Best TWAS P=1.31e-09 · Best GWAS P=3.72e-11 conditioned to 0.0654
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -5.3 | 5.3 | 1.1e-07 | -0.12 | 0.54 | 0.27 | TRUE |
| 2 | YFS | Blood | R3HCC1 | 0.03 | 0.01 | lasso | 6 | 0.01 | 5.3e-04 | -5.8 | 5.6 | 1.9e-08 | -0.73 | 0.03 | 0.97 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STC1 | 0.04 | 0.05 | enet | 7 | 0.06 | 8.9e-12 | -5.7 | 5.5 | 3.7e-08 | -0.05 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC25A37 | 0.11 | 0.09 | lasso | 5 | 0.09 | 7.8e-10 | -4.7 | -5.2 | 2.7e-07 | 0.07 | 0.82 | 0.17 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 3.0 | -5.3 | 1.2e-07 | 0.51 | 0.06 | 0.12 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CHMP7 | 0.10 | 0.02 | lasso | 6 | 0.04 | 5.4e-05 | 3.0 | -6.1 | 1.3e-09 | 0.74 | 0.00 | 0.99 | TRUE |