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chr10:103,527,782-105,647,095

Best TWAS P=6.53e-15 · Best GWAS P=4.35e-14 conditioned to 0.0468

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	4.111	6.5	1.1e-10	0.74	0.06	0.68	FALSE
2	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	5.098	7.6	2.4e-14	0.63	0.10	0.72	FALSE
3	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-4.120	-6.1	1.3e-09	-0.34	0.56	0.20	FALSE
4	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-4.082	-5.8	5.3e-09	-0.55	0.09	0.74	FALSE
5	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	0.078	5.2	2.5e-07	0.39	0.06	0.20	FALSE
6	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	7.265	-7.5	4.3e-14	-0.95	0.04	0.90	FALSE
7	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	7.265	7.2	4.3e-13	0.95	0.03	0.96	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-5.795	5.8	9.2e-09	0.44	0.11	0.18	FALSE
9	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	6.682	6.7	2.2e-11	0.57	0.09	0.80	FALSE
10	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-1.018	-6.3	3.4e-10	-0.46	0.07	0.38	FALSE
11	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	6.682	7.8	6.5e-15	0.82	0.07	0.79	TRUE
12	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	7.352	7.6	2.2e-14	0.70	0.05	0.66	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.604	6.5	8.8e-11	0.84	0.14	0.43	FALSE
14	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	7.321	7.2	8.2e-13	0.64	0.10	0.46	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-6.121	6.8	9.7e-12	0.51	0.04	0.08	FALSE
16	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-4.583	-5.3	8.6e-08	-0.26	0.25	0.20	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	5.829	7.7	1.3e-14	0.60	0.06	0.26	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-5.333	6.8	1.3e-11	0.62	0.46	0.20	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-6.473	7.0	3.4e-12	0.42	0.21	0.13	FALSE
20	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-6.568	6.6	4.9e-11	0.41	0.26	0.21	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	CYP17A1-AS1	0.23	0.08	enet	23	0.13	1.9e-05	6.925	5.7	1.1e-08	0.62	0.08	0.67	FALSE
22	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-1.671	-5.4	6.4e-08	-0.55	0.62	0.18	FALSE
23	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-4.348	-6.5	5.9e-11	-0.53	0.18	0.69	FALSE
24	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-2.681	-6.6	3.0e-11	-0.52	0.05	0.34	FALSE
25	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-6.468	-7.8	7.5e-15	-0.46	0.53	0.34	FALSE
26	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.604	7.0	3.3e-12	0.83	0.13	0.83	FALSE
27	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.594	6.7	1.8e-11	0.82	0.38	0.40	FALSE
28	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	-4.583	-5.6	2.1e-08	-0.25	0.07	0.07	FALSE
29	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-6.468	6.5	6.4e-11	0.40	0.86	0.11	FALSE
30	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-6.580	5.3	1.2e-07	0.33	0.81	0.11	FALSE
31	GTEx	Testis	CYP17A1-AS1	0.14	0.08	enet	5	0.10	2.3e-05	5.787	-5.9	4.6e-09	-0.38	0.68	0.08	FALSE
32	GTEx	Thyroid	SFXN2	0.28	0.06	enet	32	0.15	1.1e-11	-1.986	-5.4	7.9e-08	-0.60	0.16	0.84	FALSE
33	GTEx	Thyroid	WBP1L	0.26	0.10	enet	9	0.13	2.1e-10	3.135	-5.4	7.2e-08	-0.20	1.00	0.00	FALSE
34	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-4.348	6.3	2.3e-10	0.49	0.99	0.01	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	CNNM2	0.11	0.08	lasso	3	0.07	2.2e-09	6.255	6.2	5.7e-10	0.37	0.93	0.07	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	6.682	7.1	1.4e-12	0.81	0.80	0.20	FALSE
37	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	3.175	5.9	3.9e-09	0.46	1.00	0.00	FALSE
38	YFS	Blood	NT5C2	0.13	0.10	bslmm	382	0.11	7.3e-35	6.556	5.5	3.6e-08	0.22	0.92	0.08	FALSE
39	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	-4.630	5.2	1.6e-07	0.38	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.561	-7.2	7.4e-13	-0.80	0.12	0.88	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	3.494	-5.2	1.8e-07	-0.81	0.48	0.52	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.561	-6.0	1.7e-09	-0.82	0.25	0.75	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-6.012	-5.8	8.8e-09	-0.40	0.90	0.02	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	SFXN2	0.12	0.09	lasso	4	0.10	4.4e-19	5.407	-5.4	6.6e-08	-0.16	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	3.494	-5.4	7.0e-08	-0.80	0.08	0.85	FALSE
46	The Cancer Genome Atlas	Esophageal Carcinoma	SFXN2	0.26	0.02	blup	48	0.10	4.9e-04	5.407	-5.8	8.5e-09	-0.37	0.01	0.71	FALSE
47	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	3.494	-5.6	2.6e-08	-0.83	0.04	0.57	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	SFXN2	0.27	0.02	blup	47	0.11	3.1e-04	5.407	-5.2	2.1e-07	-0.36	0.02	0.55	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	7.550	-5.8	8.7e-09	-0.88	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.561	-6.5	5.6e-11	-0.85	0.12	0.86	FALSE
51	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFXN2	0.20	0.08	blup	48	0.13	9.3e-07	5.407	-5.6	2.8e-08	-0.33	0.13	0.82	FALSE
52	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-6.473	6.2	4.8e-10	0.39	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM180	0.05	0.02	blup	52	0.04	1.5e-05	-5.634	5.9	4.8e-09	0.39	0.02	0.94	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-6.568	-6.0	1.6e-09	-0.33	0.03	0.77	FALSE
55	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	7.265	-6.6	3.4e-11	-0.92	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	6.531	-5.4	7.0e-08	-0.84	0.39	0.61	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-6.395	-6.4	2.0e-10	-0.40	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	7.265	-7.1	9.5e-13	-0.94	0.02	0.75	FALSE
59	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.531	-6.2	4.4e-10	-0.85	0.83	0.17	FALSE
60	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	6.925	-6.6	3.2e-11	-0.75	0.07	0.88	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	7.550	-7.5	4.3e-14	-1.00	0.01	0.92	FALSE