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chr5:136,723,696-141,087,689

Best TWAS P=6.28e-15 · Best GWAS P=2.46e-20 conditioned to 1.62e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	5.1	7.8	6.3e-15	0.76	0.01	0.97	TRUE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	6.8	-6.5	5.8e-11	0.03	0.00	0.98	TRUE
17	GTEx	Nerve Tibial	HARS	0.07	0.01	enet	16	0.04	1.1e-03	-4.9	6.1	1.3e-09	-0.03	0.06	0.89	TRUE
13	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	4.1	7.4	1.2e-13	0.77	0.03	0.85	FALSE
24	YFS	Blood	CXXC5	0.01	0.00	bslmm	244	0.01	2.6e-03	9.2	-7.1	1.3e-12	-0.67	0.00	0.95	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	WNT8A	0.05	0.01	blup	300	0.03	1.0e-04	-1.6	-6.5	8.0e-11	0.05	0.11	0.83	FALSE
20	GTEx	Vagina	PURA	0.52	0.05	enet	51	0.09	3.6e-03	5.9	-6.5	1.0e-10	-0.44	0.06	0.10	FALSE
14	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	9.2	-6.3	2.6e-10	-0.60	0.01	0.97	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	DNAJC18	0.26	0.09	lasso	2	0.12	9.7e-05	4.1	5.9	3.9e-09	0.49	0.18	0.30	FALSE
18	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-4.9	-5.9	3.9e-09	-0.02	0.06	0.88	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	KDM3B	0.07	0.01	blup	307	0.03	1.0e-04	5.3	-5.8	5.1e-09	-0.03	0.11	0.82	FALSE
15	GTEx	Esophagus Muscularis	DNAJC18	0.22	0.10	lasso	6	0.13	3.2e-08	4.1	5.8	6.6e-09	0.40	0.56	0.10	FALSE
25	YFS	Blood	TMCO6	0.01	0.00	blup	329	0.01	4.1e-03	-4.8	-5.7	1.5e-08	-0.03	0.07	0.92	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM173	0.02	0.03	blup	7	0.03	4.6e-07	4.8	-5.6	1.7e-08	-0.40	0.07	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DNAJC18	0.09	0.10	bslmm	260	0.10	2.5e-12	3.5	5.6	1.8e-08	0.41	1.00	0.00	FALSE
11	GTEx	Colon Transverse	TMCO6	0.15	0.06	enet	16	0.05	1.4e-03	4.8	-5.6	2.1e-08	-0.07	0.14	0.60	FALSE
12	GTEx	Colon Transverse	DNAJC18	0.37	-0.01	lasso	5	0.01	1.1e-01	4.1	5.6	2.2e-08	0.39	0.06	0.06	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM53C	0.05	0.02	bslmm	291	0.03	4.1e-04	7.3	5.5	3.0e-08	-0.06	0.02	0.93	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR55	0.09	0.08	enet	12	0.12	1.5e-07	-5.1	-5.5	3.9e-08	-0.05	0.02	0.97	FALSE
16	GTEx	Esophagus Muscularis	TMEM173	0.24	0.00	lasso	6	0.06	1.5e-04	4.1	-5.5	4.0e-08	-0.40	0.77	0.06	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PCDHA2	0.04	0.03	blup	478	0.03	5.0e-05	-5.1	-5.5	4.5e-08	-0.05	0.05	0.94	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR55	0.07	0.06	blup	44	0.06	1.7e-06	-5.1	-5.5	4.5e-08	-0.05	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR55	0.10	0.03	enet	8	0.04	3.3e-09	-5.1	-5.4	5.9e-08	0.01	0.02	0.98	FALSE
10	GTEx	Cells Transformed fibroblasts	CD14	0.09	0.05	lasso	4	0.06	2.7e-05	-3.8	-5.4	7.4e-08	-0.05	0.22	0.71	FALSE
19	GTEx	Spleen	DNAJC18	0.30	0.13	lasso	5	0.20	6.5e-06	4.1	5.4	7.7e-08	0.47	0.15	0.48	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD14	0.01	0.01	blup	38	0.00	3.5e-02	4.7	-5.3	8.9e-08	-0.07	0.01	0.41	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	FAM53C	0.13	0.06	lasso	4	0.05	4.6e-07	5.3	5.3	1.0e-07	0.05	1.00	0.00	FALSE
4	GTEx	Artery Tibial	TMEM173	0.24	0.14	lasso	3	0.13	1.2e-10	4.8	-5.2	1.6e-07	-0.36	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	WDR55	0.05	0.08	lasso	13	0.07	4.0e-06	-5.0	-5.2	1.9e-07	-0.01	0.05	0.95	FALSE
9	GTEx	Cells Transformed fibroblasts	ZMAT2	0.04	0.02	lasso	4	0.02	2.4e-02	-4.9	-5.2	2.0e-07	0.00	0.08	0.82	FALSE
7	GTEx	Cells Transformed fibroblasts	HARS2	0.04	0.01	enet	15	0.02	1.1e-02	4.2	-5.2	2.4e-07	-0.07	0.10	0.76	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WDR55	0.04	0.04	blup	44	0.03	8.2e-03	-5.1	-5.2	2.6e-07	-0.03	0.02	0.77	FALSE
5	GTEx	Brain Cerebellum	HARS	0.11	0.17	enet	19	0.12	1.6e-04	-5.1	5.2	2.7e-07	0.02	0.06	0.90	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NDUFA2	0.03	0.02	blup	42	0.04	1.1e-03	4.8	5.1	3.0e-07	0.06	0.02	0.75	FALSE
35	The Cancer Genome Atlas	Thyroid Carcinoma	SLC4A9	0.07	0.02	blup	30	0.06	3.1e-06	4.0	-5.1	3.1e-07	-0.03	0.08	0.68	FALSE