 0.12 | 7.5e-05 | -5.2 | -5.2 | 1.9e-07 | 0.97 | 0.06 | 0.89 | FALSE |
6 | GTEx | Liver | DDHD2 | 0.29 | 0.01 | lasso | 5 | -0.01 | 5.4e-01 | -5.2 | -5.1 | 2.8e-07 | 0.90 | 0.03 | 0.64 | FALSE |
7 | GTEx | Spleen | DDHD2 | 0.17 | 0.17 | lasso | 2 | 0.11 | 7.8e-04 | -5.4 | -5.4 | 6.2e-08 | 1.00 | 0.04 | 0.89 | FALSE |
8 | GTEx | Stomach | DDHD2 | 0.13 | 0.06 | lasso | 2 | 0.06 | 1.1e-03 | -5.4 | -5.4 | 5.9e-08 | 0.97 | 0.04 | 0.90 | FALSE |
9 | NTR | Blood | BAG4 | 0.01 | 0.01 | blup | 253 | 0.01 | 3.9e-03 | -5.0 | 5.6 | 1.8e-08 | -0.95 | 0.05 | 0.92 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | PPAPDC1B | 0.06 | 0.08 | enet | 14 | 0.09 | 4.0e-11 | -5.4 | -5.4 | 8.2e-08 | 0.99 | 0.03 | 0.97 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | LSM1 | 0.09 | 0.16 | lasso | 6 | 0.16 | 7.3e-20 | -5.0 | 5.2 | 2.4e-07 | -0.96 | 0.16 | 0.83 | FALSE |
12 | YFS | Blood | BAG4 | 0.01 | 0.01 | bslmm | 234 | 0.00 | 2.6e-02 | -4.6 | -5.8 | 6.9e-09 | 0.84 | 0.06 | 0.70 | TRUE |
13 | YFS | Blood | LSM1 | 0.02 | 0.00 | bslmm | 218 | 0.01 | 4.1e-04 | -2.8 | 5.7 | 9.6e-09 | -0.84 | 0.04 | 0.94 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DDHD2 | 0.01 | 0.01 | blup | 21 | 0.01 | 2.3e-03 | -5.4 | -5.5 | 3.1e-08 | 0.98 | 0.02 | 0.75 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DDHD2 | 0.03 | 0.03 | blup | 21 | 0.03 | 3.5e-04 | -5.3 | -5.5 | 3.5e-08 | 0.99 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPAPDC1B | 0.02 | 0.00 | blup | 18 | 0.01 | 4.2e-02 | -5.2 | -5.7 | 1.6e-08 | 0.97 | 0.01 | 0.54 | FALSE |
17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DDHD2 | 0.07 | 0.05 | blup | 21 | 0.05 | 2.7e-03 | -5.2 | -5.4 | 7.9e-08 | 0.98 | 0.02 | 0.70 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DDHD2 | 0.11 | 0.08 | lasso | 3 | 0.08 | 1.9e-08 | -5.2 | -5.2 | 1.9e-07 | 0.97 | 0.03 | 0.97 | FALSE |
19 | The Cancer Genome Atlas | Thyroid Carcinoma | DDHD2 | 0.02 | 0.01 | blup | 21 | 0.01 | 2.4e-02 | -5.4 | -5.3 | 9.4e-08 | 0.99 | 0.01 | 0.78 | FALSE |