Best TWAS P=5.8e-11 · Best GWAS P=5.53e-11 conditioned to 0.278
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DDX4 | 0.08 | 0.07 | bslmm | 390 | 0.08 | 1.7e-10 | 5.7 | -5.6 | 2.0e-08 | -0.85 | 0.05 | 0.95 | FALSE |
| 2 | GTEx | Brain Cerebellum | SLC38A9 | 0.26 | 0.13 | lasso | 4 | 0.10 | 7.4e-04 | 6.2 | 6.1 | 8.4e-10 | 0.84 | 0.04 | 0.92 | FALSE |
| 3 | GTEx | Brain Hippocampus | GZMA | 0.32 | 0.00 | lasso | 6 | 0.02 | 1.3e-01 | 4.2 | 6.1 | 1.3e-09 | 0.37 | 0.06 | 0.38 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | GPX8 | 0.04 | 0.00 | lasso | 2 | 0.03 | 5.0e-02 | 6.3 | -6.1 | 1.2e-09 | -0.89 | 0.05 | 0.24 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | DDX4 | 0.07 | 0.08 | lasso | 2 | 0.07 | 1.5e-09 | 5.6 | -5.7 | 1.6e-08 | -0.79 | 0.17 | 0.83 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPAP2A | 0.06 | 0.03 | lasso | 1 | 0.03 | 1.1e-06 | 6.4 | -6.4 | 1.4e-10 | -0.78 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC38A9 | 0.04 | 0.02 | enet | 7 | 0.03 | 6.6e-03 | 6.1 | 6.1 | 1.1e-09 | 0.86 | 0.02 | 0.72 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC38A9 | 0.03 | 0.04 | blup | 52 | 0.04 | 2.0e-04 | 6.3 | 6.5 | 5.8e-11 | 0.95 | 0.03 | 0.96 | TRUE |