[Hub]/) : Traits : Basal metabolic rate :

chr10:103,527,782-105,647,095

Best TWAS P=2.17e-14 · Best GWAS P=5.52e-14 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ACTR1A 0.03 0.01 blup 347 0.01 5.6e-02 3.9 6.3 3.8e-10 0.74 0.06 0.70 FALSE
2 GTEx Adipose Subcutaneous CYP17A1-AS1 0.05 0.02 enet 10 0.03 2.8e-03 4.8 7.3 2.1e-13 0.63 0.14 0.62 FALSE
3 GTEx Adrenal Gland TMEM180 0.19 0.15 enet 12 0.09 3.5e-04 -3.8 -5.8 7.9e-09 -0.34 0.65 0.07 FALSE
4 GTEx Artery Aorta NT5C2 0.08 0.02 lasso 7 0.01 1.2e-01 -3.9 -5.7 1.2e-08 -0.55 0.17 0.51 FALSE
5 GTEx Artery Tibial NT5C2 0.06 0.04 lasso 9 0.02 1.5e-02 7.3 -7.5 5.7e-14 -0.95 0.03 0.93 FALSE
6 GTEx Artery Tibial CYP17A1-AS1 0.08 0.08 lasso 8 0.06 2.8e-05 7.3 7.2 4.2e-13 0.95 0.02 0.98 FALSE
7 GTEx Brain Cerebellar Hemisphere ARL3 0.15 0.02 enet 18 0.11 1.1e-03 -5.4 5.5 3.8e-08 0.44 0.11 0.15 FALSE
8 GTEx Brain Cerebellum ARL3 0.20 0.09 enet 32 0.07 3.7e-03 6.7 6.7 1.6e-11 0.57 0.11 0.76 FALSE
9 GTEx Brain Cerebellum TRIM8 0.34 -0.01 enet 25 0.07 4.7e-03 -1.2 -6.3 3.3e-10 -0.46 0.06 0.39 FALSE
10 GTEx Brain Cortex CYP17A1-AS1 0.15 0.13 lasso 7 0.14 1.3e-04 6.7 7.6 2.2e-14 0.82 0.07 0.79 TRUE
11 GTEx Brain Hypothalamus CYP17A1-AS1 0.34 0.10 lasso 10 0.05 2.6e-02 7.0 7.3 4.1e-13 0.70 0.09 0.44 TRUE
12 GTEx Brain Nucleus accumbens basal ganglia CYP17A1-AS1 0.39 0.22 lasso 3 0.19 8.2e-06 6.6 6.5 9.4e-11 0.84 0.14 0.42 TRUE
13 GTEx Breast Mammary Tissue CYP17A1-AS1 0.10 -0.01 enet 28 0.00 2.4e-01 7.0 7.1 1.7e-12 0.64 0.12 0.37 FALSE
14 GTEx Breast Mammary Tissue (Male) CYP17A1-AS1 0.06 0.00 lasso 3 0.01 2.1e-01 -5.9 6.6 3.8e-11 0.51 0.04 0.06 FALSE
15 GTEx Breast Mammary Tissue (Female) CYP17A1-AS1 0.14 0.01 lasso 11 0.00 4.7e-01 5.8 7.6 3.0e-14 0.60 0.06 0.32 FALSE
16 GTEx Cells EBV-transformed lymphocytes ACTR1A 0.22 0.18 lasso 3 0.19 8.0e-07 -5.0 6.5 6.1e-11 0.62 0.45 0.22 FALSE
17 GTEx Cells EBV-transformed lymphocytes RP11-18I14.11 0.17 0.08 lasso 8 0.09 8.7e-04 -6.2 6.7 2.5e-11 0.42 0.21 0.12 FALSE
18 GTEx Cells Transformed fibroblasts TMEM180 0.05 0.04 lasso 2 0.01 3.3e-02 -6.2 6.2 4.5e-10 0.41 0.26 0.21 TRUE
19 GTEx Esophagus Gastroesophageal Junction CYP17A1-AS1 0.23 0.08 enet 23 0.13 1.9e-05 6.9 5.9 4.4e-09 0.62 0.08 0.68 FALSE
20 GTEx Esophagus Mucosa SUFU 0.08 0.02 enet 18 0.01 4.2e-02 -1.6 -5.3 1.3e-07 -0.55 0.65 0.14 FALSE
21 GTEx Esophagus Muscularis SUFU 0.07 0.04 enet 18 0.03 5.2e-03 -4.0 -6.2 6.6e-10 -0.53 0.14 0.75 FALSE
22 GTEx Liver ACTR1A 0.15 0.00 lasso 10 0.00 4.6e-01 -2.3 -6.3 2.2e-10 -0.52 0.06 0.22 FALSE
23 GTEx Liver TMEM180 0.28 0.17 enet 36 0.17 1.7e-05 -6.2 -7.4 1.6e-13 -0.46 0.55 0.31 TRUE
24 GTEx Lung CYP17A1-AS1 0.06 0.08 lasso 3 0.06 1.6e-05 6.6 6.9 5.4e-12 0.83 0.18 0.78 FALSE
25 GTEx Nerve Tibial CYP17A1-AS1 0.14 0.08 lasso 6 0.06 7.2e-05 6.6 6.7 1.6e-11 0.82 0.32 0.50 FALSE
26 GTEx Pituitary NT5C2 0.19 -0.01 lasso 10 0.01 1.8e-01 -4.3 -5.3 1.3e-07 -0.25 0.07 0.07 FALSE
27 GTEx Skin Sun Exposed Lower leg SUFU 0.06 0.05 enet 12 0.06 8.4e-06 -6.2 6.2 5.0e-10 0.40 0.94 0.04 FALSE
28 GTEx Testis CYP17A1-AS1 0.14 0.08 enet 5 0.10 2.3e-05 5.7 -5.8 6.6e-09 -0.38 0.66 0.10 FALSE
29 GTEx Thyroid SFXN2 0.28 0.06 enet 32 0.15 1.1e-11 -1.8 -5.2 1.6e-07 -0.60 0.52 0.48 FALSE
30 GTEx Thyroid WBP1L 0.26 0.10 enet 9 0.13 2.1e-10 3.0 -5.1 2.7e-07 -0.20 0.99 0.01 FALSE
31 NTR Blood ACTR1A 0.03 0.03 enet 19 0.03 1.4e-09 -4.0 5.9 2.7e-09 0.49 0.99 0.01 FALSE
32 ROSMAP Brain Pre-frontal Cortex CNNM2 0.11 0.08 lasso 3 0.07 2.2e-09 6.3 6.2 5.3e-10 0.37 0.87 0.13 FALSE
33 ROSMAP Brain Pre-frontal Cortex CYP17A1-AS1 0.15 0.18 lasso 6 0.19 1.3e-23 6.7 7.1 1.3e-12 0.81 0.63 0.37 FALSE
34 YFS Blood ARL3 0.39 0.14 enet 30 0.20 7.0e-63 3.1 5.6 2.1e-08 0.46 1.00 0.00 FALSE
35 YFS Blood NT5C2 0.13 0.10 bslmm 382 0.11 7.3e-35 6.6 5.6 2.1e-08 0.22 0.84 0.16 TRUE
36 The Cancer Genome Atlas Bladder Urothelial Carcinoma AS3MT 0.06 0.09 enet 6 0.07 1.3e-06 6.6 -7.2 5.6e-13 -0.80 0.10 0.90 TRUE
37 The Cancer Genome Atlas Bladder Urothelial Carcinoma C10orf32 0.06 0.06 blup 54 0.08 1.2e-07 3.6 -5.2 2.6e-07 -0.81 0.50 0.50 FALSE
38 The Cancer Genome Atlas Breast Invasive Carcinoma AS3MT 0.05 0.05 enet 10 0.05 4.7e-11 6.6 -6.1 1.4e-09 -0.82 0.18 0.82 FALSE
39 The Cancer Genome Atlas Breast Invasive Carcinoma C10orf26 0.03 0.02 enet 5 0.02 1.6e-04 -5.8 -5.6 2.7e-08 -0.40 0.91 0.01 FALSE
40 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C10orf32 0.16 0.06 blup 54 0.10 1.3e-05 3.6 -5.4 7.5e-08 -0.80 0.10 0.82 FALSE
41 The Cancer Genome Atlas Esophageal Carcinoma SFXN2 0.26 0.02 blup 48 0.10 4.9e-04 5.0 -5.3 9.8e-08 -0.37 0.02 0.71 FALSE
42 The Cancer Genome Atlas Glioblastoma Multiforme AS3MT 0.15 0.05 blup 62 0.10 5.1e-04 3.6 -5.4 6.1e-08 -0.83 0.05 0.51 FALSE
43 The Cancer Genome Atlas Glioblastoma Multiforme C10orf32 0.27 0.09 lasso 8 0.17 7.3e-06 4.1 -5.1 2.7e-07 -0.79 0.06 0.80 FALSE
44 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AS3MT 0.05 0.05 blup 62 0.06 1.1e-07 7.5 -5.7 1.0e-08 -0.88 0.01 0.99 FALSE
45 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AS3MT 0.04 0.05 enet 3 0.04 8.6e-06 6.6 -6.6 4.3e-11 -0.85 0.13 0.84 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma AS3MT 0.34 0.38 lasso 6 0.38 4.4e-46 3.6 -5.1 3.1e-07 -0.81 1.00 0.00 FALSE
47 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SFXN2 0.20 0.08 blup 48 0.13 9.3e-07 5.0 -5.2 2.4e-07 -0.33 0.13 0.82 FALSE
48 The Cancer Genome Atlas Lung Adenocarcinoma TMEM180 0.08 0.07 blup 52 0.09 1.9e-10 -6.2 6.0 1.7e-09 0.39 0.01 0.99 FALSE
49 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM180 0.05 0.02 blup 52 0.04 1.5e-05 -5.3 5.7 1.2e-08 0.39 0.02 0.94 FALSE
50 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SUFU 0.03 0.02 blup 90 0.02 1.5e-02 -6.2 -5.7 1.2e-08 -0.33 0.03 0.76 FALSE
51 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma AS3MT 0.13 0.14 blup 62 0.13 5.6e-06 7.3 -6.6 4.5e-11 -0.92 0.02 0.98 FALSE
52 The Cancer Genome Atlas Prostate Adenocarcinoma AS3MT 0.16 0.21 lasso 9 0.24 2.5e-24 6.6 -5.4 6.1e-08 -0.84 0.30 0.70 FALSE
53 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM180 0.16 0.27 lasso 4 0.27 4.3e-28 -6.1 -6.0 1.4e-09 -0.40 0.03 0.97 FALSE
54 The Cancer Genome Atlas Rectum Adenocarcinoma C10orf32 0.17 0.14 blup 52 0.14 3.2e-04 7.3 -7.1 1.3e-12 -0.94 0.02 0.77 FALSE
55 The Cancer Genome Atlas Thyroid Carcinoma AS3MT 0.23 0.18 lasso 3 0.18 1.8e-17 6.6 -6.3 3.2e-10 -0.85 0.71 0.29 FALSE
56 The Cancer Genome Atlas Thyroid Carcinoma C10orf26 0.06 0.05 lasso 5 0.04 4.1e-05 6.9 -6.6 3.8e-11 -0.75 0.07 0.89 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma CYP17A1 0.04 0.02 lasso 1 0.02 3.9e-03 7.5 -7.5 5.5e-14 -1.00 0.01 0.92 TRUE