Hub : Genes

WNT8B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Brain Lower Grade Glioma 0.0741 0.0424 2.2e-12 0.100 0.110 0.107 NA 0.101 1.8e-11 1.7e-12 3.7e-12 NA 1.7e-11
2 TCGA Prostate Adenocarcinoma 0.0532 0.0441 6.5e-04 0.035 0.012 0.014 NA 0.015 1.2e-04 1.9e-02 1.2e-02 NA 9.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.1 1.3 1.0 -1.1
Bipolar Disorder or Schizophrenia 0.0 0.0 0.1 0.1 0.3
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 0.1 0.1
Depression (Nagel 2018) 0.1 0.2 0.3 -0.5 0.3
Intelligence (Savage-Jansen 2018) 1.5 4.6 4.8 -2.1 2.2
Neuroticism (Nagel 2018) 0.0 0.0 0.0 0.1 -0.0
Schizophrenia (2018) 0.5 1.0 1.6 -0.6 1.3
Schizophrenia vs Biploar Disorder 0.5 0.6 0.8 -0.6 0.9
Worry (Nagel 2018) 0.0 0.0 0.0 0.2 -0.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.2 0.5 -0.5
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.4 0.3
Alzheimer’s Disease (including proxy) 0.2 0.3 0.4 0.6 -0.5
Crohns Disease (2017) 0.8 1.8 1.8 1.3 -1.3
Irritable Bowel Disease (IBD) 0.4 0.9 1.2 0.8 -1.1
Ulcerative Colitis (UC) 0.2 0.5 0.8 0.3 -0.9
Major Depression (MDD) 0.7 0.9 1.0 0.9 -1.0
Reaction Time 0.6 1.1 1.3 0.9 -1.2
Verbal and Numeric Reasoning (VNR) 1.3 3.1 3.4 -1.8 1.7
Breast Cancer 0.3 0.7 0.9 -0.6 1.0
Ovarian Cancer 0.3 0.3 0.4 0.5 -0.6
Prostate Cancer 0.2 0.3 0.6 0.7 -0.3
Age at First Birth 1.1 1.6 1.6 -1.2 1.3
Bipolar Disorder (2011) 1.5 1.5 1.7 -1.3 1.1
Body Mass Index (BMI) (2010) 0.2 0.3 0.4 -0.7 0.3
Coronary Artery Disease (CAD) 1.5 1.8 2.2 1.2 -1.5
Crohns Disease (2012) 1.4 2.2 2.4 1.6 -1.4
Mean Putamen Volume 2.1 2.5 2.7 -1.6 1.5
Fasting Glucose 0.2 0.3 0.3 0.4 -0.6
HbA1C 0.4 0.4 0.6 -0.8 0.5
HDL Cholesterol 0.0 0.1 0.1 -0.4 -0.1
LDL Cholesterol 1.5 2.3 3.1 1.8 -1.2
Lupus 1.3 2.0 2.1 1.4 -1.4
Neuroticism (2016) 0.2 0.3 0.5 -0.2 0.7
Primary Biliary Cirrhosis 1.7 2.4 2.5 1.5 -1.6
Rheumatoid Arthritis 0.3 0.5 0.5 -0.6 0.7
Schizophrenia (2014) 0.3 0.6 1.0 -0.4 1.0
Triglycerides 0.1 0.2 0.2 0.3 -0.5
Type 2 Diabetes (T2D) (2012) 1.2 1.4 1.7 -1.3 1.0
Ulcerative Colitis 2.0 2.9 3.3 1.5 -1.8
Blood Eosinophil Count 0.7 5.3 5.8 2.4 -2.2
Blood Platelet Count 0.0 0.3 0.3 -0.5 0.5
Blood Red Count 0.2 1.9 2.2 1.3 -1.5
Blood White Count 1.3 9.4 10.0 3.2 -3.0
Heel T-Score 2.1 17.1 20.9 4.6 -3.6
BMI 0.9 5.0 7.3 -2.7 1.6
Height 2.0 38.8 42.0 -6.5 6.0
Waist Hip Ratio (WHR) 0.5 2.4 3.3 1.8 -1.2
Systolic Blood Pressure 0.0 0.1 0.2 -0.5 0.2
Smoking Status 0.2 0.4 0.5 -0.7 0.5
Allergy or Eczema 0.9 2.4 2.5 -1.5 1.6
Cardiovascular Disease 0.0 0.2 0.2 -0.5 0.3
Hypothyroidism (self reported) 2.4 5.5 5.6 -2.4 2.3
Respiratory disease 0.1 0.2 0.3 0.5 -0.4
Type 2 Diabetes (T2D) (2018) 3.7 7.0 8.5 -2.9 2.3
Lung FEV1/FVC ratio 0.0 0.1 0.2 -0.5 0.1
Lung FVC 0.2 1.0 1.4 -0.8 1.2
Neuroticism 0.1 0.3 0.4 -0.5 0.6
Chronotype (morning person) 0.2 0.4 0.5 -0.7 0.6
Hair Pigment 0.0 0.7 0.9 -0.8 0.9
Tanning 0.1 1.8 2.0 -1.2 1.4
Hand grip strength (left) 3.3 8.6 9.0 -3.0 2.9
Number of treatments/medications taken 0.6 1.1 1.6 0.8 -1.2
Average weekly spirits intake 0.6 0.8 1.1 -1.1 0.6
Sensitivity / hurt feelings 0.6 1.0 1.1 1.0 -1.0
Frequency of depressed mood in last 2 weeks 1.4 1.9 2.0 1.4 -1.3
Hearing difficulty/problems: Yes 5.1 7.7 8.6 -2.9 2.6
Relative age of first facial hair 0.9 1.9 2.8 1.7 -1.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.8 1.4 -0.6 1.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 0.2 -0.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.5 0.5
Systolic blood pressure, automated reading 0.0 0.0 0.0 -0.1 0.2
Eye problems/disorders: Diabetes related eye disease 3.2 3.5 3.8 -1.8 2.0
Angina 0.1 0.1 0.1 0.2 -0.4
Medication for hormone replacement therapy 0.3 0.3 0.4 -0.4 0.7
Vitamin and mineral supplements 0.8 1.1 1.2 -1.0 1.1
Supplements: Zinc 1.2 1.4 1.6 -1.3 1.0
Medication: Co-codamol 0.6 0.7 0.7 0.8 -0.8
Medication: Metformin 5.4 7.6 8.9 -3.0 2.5
Diabetes (father) 4.2 5.1 5.8 -2.4 2.1
Diabetes (mother) 0.2 0.2 0.2 -0.5 0.5
Severe depression (siblings) 0.4 0.5 0.9 1.0 -0.2
Pack years adult smoking proportion 0.1 0.2 0.3 0.5 -0.2
Impedance of leg (right) 2.7 13.2 16.9 4.1 -3.1
Leg fat-free mass (left) 5.5 29.3 36.4 -6.0 4.7
Trunk fat percentage 0.6 2.5 3.0 -1.7 1.4
Hand grip strength (right) 3.2 8.6 10.3 -3.2 2.6
Townsend deprivation index at recruitment 0.1 0.1 0.1 0.4 0.2
Current tobacco smoking 0.1 0.1 0.3 0.0 0.5
Average weekly fortified wine intake 0.4 0.5 0.6 -0.7 0.7
Maternal smoking around birth 1.4 2.0 2.3 1.5 -1.3
Fed-up feelings 0.3 0.6 0.9 -0.6 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.2 2.6 -1.3 1.6
Relative age voice broke 0.5 0.8 1.4 1.2 -0.4
Taking other prescription medications 3.3 5.1 6.0 2.5 -2.0
Age when periods started (menarche) 0.0 0.0 0.1 0.2 0.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.5 0.7 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.2 0.5 -0.5
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.3 0.6 -0.5
Qualifications: CSEs or equivalent 0.5 0.6 1.0 0.5 -1.0
Serious illness, injury or assault to yourself 2.2 2.6 2.7 -1.6 1.6
High blood pressure 0.0 0.0 0.1 0.2 -0.2
Hayfever, allergic rhinitis or eczema 1.0 2.1 2.2 -1.5 1.4
Multivitamins +/- minerals 1.0 1.2 1.5 1.0 -1.2
Stomach or abdominal pain in last month 0.0 0.1 0.1 0.3 -0.1
Supplements: Glucosamine 0.0 0.0 0.0 0.0 0.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 0.8 0.9 -0.9
Medication: Atenolol 0.0 0.0 0.0 -0.1 -0.0
Medication: Levothyroxine sodium 0.6 1.0 1.0 -1.0 1.0
Sitting height 4.0 28.1 32.4 -5.7 4.9
Chronic bronchitis/emphysema (father) 5.4 6.3 7.2 2.7 -2.3
High blood pressure (mother) 0.0 0.0 0.0 -0.1 0.2
Body mass index (BMI) 0.7 3.0 4.5 -2.1 1.2
Impedance of leg (left) 3.9 18.8 23.7 4.9 -3.7
Leg predicted mass (left) 5.4 28.8 36.0 -6.0 4.6
Trunk fat mass 1.6 7.0 8.8 -3.0 2.3
Waist circumference 1.1 4.0 5.3 -2.3 1.7
Number of incorrect matches in round 2.3 3.8 5.1 2.2 -1.6
Past tobacco smoking 0.2 0.4 0.6 0.8 -0.5
Alcohol usually taken with meals 0.5 0.8 0.9 0.8 -0.9
Nervous feelings 0.1 0.1 0.2 0.0 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.0 -0.1 0.2
Hearing difficulty/problems with background noise 0.0 0.0 0.1 -0.3 0.1
Hair/balding pattern: Pattern 2 0.0 0.0 0.1 0.1 -0.3
Had menopause 0.0 0.1 0.1 -0.2 0.3
Had other major operations 0.0 0.0 0.1 -0.3 0.1
Forced vital capacity (FVC) 1.8 7.0 8.7 -3.0 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 0.7 -0.2
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.2 -0.2 0.4
Qualifications: None of the above 0.1 0.3 0.4 0.6 -0.4
Financial difficulties in last 2 years 0.2 0.3 0.3 0.6 -0.5
Mouth/teeth dental problems 0.2 0.4 0.5 0.5 -0.7
Heart attack 0.6 0.8 1.0 -0.7 1.0
Allergy 0.6 1.5 1.7 1.1 -1.3
Pain all over the body in last month 0.3 0.3 0.4 -0.6 0.5
Diabetes (self-reported) 5.1 7.9 8.9 -3.0 2.6
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 0.3 -0.3
Medication: Ramipril 0.8 1.0 1.2 -1.1 0.9
Medication: Simvastatin 0.1 0.1 0.1 -0.4 -0.3
Fluid intelligence score 0.9 1.9 2.2 -1.3 1.5
Illnesses of siblings 0.4 0.6 0.8 -0.9 0.7
Neuroticism score 0.2 0.3 0.3 0.6 -0.6
Weight 3.3 16.2 20.5 -4.5 3.4
Impedance of arm (right) 0.2 0.8 1.5 1.2 -0.2
Arm fat percentage (right) 0.9 3.4 4.3 -2.1 1.6
Trunk fat-free mass 3.1 17.7 23.9 -4.9 3.4
Hip circumference 2.4 10.4 13.5 -3.7 2.7
Time employed in main current job 1.7 2.0 2.1 -1.4 1.4
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.1 0.6
Father’s age at death 0.0 0.0 0.1 -0.2 0.1
Worrier / anxious feelings 0.2 0.4 0.6 -0.6 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 1.5 -1.2 1.2
Falls in the last year 1.0 1.3 2.1 -0.7 1.4
Hair/balding pattern: Pattern 3 0.4 0.7 0.9 -0.7 1.0
Number of live births 2.6 3.6 4.2 1.7 -2.0
Forced expiratory volume in 1-second (FEV1) 2.3 7.9 10.1 -3.2 2.4
Pulse rate 3.1 5.2 6.3 -2.0 2.5
Happiness 2.6 3.2 3.2 -1.8 1.8
Noisy workplace 0.5 0.6 0.6 -0.7 0.8
Qualifications: A levels/AS levels or equivalent 1.4 3.0 3.9 -2.0 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 0.8 0.7 -0.9
Mouth/teeth dental problems: Dentures 4.1 6.9 8.1 -2.4 2.8
Asthma 0.3 0.6 0.7 0.8 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 0.8 -0.9 0.9
Medication: Cholesterol lowering 0.1 0.2 0.2 -0.5 0.3
Depression (self-reported) 0.5 0.6 1.2 1.1 -0.3
Medication: Lansoprazole 1.6 1.9 2.1 1.4 -1.3
Prospective memory result 1.7 2.1 2.4 1.3 -1.6
Lung cancer (father) 0.0 0.0 0.0 0.2 -0.0
Illnesses of mother 0.0 0.0 0.0 -0.1 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.5 8.0 -2.8 2.3
Pulse wave Arterial Stiffness index 0.2 0.3 0.5 -0.3 0.7
Impedance of arm (left) 0.2 0.8 1.5 1.2 -0.3
Arm fat mass (right) 1.7 6.9 9.3 -3.0 2.1
Trunk predicted mass 3.1 17.8 23.9 -4.9 3.4
Standing height 2.8 28.2 31.0 -5.6 5.0
Length of working week for main job 2.2 2.4 2.6 -1.5 1.6
Exposure to tobacco smoke at home 0.9 1.0 1.8 1.3 -0.4
Breastfed as a baby 1.0 1.3 1.7 -0.9 1.3
Tense / ‘highly strung’ 2.2 3.6 4.4 2.1 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 4.4 2.1 -1.8
Hair/balding pattern: Pattern 4 0.4 1.0 1.0 1.0 -1.0
Birth weight of first child 3.9 7.1 7.7 -2.8 2.5
Peak expiratory flow (PEF) 2.5 5.8 7.3 -2.7 2.1
Pulse wave reflection index 0.1 0.1 0.1 -0.2 0.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 0.8 -0.8 0.9
Loud music exposure frequency 1.4 1.5 1.8 1.3 -1.1
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 0.9 -1.0 0.7
Mouth/teeth dental problems: Bleeding gums 2.4 3.2 3.2 1.8 -1.8
Blood clot in the leg (DVT) 1.9 2.5 2.8 -1.5 1.7
Medication: Paracetamol 0.5 0.8 0.8 0.9 -0.8
Headache pain in last month 2.9 5.0 6.0 -2.0 2.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 2.3 -1.0 1.5
Glaucoma (self-reported) 0.2 0.2 0.4 0.1 0.6
Gout (self-reported) 0.9 1.2 1.4 1.2 -1.0
Hypothyroidism/myxoedema (self-reported) 1.3 2.5 3.0 -1.4 1.7
Medication: Amlodipine 0.0 0.0 0.0 0.1 -0.1
Medication: Ventolin 100micrograms inhaler 0.4 0.6 0.6 0.8 -0.7
Birth weight 7.8 16.9 17.6 -4.2 4.0
Chronic bronchitis/emphysema (mother) 2.1 2.4 2.5 1.5 -1.6
High blood pressure (siblings) 0.3 0.4 0.5 0.7 -0.5
Forced vital capacity (FVC), Best measure 1.8 6.7 8.1 -2.8 2.3
Body fat percentage 0.3 1.0 1.4 -1.2 0.8
Leg fat percentage (right) 0.0 0.0 0.0 -0.2 -0.1
Arm fat-free mass (right) 3.1 15.7 21.3 -4.6 3.2
Exposure to tobacco smoke outside home 0.3 0.4 0.6 -0.6 0.8
Comparative body size at age 10 0.1 0.2 0.3 0.3 -0.6
Number of full brothers 1.4 1.8 2.1 -1.2 1.4
Worry too long after embarrassment 2.6 4.4 4.9 2.0 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.4 1.2 -0.5
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 0.0 0.7
Number of children fathered 0.4 0.5 0.6 0.6 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 3.0 1.6 -1.7
Age at first live birth 0.3 0.5 0.6 0.6 -0.8
Pulse wave peak to peak time 0.0 0.1 0.1 -0.3 -0.1
Health satisfaction 2.1 2.7 3.3 -1.8 1.5
Shortness of breath walking on level ground 0.5 0.6 0.7 -0.8 0.8
Qualifications: College or University degree 0.1 0.3 0.3 -0.6 0.6
Eye problems/disorders: None of the above 0.7 0.9 1.4 0.5 -1.2
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.1 -0.3 0.2
Emphysema/chronic bronchitis 0.0 0.0 0.0 -0.0 0.0
Medication for pain relief, constipation, heartburn 0.6 1.0 1.1 -1.0 1.0
Neck or shoulder pain in last month 5.4 7.7 8.3 -2.9 2.7
Medication: Blood pressure 0.8 1.4 2.0 0.8 -1.4
Angina (self-reported) 0.1 0.2 0.2 0.3 -0.5
Migraine (self-reported) 0.2 0.3 0.5 -0.3 0.7
Medication: Ibuprofen 0.5 0.6 0.8 -0.9 0.7
Medication: Allopurinol 0.7 1.0 1.0 1.0 -1.0
Medication: Omeprazole 0.0 0.0 0.0 0.2 0.1
Medication: Seretide 50 evohaler 0.3 0.4 0.4 0.7 -0.5
Mean time to correctly identify matches 1.0 1.9 2.1 1.3 -1.4
Heart disease (mother) 0.3 0.4 0.4 -0.6 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 0.9 0.9 -0.9
Whole body fat mass 1.5 6.1 7.9 -2.8 2.1
Leg fat mass (right) 1.1 4.3 5.8 -2.4 1.7
Arm predicted mass (right) 2.9 14.8 20.2 -4.5 3.0
Pulse rate, automated reading 10.6 34.1 35.5 -6.0 5.7
Alcohol intake frequency. 0.2 0.5 0.6 -0.6 0.8
Comparative height size at age 10 3.5 19.4 22.8 -4.8 4.0
Number of full sisters 1.2 1.5 1.5 -1.2 1.2
Suffer from ‘nerves’ 0.3 0.5 0.7 0.8 -0.5
Overall health rating 0.1 0.3 0.3 0.5 -0.6
Chest pain or discomfort 0.1 0.2 0.4 0.2 -0.6
Had major operations 1.3 1.6 1.8 -1.2 1.3
Age at last live birth 1.5 2.2 2.9 1.3 -1.7
Family relationship satisfaction 0.7 0.9 1.3 -1.1 0.7
Leg pain on walking 0.3 0.4 0.4 -0.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 -0.2 0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 0.9 1.0 -0.6
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.4 0.6 -0.6
Medication: Aspirin 0.2 0.2 0.4 -0.6 0.4
Supplements: Vitamin C 0.1 0.1 0.1 -0.2 0.3
Knee pain experienced in last month 0.0 0.0 0.1 -0.1 0.3
Hypertension (Self-reported) 0.0 0.0 0.0 0.1 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.6 0.7 -0.1
Illnesses of father: Heart disease 2.6 3.6 5.2 -1.4 2.3
Illnesses of siblings: Diabetes 1.8 2.3 3.2 -1.1 1.8
Smoking status: Previous 0.3 0.4 0.7 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted 3.4 7.1 8.7 -2.9 2.4
Whole body fat-free mass 3.9 22.3 29.2 -5.4 3.9
Leg fat-free mass (right) 5.4 28.6 35.6 -6.0 4.7
Arm fat percentage (left) 0.9 3.5 4.5 -2.1 1.6
Average weekly red wine intake 0.0 0.1 0.1 -0.4 0.1
Handedness (chirality/laterality): Left-handed 0.9 1.0 1.1 1.1 -1.0
Mood swings 0.2 0.4 0.4 0.6 -0.7
Loneliness, isolation 0.7 0.9 1.0 1.0 -0.9
Long-standing illness, disability or infirmity 0.5 0.8 0.9 -0.9 0.9
Ever had bowel cancer screening 0.0 0.0 0.0 0.1 0.0
Diabetes diagnosed by doctor 3.3 5.4 6.2 -2.5 2.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.2 1.7 1.3 -0.9
Friendships satisfaction 1.4 1.7 2.3 -1.5 1.1
Qualifications: nursing, teaching 0.3 0.5 0.5 -0.7 0.7
Commuting to job workplace: Walk 3.9 4.2 4.2 -2.0 2.0
Eye problems/disorders: Cataract 0.7 0.8 1.5 -0.4 1.2
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.3 0.5 -0.5
Medication for cholesterol 0.3 0.5 0.7 0.6 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 1.7 1.3 -1.3
Back pain experienced in last month 1.8 2.6 3.3 1.8 -1.4
Mineral and other dietary supplements 0.9 1.2 1.2 -1.1 1.1
Breast cancer (self-reported) 0.1 0.1 0.1 0.4 0.2
Asthma (self-reported) 0.1 0.1 0.2 0.4 -0.2
Osteoporosis (self-reported) 0.0 0.0 0.0 0.0 0.1
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.5 0.1
Medication: Aspirin 0.2 0.3 0.4 -0.6 0.4
Medication: Gliclazide 0.7 0.8 1.0 -0.8 1.0
Illnesses of father: None of the above (group 1) 4.2 5.2 6.3 2.0 -2.5
Smoking status: Current 0.1 0.1 0.2 0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.8 -0.9 0.4
Whole body water mass 3.9 22.0 28.7 -5.4 3.9
Leg predicted mass (right) 5.2 27.7 34.6 -5.9 4.6
Arm fat mass (left) 1.8 7.5 10.0 -3.2 2.2
Number of self-reported non-cancer illnesses 0.0 0.0 0.1 0.3 0.1
Average weekly champagne plus white wine intake 1.8 2.5 3.2 1.4 -1.8
Miserableness 0.6 1.0 1.2 -0.9 1.1
Guilty feelings 0.2 0.2 0.4 0.6 -0.4
Wears glasses or contact lenses 1.3 1.5 1.9 1.4 -1.0
Ever taken oral contraceptive pill 0.1 0.1 0.1 -0.0 -0.4
Hearing aid user 2.6 3.0 3.1 -1.7 1.8
Mother’s age at death 0.4 0.5 0.5 -0.7 0.7
Financial situation satisfaction 0.1 0.2 0.2 -0.4 0.4
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.4 0.7 -0.4
Commuting to job workplace: Public transport 1.3 1.5 2.2 -1.5 0.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.6 -0.2
Medication: Blood pressure 0.4 0.8 0.9 -0.9 1.0
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.5 -0.3 0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.5 0.6 -0.7
High cholesterol (Self-reported) 0.7 1.2 1.5 1.2 -1.0
Medication: Bendroflumethiazide 0.3 0.5 0.7 -0.9 0.5
Medication: Paracetamol 0.9 1.4 1.5 1.2 -1.2
Medication: Lisinopril 1.5 1.9 2.3 1.3 -1.5
Medication: Atorvastatin 1.2 1.5 1.8 1.4 -1.0
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.2 0.3
Alcohol drinker status: Never 0.5 0.6 0.7 -0.9 0.6
Ever smoked 0.4 0.7 0.8 -0.9 0.7
Basal metabolic rate 4.0 22.0 28.6 -5.3 3.9
Leg fat percentage (left) 0.0 0.1 0.2 0.2 -0.5
Arm fat-free mass (left) 3.1 15.9 21.3 -4.6 3.2
Number of operations (self-reported) 0.1 0.2 0.3 -0.0 0.6
Average weekly beer plus cider intake 4.4 6.4 7.3 2.7 -2.4
Irritability 2.5 4.2 4.7 -2.2 1.9
Risk taking 1.3 1.9 2.3 1.5 -1.3
Ever had prostate specific antigen (PSA) test 1.0 1.1 1.7 1.3 -0.7
Fractured/broken bones in last 5 years 4.8 6.2 6.5 -2.6 2.4
Age started oral contraceptive pill 1.2 1.5 2.2 -0.9 1.5
Diastolic blood pressure, automated reading 2.0 6.1 6.4 -2.5 2.4
Ever depressed for a whole week 0.1 0.1 0.2 0.4 -0.2
Unable to work because of sickness or disability 0.3 0.3 0.5 -0.4 0.7
Commuting to job workplace: Cycle 0.3 0.4 0.4 -0.7 0.6
Myopia 0.1 0.1 0.2 0.4 -0.3
Vascular/heart problems diagnosed by doctor 0.0 0.0 0.0 -0.1 0.2
Cholesterol lowering medication 0.0 0.0 0.0 -0.0 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 0.7 -0.2
Pain experienced in last month 1.6 2.7 3.5 1.4 -1.9
Supplements: Calcium 2.8 3.1 4.1 1.5 -2.0
Basal cell carcinoma (self-reported) 0.4 0.5 0.6 -0.5 0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.7 0.9 -0.7 0.9
Deep venous thrombosis (DVT) (self-reported) 2.2 2.8 3.0 -1.6 1.7
Heart disease (siblings) 0.1 0.1 0.1 0.4 -0.2
Alcohol drinker status: Previous 0.1 0.2 0.2 0.4 -0.4
Pack years of smoking 0.2 0.3 0.5 0.7 -0.3
Impedance of whole body 1.6 8.1 11.1 3.3 -2.3
Leg fat mass (left) 0.9 3.4 4.7 -2.2 1.5
Arm predicted mass (left) 3.0 15.2 20.8 -4.6 3.1