TWAS hub - TMEM155

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0240	0.0014	0.045	0.010	0.018	0.017	0.024	3.0e-06	0.021	0.0027	0.0033	0.00055
2	ROSMAP	Brain Pre-frontal Cortex	0.0483	0.0204	0.0051	0.011	0.009	0.007	0.010	0.008	1.1e-02	0.024	0.0410	0.0170	0.02900

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of full sisters	10.3	12.6	20.7	4.5	2.1
High blood pressure (mother)	5.2	7.3	7.4	-2.7	-2.7
Diabetes (father)	5.1	6.3	8.6	-2.0	-2.9
Hayfever/allergic rhinitis (self-reported)	5.1	6.8	10.0	-1.9	-3.2
Osteoarthritis (self-reported)	5.1	6.6	9.7	1.9	3.1
Heart attack	4.9	6.3	8.2	2.9	2.1
Alzheimer’s Disease (in father)	4.7	5.1	5.3	-2.2	-2.3
Height	4.5	85.8	116.6	-10.8	-7.4
Trunk predicted mass	4.4	25.1	39.1	-6.2	-3.4
Medication: Blood pressure	4.4	8.4	12.0	-3.5	-2.2
Trunk fat-free mass	4.3	24.5	38.1	-6.2	-3.3
Breast Cancer	4.2	10.1	13.0	-2.7	-3.6
Arm predicted mass (left)	4.2	21.2	31.5	-5.6	-3.3
High blood pressure	4.1	11.5	12.6	-3.5	-3.2
Heart attack/myocardial infarction (self-reported)	4.0	5.2	6.6	2.6	1.9
Arm fat-free mass (left)	3.8	19.4	30.2	-5.5	-2.9
Medication for cholesterol	3.7	5.7	7.2	2.7	2.0
Whole body water mass	3.6	20.4	31.8	-5.6	-3.0
Peak expiratory flow (PEF)	3.4	8.0	9.5	-2.5	-3.1
Hypertension (Self-reported)	3.4	9.4	10.1	-3.2	-3.0
Whole body fat-free mass	3.4	19.6	30.7	-5.5	-2.9
Basal metabolic rate	3.4	18.8	30.4	-5.5	-2.7
Ever depressed for a whole week	3.4	4.1	7.1	2.7	1.1
Arm predicted mass (right)	3.3	17.0	26.6	-5.2	-2.7
Blood Red Count	3.2	30.7	30.8	-5.5	-5.5
Body Mass Index (BMI) (2010)	3.0	4.2	6.0	-2.5	-1.5
Illnesses of mother	3.0	3.8	4.6	1.7	2.1
Arm fat-free mass (right)	3.0	15.3	23.5	-4.8	-2.7
Ever had bowel cancer screening	3.0	3.5	3.9	-2.0	-1.8
Chronic bronchitis/emphysema (father)	2.9	3.4	3.5	1.8	1.9
Vascular/heart problems diagnosed by doctor	2.9	8.0	8.9	3.0	2.7
Major Depression (MDD)	2.8	3.4	6.4	-0.6	-2.5
Average weekly spirits intake	2.8	3.4	4.0	1.7	2.0
Standing height	2.8	28.0	37.2	-6.1	-4.3
Lupus	2.7	4.1	5.4	-1.7	-2.3
Comparative height size at age 10	2.6	14.4	23.9	-4.9	-2.2
Loneliness, isolation	2.6	3.5	6.0	2.4	1.0
Leg predicted mass (right)	2.6	13.9	22.2	-4.7	-2.4
Noisy workplace	2.5	3.0	3.0	1.7	1.7
Leg fat-free mass (right)	2.5	13.5	21.5	-4.6	-2.3
Leg fat-free mass (left)	2.4	12.8	20.4	-4.5	-2.3
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	5.8	2.4	0.4
Allergy	2.4	5.6	10.2	1.0	3.2
Time employed in main current job	2.4	2.7	3.2	-1.5	-1.8
Medication: Paracetamol	2.4	4.0	4.4	2.1	1.9
Leg predicted mass (left)	2.3	12.2	19.4	-4.4	-2.2
Number of incorrect matches in round	2.3	3.8	5.1	1.6	2.3
Weight	2.2	10.6	18.5	-4.3	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	5.4	2.3	0.1
Coronary Artery Disease (CAD)	2.0	2.4	4.0	-2.0	-0.9
Ever had hysterectomy (womb removed)	1.9	2.2	3.1	-1.8	-1.1
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	2.9	-1.2	-1.7
Sitting height	1.9	13.3	16.6	-4.1	-3.1
Alcohol intake versus 10 years previously	1.9	2.8	3.0	-1.7	-1.6
Medication: Cholesterol lowering	1.9	3.0	3.9	2.0	1.5
Mouth/teeth dental problems: Loose teeth	1.9	2.3	2.9	1.7	1.3
Hip circumference	1.8	7.6	15.1	-3.9	-0.5
Pulse rate, automated reading	1.8	5.8	8.4	2.9	1.8
Depression (self-reported)	1.7	2.1	2.8	1.7	1.2
Birth weight of first child	1.7	3.1	3.9	-2.0	-1.6
Number of self-reported non-cancer illnesses	1.7	2.9	3.7	-1.5	-1.9
Medication: Paracetamol	1.7	2.6	3.4	1.9	1.3
Ever had prostate specific antigen (PSA) test	1.7	1.9	2.1	-1.5	-1.3
Diastolic blood pressure, automated reading	1.7	5.4	5.7	-2.4	-2.3
Fasting Glucose	1.6	1.9	2.1	-1.3	-1.5
Lung FEV1/FVC ratio	1.6	8.0	12.7	-3.6	-1.8
Health satisfaction	1.6	2.0	2.5	-1.6	-1.3
Pack years of smoking	1.6	2.4	2.5	1.5	1.6
Type 2 Diabetes (T2D) (2012)	1.5	1.7	3.0	-0.7	-1.7
Smoking status: Current	1.5	2.5	3.8	1.9	1.1
Blood Platelet Count	1.4	16.4	23.8	-3.0	-4.9
Hypothyroidism (self reported)	1.4	3.3	4.9	2.2	1.3
Chronotype (morning person)	1.4	3.2	5.8	0.7	2.4
Past tobacco smoking	1.4	2.5	4.6	-2.1	-0.6
Had other major operations	1.4	1.7	2.7	-1.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	6.9	-2.6	-1.4
Exposure to tobacco smoke at home	1.4	1.5	2.0	1.4	1.0
Number of children fathered	1.4	1.6	3.1	-0.0	-1.8
Asthma (self-reported)	1.4	2.8	5.3	-0.5	-2.3
Illnesses of father: High blood pressure	1.4	1.7	1.8	-1.3	-1.3
Allergy or Eczema	1.3	3.3	6.3	0.6	-2.5
Pack years adult smoking proportion	1.3	2.0	2.0	1.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.7	-0.7	-1.9
Asthma	1.3	2.5	4.5	-0.6	-2.1
Impedance of arm (left)	1.3	5.9	9.3	3.0	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	2.4	-1.3	-1.6
Medication: Bendroflumethiazide	1.3	1.9	3.3	-0.7	-1.8
Alcohol drinker status: Previous	1.3	1.5	1.8	-1.0	-1.4
Average weekly fortified wine intake	1.2	1.4	2.6	1.6	0.5
Glaucoma (self-reported)	1.2	1.4	2.7	-1.6	-0.4
Irritability	1.2	2.0	3.4	1.9	0.7
Age started oral contraceptive pill	1.2	1.5	2.1	-1.5	-0.9
Blood White Count	1.1	7.9	12.5	3.5	1.9
Supplements: Glucosamine	1.1	1.4	2.8	0.1	1.7
Hair/balding pattern: Pattern 2	1.1	1.4	1.5	1.2	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	1.7	1.1	1.3
Tense / ‘highly strung’	1.1	1.8	1.8	1.4	1.3
Miserableness	1.1	1.8	3.3	1.8	0.6
Wears glasses or contact lenses	1.1	1.3	1.6	1.3	1.0
Risk taking	1.1	1.6	3.2	1.8	0.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.2	1.5	0.6
Impedance of whole body	1.1	5.8	10.0	3.2	1.3
Depression (Nagel 2018)	1.0	1.4	2.8	1.7	0.2
LDL Cholesterol	1.0	1.6	2.5	1.6	0.9
Relative age voice broke	1.0	1.5	2.8	0.4	1.7
Hayfever, allergic rhinitis or eczema	1.0	2.2	4.4	-0.2	-2.1
Stomach or abdominal pain in last month	1.0	1.3	1.5	-1.1	-1.2
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.2	-0.6	-1.5
Wheeze or whistling in the chest in last year	1.0	1.7	3.4	0.3	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.2	0.1	-1.5
Age at last live birth	1.0	1.4	2.5	0.5	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	2.3	-1.3	-1.5
Illnesses of father: None of the above (group 1)	1.0	1.2	1.5	1.0	1.2
Eye problems/disorders: Glaucoma	1.0	1.1	1.8	-1.3	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.3	1.6	-1.0	-1.2
Age at First Birth	0.9	1.4	1.8	1.0	1.3
Heel T-Score	0.9	7.0	7.9	2.8	2.5
Smoking Status	0.9	2.1	3.0	1.7	1.1
Respiratory disease	0.9	2.1	4.1	0.3	-2.0
Medication: Atenolol	0.9	1.1	2.0	-1.4	-0.6
Waist circumference	0.9	3.4	6.1	-2.5	-0.9
Mouth/teeth dental problems	0.9	1.4	2.5	-1.6	-0.5
Pulse rate	0.9	1.5	1.9	1.4	1.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.9	2.6	1.6	1.1
Forced vital capacity (FVC), Best measure	0.9	3.4	5.1	-2.3	-1.3
Emphysema/chronic bronchitis	0.9	1.0	1.1	-0.9	-1.0
Supplements: Vitamin C	0.9	1.1	1.1	1.0	1.0
Mood swings	0.9	1.6	3.1	1.8	0.3
Ovarian Cancer	0.8	1.0	2.0	1.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.8	-0.2	-1.7
Impedance of arm (right)	0.8	3.5	5.7	2.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	3.0	-1.7	-1.6
Headache pain in last month	0.8	1.4	2.6	-1.6	-0.5
Had major operations	0.8	0.9	1.2	1.1	-0.8
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.8	1.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.7	-0.6	-1.3
Depressed Affect (Nagel 2018)	0.7	1.6	3.1	1.8	0.0
Waist Hip Ratio (WHR)	0.7	3.3	6.6	2.6	0.2
Systolic Blood Pressure	0.7	3.7	4.6	-2.1	-1.7
Systolic blood pressure, automated reading	0.7	2.1	3.3	-1.8	-1.0
Current tobacco smoking	0.7	1.2	1.8	1.3	0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.4	0.3	-1.2
Medication: Ramipril	0.7	0.9	1.6	-1.3	0.4
Mouth/teeth dental problems: Dentures	0.7	1.2	1.9	1.4	0.7
Arm fat mass (right)	0.7	2.8	5.6	-2.4	-0.2
Age at first live birth	0.7	1.3	2.4	0.5	1.5
Medication: Allopurinol	0.7	0.9	1.0	0.9	1.0
Overall health rating	0.7	1.4	1.8	-1.0	-1.3
Illnesses of siblings: Diabetes	0.7	0.9	1.6	1.3	-0.5
Medication: Aspirin	0.7	0.9	1.6	0.3	-1.3
Arm fat mass (left)	0.7	3.0	5.9	-2.4	-0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	1.0	0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.8	1.0	-1.0	-0.8
Leg fat mass (left)	0.7	2.6	5.1	-2.3	-0.0
Prostate Cancer	0.6	0.8	1.0	-1.0	-0.8
Cardiovascular Disease	0.6	2.0	2.4	-1.6	-1.3
Medication for hormone replacement therapy	0.6	0.6	1.1	-1.0	-0.4
Supplements: Zinc	0.6	0.7	1.3	-0.2	-1.1
Severe depression (siblings)	0.6	0.7	0.8	0.7	0.9
Impedance of leg (right)	0.6	3.1	5.6	2.4	0.7
Taking other prescription medications	0.6	0.9	1.4	-0.6	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.4	1.1
Multivitamins +/- minerals	0.6	0.7	1.4	-0.2	-1.2
Lung cancer (father)	0.6	0.7	1.3	1.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.9	1.4	-0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.4	1.2	-0.2
High blood pressure (siblings)	0.6	0.9	1.6	-0.4	-1.3
Comparative body size at age 10	0.6	1.6	2.2	1.5	0.9
Worry too long after embarrassment	0.6	1.0	1.4	-0.8	-1.2
Pulse wave peak to peak time	0.6	0.7	1.1	-0.6	-1.0
Medication for pain relief, constipation, heartburn	0.6	1.0	1.6	-1.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.1	0.6	1.1
Smoking status: Previous	0.6	1.0	1.9	1.4	0.0
Number of operations (self-reported)	0.6	0.9	1.3	-0.7	-1.1
Ulcerative Colitis (UC)	0.5	0.9	1.8	0.2	-1.3
Blood Eosinophil Count	0.5	4.1	7.3	2.7	1.0
Hand grip strength (left)	0.5	1.3	1.8	0.9	1.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.8	-0.9	0.7
Impedance of leg (left)	0.5	2.5	4.7	2.2	0.6
Pain all over the body in last month	0.5	0.6	0.7	0.9	-0.6
Hair/balding pattern: Pattern 3	0.5	0.7	0.7	0.9	0.8
Medication: Lansoprazole	0.5	0.6	1.1	1.0	0.4
Prospective memory result	0.5	0.6	0.7	-0.8	-0.8
Length of working week for main job	0.5	0.5	1.1	0.1	-1.0
Loud music exposure frequency	0.5	0.5	0.8	0.9	-0.5
Gout (self-reported)	0.5	0.6	0.8	0.9	0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	1.1	-0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.1	-0.5	-1.1
Eye problems/disorders: None of the above	0.5	0.6	0.8	-0.9	-0.6
Medication: Ibuprofen	0.5	0.6	0.7	0.7	0.8
Medication: Omeprazole	0.5	0.6	0.7	-0.7	-0.8
Whole body fat mass	0.5	2.2	4.4	-2.1	-0.1
Leg fat mass (right)	0.5	2.0	3.9	-2.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.8	0.7	-0.9
Eye problems/disorders: Cataract	0.5	0.6	1.0	1.0	0.5
Fractured/broken bones in last 5 years	0.5	0.7	1.1	-1.1	-0.5
Cholesterol lowering medication	0.5	0.8	0.9	-0.8	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	1.2	0.0	-1.1
Lung FVC	0.4	2.3	2.9	1.7	1.3
Trunk fat mass	0.4	1.8	3.6	-1.9	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	-0.5	-0.9
Forced vital capacity (FVC)	0.4	1.6	2.1	-1.4	-1.1
Diabetes (self-reported)	0.4	0.6	1.1	-0.2	-1.0
Number of live births	0.4	0.6	0.8	0.9	0.6
Breastfed as a baby	0.4	0.5	0.7	0.5	0.8
Medication: Amlodipine	0.4	0.5	1.0	1.0	-0.2
Birth weight	0.4	0.8	1.3	1.2	0.5
Migraine (self-reported)	0.4	0.5	0.5	-0.6	0.7
Heart disease (mother)	0.4	0.5	0.9	1.0	-0.2
Suffer from ‘nerves’	0.4	0.6	0.7	0.7	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.7	-0.8	0.5
Medication: Aspirin	0.4	0.5	0.8	0.3	-0.9
Ever smoked	0.4	0.7	1.4	1.2	-0.1
Neuroticism (Nagel 2018)	0.3	0.8	1.6	1.3	-0.1
Schizophrenia (2018)	0.3	0.7	1.3	-1.1	-0.2
Reaction Time	0.3	0.5	1.0	-1.0	-0.1
Crohns Disease (2012)	0.3	0.5	1.1	-1.0	-0.1
HbA1C	0.3	0.3	0.6	-0.7	-0.2
Neuroticism (2016)	0.3	0.4	0.7	0.8	-0.3
Schizophrenia (2014)	0.3	0.6	1.2	-1.1	-0.3
Tanning	0.3	4.2	7.1	2.7	1.1
Sensitivity / hurt feelings	0.3	0.5	1.1	0.0	-1.0
Relative age of first facial hair	0.3	0.5	0.8	-0.9	-0.5
Diabetes (mother)	0.3	0.4	0.7	-0.4	-0.8
Qualifications: CSEs or equivalent	0.3	0.4	0.4	0.6	0.6
Body mass index (BMI)	0.3	1.4	2.7	-1.7	0.2
Fluid intelligence score	0.3	0.6	1.2	0.0	1.1
Happiness	0.3	0.4	0.5	-0.7	-0.5
Shortness of breath walking on level ground	0.3	0.3	0.4	-0.4	-0.7
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.0	0.9
Angina (self-reported)	0.3	0.4	0.9	0.9	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.5	-0.7	0.3
Illnesses of father: Heart disease	0.3	0.4	0.7	0.4	0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	-0.4	-0.9
Diabetes diagnosed by doctor	0.3	0.5	1.0	0.0	-1.0
Back pain experienced in last month	0.3	0.5	0.8	-0.3	-0.9
Mineral and other dietary supplements	0.3	0.4	0.7	0.1	-0.8
Medication: Gliclazide	0.3	0.3	0.5	0.7	-0.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.2	0.9
Alcohol drinker status: Never	0.3	0.3	0.6	-0.2	-0.8
Leg fat percentage (left)	0.3	1.1	2.0	-1.4	0.4
Primary Biliary Cirrhosis	0.2	0.3	0.3	-0.5	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.2	0.5	-0.4
Angina	0.2	0.3	0.5	0.7	-0.1
Fed-up feelings	0.2	0.4	0.5	0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	0.7
Alcohol usually taken with meals	0.2	0.4	0.7	-0.8	-0.2
Qualifications: None of the above	0.2	0.4	0.6	0.8	-0.4
Neuroticism score	0.2	0.4	0.8	0.9	-0.2
Arm fat percentage (right)	0.2	0.9	1.2	-0.8	1.1
Worrier / anxious feelings	0.2	0.3	0.6	0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.2	-0.4	0.4
Hair/balding pattern: Pattern 4	0.2	0.6	0.8	0.9	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.2	-0.4	-0.5
Blood clot in the leg (DVT)	0.2	0.3	0.3	-0.6	-0.5
Leg fat percentage (right)	0.2	0.9	1.3	-1.1	0.7
Number of full brothers	0.2	0.3	0.6	0.2	-0.7
Qualifications: College or University degree	0.2	0.8	1.4	-0.3	1.2
Mean time to correctly identify matches	0.2	0.5	0.9	-0.9	0.2
Alcohol intake frequency.	0.2	0.4	0.7	-0.4	-0.8
Family relationship satisfaction	0.2	0.3	0.5	-0.3	-0.7
Knee pain experienced in last month	0.2	0.4	0.7	0.2	0.8
Arm fat percentage (left)	0.2	0.9	1.5	-0.6	1.2
Friendships satisfaction	0.2	0.2	0.4	0.6	-0.1
Qualifications: nursing, teaching	0.2	0.4	0.5	-0.5	0.7
Breast cancer (self-reported)	0.2	0.2	0.3	0.3	-0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.3	0.6	0.6
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	0.2
Unable to work because of sickness or disability	0.2	0.3	0.4	0.5	0.6
Supplements: Calcium	0.2	0.2	0.3	-0.6	-0.1
Bipolar Disorder (2018)	0.1	0.2	0.2	0.3	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.7	0.2
Worry (Nagel 2018)	0.1	0.2	0.4	0.6	0.0
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.1	-0.6
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	0.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.3	0.5
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.4	0.2
HDL Cholesterol	0.1	0.1	0.3	0.1	0.5
Triglycerides	0.1	0.1	0.1	-0.3	0.4
Ulcerative Colitis	0.1	0.1	0.2	0.2	-0.5
BMI	0.1	0.6	1.1	-1.1	-0.1
Neuroticism	0.1	0.3	0.3	0.6	-0.5
Number of treatments/medications taken	0.1	0.1	0.3	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.5	-0.1
Vitamin and mineral supplements	0.1	0.2	0.2	-0.4	0.4
Medication: Co-codamol	0.1	0.1	0.2	0.1	-0.5
Medication: Metformin	0.1	0.1	0.1	-0.4	-0.3
Trunk fat percentage	0.1	0.2	0.3	-0.4	0.5
Hand grip strength (right)	0.1	0.3	0.5	-0.3	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.5	0.3
Age when periods started (menarche)	0.1	0.2	0.3	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.2	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.6	0.1
Nervous feelings	0.1	0.1	0.2	0.3	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	-0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	0.0	0.5
Illnesses of siblings	0.1	0.2	0.3	-0.2	0.5
Father’s age at death	0.1	0.2	0.2	-0.5	0.4
Falls in the last year	0.1	0.1	0.2	-0.3	0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	0.3	0.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.0	0.5
Pulse wave reflection index	0.1	0.2	0.3	0.6	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.5	-0.2
Body fat percentage	0.1	0.6	0.9	-0.4	1.0
Medication: Blood pressure	0.1	0.1	0.2	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.6	-0.0
Chest pain or discomfort	0.1	0.2	0.4	0.1	-0.6
Leg pain on walking	0.1	0.1	0.2	-0.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.4	-0.0
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.2	0.3
Ever taken oral contraceptive pill	0.1	0.2	0.3	0.6	-0.1
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.2	-0.4
Medication: Lisinopril	0.1	0.2	0.3	-0.3	-0.5
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.3	-0.4
Myopia	0.1	0.1	0.2	0.5	0.1
Pain experienced in last month	0.1	0.1	0.2	0.1	0.5
Heart disease (siblings)	0.1	0.2	0.3	0.6	-0.1
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.2	0.2
Crohns Disease (2017)	0.0	0.1	0.1	-0.1	0.4
Mean Putamen Volume	0.0	0.0	0.0	-0.0	-0.0
Rheumatoid Arthritis	0.0	0.1	0.1	0.4	0.0
Hair Pigment	0.0	0.0	0.1	-0.2	0.0
Hearing difficulty/problems: Yes	0.0	0.0	0.1	0.0	0.2
Maternal smoking around birth	0.0	0.0	0.0	-0.1	-0.0
Had menopause	0.0	0.0	0.1	-0.0	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.0	0.1
Medication: Simvastatin	0.0	0.1	0.1	0.0	-0.4
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.0	0.2
Average weekly red wine intake	0.0	0.0	0.0	-0.1	0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.3	-0.3
Guilty feelings	0.0	0.0	0.1	-0.1	-0.2
Hearing aid user	0.0	0.0	0.1	0.2	0.3
Mother’s age at death	0.0	0.0	0.1	-0.1	-0.3
Financial situation satisfaction	0.0	0.0	0.0	0.1	-0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	0.1	-0.3

Hub : Genes

TMEM155

Models

Trait associations