Best TWAS P=4.51e-16 · Best GWAS P=1.07e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | S1PR2 | 0.07 | 0.02 | bslmm | 369 | 0.03 | 5.3e-05 | -5.0 | 5.3 | 1.2e-07 | 0.31 | 0.33 | 0.12 | FALSE |
| 2 | GTEx | Esophagus Mucosa | SLC44A2 | 0.13 | 0.00 | lasso | 6 | 0.02 | 1.4e-02 | 4.8 | -6.1 | 1.2e-09 | -0.46 | 0.07 | 0.56 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ILF3-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 7.9 | -6.2 | 6.2e-10 | -0.77 | 0.02 | 0.85 | FALSE |
| 4 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 6.9 | 7.4 | 1.5e-13 | 0.79 | 0.83 | 0.17 | FALSE |
| 5 | GTEx | Nerve Tibial | ILF3-AS1 | 0.14 | 0.04 | lasso | 3 | 0.08 | 3.8e-06 | 7.9 | -6.5 | 6.1e-11 | -0.77 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | SMARCA4 | 0.15 | 0.10 | enet | 25 | 0.15 | 1.4e-12 | 2.3 | -5.2 | 1.6e-07 | -0.61 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Testis | PDE4A | 0.20 | 0.02 | enet | 39 | 0.04 | 6.4e-03 | 5.5 | 6.3 | 2.9e-10 | 0.06 | 0.06 | 0.04 | TRUE |
| 8 | GTEx | Vagina | CTD-2369P2.2 | 0.50 | -0.01 | lasso | 9 | 0.01 | 2.0e-01 | 5.0 | 5.3 | 1.3e-07 | 0.01 | 0.22 | 0.12 | TRUE |
| 9 | GTEx | Whole Blood | CTD-2369P2.8 | 0.12 | 0.11 | lasso | 3 | 0.10 | 9.2e-10 | 5.9 | 6.4 | 1.3e-10 | 0.06 | 1.00 | 0.00 | TRUE |
| 10 | NTR | Blood | SMARCA4 | 0.07 | 0.06 | lasso | 11 | 0.06 | 9.0e-18 | 5.0 | -5.3 | 9.9e-08 | -0.43 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S1PR2 | 0.02 | 0.00 | blup | 32 | 0.01 | 1.5e-02 | -5.5 | 5.5 | 4.0e-08 | 0.04 | 0.00 | 0.61 | TRUE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FDX1L | 0.06 | 0.02 | lasso | 3 | 0.04 | 2.4e-05 | -4.3 | -5.4 | 8.6e-08 | -0.04 | 0.15 | 0.33 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC147727 | 0.13 | 0.02 | blup | 28 | 0.04 | 7.2e-05 | 7.9 | -5.8 | 7.7e-09 | -0.76 | 0.01 | 0.88 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FDX1L | 0.06 | 0.00 | blup | 53 | 0.02 | 5.1e-03 | -4.3 | -5.9 | 4.4e-09 | 0.05 | 0.01 | 0.31 | TRUE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 7.9 | -8.1 | 4.5e-16 | -0.99 | 0.01 | 0.85 | TRUE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC44A2 | 0.32 | 0.22 | enet | 14 | 0.25 | 3.8e-24 | 7.8 | 6.2 | 5.8e-10 | 0.85 | 0.05 | 0.95 | FALSE |