[Hub]/) : Traits : Whole body water mass :

chr14:24,039,559-25,605,046

Best TWAS P=6.19e-15 · Best GWAS P=2.31e-14 conditioned to 0

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ADCY4 0.08 0.04 lasso 3 0.03 3.3e-03 5.0 5.4 7.6e-08 0.62 0.19 0.30 FALSE
2 GTEx Breast Mammary Tissue LTB4R 0.30 0.18 lasso 4 0.16 2.3e-08 5.2 -5.2 1.9e-07 -0.63 0.72 0.27 FALSE
3 GTEx Heart Atrial Appendage ADCY4 0.28 0.14 lasso 4 0.10 2.1e-05 7.1 6.1 1.2e-09 0.48 0.06 0.85 TRUE
4 GTEx Lung LTB4R 0.19 0.15 lasso 6 0.12 2.0e-09 5.0 -5.5 2.9e-08 -0.66 0.99 0.01 FALSE
5 GTEx Muscle Skeletal CBLN3 0.14 0.13 enet 7 0.13 4.8e-13 4.8 -5.2 2.0e-07 -0.13 1.00 0.00 TRUE
6 GTEx Spleen NFATC4 0.45 0.00 enet 24 0.00 2.5e-01 4.8 -6.2 6.1e-10 -0.22 0.07 0.06 TRUE
7 GTEx Thyroid ADCY4 0.13 0.13 lasso 6 0.09 1.0e-07 4.3 5.8 8.3e-09 0.51 0.30 0.70 FALSE
8 METSIM Adipose ADCY4 0.07 0.03 lasso 5 0.03 2.2e-05 7.3 7.8 6.2e-15 0.71 0.03 0.97 TRUE
9 METSIM Adipose LTB4R 0.15 0.07 blup 498 0.07 6.2e-11 5.2 -5.2 2.1e-07 -0.61 0.40 0.60 TRUE
10 METSIM Adipose RABGGTA 0.10 0.06 lasso 9 0.08 5.5e-12 5.7 5.2 1.6e-07 0.62 0.99 0.01 TRUE
11 YFS Blood KHNYN 0.36 0.20 enet 50 0.29 1.2e-96 4.1 5.1 3.0e-07 0.14 1.00 0.00 TRUE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma ADCY4 0.03 0.01 blup 75 0.03 1.1e-03 4.7 6.0 1.9e-09 0.71 0.05 0.74 FALSE
13 The Cancer Genome Atlas Colon Adenocarcinoma ADCY4 0.07 0.02 lasso 4 0.03 4.7e-03 5.1 6.0 1.9e-09 0.70 0.03 0.76 TRUE
14 The Cancer Genome Atlas Colon Adenocarcinoma CBLN3 0.24 0.14 enet 8 0.13 4.0e-08 4.8 -5.1 2.7e-07 -0.14 0.51 0.48 FALSE
15 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY4 0.06 0.06 lasso 6 0.09 3.0e-10 6.6 7.6 3.9e-14 0.75 0.04 0.96 FALSE
16 The Cancer Genome Atlas Lung Adenocarcinoma ADCY4 0.07 0.09 lasso 3 0.08 4.4e-10 5.2 6.5 6.5e-11 0.73 0.85 0.15 FALSE
17 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LTB4R 0.16 0.05 blup 73 0.08 4.9e-04 3.5 -5.6 2.2e-08 -0.70 0.03 0.56 FALSE
18 The Cancer Genome Atlas Stomach Adenocarcinoma LTB4R 0.04 0.01 blup 73 0.01 4.2e-02 6.2 -5.8 8.1e-09 -0.63 0.01 0.46 FALSE
19 The Cancer Genome Atlas Stomach Adenocarcinoma LTB4R2 0.04 0.04 lasso 1 0.02 2.5e-02 6.2 -6.2 4.7e-10 -0.70 0.04 0.52 FALSE