[Hub]/) : Traits : Basal metabolic rate : ← →

chr10:101,548,177-103,428,898

Best TWAS P=1.19e-30 · Best GWAS P=8.1e-28 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Brain Cerebellum	RP11-179B2.2	0.37	0.21	lasso	4	0.20	1.4e-06	10.9	11.5	1.2e-30	0.96	0.00	0.99	TRUE
45	GTEx	Testis	HIF1AN	0.12	0.08	lasso	3	0.06	1.6e-03	-6.2	6.2	5.4e-10	0.08	0.34	0.04	TRUE
28	GTEx	Heart Left Ventricle	RP11-179B2.2	0.15	0.18	enet	2	0.14	4.8e-08	10.9	10.9	8.1e-28	1.00	0.00	1.00	FALSE
7	GTEx	Artery Aorta	RP11-179B2.2	0.16	0.11	lasso	2	0.09	7.6e-06	10.9	10.8	3.8e-27	0.98	0.00	1.00	FALSE
25	GTEx	Esophagus Muscularis	RP11-179B2.2	0.15	0.16	lasso	3	0.16	8.1e-10	10.8	10.7	6.4e-27	0.98	0.01	0.99	FALSE
9	GTEx	Artery Tibial	RP11-179B2.2	0.11	0.09	lasso	4	0.08	8.8e-07	10.9	10.7	8.8e-27	0.96	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-179B2.2	0.13	0.02	lasso	3	0.03	6.5e-03	10.9	10.5	1.2e-25	0.99	0.00	0.99	FALSE
30	GTEx	Lung	RP11-179B2.2	0.18	0.12	lasso	3	0.12	1.7e-09	10.9	10.4	1.7e-25	0.99	0.00	1.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	RP11-179B2.2	0.16	-0.01	enet	4	-0.01	7.1e-01	-10.2	10.4	2.5e-25	0.77	0.03	0.46	FALSE
12	GTEx	Brain Frontal Cortex BA9	RP11-179B2.2	0.22	0.15	lasso	2	0.11	7.2e-04	10.9	10.3	6.2e-25	0.98	0.01	0.97	FALSE
14	GTEx	Breast Mammary Tissue	RP11-179B2.2	0.11	0.09	lasso	2	0.07	1.8e-04	10.9	10.2	2.8e-24	0.96	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL43	0.07	0.02	blup	52	0.00	1.7e-01	10.3	-9.8	1.1e-22	-0.80	0.01	0.82	FALSE
3	GTEx	Adipose Subcutaneous	RP11-179B2.2	0.15	0.08	lasso	6	0.08	3.2e-07	8.8	9.6	1.0e-21	0.90	0.02	0.98	FALSE
47	GTEx	Thyroid	RP11-179B2.2	0.18	0.12	lasso	7	0.11	8.3e-09	8.8	9.5	1.4e-21	0.91	0.04	0.96	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	RP11-179B2.2	0.27	0.15	enet	36	0.15	2.0e-08	10.9	9.4	7.2e-21	0.75	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEMA4G	0.04	0.01	blup	52	0.02	1.2e-03	8.7	9.0	2.3e-19	0.83	0.01	0.79	FALSE
34	GTEx	Nerve Tibial	RP11-179B2.2	0.15	0.08	lasso	2	0.12	6.4e-09	10.8	8.6	6.2e-18	0.88	0.01	0.99	FALSE
42	GTEx	Skin Sun Exposed Lower leg	RP11-179B2.2	0.12	0.09	lasso	2	0.08	1.7e-07	8.7	8.4	5.5e-17	0.86	0.06	0.94	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEMA4G	0.03	0.01	blup	52	0.01	4.2e-02	10.8	8.1	5.0e-16	0.83	0.00	0.90	FALSE
51	METSIM	Adipose	MRPL43	0.05	0.04	bslmm	422	0.04	1.9e-06	-4.7	7.6	3.1e-14	0.46	0.94	0.03	FALSE
76	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FAM178A	0.14	0.08	lasso	2	0.08	5.9e-04	-8.6	-7.5	6.2e-14	-0.54	0.07	0.13	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	SEMA4G	0.07	0.08	blup	52	0.08	5.1e-08	-4.4	7.3	3.7e-13	0.75	0.04	0.96	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MRPL43	0.03	0.02	blup	52	0.03	3.0e-04	-4.4	-6.8	7.7e-12	-0.68	0.10	0.50	FALSE
17	GTEx	Breast Mammary Tissue (Female)	RP11-179B2.2	0.19	0.00	lasso	3	-0.01	5.1e-01	8.8	6.4	1.3e-10	0.65	0.03	0.44	FALSE
50	GTEx	Whole Blood	HIF1AN	0.15	0.12	enet	7	0.12	8.7e-11	-6.2	6.1	8.6e-10	0.06	1.00	0.00	FALSE
43	GTEx	Spleen	SEC31B	0.21	0.12	lasso	3	0.05	2.3e-02	-6.0	6.1	1.0e-09	0.05	0.28	0.09	FALSE
53	NTR	Blood	HIF1AN	0.02	0.03	lasso	2	0.02	1.4e-07	-6.0	6.1	1.1e-09	0.05	1.00	0.00	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	HIF1AN	0.13	0.03	lasso	5	0.02	3.4e-02	-6.1	6.1	1.2e-09	0.04	0.26	0.03	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SEC31B	0.14	0.10	lasso	7	0.10	1.6e-06	-6.1	6.1	1.2e-09	0.05	0.03	0.97	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEC31B	0.06	0.06	blup	51	0.06	1.1e-07	-6.0	6.1	1.2e-09	0.05	0.03	0.97	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	HIF1AN	0.07	0.03	blup	40	0.05	4.9e-04	-6.0	6.1	1.3e-09	0.05	0.03	0.84	FALSE
23	GTEx	Esophagus Mucosa	HIF1AN	0.14	0.08	lasso	7	0.09	2.2e-06	-6.1	6.0	1.5e-09	0.09	0.98	0.00	FALSE
32	GTEx	Muscle Skeletal	HIF1AN	0.05	0.06	lasso	1	0.05	1.6e-05	-6.0	-6.0	1.5e-09	-0.06	0.94	0.00	FALSE
44	GTEx	Testis	SEC31B	0.11	0.11	lasso	5	0.08	2.5e-04	-6.0	6.0	1.6e-09	0.05	0.84	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SEC31B	0.13	0.21	lasso	3	0.20	4.1e-24	-6.0	6.0	1.7e-09	0.05	1.00	0.00	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	MRPL43	0.10	0.08	bslmm	411	0.09	1.2e-11	-4.7	-6.0	1.7e-09	-0.56	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	1.3e-06	-6.0	6.0	1.8e-09	0.05	0.03	0.97	FALSE
36	GTEx	Prostate	SEC31B	0.18	0.14	lasso	2	0.12	6.7e-04	-6.0	6.0	2.0e-09	0.05	0.38	0.05	FALSE
41	GTEx	Skin Sun Exposed Lower leg	HIF1AN	0.07	0.05	lasso	8	0.03	2.2e-03	-6.2	6.0	2.0e-09	0.06	0.93	0.00	FALSE
15	GTEx	Breast Mammary Tissue (Male)	SEC31B	0.13	0.08	lasso	4	0.10	3.0e-03	-6.0	6.0	2.1e-09	0.05	0.27	0.04	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	SEC31B	0.15	0.21	lasso	4	0.20	8.0e-08	-6.0	6.0	2.1e-09	0.05	0.96	0.00	FALSE
22	GTEx	Esophagus Mucosa	SEC31B	0.14	0.18	lasso	4	0.17	2.0e-11	-6.0	6.0	2.1e-09	0.05	1.00	0.00	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	SEC31B	0.15	0.16	lasso	4	0.15	8.3e-09	-6.0	6.0	2.1e-09	0.05	0.99	0.00	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFB8	0.02	0.01	blup	38	0.01	1.6e-02	-5.4	-6.0	2.1e-09	-0.06	0.03	0.60	FALSE
54	NTR	Blood	SEC31B	0.03	0.03	lasso	4	0.03	1.1e-10	-6.0	6.0	2.2e-09	0.06	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SEC31B	0.15	0.14	lasso	12	0.15	8.5e-07	-5.9	6.0	2.2e-09	0.06	0.03	0.96	FALSE
20	GTEx	Colon Transverse	SEC31B	0.28	0.12	lasso	3	0.09	3.3e-05	-6.0	6.0	2.3e-09	0.07	0.98	0.00	FALSE
24	GTEx	Esophagus Muscularis	SEC31B	0.18	0.19	lasso	4	0.20	4.5e-12	-6.0	6.0	2.4e-09	0.05	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	SEC31B	0.32	0.39	lasso	5	0.38	5.1e-33	-6.0	6.0	2.5e-09	0.05	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEC31B	0.05	0.05	blup	51	0.05	8.9e-07	-6.0	6.0	2.5e-09	0.06	0.03	0.97	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC31B	0.06	0.07	blup	51	0.08	2.9e-05	-5.4	5.9	3.0e-09	0.06	0.04	0.95	FALSE
48	GTEx	Uterus	SEC31B	0.40	0.14	lasso	18	0.05	3.1e-02	-6.1	5.9	3.6e-09	0.02	0.36	0.04	FALSE
40	GTEx	Skin Sun Exposed Lower leg	SEC31B	0.20	0.34	lasso	4	0.34	8.3e-29	-6.0	5.9	4.2e-09	0.06	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	SEC31B	0.18	0.28	lasso	10	0.27	1.5e-14	-5.4	5.9	4.5e-09	0.07	1.00	0.00	FALSE
33	GTEx	Nerve Tibial	SEC31B	0.42	0.42	lasso	9	0.43	1.4e-32	-6.0	5.9	4.5e-09	0.06	1.00	0.00	FALSE
13	GTEx	Breast Mammary Tissue	SEC31B	0.17	0.26	lasso	5	0.25	2.9e-13	-6.0	5.9	4.8e-09	0.05	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Lung Adenocarcinoma	SEC31B	0.06	0.08	enet	10	0.09	4.6e-11	-6.0	5.8	6.2e-09	0.06	0.03	0.97	FALSE
35	GTEx	Pancreas	SEC31B	0.24	0.19	lasso	5	0.17	9.9e-08	-6.0	5.8	6.3e-09	0.06	0.97	0.00	FALSE
72	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SEC31B	0.11	0.12	enet	15	0.13	1.5e-14	-6.1	5.8	7.0e-09	0.06	0.03	0.97	FALSE
46	GTEx	Thyroid	SEC31B	0.28	0.32	lasso	5	0.31	4.9e-24	-6.0	5.8	8.6e-09	0.03	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	SEC31B	0.14	0.19	enet	17	0.22	1.6e-16	-6.0	5.7	9.4e-09	0.06	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SEC31B	0.24	0.20	blup	51	0.28	1.7e-10	-6.1	5.7	9.5e-09	0.06	0.05	0.95	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	SEC31B	0.12	0.19	blup	51	0.20	1.1e-18	-5.4	5.7	1.1e-08	0.07	0.44	0.56	FALSE
11	GTEx	Brain Cortex	SEC31B	0.18	0.09	lasso	7	0.07	7.1e-03	-5.4	5.7	1.3e-08	0.07	0.40	0.03	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC31B	0.09	0.13	blup	51	0.15	7.1e-29	-6.0	5.7	1.4e-08	0.05	0.04	0.96	FALSE
8	GTEx	Artery Tibial	SEC31B	0.25	0.32	lasso	6	0.33	1.3e-26	-5.4	5.6	1.6e-08	0.07	1.00	0.00	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	SEC31B	0.13	0.17	enet	36	0.18	3.0e-22	-5.9	5.6	1.7e-08	0.05	1.00	0.00	FALSE
6	GTEx	Artery Aorta	SEC31B	0.26	0.24	lasso	3	0.23	1.0e-12	-6.0	5.6	1.9e-08	0.06	1.00	0.00	FALSE
29	GTEx	Lung	SEC31B	0.19	0.21	enet	18	0.20	2.0e-15	-5.4	5.6	1.9e-08	0.07	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Stomach Adenocarcinoma	SEC31B	0.07	0.09	blup	51	0.09	4.1e-07	-5.4	5.6	1.9e-08	0.07	0.11	0.89	FALSE
52	METSIM	Adipose	SEC31B	0.15	0.27	enet	29	0.28	1.0e-41	-5.9	5.6	2.0e-08	0.05	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL43	0.06	0.04	blup	51	0.04	7.4e-04	-4.6	-5.6	2.1e-08	-0.52	0.55	0.08	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC31B	0.23	0.23	enet	20	0.26	8.6e-27	-5.9	5.4	5.1e-08	0.06	0.06	0.94	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SEC31B	0.10	0.09	blup	51	0.10	2.5e-07	-4.4	5.4	5.3e-08	0.07	0.07	0.93	FALSE
27	GTEx	Heart Left Ventricle	SEC31B	0.09	0.07	lasso	1	0.04	2.1e-03	-5.4	5.4	7.4e-08	0.08	0.48	0.02	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	SEC31B	0.23	0.11	enet	13	0.12	9.2e-05	-6.0	5.4	7.8e-08	0.07	0.75	0.01	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	WNT8B	0.07	0.10	blup	34	0.11	1.7e-12	-5.4	-5.3	9.0e-08	-0.07	0.09	0.91	FALSE
57	YFS	Blood	HIF1AN	0.06	0.06	lasso	30	0.07	2.5e-22	-5.4	5.3	1.0e-07	0.07	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	SEC31B	0.08	0.09	lasso	5	0.08	4.9e-08	-5.4	5.2	1.6e-07	0.07	1.00	0.00	FALSE
49	GTEx	Whole Blood	SEC31B	0.11	0.14	lasso	7	0.12	1.8e-11	-5.4	5.2	1.7e-07	0.09	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	MRPL43	0.16	0.07	lasso	4	0.09	5.8e-05	-4.4	-5.2	1.9e-07	-0.62	0.39	0.15	FALSE
77	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HIF1AN	0.19	-0.01	blup	40	0.06	2.9e-03	-5.3	-5.1	2.8e-07	-0.05	0.03	0.64	FALSE