Best TWAS P=6.28e-15 · Best GWAS P=2.46e-20 conditioned to 1.62e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC18 | 0.09 | 0.10 | bslmm | 260 | 0.10 | 2.5e-12 | 3.5 | 5.6 | 1.8e-08 | 0.41 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FAM53C | 0.05 | 0.02 | bslmm | 291 | 0.03 | 4.1e-04 | 7.3 | 5.5 | 3.0e-08 | -0.06 | 0.02 | 0.93 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -5.1 | -5.5 | 4.5e-08 | -0.05 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Artery Tibial | TMEM173 | 0.24 | 0.14 | lasso | 3 | 0.13 | 1.2e-10 | 4.8 | -5.2 | 1.6e-07 | -0.36 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Cerebellum | HARS | 0.11 | 0.17 | enet | 19 | 0.12 | 1.6e-04 | -5.1 | 5.2 | 2.7e-07 | 0.02 | 0.06 | 0.90 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | DNAJC18 | 0.26 | 0.09 | lasso | 2 | 0.12 | 9.7e-05 | 4.1 | 5.9 | 3.9e-09 | 0.49 | 0.18 | 0.30 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | HARS2 | 0.04 | 0.01 | enet | 15 | 0.02 | 1.1e-02 | 4.2 | -5.2 | 2.4e-07 | -0.07 | 0.10 | 0.76 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | WDR55 | 0.05 | 0.08 | lasso | 13 | 0.07 | 4.0e-06 | -5.0 | -5.2 | 1.9e-07 | -0.01 | 0.05 | 0.95 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | ZMAT2 | 0.04 | 0.02 | lasso | 4 | 0.02 | 2.4e-02 | -4.9 | -5.2 | 2.0e-07 | 0.00 | 0.08 | 0.82 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CD14 | 0.09 | 0.05 | lasso | 4 | 0.06 | 2.7e-05 | -3.8 | -5.4 | 7.4e-08 | -0.05 | 0.22 | 0.71 | FALSE |
| 11 | GTEx | Colon Transverse | TMCO6 | 0.15 | 0.06 | enet | 16 | 0.05 | 1.4e-03 | 4.8 | -5.6 | 2.1e-08 | -0.07 | 0.14 | 0.60 | FALSE |
| 12 | GTEx | Colon Transverse | DNAJC18 | 0.37 | -0.01 | lasso | 5 | 0.01 | 1.1e-01 | 4.1 | 5.6 | 2.2e-08 | 0.39 | 0.06 | 0.06 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | DNAJC18 | 0.17 | 0.01 | lasso | 10 | 0.04 | 2.0e-02 | 4.1 | 7.4 | 1.2e-13 | 0.77 | 0.03 | 0.85 | FALSE |
| 14 | GTEx | Esophagus Mucosa | TMEM173 | 0.10 | 0.03 | enet | 20 | 0.10 | 1.8e-07 | 9.2 | -6.3 | 2.6e-10 | -0.60 | 0.01 | 0.97 | FALSE |
| 15 | GTEx | Esophagus Muscularis | DNAJC18 | 0.22 | 0.10 | lasso | 6 | 0.13 | 3.2e-08 | 4.1 | 5.8 | 6.6e-09 | 0.40 | 0.56 | 0.10 | FALSE |
| 16 | GTEx | Esophagus Muscularis | TMEM173 | 0.24 | 0.00 | lasso | 6 | 0.06 | 1.5e-04 | 4.1 | -5.5 | 4.0e-08 | -0.40 | 0.77 | 0.06 | FALSE |
| 17 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -4.9 | 6.1 | 1.3e-09 | -0.03 | 0.06 | 0.89 | TRUE |
| 18 | GTEx | Skin Sun Exposed Lower leg | WDR55 | 0.04 | 0.01 | enet | 10 | 0.01 | 2.8e-02 | -4.9 | -5.9 | 3.9e-09 | -0.02 | 0.06 | 0.88 | FALSE |
| 19 | GTEx | Spleen | DNAJC18 | 0.30 | 0.13 | lasso | 5 | 0.20 | 6.5e-06 | 4.1 | 5.4 | 7.7e-08 | 0.47 | 0.15 | 0.48 | FALSE |
| 20 | GTEx | Vagina | PURA | 0.52 | 0.05 | enet | 51 | 0.09 | 3.6e-03 | 5.9 | -6.5 | 1.0e-10 | -0.44 | 0.06 | 0.10 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | WNT8A | 0.05 | 0.01 | blup | 300 | 0.03 | 1.0e-04 | -1.6 | -6.5 | 8.0e-11 | 0.05 | 0.11 | 0.83 | FALSE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | FAM53C | 0.13 | 0.06 | lasso | 4 | 0.05 | 4.6e-07 | 5.3 | 5.3 | 1.0e-07 | 0.05 | 1.00 | 0.00 | FALSE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | KDM3B | 0.07 | 0.01 | blup | 307 | 0.03 | 1.0e-04 | 5.3 | -5.8 | 5.1e-09 | -0.03 | 0.11 | 0.82 | FALSE |
| 24 | YFS | Blood | CXXC5 | 0.01 | 0.00 | bslmm | 244 | 0.01 | 2.6e-03 | 9.2 | -7.1 | 1.3e-12 | -0.67 | 0.00 | 0.95 | FALSE |
| 25 | YFS | Blood | TMCO6 | 0.01 | 0.00 | blup | 329 | 0.01 | 4.1e-03 | -4.8 | -5.7 | 1.5e-08 | -0.03 | 0.07 | 0.92 | FALSE |
| 26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD14 | 0.01 | 0.01 | blup | 38 | 0.00 | 3.5e-02 | 4.7 | -5.3 | 8.9e-08 | -0.07 | 0.01 | 0.41 | FALSE |
| 27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM173 | 0.02 | 0.03 | blup | 7 | 0.03 | 4.6e-07 | 4.8 | -5.6 | 1.7e-08 | -0.40 | 0.07 | 0.92 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | WDR55 | 0.10 | 0.03 | enet | 8 | 0.04 | 3.3e-09 | -5.1 | -5.4 | 5.9e-08 | 0.01 | 0.02 | 0.98 | FALSE |
| 29 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | WDR55 | 0.04 | 0.04 | blup | 44 | 0.03 | 8.2e-03 | -5.1 | -5.2 | 2.6e-07 | -0.03 | 0.02 | 0.77 | FALSE |
| 30 | The Cancer Genome Atlas | Colon Adenocarcinoma | WDR55 | 0.09 | 0.08 | enet | 12 | 0.12 | 1.5e-07 | -5.1 | -5.5 | 3.9e-08 | -0.05 | 0.02 | 0.97 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2D2 | 0.05 | 0.02 | enet | 6 | 0.03 | 4.4e-04 | 5.1 | 7.8 | 6.3e-15 | 0.76 | 0.01 | 0.97 | TRUE |
| 32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BRD8 | 0.12 | 0.07 | lasso | 4 | 0.05 | 1.2e-03 | 6.8 | -6.5 | 5.8e-11 | 0.03 | 0.00 | 0.98 | TRUE |
| 33 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NDUFA2 | 0.03 | 0.02 | blup | 42 | 0.04 | 1.1e-03 | 4.8 | 5.1 | 3.0e-07 | 0.06 | 0.02 | 0.75 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | WDR55 | 0.07 | 0.06 | blup | 44 | 0.06 | 1.7e-06 | -5.1 | -5.5 | 4.5e-08 | -0.05 | 0.02 | 0.98 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC4A9 | 0.07 | 0.02 | blup | 30 | 0.06 | 3.1e-06 | 4.0 | -5.1 | 3.1e-07 | -0.03 | 0.08 | 0.68 | FALSE |