[Hub]/) : Traits : Whole body water mass :

chr10:101,548,177-103,428,898

Best TWAS P=5.81e-33 · Best GWAS P=1.38e-30 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex SEC31B 0.13 0.21 lasso 3 0.20 4.1e-24 -6.0 6.0 1.8e-09 0.05 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous SEC31B 0.32 0.39 lasso 5 0.38 5.1e-33 -6.0 6.0 2.6e-09 0.05 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RP11-179B2.2 0.15 0.08 lasso 6 0.08 3.2e-07 9.3 10.2 3.2e-24 0.90 0.02 0.98 FALSE
4 GTEx Adipose Visceral Omentum SEC31B 0.18 0.28 lasso 10 0.27 1.5e-14 -5.4 5.9 3.7e-09 0.07 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum RP11-179B2.2 0.13 0.02 lasso 3 0.03 6.5e-03 11.5 11.0 2.4e-28 0.99 0.00 0.99 FALSE
6 GTEx Artery Aorta SEC31B 0.26 0.24 lasso 3 0.23 1.0e-12 -6.0 5.6 2.3e-08 0.06 1.00 0.00 FALSE
7 GTEx Artery Aorta RP11-179B2.2 0.16 0.11 lasso 2 0.09 7.6e-06 11.5 11.3 1.3e-29 0.98 0.00 1.00 FALSE
8 GTEx Artery Tibial SEC31B 0.25 0.32 lasso 6 0.33 1.3e-26 -5.4 5.7 1.3e-08 0.07 1.00 0.00 FALSE
9 GTEx Artery Tibial RP11-179B2.2 0.11 0.09 lasso 4 0.08 8.8e-07 11.5 11.3 1.1e-29 0.96 0.00 1.00 FALSE
10 GTEx Brain Cerebellum SEC31B 0.24 0.12 enet 52 0.08 2.0e-03 -5.4 5.2 2.6e-07 0.05 0.63 0.04 FALSE
11 GTEx Brain Cerebellum RP11-179B2.2 0.37 0.21 lasso 4 0.20 1.4e-06 11.5 12.0 5.8e-33 0.96 0.00 0.99 TRUE
12 GTEx Brain Cortex SEC31B 0.18 0.09 lasso 7 0.07 7.1e-03 -5.4 5.7 1.1e-08 0.07 0.40 0.03 FALSE
13 GTEx Brain Frontal Cortex BA9 RP11-179B2.2 0.22 0.15 lasso 2 0.11 7.2e-04 11.5 10.9 1.4e-27 0.98 0.00 0.97 FALSE
14 GTEx Breast Mammary Tissue SEC31B 0.17 0.26 lasso 5 0.25 2.9e-13 -6.0 5.8 5.2e-09 0.05 1.00 0.00 FALSE
15 GTEx Breast Mammary Tissue RP11-179B2.2 0.11 0.09 lasso 2 0.07 1.8e-04 11.5 10.7 7.4e-27 0.96 0.01 0.99 FALSE
16 GTEx Breast Mammary Tissue (Male) SEC31B 0.13 0.08 lasso 4 0.10 3.0e-03 -6.0 6.0 2.4e-09 0.05 0.27 0.04 FALSE
17 GTEx Breast Mammary Tissue (Male) RP11-179B2.2 0.16 -0.01 enet 4 -0.01 7.1e-01 -10.8 11.0 5.9e-28 0.77 0.03 0.46 FALSE
18 GTEx Breast Mammary Tissue (Female) RP11-179B2.2 0.19 0.00 lasso 3 -0.01 5.1e-01 9.3 6.8 8.4e-12 0.65 0.03 0.44 FALSE
19 GTEx Cells EBV-transformed lymphocytes SEC31B 0.23 0.11 enet 13 0.12 9.2e-05 -6.0 5.5 4.6e-08 0.07 0.75 0.01 FALSE
20 GTEx Cells Transformed fibroblasts SEC31B 0.14 0.19 enet 17 0.22 1.6e-16 -6.0 5.8 8.5e-09 0.06 1.00 0.00 FALSE
21 GTEx Colon Transverse SEC31B 0.28 0.12 lasso 3 0.09 3.3e-05 -6.0 6.0 1.5e-09 0.07 0.98 0.00 FALSE
22 GTEx Esophagus Gastroesophageal Junction SEC31B 0.15 0.21 lasso 4 0.20 8.0e-08 -6.0 6.0 2.4e-09 0.05 0.96 0.00 FALSE
23 GTEx Esophagus Mucosa SEC31B 0.14 0.18 lasso 4 0.17 2.0e-11 -6.0 6.0 2.4e-09 0.05 1.00 0.00 FALSE
24 GTEx Esophagus Mucosa HIF1AN 0.14 0.08 lasso 7 0.09 2.2e-06 -6.1 6.0 1.9e-09 0.09 0.98 0.00 FALSE
25 GTEx Esophagus Muscularis SEC31B 0.18 0.19 lasso 4 0.20 4.5e-12 -6.0 6.0 2.6e-09 0.05 1.00 0.00 FALSE
26 GTEx Esophagus Muscularis RP11-179B2.2 0.15 0.16 lasso 3 0.16 8.1e-10 11.3 11.3 1.1e-29 0.98 0.01 0.99 FALSE
27 GTEx Heart Atrial Appendage MRPL43 0.16 0.07 lasso 4 0.09 5.8e-05 -4.8 -5.6 2.3e-08 -0.62 0.39 0.15 FALSE
28 GTEx Heart Left Ventricle SEC31B 0.09 0.07 lasso 1 0.04 2.1e-03 -5.4 5.4 5.5e-08 0.08 0.48 0.02 FALSE
29 GTEx Heart Left Ventricle RP11-179B2.2 0.15 0.18 enet 2 0.14 4.8e-08 11.5 11.5 1.4e-30 1.00 0.00 1.00 FALSE
30 GTEx Lung SEC31B 0.19 0.21 enet 18 0.20 2.0e-15 -5.4 5.7 1.6e-08 0.07 1.00 0.00 FALSE
31 GTEx Lung RP11-179B2.2 0.18 0.12 lasso 3 0.12 1.7e-09 11.5 11.0 3.8e-28 0.99 0.00 1.00 FALSE
32 GTEx Muscle Skeletal SEC31B 0.08 0.09 lasso 5 0.08 4.9e-08 -5.4 5.3 1.2e-07 0.07 1.00 0.00 FALSE
33 GTEx Muscle Skeletal HIF1AN 0.05 0.06 lasso 1 0.05 1.6e-05 -6.0 -6.0 1.7e-09 -0.06 0.94 0.00 FALSE
34 GTEx Nerve Tibial SEC31B 0.42 0.42 lasso 9 0.43 1.4e-32 -6.0 5.9 4.4e-09 0.06 1.00 0.00 FALSE
35 GTEx Nerve Tibial RP11-179B2.2 0.15 0.08 lasso 2 0.12 6.4e-09 11.3 9.2 4.8e-20 0.88 0.01 0.99 FALSE
36 GTEx Pancreas SEC31B 0.24 0.19 lasso 5 0.17 9.9e-08 -6.0 5.8 5.7e-09 0.06 0.97 0.00 FALSE
37 GTEx Prostate SEC31B 0.18 0.14 lasso 2 0.12 6.7e-04 -6.0 6.0 2.4e-09 0.05 0.38 0.05 FALSE
38 GTEx Skin Not Sun Exposed Suprapubic SEC31B 0.15 0.16 lasso 4 0.15 8.3e-09 -6.0 6.0 2.4e-09 0.05 0.99 0.00 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic HIF1AN 0.13 0.03 lasso 5 0.02 3.4e-02 -6.1 6.2 4.1e-10 0.04 0.26 0.03 TRUE
40 GTEx Skin Not Sun Exposed Suprapubic RP11-179B2.2 0.27 0.15 enet 36 0.15 2.0e-08 11.5 9.8 1.7e-22 0.75 0.00 1.00 FALSE
41 GTEx Skin Sun Exposed Lower leg SEC31B 0.20 0.34 lasso 4 0.34 8.3e-29 -6.0 5.9 4.1e-09 0.06 1.00 0.00 FALSE
42 GTEx Skin Sun Exposed Lower leg HIF1AN 0.07 0.05 lasso 8 0.03 2.2e-03 -6.2 6.0 1.6e-09 0.06 0.93 0.00 FALSE
43 GTEx Skin Sun Exposed Lower leg RP11-179B2.2 0.12 0.09 lasso 2 0.08 1.7e-07 9.2 8.9 8.1e-19 0.86 0.06 0.94 FALSE
44 GTEx Spleen SEC31B 0.21 0.12 lasso 3 0.05 2.3e-02 -6.0 6.1 1.0e-09 0.05 0.28 0.09 FALSE
45 GTEx Testis SEC31B 0.11 0.11 lasso 5 0.08 2.5e-04 -6.0 6.0 1.6e-09 0.05 0.84 0.01 FALSE
46 GTEx Testis HIF1AN 0.12 0.08 lasso 3 0.06 1.6e-03 -6.2 6.2 4.1e-10 0.08 0.34 0.04 FALSE
47 GTEx Thyroid SEC31B 0.28 0.32 lasso 5 0.31 4.9e-24 -6.0 5.7 1.0e-08 0.03 1.00 0.00 FALSE
48 GTEx Thyroid RP11-179B2.2 0.18 0.12 lasso 7 0.11 8.3e-09 9.3 10.1 7.3e-24 0.91 0.04 0.96 FALSE
49 GTEx Uterus SEC31B 0.40 0.14 lasso 18 0.05 3.1e-02 -6.1 5.9 3.3e-09 0.02 0.36 0.04 FALSE
50 GTEx Whole Blood SEC31B 0.11 0.14 lasso 7 0.12 1.8e-11 -5.4 5.2 1.6e-07 0.09 1.00 0.00 FALSE
51 GTEx Whole Blood HIF1AN 0.15 0.12 enet 7 0.12 8.7e-11 -6.2 6.1 8.1e-10 0.06 1.00 0.00 FALSE
52 METSIM Adipose MRPL43 0.05 0.04 bslmm 422 0.04 1.9e-06 -5.1 7.9 2.1e-15 0.46 0.94 0.02 FALSE
53 METSIM Adipose SEC31B 0.15 0.27 enet 29 0.28 1.0e-41 -5.9 5.6 1.7e-08 0.05 1.00 0.00 FALSE
54 NTR Blood HIF1AN 0.02 0.03 lasso 2 0.02 1.4e-07 -6.0 6.1 1.2e-09 0.05 1.00 0.00 FALSE
55 NTR Blood SEC31B 0.03 0.03 lasso 4 0.03 1.1e-10 -6.0 6.0 2.6e-09 0.06 1.00 0.00 FALSE
56 ROSMAP Brain Pre-frontal Cortex MRPL43 0.10 0.08 bslmm 411 0.09 1.2e-11 -5.1 -6.5 5.8e-11 -0.56 1.00 0.00 FALSE
57 ROSMAP Brain Pre-frontal Cortex SEC31B 0.13 0.17 enet 36 0.18 3.0e-22 -5.9 5.6 2.1e-08 0.05 1.00 0.00 FALSE
58 YFS Blood HIF1AN 0.06 0.06 lasso 30 0.07 2.5e-22 -5.4 5.5 3.9e-08 0.07 1.00 0.00 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma MRPL43 0.02 0.02 enet 4 0.03 1.5e-06 -5.1 -5.4 6.2e-08 -0.51 0.98 0.00 FALSE
60 The Cancer Genome Atlas Breast Invasive Carcinoma SEC31B 0.09 0.13 blup 51 0.15 7.1e-29 -6.0 5.7 1.0e-08 0.05 0.04 0.96 FALSE
61 The Cancer Genome Atlas Colon Adenocarcinoma HIF1AN 0.07 0.03 blup 40 0.05 4.9e-04 -6.0 6.1 9.9e-10 0.05 0.03 0.84 FALSE
62 The Cancer Genome Atlas Colon Adenocarcinoma MRPL43 0.07 0.02 blup 52 0.00 1.7e-01 10.9 -10.4 3.8e-25 -0.80 0.01 0.82 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma SEC31B 0.06 0.07 blup 51 0.08 2.9e-05 -5.4 6.0 2.6e-09 0.06 0.04 0.95 FALSE
64 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MRPL43 0.03 0.02 blup 52 0.03 3.0e-04 -4.8 -7.4 1.7e-13 -0.68 0.10 0.50 FALSE
65 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 1.3e-06 -6.0 6.0 2.1e-09 0.05 0.03 0.97 FALSE
66 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEC31B 0.05 0.05 blup 51 0.05 8.9e-07 -6.0 6.0 2.3e-09 0.06 0.03 0.97 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SEMA4G 0.04 0.01 blup 52 0.02 1.2e-03 9.2 9.4 4.0e-21 0.83 0.01 0.79 FALSE
68 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SEC31B 0.14 0.10 lasso 7 0.10 1.6e-06 -6.1 6.1 1.1e-09 0.05 0.03 0.97 FALSE
69 The Cancer Genome Atlas Brain Lower Grade Glioma NDUFB8 0.02 0.01 blup 38 0.01 1.6e-02 -5.4 -6.0 1.4e-09 -0.06 0.03 0.59 FALSE
70 The Cancer Genome Atlas Brain Lower Grade Glioma SEC31B 0.06 0.06 blup 51 0.06 1.1e-07 -6.0 6.2 7.6e-10 0.05 0.03 0.97 FALSE
71 The Cancer Genome Atlas Brain Lower Grade Glioma SEMA4G 0.03 0.01 blup 52 0.01 4.2e-02 11.3 8.7 4.9e-18 0.83 0.00 0.90 FALSE
72 The Cancer Genome Atlas Brain Lower Grade Glioma WNT8B 0.07 0.10 blup 34 0.11 1.7e-12 -5.4 -5.4 8.5e-08 -0.07 0.08 0.92 FALSE
73 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MRPL43 0.05 0.05 enet 9 0.05 3.0e-03 -5.1 -5.4 6.0e-08 -0.44 0.12 0.07 FALSE
74 The Cancer Genome Atlas Lung Adenocarcinoma SEC31B 0.06 0.08 enet 10 0.09 4.6e-11 -6.0 5.8 5.9e-09 0.06 0.03 0.97 FALSE
75 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SEC31B 0.11 0.12 enet 15 0.13 1.5e-14 -6.1 5.8 8.9e-09 0.06 0.03 0.97 FALSE
76 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MRPL43 0.06 0.04 blup 51 0.04 7.4e-04 -5.1 -6.1 9.9e-10 -0.52 0.55 0.08 FALSE
77 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SEC31B 0.10 0.09 blup 51 0.10 2.5e-07 -4.4 5.4 5.9e-08 0.07 0.07 0.93 FALSE
78 The Cancer Genome Atlas Pancreatic Adenocarcinoma SEC31B 0.15 0.14 lasso 12 0.15 8.5e-07 -5.9 6.0 2.1e-09 0.06 0.03 0.96 FALSE
79 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FAM178A 0.14 0.08 lasso 2 0.08 5.9e-04 -9.1 -8.1 7.4e-16 -0.54 0.07 0.13 FALSE
80 The Cancer Genome Atlas Prostate Adenocarcinoma MRPL43 0.13 0.16 lasso 10 0.15 2.4e-15 -5.1 -5.3 8.9e-08 -0.41 1.00 0.00 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma SEC31B 0.23 0.23 enet 20 0.26 8.6e-27 -5.9 5.4 6.2e-08 0.06 0.06 0.94 FALSE
82 The Cancer Genome Atlas Stomach Adenocarcinoma MRPL43 0.10 0.07 blup 51 0.09 3.3e-07 -5.1 -5.3 9.4e-08 -0.42 0.98 0.01 FALSE
83 The Cancer Genome Atlas Stomach Adenocarcinoma SEC31B 0.07 0.09 blup 51 0.09 4.1e-07 -5.5 5.6 1.7e-08 0.07 0.12 0.88 FALSE
84 The Cancer Genome Atlas Testicular Germ Cell Tumors SEC31B 0.24 0.20 blup 51 0.28 1.7e-10 -6.1 5.8 7.1e-09 0.06 0.05 0.95 FALSE
85 The Cancer Genome Atlas Thyroid Carcinoma SEC31B 0.12 0.19 blup 51 0.20 1.1e-18 -5.4 5.8 6.9e-09 0.07 0.41 0.59 FALSE
86 The Cancer Genome Atlas Thyroid Carcinoma SEMA4G 0.07 0.08 blup 52 0.08 5.1e-08 -4.8 7.8 8.4e-15 0.75 0.04 0.96 FALSE