TWAS hub - WNT8B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0741	0.0424	2.2e-12	0.100	0.110	0.107	NA	0.101	1.8e-11	1.7e-12	3.7e-12	NA	1.7e-11
2	TCGA	Prostate Adenocarcinoma	0.0532	0.0441	6.5e-04	0.035	0.012	0.014	NA	0.015	1.2e-04	1.9e-02	1.2e-02	NA	9.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Pulse rate, automated reading	10.6	34.1	35.5	-6.0	5.7
Birth weight	7.8	16.9	17.6	-4.2	4.0
Leg fat-free mass (left)	5.5	29.3	36.4	-6.0	4.7
Medication: Metformin	5.4	7.6	8.9	-3.0	2.5
Chronic bronchitis/emphysema (father)	5.4	6.3	7.2	2.7	-2.3
Leg predicted mass (left)	5.4	28.8	36.0	-6.0	4.6
Neck or shoulder pain in last month	5.4	7.7	8.3	-2.9	2.7
Leg fat-free mass (right)	5.4	28.6	35.6	-6.0	4.7
Leg predicted mass (right)	5.2	27.7	34.6	-5.9	4.6
Hearing difficulty/problems: Yes	5.1	7.7	8.6	-2.9	2.6
Diabetes (self-reported)	5.1	7.9	8.9	-3.0	2.6
Fractured/broken bones in last 5 years	4.8	6.2	6.5	-2.6	2.4
Average weekly beer plus cider intake	4.4	6.4	7.3	2.7	-2.4
Diabetes (father)	4.2	5.1	5.8	-2.4	2.1
Illnesses of father: None of the above (group 1)	4.2	5.2	6.3	2.0	-2.5
Mouth/teeth dental problems: Dentures	4.1	6.9	8.1	-2.4	2.8
Sitting height	4.0	28.1	32.4	-5.7	4.9
Basal metabolic rate	4.0	22.0	28.6	-5.3	3.9
Impedance of leg (left)	3.9	18.8	23.7	4.9	-3.7
Birth weight of first child	3.9	7.1	7.7	-2.8	2.5
Whole body fat-free mass	3.9	22.3	29.2	-5.4	3.9
Commuting to job workplace: Walk	3.9	4.2	4.2	-2.0	2.0
Whole body water mass	3.9	22.0	28.7	-5.4	3.9
Type 2 Diabetes (T2D) (2018)	3.7	7.0	8.5	-2.9	2.3
Comparative height size at age 10	3.5	19.4	22.8	-4.8	4.0
Forced expiratory volume in 1-second (FEV1), predicted	3.4	7.1	8.7	-2.9	2.4
Hand grip strength (left)	3.3	8.6	9.0	-3.0	2.9
Taking other prescription medications	3.3	5.1	6.0	2.5	-2.0
Weight	3.3	16.2	20.5	-4.5	3.4
Diabetes diagnosed by doctor	3.3	5.4	6.2	-2.5	2.1
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	3.8	-1.8	2.0
Hand grip strength (right)	3.2	8.6	10.3	-3.2	2.6
Trunk fat-free mass	3.1	17.7	23.9	-4.9	3.4
Pulse rate	3.1	5.2	6.3	-2.0	2.5
Trunk predicted mass	3.1	17.8	23.9	-4.9	3.4
Arm fat-free mass (right)	3.1	15.7	21.3	-4.6	3.2
Arm fat-free mass (left)	3.1	15.9	21.3	-4.6	3.2
Arm predicted mass (left)	3.0	15.2	20.8	-4.6	3.1
Headache pain in last month	2.9	5.0	6.0	-2.0	2.5
Arm predicted mass (right)	2.9	14.8	20.2	-4.5	3.0
Standing height	2.8	28.2	31.0	-5.6	5.0
Supplements: Calcium	2.8	3.1	4.1	1.5	-2.0
Impedance of leg (right)	2.7	13.2	16.9	4.1	-3.1
Number of live births	2.6	3.6	4.2	1.7	-2.0
Happiness	2.6	3.2	3.2	-1.8	1.8
Worry too long after embarrassment	2.6	4.4	4.9	2.0	-2.2
Illnesses of father: Heart disease	2.6	3.6	5.2	-1.4	2.3
Hearing aid user	2.6	3.0	3.1	-1.7	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	4.4	2.1	-1.8
Peak expiratory flow (PEF)	2.5	5.8	7.3	-2.7	2.1
Irritability	2.5	4.2	4.7	-2.2	1.9
Hypothyroidism (self reported)	2.4	5.5	5.6	-2.4	2.3
Hip circumference	2.4	10.4	13.5	-3.7	2.7
Mouth/teeth dental problems: Bleeding gums	2.4	3.2	3.2	1.8	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.8	3.0	1.6	-1.7
Number of incorrect matches in round	2.3	3.8	5.1	2.2	-1.6
Forced expiratory volume in 1-second (FEV1)	2.3	7.9	10.1	-3.2	2.4
Serious illness, injury or assault to yourself	2.2	2.6	2.7	-1.6	1.6
Length of working week for main job	2.2	2.4	2.6	-1.5	1.6
Tense / ‘highly strung’	2.2	3.6	4.4	2.1	-1.7
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	3.0	-1.6	1.7
Mean Putamen Volume	2.1	2.5	2.7	-1.6	1.5
Heel T-Score	2.1	17.1	20.9	4.6	-3.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.5	8.0	-2.8	2.3
Chronic bronchitis/emphysema (mother)	2.1	2.4	2.5	1.5	-1.6
Health satisfaction	2.1	2.7	3.3	-1.8	1.5
Ulcerative Colitis	2.0	2.9	3.3	1.5	-1.8
Height	2.0	38.8	42.0	-6.5	6.0
Diastolic blood pressure, automated reading	2.0	6.1	6.4	-2.5	2.4
Blood clot in the leg (DVT)	1.9	2.5	2.8	-1.5	1.7
Forced vital capacity (FVC)	1.8	7.0	8.7	-3.0	2.3
Forced vital capacity (FVC), Best measure	1.8	6.7	8.1	-2.8	2.3
Illnesses of siblings: Diabetes	1.8	2.3	3.2	-1.1	1.8
Back pain experienced in last month	1.8	2.6	3.3	1.8	-1.4
Arm fat mass (left)	1.8	7.5	10.0	-3.2	2.2
Average weekly champagne plus white wine intake	1.8	2.5	3.2	1.4	-1.8
Primary Biliary Cirrhosis	1.7	2.4	2.5	1.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	2.6	-1.3	1.6
Time employed in main current job	1.7	2.0	2.1	-1.4	1.4
Prospective memory result	1.7	2.1	2.4	1.3	-1.6
Arm fat mass (right)	1.7	6.9	9.3	-3.0	2.1
Trunk fat mass	1.6	7.0	8.8	-3.0	2.3
Medication: Lansoprazole	1.6	1.9	2.1	1.4	-1.3
Pain experienced in last month	1.6	2.7	3.5	1.4	-1.9
Impedance of whole body	1.6	8.1	11.1	3.3	-2.3
Intelligence (Savage-Jansen 2018)	1.5	4.6	4.8	-2.1	2.2
Bipolar Disorder (2011)	1.5	1.5	1.7	-1.3	1.1
Coronary Artery Disease (CAD)	1.5	1.8	2.2	1.2	-1.5
LDL Cholesterol	1.5	2.3	3.1	1.8	-1.2
Whole body fat mass	1.5	6.1	7.9	-2.8	2.1
Age at last live birth	1.5	2.2	2.9	1.3	-1.7
Medication: Lisinopril	1.5	1.9	2.3	1.3	-1.5
Crohns Disease (2012)	1.4	2.2	2.4	1.6	-1.4
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.0	1.4	-1.3
Maternal smoking around birth	1.4	2.0	2.3	1.5	-1.3
Qualifications: A levels/AS levels or equivalent	1.4	3.0	3.9	-2.0	1.5
Loud music exposure frequency	1.4	1.5	1.8	1.3	-1.1
Number of full brothers	1.4	1.8	2.1	-1.2	1.4
Friendships satisfaction	1.4	1.7	2.3	-1.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	1.7	1.3	-1.3
Verbal and Numeric Reasoning (VNR)	1.3	3.1	3.4	-1.8	1.7
Lupus	1.3	2.0	2.1	1.4	-1.4
Blood White Count	1.3	9.4	10.0	3.2	-3.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	3.0	-1.4	1.7
Had major operations	1.3	1.6	1.8	-1.2	1.3
Wears glasses or contact lenses	1.3	1.5	1.9	1.4	-1.0
Commuting to job workplace: Public transport	1.3	1.5	2.2	-1.5	0.9
Risk taking	1.3	1.9	2.3	1.5	-1.3
Type 2 Diabetes (T2D) (2012)	1.2	1.4	1.7	-1.3	1.0
Supplements: Zinc	1.2	1.4	1.6	-1.3	1.0
Number of full sisters	1.2	1.5	1.5	-1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	1.7	1.3	-0.9
Medication: Atorvastatin	1.2	1.5	1.8	1.4	-1.0
Age started oral contraceptive pill	1.2	1.5	2.2	-0.9	1.5
Age at First Birth	1.1	1.6	1.6	-1.2	1.3
Waist circumference	1.1	4.0	5.3	-2.3	1.7
Leg fat mass (right)	1.1	4.3	5.8	-2.4	1.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	2.2	-1.5	1.4
Multivitamins +/- minerals	1.0	1.2	1.5	1.0	-1.2
Falls in the last year	1.0	1.3	2.1	-0.7	1.4
Breastfed as a baby	1.0	1.3	1.7	-0.9	1.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	2.3	-1.0	1.5
Mean time to correctly identify matches	1.0	1.9	2.1	1.3	-1.4
Ever had prostate specific antigen (PSA) test	1.0	1.1	1.7	1.3	-0.7
BMI	0.9	5.0	7.3	-2.7	1.6
Allergy or Eczema	0.9	2.4	2.5	-1.5	1.6
Relative age of first facial hair	0.9	1.9	2.8	1.7	-1.0
Fluid intelligence score	0.9	1.9	2.2	-1.3	1.5
Arm fat percentage (right)	0.9	3.4	4.3	-2.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	1.5	-1.2	1.2
Exposure to tobacco smoke at home	0.9	1.0	1.8	1.3	-0.4
Gout (self-reported)	0.9	1.2	1.4	1.2	-1.0
Arm fat percentage (left)	0.9	3.5	4.5	-2.1	1.6
Handedness (chirality/laterality): Left-handed	0.9	1.0	1.1	1.1	-1.0
Mineral and other dietary supplements	0.9	1.2	1.2	-1.1	1.1
Medication: Paracetamol	0.9	1.4	1.5	1.2	-1.2
Leg fat mass (left)	0.9	3.4	4.7	-2.2	1.5
Crohns Disease (2017)	0.8	1.8	1.8	1.3	-1.3
Vitamin and mineral supplements	0.8	1.1	1.2	-1.0	1.1
Medication: Ramipril	0.8	1.0	1.2	-1.1	0.9
Medication: Blood pressure	0.8	1.4	2.0	0.8	-1.4
Bipolar Disorder (2018)	0.7	1.1	1.3	1.0	-1.1
Major Depression (MDD)	0.7	0.9	1.0	0.9	-1.0
Blood Eosinophil Count	0.7	5.3	5.8	2.4	-2.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	1.4	-0.6	1.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	0.8	0.9	-0.9
Body mass index (BMI)	0.7	3.0	4.5	-2.1	1.2
Eye problems/disorders: None of the above	0.7	0.9	1.4	0.5	-1.2
Medication: Allopurinol	0.7	1.0	1.0	1.0	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	0.9	0.9	-0.9
Family relationship satisfaction	0.7	0.9	1.3	-1.1	0.7
Loneliness, isolation	0.7	0.9	1.0	1.0	-0.9
Eye problems/disorders: Cataract	0.7	0.8	1.5	-0.4	1.2
Medication: Gliclazide	0.7	0.8	1.0	-0.8	1.0
High cholesterol (Self-reported)	0.7	1.2	1.5	1.2	-1.0
Reaction Time	0.6	1.1	1.3	0.9	-1.2
Number of treatments/medications taken	0.6	1.1	1.6	0.8	-1.2
Average weekly spirits intake	0.6	0.8	1.1	-1.1	0.6
Sensitivity / hurt feelings	0.6	1.0	1.1	1.0	-1.0
Medication: Co-codamol	0.6	0.7	0.7	0.8	-0.8
Trunk fat percentage	0.6	2.5	3.0	-1.7	1.4
Medication: Levothyroxine sodium	0.6	1.0	1.0	-1.0	1.0
Heart attack	0.6	0.8	1.0	-0.7	1.0
Allergy	0.6	1.5	1.7	1.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	0.8	0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	0.8	-0.9	0.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	0.8	-0.8	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	1.2	-0.5
Medication for pain relief, constipation, heartburn	0.6	1.0	1.1	-1.0	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.9	1.0	-0.6
Miserableness	0.6	1.0	1.2	-0.9	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	0.9	-0.7	0.9
Schizophrenia (2018)	0.5	1.0	1.6	-0.6	1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	0.8	-0.6	0.9
Waist Hip Ratio (WHR)	0.5	2.4	3.3	1.8	-1.2
Relative age voice broke	0.5	0.8	1.4	1.2	-0.4
Qualifications: CSEs or equivalent	0.5	0.6	1.0	0.5	-1.0
Alcohol usually taken with meals	0.5	0.8	0.9	0.8	-0.9
Noisy workplace	0.5	0.6	0.6	-0.7	0.8
Depression (self-reported)	0.5	0.6	1.2	1.1	-0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	0.9	-1.0	0.7
Medication: Paracetamol	0.5	0.8	0.8	0.9	-0.8
Shortness of breath walking on level ground	0.5	0.6	0.7	-0.8	0.8
Medication: Ibuprofen	0.5	0.6	0.8	-0.9	0.7
Long-standing illness, disability or infirmity	0.5	0.8	0.9	-0.9	0.9
Alcohol drinker status: Never	0.5	0.6	0.7	-0.9	0.6
Irritable Bowel Disease (IBD)	0.4	0.9	1.2	0.8	-1.1
HbA1C	0.4	0.4	0.6	-0.8	0.5
Severe depression (siblings)	0.4	0.5	0.9	1.0	-0.2
Average weekly fortified wine intake	0.4	0.5	0.6	-0.7	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.5	0.7	-0.7
Illnesses of siblings	0.4	0.6	0.8	-0.9	0.7
Hair/balding pattern: Pattern 3	0.4	0.7	0.9	-0.7	1.0
Hair/balding pattern: Pattern 4	0.4	1.0	1.0	1.0	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	0.6	0.8	-0.7
Number of children fathered	0.4	0.5	0.6	0.6	-0.8
Mother’s age at death	0.4	0.5	0.5	-0.7	0.7
Medication: Blood pressure	0.4	0.8	0.9	-0.9	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.5	0.6	-0.7
Ever smoked	0.4	0.7	0.8	-0.9	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	0.6	-0.5	0.8
Breast Cancer	0.3	0.7	0.9	-0.6	1.0
Ovarian Cancer	0.3	0.3	0.4	0.5	-0.6
Rheumatoid Arthritis	0.3	0.5	0.5	-0.6	0.7
Schizophrenia (2014)	0.3	0.6	1.0	-0.4	1.0
Medication for hormone replacement therapy	0.3	0.3	0.4	-0.4	0.7
Fed-up feelings	0.3	0.6	0.9	-0.6	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.3	0.6	-0.5
Pain all over the body in last month	0.3	0.3	0.4	-0.6	0.5
Asthma	0.3	0.6	0.7	0.8	-0.7
High blood pressure (siblings)	0.3	0.4	0.5	0.7	-0.5
Body fat percentage	0.3	1.0	1.4	-1.2	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.6	0.8
Age at first live birth	0.3	0.5	0.6	0.6	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.4	0.7	-0.5
Heart disease (mother)	0.3	0.4	0.4	-0.6	0.6
Suffer from ‘nerves’	0.3	0.5	0.7	0.8	-0.5
Leg pain on walking	0.3	0.4	0.4	-0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.4	0.6	-0.6
Smoking status: Previous	0.3	0.4	0.7	-0.8	0.3
Qualifications: nursing, teaching	0.3	0.5	0.5	-0.7	0.7
Medication for cholesterol	0.3	0.5	0.7	0.6	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.4	0.7	-0.4
Medication: Bendroflumethiazide	0.3	0.5	0.7	-0.9	0.5
Unable to work because of sickness or disability	0.3	0.3	0.5	-0.4	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.4	-0.7	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.2	0.5	-0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	0.6	-0.5
Ulcerative Colitis (UC)	0.2	0.5	0.8	0.3	-0.9
Prostate Cancer	0.2	0.3	0.6	0.7	-0.3
Body Mass Index (BMI) (2010)	0.2	0.3	0.4	-0.7	0.3
Fasting Glucose	0.2	0.3	0.3	0.4	-0.6
Neuroticism (2016)	0.2	0.3	0.5	-0.2	0.7
Blood Red Count	0.2	1.9	2.2	1.3	-1.5
Smoking Status	0.2	0.4	0.5	-0.7	0.5
Lung FVC	0.2	1.0	1.4	-0.8	1.2
Chronotype (morning person)	0.2	0.4	0.5	-0.7	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.5	0.5
Diabetes (mother)	0.2	0.2	0.2	-0.5	0.5
Past tobacco smoking	0.2	0.4	0.6	0.8	-0.5
Financial difficulties in last 2 years	0.2	0.3	0.3	0.6	-0.5
Mouth/teeth dental problems	0.2	0.4	0.5	0.5	-0.7
Neuroticism score	0.2	0.3	0.3	0.6	-0.6
Impedance of arm (right)	0.2	0.8	1.5	1.2	-0.2
Worrier / anxious feelings	0.2	0.4	0.6	-0.6	0.8
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.3	0.7
Impedance of arm (left)	0.2	0.8	1.5	1.2	-0.3
Glaucoma (self-reported)	0.2	0.2	0.4	0.1	0.6
Migraine (self-reported)	0.2	0.3	0.5	-0.3	0.7
Alcohol intake frequency.	0.2	0.5	0.6	-0.6	0.8
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	0.7	-0.1
Mood swings	0.2	0.4	0.4	0.6	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.3	0.5	-0.5
Medication: Aspirin	0.2	0.3	0.4	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	-0.9	0.4
Guilty feelings	0.2	0.2	0.4	0.6	-0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.6	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	-0.3	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	0.7	-0.2
Pack years of smoking	0.2	0.3	0.5	0.7	-0.3
Depression (Nagel 2018)	0.1	0.2	0.3	-0.5	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.4	0.3
Triglycerides	0.1	0.2	0.2	0.3	-0.5
Respiratory disease	0.1	0.2	0.3	0.5	-0.4
Neuroticism	0.1	0.3	0.4	-0.5	0.6
Tanning	0.1	1.8	2.0	-1.2	1.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.2	-0.4
Angina	0.1	0.1	0.1	0.2	-0.4
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	-0.2
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	0.2
Current tobacco smoking	0.1	0.1	0.3	0.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	0.5	-0.5
Nervous feelings	0.1	0.1	0.2	0.0	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.7	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.2	0.4
Qualifications: None of the above	0.1	0.3	0.4	0.6	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Simvastatin	0.1	0.1	0.1	-0.4	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.1	0.6
Medication: Cholesterol lowering	0.1	0.2	0.2	-0.5	0.3
Pulse wave reflection index	0.1	0.1	0.1	-0.2	0.3
Comparative body size at age 10	0.1	0.2	0.3	0.3	-0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.0	0.7
Qualifications: College or University degree	0.1	0.3	0.3	-0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.3	0.2
Angina (self-reported)	0.1	0.2	0.2	0.3	-0.5
Overall health rating	0.1	0.3	0.3	0.5	-0.6
Chest pain or discomfort	0.1	0.2	0.4	0.2	-0.6
Supplements: Vitamin C	0.1	0.1	0.1	-0.2	0.3
Breast cancer (self-reported)	0.1	0.1	0.1	0.4	0.2
Asthma (self-reported)	0.1	0.1	0.2	0.4	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.5	0.1
Smoking status: Current	0.1	0.1	0.2	0.1	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.0	-0.4
Financial situation satisfaction	0.1	0.2	0.2	-0.4	0.4
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.2	0.3
Number of operations (self-reported)	0.1	0.2	0.3	-0.0	0.6
Ever depressed for a whole week	0.1	0.1	0.2	0.4	-0.2
Myopia	0.1	0.1	0.2	0.4	-0.3
Heart disease (siblings)	0.1	0.1	0.1	0.4	-0.2
Alcohol drinker status: Previous	0.1	0.2	0.2	0.4	-0.4
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.1	0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.1	0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	-0.0
Worry (Nagel 2018)	0.0	0.0	0.0	0.2	-0.1
HDL Cholesterol	0.0	0.1	0.1	-0.4	-0.1
Blood Platelet Count	0.0	0.3	0.3	-0.5	0.5
Systolic Blood Pressure	0.0	0.1	0.2	-0.5	0.2
Cardiovascular Disease	0.0	0.2	0.2	-0.5	0.3
Lung FEV1/FVC ratio	0.0	0.1	0.2	-0.5	0.1
Hair Pigment	0.0	0.7	0.9	-0.8	0.9
Systolic blood pressure, automated reading	0.0	0.0	0.0	-0.1	0.2
Age when periods started (menarche)	0.0	0.0	0.1	0.2	0.0
High blood pressure	0.0	0.0	0.1	0.2	-0.2
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.3	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	0.0	0.1
Medication: Atenolol	0.0	0.0	0.0	-0.1	-0.0
High blood pressure (mother)	0.0	0.0	0.0	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	-0.1	0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	-0.3	0.1
Hair/balding pattern: Pattern 2	0.0	0.0	0.1	0.1	-0.3
Had menopause	0.0	0.1	0.1	-0.2	0.3
Had other major operations	0.0	0.0	0.1	-0.3	0.1
Father’s age at death	0.0	0.0	0.1	-0.2	0.1
Lung cancer (father)	0.0	0.0	0.0	0.2	-0.0
Illnesses of mother	0.0	0.0	0.0	-0.1	-0.1
Medication: Amlodipine	0.0	0.0	0.0	0.1	-0.1
Leg fat percentage (right)	0.0	0.0	0.0	-0.2	-0.1
Pulse wave peak to peak time	0.0	0.1	0.1	-0.3	-0.1
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.0	0.0
Medication: Omeprazole	0.0	0.0	0.0	0.2	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.2	0.2
Knee pain experienced in last month	0.0	0.0	0.1	-0.1	0.3
Hypertension (Self-reported)	0.0	0.0	0.0	0.1	-0.2
Average weekly red wine intake	0.0	0.1	0.1	-0.4	0.1
Ever had bowel cancer screening	0.0	0.0	0.0	0.1	0.0
Osteoporosis (self-reported)	0.0	0.0	0.0	0.0	0.1
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	0.3	0.1
Leg fat percentage (left)	0.0	0.1	0.2	0.2	-0.5
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.0	-0.1	0.2
Cholesterol lowering medication	0.0	0.0	0.0	-0.0	0.1

Hub : Genes

WNT8B

Models

Trait associations