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chr9:97,520,168-100,366,953

Best TWAS P=1.19e-18 · Best GWAS P=1.05e-21 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Tibial	RP11-435O5.5	0.09	0.04	lasso	2	0.02	7.3e-03	9.0	-8.8	1.2e-18	-0.95	0.02	0.91	TRUE
21	The Cancer Genome Atlas	Stomach Adenocarcinoma	CDC14B	0.08	0.02	blup	41	0.04	1.0e-03	5.6	-7.8	6.9e-15	-0.08	0.03	0.56	TRUE
10	NTR	Blood	PTCH1	0.04	0.02	blup	433	0.02	4.1e-08	6.6	5.7	1.2e-08	0.09	0.78	0.20	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	PTCH1	0.02	0.01	blup	54	0.02	1.1e-03	7.8	-7.7	1.9e-14	-0.86	0.02	0.63	FALSE
15	The Cancer Genome Atlas	Glioblastoma Multiforme	HABP4	0.08	0.06	blup	44	0.05	1.6e-02	6.7	-7.5	7.4e-14	-0.06	0.03	0.48	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HABP4	0.02	0.02	blup	44	0.02	7.1e-03	7.1	7.4	1.0e-13	0.04	0.04	0.60	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC14B	0.02	0.01	lasso	1	0.01	3.0e-03	7.4	-7.4	1.9e-13	-0.04	0.04	0.45	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC14B	0.03	0.02	blup	42	0.02	2.1e-03	7.1	-7.3	2.0e-13	-0.04	0.05	0.50	FALSE
12	YFS	Blood	PTCH1	0.09	0.05	lasso	8	0.05	1.2e-15	6.5	7.3	3.9e-13	0.42	0.79	0.21	FALSE
8	GTEx	Testis	HABP4	0.19	0.22	lasso	9	0.21	1.1e-09	7.2	7.2	5.3e-13	0.04	0.11	0.89	FALSE
22	The Cancer Genome Atlas	Thyroid Carcinoma	CDC14B	0.05	0.07	blup	42	0.08	4.8e-08	7.2	-7.1	9.2e-13	-0.03	0.09	0.91	FALSE
9	GTEx	Thyroid	CDC14B	0.15	0.10	lasso	5	0.08	5.3e-07	6.8	-7.0	3.1e-12	-0.04	0.30	0.70	FALSE
11	YFS	Blood	HABP4	0.08	0.09	enet	24	0.11	5.9e-34	7.5	-7.0	3.6e-12	-0.09	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	HABP4	0.05	0.08	lasso	5	0.08	6.9e-09	6.6	-6.8	9.1e-12	-0.05	0.18	0.82	FALSE
7	GTEx	Nerve Tibial	ZNF367	0.10	0.05	lasso	3	0.02	7.9e-03	7.5	6.7	1.6e-11	0.04	0.04	0.95	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	CDC14B	0.05	0.06	lasso	5	0.06	6.5e-07	7.1	-6.5	8.6e-11	-0.04	0.12	0.88	FALSE
14	The Cancer Genome Atlas	Glioblastoma Multiforme	CDC14B	0.16	0.17	blup	41	0.19	2.6e-06	7.1	-6.4	1.2e-10	-0.01	0.07	0.88	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	AAED1	0.17	0.02	lasso	3	0.04	2.4e-02	7.1	6.3	2.4e-10	0.02	0.06	0.42	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC441454	0.05	0.01	lasso	3	0.02	1.5e-03	5.6	6.2	4.6e-10	0.04	0.05	0.50	FALSE
3	GTEx	Breast Mammary Tissue	CDC14B	0.16	0.02	enet	21	0.02	3.7e-02	7.1	-6.0	2.4e-09	-0.02	0.10	0.79	FALSE
5	GTEx	Liver	PTCH1	0.25	0.06	enet	11	0.03	4.9e-02	8.9	5.8	5.0e-09	0.26	0.15	0.11	FALSE
6	GTEx	Nerve Tibial	HSD17B3	0.14	0.00	enet	20	0.00	2.4e-01	7.0	5.2	2.0e-07	0.05	0.10	0.30	FALSE