[Hub]/) : Traits : Whole body water mass : ← →

chr2:217,456,567-220,226,393

Best TWAS P=1.07e-18 · Best GWAS P=1.54e-33 conditioned to 1.63e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	BCS1L	0.06	0.01	enet	9	0.04	2.3e-04	-3.3	6.2	8.0e-10	-0.04	0.07	0.24	FALSE
2	GTEx	Adipose Visceral Omentum	PNKD	0.11	0.00	enet	31	0.00	2.3e-01	-6.4	6.8	1.1e-11	0.06	0.01	0.93	TRUE
3	GTEx	Adipose Visceral Omentum	TMBIM1	0.17	0.03	enet	31	0.03	1.1e-02	-5.1	5.7	1.2e-08	0.09	0.02	0.96	FALSE
4	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	-5.3	5.7	1.3e-08	0.07	0.04	0.96	FALSE
5	GTEx	Artery Tibial	RP11-378A13.1	0.20	0.17	enet	13	0.24	7.6e-19	-6.4	5.3	1.1e-07	0.07	0.01	0.99	FALSE
6	GTEx	Brain Caudate basal ganglia	RP11-378A13.1	0.55	0.38	enet	17	0.52	4.0e-17	-5.1	5.3	1.2e-07	0.09	0.02	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	-5.1	5.5	5.1e-08	0.07	0.05	0.95	FALSE
8	GTEx	Brain Cortex	RP11-378A13.1	0.61	0.56	enet	23	0.61	6.7e-21	-5.1	5.2	1.8e-07	0.10	0.10	0.90	FALSE
9	GTEx	Brain Frontal Cortex BA9	RP11-378A13.1	0.38	0.54	enet	24	0.49	7.2e-15	-5.1	5.1	3.0e-07	0.10	0.16	0.84	FALSE
10	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	-5.1	5.7	9.5e-09	0.10	0.01	0.99	FALSE
11	GTEx	Colon Sigmoid	RP11-378A13.1	0.31	0.33	enet	23	0.34	6.0e-13	-5.1	5.2	2.2e-07	0.09	0.10	0.90	FALSE
12	GTEx	Esophagus Mucosa	RP11-378A13.1	0.28	0.32	enet	27	0.39	1.3e-27	-5.1	5.2	1.6e-07	0.10	0.56	0.44	FALSE
13	GTEx	Esophagus Muscularis	RP11-378A13.1	0.37	0.42	enet	21	0.41	6.9e-27	-5.1	5.1	2.7e-07	0.10	0.42	0.58	FALSE
14	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	-6.0	5.6	1.9e-08	0.08	0.02	0.98	FALSE
15	GTEx	Pancreas	PNKD	0.12	0.10	lasso	3	0.08	3.6e-04	-6.4	6.0	2.1e-09	0.05	0.00	0.97	FALSE
16	GTEx	Pancreas	RP11-378A13.1	0.29	0.14	enet	24	0.16	4.4e-07	-5.1	5.2	1.6e-07	0.08	0.03	0.97	FALSE
17	GTEx	Pituitary	PNKD	0.29	0.23	enet	21	0.24	8.9e-07	-6.4	5.9	3.0e-09	0.09	0.01	0.99	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	-5.3	5.5	4.0e-08	0.08	0.27	0.73	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	-5.3	5.4	8.2e-08	0.09	0.34	0.66	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	-5.3	5.5	4.7e-08	0.08	0.29	0.71	FALSE
21	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	-5.1	5.6	1.7e-08	0.06	0.03	0.93	FALSE
22	GTEx	Spleen	RP11-378A13.1	0.37	0.41	enet	27	0.41	1.2e-11	-4.4	5.4	6.5e-08	0.07	0.02	0.98	FALSE
23	GTEx	Testis	RP11-378A13.1	0.37	0.18	enet	22	0.22	2.7e-10	-4.1	5.4	6.0e-08	0.09	0.49	0.51	FALSE
24	GTEx	Thyroid	PNKD	0.13	0.12	enet	13	0.14	6.3e-11	-6.4	5.7	1.1e-08	0.07	0.00	1.00	FALSE
25	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	-5.1	5.4	6.4e-08	0.10	0.11	0.89	FALSE
26	GTEx	Vagina	RP11-378A13.1	0.22	0.07	enet	11	0.03	7.1e-02	-5.1	5.2	1.8e-07	0.10	0.11	0.36	FALSE
27	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	-5.1	5.4	6.7e-08	0.10	0.05	0.93	FALSE
28	METSIM	Adipose	AAMP	0.03	0.00	bslmm	433	0.01	7.1e-03	-4.0	5.5	4.0e-08	0.08	0.06	0.83	FALSE
29	METSIM	Adipose	PNKD	0.07	0.08	lasso	7	0.08	4.8e-12	-6.4	6.3	3.9e-10	0.07	0.00	1.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	DIRC3	0.12	0.07	bslmm	697	0.08	2.7e-10	-7.3	7.8	9.2e-15	0.00	1.00	0.00	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	RP11-378A13.1	0.44	0.64	bslmm	431	0.64	1.1e-107	-5.1	5.2	1.6e-07	0.11	0.64	0.35	FALSE
32	YFS	Blood	GPBAR1	0.04	0.06	lasso	10	0.06	2.3e-18	-5.1	-5.3	1.4e-07	-0.10	0.45	0.55	FALSE
33	YFS	Blood	PNKD	0.08	0.07	lasso	6	0.09	2.9e-27	-4.6	5.9	3.6e-09	0.05	0.04	0.96	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM1	0.04	0.01	blup	49	0.02	4.8e-05	-5.1	5.7	1.2e-08	0.09	0.10	0.85	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DIRC3	0.12	0.01	blup	275	0.02	3.3e-03	-1.3	7.1	1.6e-12	-0.51	0.05	0.52	TRUE
36	The Cancer Genome Atlas	Thyroid Carcinoma	DIRC3	0.08	0.06	lasso	5	0.07	2.7e-07	-9.6	8.8	1.1e-18	-0.56	0.98	0.01	TRUE