[Hub]/) : Traits : Whole body water mass :

chr10:103,527,782-105,647,095

Best TWAS P=6.53e-15 · Best GWAS P=4.35e-14 conditioned to 0.0468

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ACTR1A 0.03 0.01 blup 347 0.01 5.6e-02 4.111 6.5 1.1e-10 0.74 0.06 0.68 FALSE
2 GTEx Adipose Subcutaneous CYP17A1-AS1 0.05 0.02 enet 10 0.03 2.8e-03 5.098 7.6 2.4e-14 0.63 0.10 0.72 FALSE
3 GTEx Adrenal Gland TMEM180 0.19 0.15 enet 12 0.09 3.5e-04 -4.120 -6.1 1.3e-09 -0.34 0.56 0.20 FALSE
4 GTEx Artery Aorta NT5C2 0.08 0.02 lasso 7 0.01 1.2e-01 -4.082 -5.8 5.3e-09 -0.55 0.09 0.74 FALSE
5 GTEx Artery Coronary CYP17A1-AS1 0.20 -0.01 enet 21 0.04 2.3e-02 0.078 5.2 2.5e-07 0.39 0.06 0.20 FALSE
6 GTEx Artery Tibial NT5C2 0.06 0.04 lasso 9 0.02 1.5e-02 7.265 -7.5 4.3e-14 -0.95 0.04 0.90 FALSE
7 GTEx Artery Tibial CYP17A1-AS1 0.08 0.08 lasso 8 0.06 2.8e-05 7.265 7.2 4.3e-13 0.95 0.03 0.96 FALSE
8 GTEx Brain Cerebellar Hemisphere ARL3 0.15 0.02 enet 18 0.11 1.1e-03 -5.795 5.8 9.2e-09 0.44 0.11 0.18 FALSE
9 GTEx Brain Cerebellum ARL3 0.20 0.09 enet 32 0.07 3.7e-03 6.682 6.7 2.2e-11 0.57 0.09 0.80 FALSE
10 GTEx Brain Cerebellum TRIM8 0.34 -0.01 enet 25 0.07 4.7e-03 -1.018 -6.3 3.4e-10 -0.46 0.07 0.38 FALSE
11 GTEx Brain Cortex CYP17A1-AS1 0.15 0.13 lasso 7 0.14 1.3e-04 6.682 7.8 6.5e-15 0.82 0.07 0.79 TRUE
12 GTEx Brain Hypothalamus CYP17A1-AS1 0.34 0.10 lasso 10 0.05 2.6e-02 7.352 7.6 2.2e-14 0.70 0.05 0.66 FALSE
13 GTEx Brain Nucleus accumbens basal ganglia CYP17A1-AS1 0.39 0.22 lasso 3 0.19 8.2e-06 6.604 6.5 8.8e-11 0.84 0.14 0.43 FALSE
14 GTEx Breast Mammary Tissue CYP17A1-AS1 0.10 -0.01 enet 28 0.00 2.4e-01 7.321 7.2 8.2e-13 0.64 0.10 0.46 FALSE
15 GTEx Breast Mammary Tissue (Male) CYP17A1-AS1 0.06 0.00 lasso 3 0.01 2.1e-01 -6.121 6.8 9.7e-12 0.51 0.04 0.08 FALSE
16 GTEx Breast Mammary Tissue (Female) TMEM180 0.18 0.06 lasso 4 0.07 4.5e-03 -4.583 -5.3 8.6e-08 -0.26 0.25 0.20 FALSE
17 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 5.829 7.7 1.3e-14 0.60 0.06 0.26 FALSE
18 GTEx Cells EBV-transformed lymphocytes ACTR1A 0.22 0.18 lasso 3 0.19 8.0e-07 -5.333 6.8 1.3e-11 0.62 0.46 0.20 FALSE
19 GTEx Cells EBV-transformed lymphocytes RP11-18I14.11 0.17 0.08 lasso 8 0.09 8.7e-04 -6.473 7.0 3.4e-12 0.42 0.21 0.13 FALSE
20 GTEx Cells Transformed fibroblasts TMEM180 0.05 0.04 lasso 2 0.01 3.3e-02 -6.568 6.6 4.9e-11 0.41 0.26 0.21 FALSE
21 GTEx Esophagus Gastroesophageal Junction CYP17A1-AS1 0.23 0.08 enet 23 0.13 1.9e-05 6.925 5.7 1.1e-08 0.62 0.08 0.67 FALSE
22 GTEx Esophagus Mucosa SUFU 0.08 0.02 enet 18 0.01 4.2e-02 -1.671 -5.4 6.4e-08 -0.55 0.62 0.18 FALSE
23 GTEx Esophagus Muscularis SUFU 0.07 0.04 enet 18 0.03 5.2e-03 -4.348 -6.5 5.9e-11 -0.53 0.18 0.69 FALSE
24 GTEx Liver ACTR1A 0.15 0.00 lasso 10 0.00 4.6e-01 -2.681 -6.6 3.0e-11 -0.52 0.05 0.34 FALSE
25 GTEx Liver TMEM180 0.28 0.17 enet 36 0.17 1.7e-05 -6.468 -7.8 7.5e-15 -0.46 0.53 0.34 FALSE
26 GTEx Lung CYP17A1-AS1 0.06 0.08 lasso 3 0.06 1.6e-05 6.604 7.0 3.3e-12 0.83 0.13 0.83 FALSE
27 GTEx Nerve Tibial CYP17A1-AS1 0.14 0.08 lasso 6 0.06 7.2e-05 6.594 6.7 1.8e-11 0.82 0.38 0.40 FALSE
28 GTEx Pituitary NT5C2 0.19 -0.01 lasso 10 0.01 1.8e-01 -4.583 -5.6 2.1e-08 -0.25 0.07 0.07 FALSE
29 GTEx Skin Sun Exposed Lower leg SUFU 0.06 0.05 enet 12 0.06 8.4e-06 -6.468 6.5 6.4e-11 0.40 0.86 0.11 FALSE
30 GTEx Skin Sun Exposed Lower leg ACTR1A 0.08 0.06 enet 10 0.07 2.7e-06 -6.580 5.3 1.2e-07 0.33 0.81 0.11 FALSE
31 GTEx Testis CYP17A1-AS1 0.14 0.08 enet 5 0.10 2.3e-05 5.787 -5.9 4.6e-09 -0.38 0.68 0.08 FALSE
32 GTEx Thyroid SFXN2 0.28 0.06 enet 32 0.15 1.1e-11 -1.986 -5.4 7.9e-08 -0.60 0.16 0.84 FALSE
33 GTEx Thyroid WBP1L 0.26 0.10 enet 9 0.13 2.1e-10 3.135 -5.4 7.2e-08 -0.20 1.00 0.00 FALSE
34 NTR Blood ACTR1A 0.03 0.03 enet 19 0.03 1.4e-09 -4.348 6.3 2.3e-10 0.49 0.99 0.01 FALSE
35 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 6.255 6.2 5.7e-10 0.37 0.93 0.07 FALSE
36 ROSMAP Brain Pre-frontal Cortex CYP17A1-AS1 0.15 0.18 lasso 6 0.19 1.3e-23 6.682 7.1 1.4e-12 0.81 0.80 0.20 FALSE
37 YFS Blood ARL3 0.39 0.14 enet 30 0.20 7.0e-63 3.175 5.9 3.9e-09 0.46 1.00 0.00 FALSE
38 YFS Blood NT5C2 0.13 0.10 bslmm 382 0.11 7.3e-35 6.556 5.5 3.6e-08 0.22 0.92 0.08 FALSE
39 YFS Blood TRIM8 0.04 0.04 lasso 6 0.05 1.2e-15 -4.630 5.2 1.6e-07 0.38 1.00 0.00 FALSE
40 The Cancer Genome Atlas Bladder Urothelial Carcinoma AS3MT 0.06 0.09 enet 6 0.07 1.3e-06 6.561 -7.2 7.4e-13 -0.80 0.12 0.88 FALSE
41 The Cancer Genome Atlas Bladder Urothelial Carcinoma C10orf32 0.06 0.06 blup 54 0.08 1.2e-07 3.494 -5.2 1.8e-07 -0.81 0.48 0.52 FALSE
42 The Cancer Genome Atlas Breast Invasive Carcinoma AS3MT 0.05 0.05 enet 10 0.05 4.7e-11 6.561 -6.0 1.7e-09 -0.82 0.25 0.75 FALSE
43 The Cancer Genome Atlas Breast Invasive Carcinoma C10orf26 0.03 0.02 enet 5 0.02 1.6e-04 -6.012 -5.8 8.8e-09 -0.40 0.90 0.02 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma SFXN2 0.12 0.09 lasso 4 0.10 4.4e-19 5.407 -5.4 6.6e-08 -0.16 1.00 0.00 FALSE
45 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C10orf32 0.16 0.06 blup 54 0.10 1.3e-05 3.494 -5.4 7.0e-08 -0.80 0.08 0.85 FALSE
46 The Cancer Genome Atlas Esophageal Carcinoma SFXN2 0.26 0.02 blup 48 0.10 4.9e-04 5.407 -5.8 8.5e-09 -0.37 0.01 0.71 FALSE
47 The Cancer Genome Atlas Glioblastoma Multiforme AS3MT 0.15 0.05 blup 62 0.10 5.1e-04 3.494 -5.6 2.6e-08 -0.83 0.04 0.57 FALSE
48 The Cancer Genome Atlas Glioblastoma Multiforme SFXN2 0.27 0.02 blup 47 0.11 3.1e-04 5.407 -5.2 2.1e-07 -0.36 0.02 0.55 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AS3MT 0.05 0.05 blup 62 0.06 1.1e-07 7.550 -5.8 8.7e-09 -0.88 0.01 0.99 FALSE
50 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AS3MT 0.04 0.05 enet 3 0.04 8.6e-06 6.561 -6.5 5.6e-11 -0.85 0.12 0.86 FALSE
51 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SFXN2 0.20 0.08 blup 48 0.13 9.3e-07 5.407 -5.6 2.8e-08 -0.33 0.13 0.82 FALSE
52 The Cancer Genome Atlas Lung Adenocarcinoma TMEM180 0.08 0.07 blup 52 0.09 1.9e-10 -6.473 6.2 4.8e-10 0.39 0.01 0.99 FALSE
53 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM180 0.05 0.02 blup 52 0.04 1.5e-05 -5.634 5.9 4.8e-09 0.39 0.02 0.94 FALSE
54 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SUFU 0.03 0.02 blup 90 0.02 1.5e-02 -6.568 -6.0 1.6e-09 -0.33 0.03 0.77 FALSE
55 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma AS3MT 0.13 0.14 blup 62 0.13 5.6e-06 7.265 -6.6 3.4e-11 -0.92 0.03 0.97 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma AS3MT 0.16 0.21 lasso 9 0.24 2.5e-24 6.531 -5.4 7.0e-08 -0.84 0.39 0.61 FALSE
57 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM180 0.16 0.27 lasso 4 0.27 4.3e-28 -6.395 -6.4 2.0e-10 -0.40 0.02 0.98 FALSE
58 The Cancer Genome Atlas Rectum Adenocarcinoma C10orf32 0.17 0.14 blup 52 0.14 3.2e-04 7.265 -7.1 9.5e-13 -0.94 0.02 0.75 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma AS3MT 0.23 0.18 lasso 3 0.18 1.8e-17 6.531 -6.2 4.4e-10 -0.85 0.83 0.17 FALSE
60 The Cancer Genome Atlas Thyroid Carcinoma C10orf26 0.06 0.05 lasso 5 0.04 4.1e-05 6.925 -6.6 3.2e-11 -0.75 0.07 0.88 FALSE
61 The Cancer Genome Atlas Thyroid Carcinoma CYP17A1 0.04 0.02 lasso 1 0.02 3.9e-03 7.550 -7.5 4.3e-14 -1.00 0.01 0.92 FALSE