Best TWAS P=1.04e-09 · Best GWAS P=2.42e-10 conditioned to 0.00585
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.7 | 5.4 | 7.6e-08 | 0.04 | 0.02 | 0.98 | FALSE |
2 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -5.7 | 5.8 | 9.0e-09 | 0.02 | 0.01 | 0.99 | FALSE |
3 | GTEx | Nerve Tibial | SYNGR1 | 0.26 | 0.18 | enet | 27 | 0.21 | 3.6e-15 | -4.5 | -5.5 | 3.0e-08 | -0.04 | 0.07 | 0.93 | FALSE |
4 | GTEx | Pituitary | APOBEC3G | 0.34 | 0.04 | enet | 11 | 0.11 | 1.2e-03 | 4.9 | 5.7 | 1.5e-08 | 0.04 | 0.14 | 0.15 | TRUE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | SUN2 | 0.13 | 0.00 | enet | 36 | 0.02 | 2.9e-02 | 3.1 | -5.1 | 2.8e-07 | -0.01 | 0.27 | 0.04 | TRUE |
6 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -5.7 | 5.8 | 7.4e-09 | 0.01 | 0.01 | 0.98 | TRUE |
7 | GTEx | Spleen | SYNGR1 | 0.36 | 0.41 | lasso | 2 | 0.36 | 3.4e-10 | 5.2 | 5.2 | 2.5e-07 | 0.01 | 0.13 | 0.86 | FALSE |
8 | GTEx | Vagina | APOBEC3G | 0.23 | 0.07 | lasso | 5 | 0.06 | 1.8e-02 | 4.6 | 5.2 | 1.7e-07 | 0.05 | 0.11 | 0.08 | FALSE |
9 | NTR | Blood | SYNGR1 | 0.03 | 0.03 | enet | 6 | 0.03 | 1.0e-10 | 5.2 | 5.2 | 1.6e-07 | 0.01 | 0.15 | 0.84 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -4.7 | -5.5 | 4.8e-08 | 0.82 | 0.02 | 0.78 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -6.2 | -5.5 | 3.1e-08 | 0.86 | 0.00 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -6.0 | -5.7 | 1.3e-08 | 0.82 | 0.01 | 0.61 | FALSE |
13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -6.1 | -6.1 | 1.4e-09 | 0.97 | 0.00 | 0.81 | FALSE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -6.3 | -6.1 | 1.0e-09 | 0.91 | 0.00 | 0.76 | TRUE |