Best TWAS P=3.42e-11 · Best GWAS P=2.89e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellum | ZNF484 | 0.21 | 0.01 | lasso | 9 | 0.01 | 1.7e-01 | -5.6 | -5.2 | 2.4e-07 | -0.04 | 0.07 | 0.35 | FALSE |
| 2 | GTEx | Esophagus Muscularis | BICD2 | 0.09 | 0.02 | enet | 26 | 0.07 | 5.0e-05 | -4.5 | -5.4 | 5.8e-08 | -0.02 | 0.05 | 0.78 | FALSE |
| 3 | GTEx | Heart Left Ventricle | ECM2 | 0.07 | 0.05 | lasso | 3 | 0.02 | 3.1e-02 | -5.6 | -5.4 | 5.2e-08 | 0.00 | 0.05 | 0.80 | TRUE |
| 4 | GTEx | Skin Sun Exposed Lower leg | IPPK | 0.17 | 0.07 | enet | 8 | 0.07 | 2.7e-06 | -5.9 | 5.3 | 1.2e-07 | 0.03 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Testis | NFIL3 | 0.47 | 0.33 | enet | 8 | 0.29 | 3.8e-13 | -6.7 | 6.6 | 3.4e-11 | -0.99 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | IPPK | 0.06 | 0.03 | blup | 49 | 0.04 | 5.8e-03 | -5.5 | 5.3 | 1.3e-07 | 0.05 | 0.01 | 0.65 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BICD2 | 0.10 | 0.03 | blup | 52 | 0.03 | 1.3e-02 | -5.6 | -5.2 | 2.0e-07 | -0.03 | 0.02 | 0.30 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BICD2 | 0.06 | 0.02 | blup | 52 | 0.05 | 2.9e-06 | -5.6 | -5.4 | 7.5e-08 | -0.04 | 0.03 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | ECM2 | 0.10 | 0.04 | lasso | 2 | 0.04 | 4.2e-05 | -5.3 | -5.3 | 9.9e-08 | -0.03 | 0.00 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IPPK | 0.03 | 0.02 | blup | 51 | 0.01 | 3.2e-02 | -5.3 | 5.4 | 7.6e-08 | 0.06 | 0.03 | 0.64 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | IPPK | 0.03 | 0.04 | blup | 50 | 0.04 | 6.7e-05 | -5.4 | 5.3 | 1.2e-07 | 0.03 | 0.01 | 0.98 | FALSE |