[Hub]/) : Traits : Whole body water mass :

chr4:121,982,122-124,538,705

Best TWAS P=4.28e-19 · Best GWAS P=1.44e-15 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BBS7 0.19 0.21 bslmm 423 0.23 1.8e-27 -7.62 -7.9 3.3e-15 -0.01 0.00 1.00 FALSE
2 CommonMind Brain Pre-frontal Cortex NUDT6 0.04 0.04 lasso 3 0.02 6.5e-04 6.18 6.2 5.3e-10 0.74 0.72 0.03 FALSE
3 CommonMind Brain Pre-frontal Cortex TMEM155 0.06 0.05 lasso 3 0.02 5.5e-04 -6.13 -5.6 1.7e-08 -0.05 0.13 0.81 FALSE
4 GTEx Adipose Subcutaneous EXOSC9 0.07 0.00 lasso 2 0.00 4.5e-01 -5.89 5.6 2.5e-08 0.04 0.05 0.33 FALSE
5 GTEx Artery Tibial FGF2 0.18 0.05 lasso 3 0.02 1.3e-02 6.19 6.4 1.6e-10 0.36 0.08 0.11 TRUE
6 GTEx Artery Tibial NUDT6 0.08 0.08 lasso 5 0.05 5.6e-05 6.06 6.2 7.3e-10 0.73 0.66 0.08 FALSE
7 GTEx Brain Cerebellar Hemisphere BBS7 0.27 0.05 lasso 3 0.08 4.7e-03 -5.88 -5.5 3.9e-08 -0.01 0.08 0.34 FALSE
8 GTEx Brain Cerebellum BBS7 0.20 -0.01 enet 24 0.01 2.2e-01 -5.82 -6.1 1.2e-09 -0.03 0.07 0.73 FALSE
9 GTEx Breast Mammary Tissue NUDT6 0.25 0.10 lasso 3 0.08 4.2e-05 6.29 6.3 2.9e-10 0.83 0.10 0.87 TRUE
10 GTEx Breast Mammary Tissue (Male) NUDT6 0.29 0.00 lasso 6 0.00 3.5e-01 6.03 6.2 6.9e-10 0.74 0.04 0.41 TRUE
11 GTEx Breast Mammary Tissue (Female) NUDT6 0.30 -0.01 enet 30 0.00 2.6e-01 6.49 5.8 7.4e-09 0.62 0.03 0.33 TRUE
12 GTEx Cells EBV-transformed lymphocytes EXOSC9 0.29 0.17 lasso 7 0.16 6.6e-06 7.01 7.6 2.7e-14 0.01 0.18 0.79 FALSE
13 GTEx Cells Transformed fibroblasts BBS7 0.16 0.09 lasso 7 0.16 2.9e-12 -7.68 -8.2 2.4e-16 -0.03 0.00 1.00 FALSE
14 GTEx Colon Transverse BBS12 0.12 0.05 enet 29 0.12 3.2e-06 0.75 6.0 2.4e-09 0.48 0.04 0.58 TRUE
15 GTEx Muscle Skeletal NUDT6 0.15 0.12 lasso 3 0.11 1.1e-10 6.18 6.2 4.5e-10 0.74 0.99 0.01 FALSE
16 GTEx Muscle Skeletal RP11-170N16.3 0.07 0.07 lasso 3 0.06 8.8e-07 5.37 6.2 7.7e-10 0.74 0.23 0.76 FALSE
17 GTEx Nerve Tibial NUDT6 0.11 0.08 lasso 3 0.05 2.1e-04 5.81 5.8 6.1e-09 0.69 0.80 0.02 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic NUDT6 0.07 0.02 lasso 6 0.03 1.5e-02 4.88 5.9 4.0e-09 0.71 0.19 0.60 TRUE
19 GTEx Skin Sun Exposed Lower leg NUDT6 0.11 0.08 lasso 3 0.08 6.2e-07 6.03 6.1 1.3e-09 0.70 0.94 0.02 TRUE
20 GTEx Testis EXOSC9 0.17 0.07 lasso 8 0.10 2.5e-05 -5.90 7.7 1.6e-14 0.04 0.01 0.98 FALSE
21 ROSMAP Brain Pre-frontal Cortex EXOSC9 0.05 0.02 lasso 7 0.02 5.3e-04 5.25 5.9 2.9e-09 -0.03 0.29 0.52 FALSE
22 ROSMAP Brain Pre-frontal Cortex NUDT6 0.04 0.04 enet 9 0.03 2.0e-04 6.15 5.6 2.8e-08 0.64 0.62 0.15 TRUE
23 YFS Blood EXOSC9 0.06 0.09 bslmm 401 0.09 7.0e-28 7.04 7.5 6.6e-14 0.00 0.23 0.77 FALSE
24 The Cancer Genome Atlas Breast Invasive Carcinoma EXOSC9 0.03 0.04 enet 9 0.04 2.8e-08 7.23 8.0 1.5e-15 0.02 0.13 0.87 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma NUDT6 0.02 0.02 lasso 4 0.01 5.4e-03 6.05 6.0 1.6e-09 0.72 0.13 0.14 FALSE
26 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCNA2 0.11 -0.01 enet 14 0.02 4.4e-02 0.73 5.5 4.1e-08 0.09 0.00 0.27 FALSE
27 The Cancer Genome Atlas Colon Adenocarcinoma BBS7 0.05 0.00 blup 47 0.02 1.9e-02 7.27 -7.3 2.1e-13 -0.03 0.02 0.18 FALSE
28 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BBS7 0.04 0.02 blup 47 0.03 1.3e-04 -5.88 -5.7 1.3e-08 -0.03 0.05 0.91 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CCNA2 0.03 0.01 blup 34 0.02 1.5e-03 -7.58 8.9 4.3e-19 0.02 0.00 0.97 TRUE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma BBS7 0.04 0.04 lasso 2 0.03 6.1e-04 -7.62 -7.6 2.3e-14 -0.03 0.00 1.00 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FGF2 0.06 0.04 blup 65 0.05 4.4e-06 6.96 6.5 6.7e-11 0.85 0.01 0.99 TRUE
32 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EXOSC9 0.03 0.02 lasso 2 0.02 1.0e-03 7.13 7.7 1.9e-14 0.01 0.07 0.44 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma NUDT6 0.10 0.07 lasso 6 0.07 1.0e-07 6.06 5.7 1.1e-08 0.71 0.97 0.03 FALSE
34 The Cancer Genome Atlas Thyroid Carcinoma EXOSC9 0.04 0.05 lasso 2 0.04 7.1e-05 7.23 8.1 4.8e-16 0.03 0.03 0.95 FALSE