Hub : Genes

SUN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.1180 0.0360 2.0e-07 0.139 NA 0.131 NA 0.140 1.5e-09 NA 4.3e-09 NA 1.3e-09
2 GTEx Skin Not Sun Exposed Suprapubic 0.1270 0.0460 2.8e-04 -0.002 NA 0.020 NA 0.002 4.6e-01 NA 2.8e-02 NA 2.3e-01
3 GTEx Skin Sun Exposed Lower leg 0.0600 0.0260 1.5e-03 0.061 NA 0.045 NA 0.050 8.8e-06 NA 1.2e-04 NA 5.3e-05
4 NTR Blood 0.0319 0.0112 1.8e-06 0.023 0.022 0.023 0.027 0.025 5.0e-08 8.8e-08 5.5e-08 4.3e-09 9.4e-09
5 TCGA Breast Invasive Carcinoma 0.0141 0.0089 5.2e-03 0.002 0.001 0.000 NA 0.000 1.3e-01 1.4e-01 4.3e-01 NA 3.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.5 0.7 2.8 -0.3 -1.7 -0.5 0.4 -0.6
Bipolar Disorder or Schizophrenia 0.1 0.3 0.7 0.4 -0.8 0.2 -0.6 0.2
Depressed Affect (Nagel 2018) 6.7 14.0 18.9 -4.3 -3.0 -4.3 3.7 -3.1
Depression (Nagel 2018) 1.8 2.7 4.5 -2.1 -0.4 -2.0 1.9 -1.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.1 -0.5 0.0 -0.9 -0.6 -1.5
Neuroticism (Nagel 2018) 4.3 10.1 14.7 -3.8 -1.9 -3.8 3.0 -2.9
Schizophrenia (2018) 0.3 0.5 1.0 0.8 0.2 0.7 -1.0 0.7
Schizophrenia vs Biploar Disorder 0.9 1.2 3.8 0.8 0.9 0.9 -0.4 2.0
Worry (Nagel 2018) 1.3 2.7 4.8 -2.2 0.1 -2.2 1.4 -1.4
Alzheimer’s Disease (in mother) 3.1 3.6 4.3 2.1 1.5 2.1 -2.1 1.8
Alzheimer’s Disease (in father) 0.5 0.5 1.0 -1.0 0.1 -0.8 0.6 -0.7
Alzheimer’s Disease (including proxy) 2.1 3.0 3.8 1.9 1.9 1.9 -1.3 1.5
Crohns Disease (2017) 2.4 5.3 7.7 2.8 1.8 2.7 -2.4 1.7
Irritable Bowel Disease (IBD) 0.5 1.3 2.5 1.6 -0.2 1.6 -1.1 0.3
Ulcerative Colitis (UC) 0.3 0.6 1.7 0.2 -1.3 0.3 0.4 -0.9
Major Depression (MDD) 2.0 2.5 4.2 -1.3 -2.0 -1.1 2.0 -1.1
Reaction Time 0.9 1.6 4.0 -0.9 -1.6 -0.5 2.0 -0.8
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.2 0.2 -0.2 -0.4 -1.1 -0.9
Breast Cancer 0.7 1.7 3.3 -1.1 -1.8 -0.9 -0.1 -1.7
Ovarian Cancer 0.3 0.3 0.9 -0.3 -0.1 -0.7 -0.4 -1.0
Prostate Cancer 0.9 1.3 5.5 0.8 0.1 0.6 -2.4 0.0
Age at First Birth 0.2 0.3 0.7 -0.8 -0.1 -0.8 -0.4 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 -0.2 -0.2 -0.1 -0.0 -0.2
Coronary Artery Disease (CAD) 4.3 5.1 7.9 2.8 1.4 2.5 -2.8 1.4
Crohns Disease (2012) 2.7 4.4 5.4 2.3 2.1 2.2 -2.3 1.6
Mean Putamen Volume 1.1 1.2 3.3 -1.1 -0.1 -1.0 1.8 -0.8
Fasting Glucose 0.5 0.5 0.7 -0.8 -0.8 -0.6 0.8 0.5
HbA1C 0.8 0.9 1.4 -1.0 -0.8 -0.7 1.0 -1.2
HDL Cholesterol 1.1 1.8 3.6 1.6 1.6 1.9 -0.2 0.4
LDL Cholesterol 0.1 0.2 0.8 -0.1 0.3 -0.2 0.1 -0.9
Lupus 0.5 0.8 1.5 0.9 0.9 0.8 -1.2 0.8
Neuroticism (2016) 0.8 1.1 3.3 -0.7 0.8 -0.5 1.8 -0.9
Primary Biliary Cirrhosis 4.1 5.9 7.1 -2.2 -2.7 -2.3 2.3 -2.6
Rheumatoid Arthritis 5.2 7.1 12.0 -2.7 -2.3 -2.2 2.5 -3.5
Schizophrenia (2014) 0.6 1.2 2.1 1.2 0.7 1.2 -0.9 1.4
Triglycerides 3.3 5.5 8.6 -2.7 -2.0 -2.9 1.0 -2.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 -0.7 0.4 -1.0 -0.1 0.7
Ulcerative Colitis 0.0 0.0 0.1 -0.0 -0.3 0.2 0.2 -0.0
Blood Eosinophil Count 0.5 3.8 7.1 -2.1 -1.4 -2.0 2.7 -1.4
Blood Platelet Count 3.5 40.1 47.3 -6.5 -5.5 -6.0 6.7 -6.9
Blood Red Count 0.1 1.4 4.0 0.6 2.0 0.7 -1.0 1.2
Blood White Count 0.7 5.2 11.7 -2.7 0.1 -2.4 3.4 -1.1
Heel T-Score 18.4 146.2 176.9 13.3 10.7 12.6 -11.8 11.9
BMI 0.9 5.2 8.8 -1.9 -3.0 -1.2 2.9 -1.9
Height 0.9 17.2 36.8 -4.3 -6.1 -4.0 1.6 -3.5
Waist Hip Ratio (WHR) 3.6 16.0 24.8 3.6 3.2 3.4 -4.4 5.0
Systolic Blood Pressure 0.1 0.3 0.4 0.5 0.3 0.7 -0.3 -0.6
Smoking Status 0.4 1.0 3.1 -0.5 -0.2 -0.3 1.8 1.1
Allergy or Eczema 0.4 0.9 2.4 -1.0 0.2 -1.6 -0.8 -0.8
Cardiovascular Disease 0.5 1.6 3.7 -1.0 -1.9 -0.7 0.4 -1.6
Hypothyroidism (self reported) 3.7 8.5 16.8 -2.7 -4.1 -2.3 2.9 -2.2
Respiratory disease 0.6 1.3 2.3 -0.8 -1.5 -1.4 -0.7 0.9
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.3 -0.5 -0.4 -0.4 0.6
Lung FEV1/FVC ratio 0.8 4.3 9.5 -0.8 -3.1 -0.0 1.7 -2.9
Lung FVC 0.2 0.9 4.1 -0.2 2.0 -0.3 0.5 -0.2
Neuroticism 2.5 6.1 10.8 -2.8 -0.8 -2.7 3.3 -2.0
Chronotype (morning person) 1.8 4.1 6.0 -2.3 -2.4 -2.4 0.6 -1.9
Hair Pigment 0.0 0.6 1.5 0.5 1.2 0.2 -1.0 -0.4
Tanning 0.2 2.8 6.2 2.3 0.0 2.5 -0.7 1.3
Hand grip strength (left) 2.4 6.2 8.5 2.9 2.2 2.9 -1.9 2.5
Number of treatments/medications taken 2.2 3.9 8.6 -1.9 -2.9 -2.0 1.0 -1.5
Average weekly spirits intake 1.4 1.7 2.5 1.4 1.4 1.5 -0.2 1.6
Sensitivity / hurt feelings 0.2 0.4 0.8 -0.5 -0.8 -0.9 -0.4 -0.4
Frequency of depressed mood in last 2 weeks 1.0 1.4 3.2 -1.5 0.6 -1.1 1.8 -0.0
Hearing difficulty/problems: Yes 0.3 0.4 1.0 -0.5 -1.0 -0.0 0.2 0.9
Relative age of first facial hair 1.0 2.0 3.7 -1.6 -0.6 -1.9 -0.0 -1.9
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.1 -0.4 -1.1 -0.7 -0.4 -0.8
Ever used hormone-replacement therapy (HRT) 8.1 10.3 13.8 -3.5 -3.3 -3.7 2.3 -3.0
Ever had hysterectomy (womb removed) 1.8 2.0 5.8 -1.1 -2.4 -1.1 1.2 -0.7
Systolic blood pressure, automated reading 0.0 0.1 0.4 0.4 -0.2 0.6 -0.0 -0.3
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.0 0.5 -0.4 0.4 -1.4 0.5
Angina 0.2 0.2 0.7 0.4 0.4 0.3 -0.9 -0.1
Medication for hormone replacement therapy 6.3 7.1 11.3 -3.3 -2.3 -3.4 2.1 -1.9
Vitamin and mineral supplements 2.7 3.7 6.6 1.6 2.6 1.5 -1.9 1.9
Supplements: Zinc 0.9 1.0 1.8 -1.0 -0.7 -1.1 1.3 -0.6
Medication: Co-codamol 0.9 1.0 3.0 -0.6 -1.7 -0.8 0.2 -1.1
Medication: Metformin 0.7 1.0 1.4 -1.1 -0.8 -1.2 0.3 -1.2
Diabetes (father) 0.6 0.8 2.5 -0.1 0.3 -1.1 -1.6 -0.3
Diabetes (mother) 1.7 2.1 3.3 -1.7 -0.5 -1.8 1.6 -1.2
Severe depression (siblings) 0.7 0.8 1.8 0.9 1.1 0.4 -1.3 0.1
Pack years adult smoking proportion 3.1 4.8 6.1 -2.5 -2.2 -2.1 2.1 -1.9
Impedance of leg (right) 0.8 4.0 5.7 1.9 2.4 1.6 -2.4 1.6
Leg fat-free mass (left) 2.4 12.8 25.9 -3.5 -5.1 -3.0 3.0 -2.9
Trunk fat percentage 2.2 9.0 13.4 -2.9 -3.7 -2.1 3.0 -3.2
Hand grip strength (right) 2.7 7.3 11.5 3.1 2.0 3.4 -2.0 2.7
Townsend deprivation index at recruitment 3.8 5.4 11.0 -2.8 -0.6 -2.4 3.3 -1.4
Current tobacco smoking 1.8 3.0 6.2 -2.0 -1.3 -1.7 2.5 -0.3
Average weekly fortified wine intake 1.3 1.5 3.1 -0.9 -1.0 -0.9 1.3 -1.8
Maternal smoking around birth 0.6 0.8 1.9 -1.1 -0.7 -0.7 1.4 -0.0
Fed-up feelings 1.9 3.5 4.8 -2.2 -1.8 -2.0 2.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 5.7 -1.8 0.1 -1.5 2.4 -0.8
Relative age voice broke 0.2 0.2 1.0 -0.2 0.2 -0.3 -0.1 -1.0
Taking other prescription medications 1.6 2.5 4.7 -1.7 -1.9 -2.2 0.5 -0.9
Age when periods started (menarche) 0.3 0.7 2.1 0.4 -1.4 0.1 -1.0 -0.2
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.3 -1.4 -0.2 -1.5 1.1 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 7.6 17.2 23.0 4.3 3.8 4.1 -3.7 4.8
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.6 -0.8 0.5 -0.3 1.6 0.1
Qualifications: CSEs or equivalent 2.9 3.8 6.1 -2.3 -1.0 -2.2 2.5 -1.4
Serious illness, injury or assault to yourself 1.9 2.3 3.3 -1.5 -1.8 -1.4 1.0 -1.7
High blood pressure 0.8 2.1 5.3 -1.2 -1.5 -1.1 0.8 -2.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.8 -1.3 -0.6 -1.7 -1.2 -0.5
Multivitamins +/- minerals 2.3 2.9 4.8 -1.3 -1.6 -1.1 2.1 -2.2
Stomach or abdominal pain in last month 2.5 3.2 4.3 -1.9 -1.5 -1.9 2.1 -1.5
Supplements: Glucosamine 0.6 0.8 1.7 -0.2 -1.3 0.3 1.0 -1.1
Diverticular disease/diverticulitis (self-reported) 9.3 11.0 17.6 -4.2 -2.5 -4.2 3.3 -1.7
Medication: Atenolol 1.6 1.9 2.7 1.5 1.3 1.3 -1.6 1.1
Medication: Levothyroxine sodium 2.4 4.1 8.0 -2.0 -2.8 -1.8 1.6 -1.6
Sitting height 0.1 0.8 3.5 -0.5 -1.9 -0.1 -0.1 -0.2
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 0.7 1.4 0.6 0.4 1.1
High blood pressure (mother) 0.7 1.0 2.8 -0.9 -1.7 -0.9 0.0 -0.7
Body mass index (BMI) 1.6 7.0 12.2 -2.4 -3.5 -1.8 2.9 -2.3
Impedance of leg (left) 0.9 4.4 6.7 2.0 2.6 1.6 -2.4 1.7
Leg predicted mass (left) 2.4 12.9 26.7 -3.5 -5.2 -3.0 2.9 -2.8
Trunk fat mass 3.1 13.5 21.6 -3.6 -4.6 -2.8 3.4 -3.7
Waist circumference 2.1 7.8 16.0 -2.9 -4.0 -2.3 2.2 -2.2
Number of incorrect matches in round 0.4 0.6 1.1 -0.9 -0.6 -1.0 0.7 -0.7
Past tobacco smoking 1.1 2.0 3.8 -1.2 -1.7 -1.3 -0.5 -2.0
Alcohol usually taken with meals 0.8 1.3 3.0 -0.6 -1.7 -0.6 -0.8 -1.5
Nervous feelings 0.2 0.3 0.6 -0.7 0.0 -0.8 0.3 -0.5
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.2 7.2 -2.7 -1.0 -2.4 2.2 -1.4
Hearing difficulty/problems with background noise 0.5 0.9 2.0 -0.8 -0.5 -0.4 1.4 1.2
Hair/balding pattern: Pattern 2 1.6 2.1 3.9 -1.5 -0.9 -2.0 1.4 -1.3
Had menopause 1.9 2.4 5.0 -1.2 -0.8 -1.0 2.0 -2.2
Had other major operations 2.8 3.4 4.6 -2.1 -2.0 -2.0 1.5 -1.4
Forced vital capacity (FVC) 0.5 2.1 4.3 -1.6 -1.3 -2.1 0.4 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 7.8 17.8 24.7 4.4 3.6 4.1 -3.8 5.0
Ever unenthusiastic/disinterested for a whole week 3.7 4.6 6.6 -2.2 -1.1 -2.2 2.3 -2.6
Qualifications: None of the above 0.3 0.6 2.5 -0.5 0.1 0.0 1.6 0.4
Financial difficulties in last 2 years 7.4 10.0 15.7 -3.4 -2.2 -2.8 4.0 -3.1
Mouth/teeth dental problems 0.8 1.2 5.0 0.9 0.1 0.5 -2.2 0.2
Heart attack 3.1 3.9 8.9 1.6 1.6 1.4 -3.0 1.9
Allergy 1.2 2.7 5.8 2.1 1.6 2.4 0.1 0.9
Pain all over the body in last month 0.4 0.4 0.7 -0.7 -0.0 -0.7 0.6 0.8
Diabetes (self-reported) 0.4 0.7 1.4 -1.2 -0.4 -1.1 0.6 -0.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.4 1.1 -0.3 0.6 -1.2 0.7
Medication: Ramipril 1.2 1.5 2.8 1.7 0.3 1.6 -1.2 0.7
Medication: Simvastatin 0.1 0.2 0.7 0.2 -0.1 0.0 -0.8 0.3
Fluid intelligence score 0.3 0.7 1.8 0.4 -0.7 0.1 -0.9 -1.3
Illnesses of siblings 0.1 0.1 0.5 0.3 0.0 0.7 -0.1 0.1
Neuroticism score 1.5 3.2 5.2 -2.2 -0.7 -2.3 1.8 -1.5
Weight 3.1 15.1 28.6 -3.8 -5.4 -3.1 3.1 -3.6
Impedance of arm (right) 0.1 0.5 1.0 -0.8 0.2 -1.0 0.2 -0.8
Arm fat percentage (right) 2.6 10.4 15.1 -3.1 -3.9 -2.5 3.3 -3.1
Trunk fat-free mass 1.4 8.1 20.8 -2.8 -4.6 -2.5 1.6 -1.8
Hip circumference 6.9 29.6 47.3 -5.4 -6.9 -4.9 4.6 -5.2
Time employed in main current job 1.8 2.0 2.9 1.6 0.9 1.7 -1.2 1.6
Alcohol intake versus 10 years previously 8.3 12.4 15.5 -3.9 -2.5 -3.9 3.8 -3.3
Father’s age at death 0.2 0.3 0.4 0.5 0.6 0.5 -0.6 0.2
Worrier / anxious feelings 1.1 2.0 2.6 -1.6 0.6 -1.6 1.4 -1.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.5 -1.5 -0.5 -1.7 1.9 -0.6
Falls in the last year 0.8 1.1 1.7 -1.3 -0.1 -1.3 1.3 -0.4
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.3 0.1 0.3 -0.6 -0.9
Number of live births 0.2 0.3 0.9 -0.4 -0.9 -0.5 0.2 -0.5
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 5.2 -1.4 -2.3 -1.8 0.3 -1.9
Pulse rate 12.2 20.6 27.2 5.2 3.5 5.0 -4.3 4.4
Happiness 4.5 5.5 6.9 -2.6 -2.0 -2.6 1.8 -2.6
Noisy workplace 1.8 2.2 2.7 -1.6 -1.6 -1.6 1.5 -0.9
Qualifications: A levels/AS levels or equivalent 1.0 2.2 4.9 -1.7 -1.1 -2.2 -0.7 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.3 -0.9 0.1 -1.5 -0.3 -1.3
Mouth/teeth dental problems: Dentures 0.4 0.7 2.5 0.1 0.2 0.7 1.6 0.6
Asthma 0.5 1.0 1.8 -0.6 -1.3 -0.9 -0.6 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 -0.9 0.0 -0.8 0.5 -0.2
Medication: Cholesterol lowering 0.7 1.0 2.0 1.1 0.1 1.3 -1.4 0.6
Depression (self-reported) 0.2 0.3 0.7 -0.4 -0.2 -0.5 0.5 0.8
Medication: Lansoprazole 0.3 0.3 0.8 -0.5 -0.4 -0.5 0.9 -0.5
Prospective memory result 0.4 0.5 0.8 -0.6 0.8 -0.9 0.9 -0.2
Lung cancer (father) 2.7 3.2 6.3 -1.8 -1.6 -1.3 2.5 -1.5
Illnesses of mother 0.0 0.0 0.1 -0.0 -0.1 0.0 0.2 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 1.5 -0.7 -1.2 -0.9 -0.1 -1.2
Pulse wave Arterial Stiffness index 2.2 2.6 4.2 1.6 1.6 1.7 -1.0 2.1
Impedance of arm (left) 0.2 1.0 1.8 -1.1 0.1 -1.3 0.5 -1.3
Arm fat mass (right) 2.9 12.0 19.8 -3.3 -4.5 -2.6 3.4 -3.2
Trunk predicted mass 1.4 7.8 20.2 -2.7 -4.5 -2.4 1.6 -1.8
Standing height 0.9 9.3 19.9 -3.1 -4.5 -2.9 0.7 -2.8
Length of working week for main job 6.9 7.6 10.4 -2.7 -3.0 -2.6 2.2 -3.2
Exposure to tobacco smoke at home 0.4 0.5 1.7 0.0 -1.3 0.2 -0.4 0.8
Breastfed as a baby 0.1 0.1 0.3 0.2 0.1 0.5 0.1 -0.4
Tense / ‘highly strung’ 0.9 1.5 3.7 0.9 1.0 0.8 -1.9 1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.6 7.9 -1.7 -0.9 -1.2 2.8 -0.4
Hair/balding pattern: Pattern 4 1.6 3.9 5.1 -2.2 -2.3 -1.8 2.2 -1.1
Birth weight of first child 3.5 6.3 9.7 -2.1 -2.6 -2.1 2.5 -3.1
Peak expiratory flow (PEF) 0.8 1.8 3.2 1.8 -0.8 1.8 -1.3 0.7
Pulse wave reflection index 0.6 0.7 2.6 -0.7 -0.3 -0.3 1.6 -0.4
Ever highly irritable/argumentative for 2 days 1.2 1.4 4.0 -1.3 0.1 -0.8 2.0 -0.9
Loud music exposure frequency 0.4 0.5 0.9 -0.7 -0.4 -0.8 0.9 -0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 -0.3 0.3 -0.5 -0.4 -0.6
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.6 0.0 0.2 0.1 0.8 0.2
Blood clot in the leg (DVT) 0.7 0.9 1.8 -0.8 -0.2 -0.4 1.3 -1.4
Medication: Paracetamol 1.8 3.0 4.3 -1.9 0.2 -2.0 1.7 -2.1
Headache pain in last month 1.4 2.5 3.9 -1.9 -0.9 -2.0 1.1 -1.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.7 -0.6 0.8 -0.6 1.3 -0.1
Glaucoma (self-reported) 0.3 0.3 0.4 -0.5 0.4 -0.6 0.5 -0.7
Gout (self-reported) 2.4 3.3 5.6 2.4 2.0 2.4 -1.1 -0.3
Hypothyroidism/myxoedema (self-reported) 2.9 5.6 10.7 -2.3 -3.3 -2.3 1.8 -1.9
Medication: Amlodipine 2.4 3.4 4.8 2.2 1.8 2.1 -1.9 0.9
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.4 0.2 -0.7 0.0 0.2 0.7
Birth weight 0.6 1.3 2.1 -1.4 -0.5 -1.2 1.4 -1.0
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.8 -0.5 0.3 -0.6 0.4 1.3
High blood pressure (siblings) 0.3 0.4 0.6 0.8 0.4 0.6 -0.5 0.8
Forced vital capacity (FVC), Best measure 0.1 0.3 0.5 -0.4 -0.1 -0.7 -0.6 -0.6
Body fat percentage 2.1 8.2 12.6 -2.7 -3.5 -2.0 2.9 -3.0
Leg fat percentage (right) 1.1 3.9 7.4 -1.7 -2.7 -0.9 2.3 -1.9
Arm fat-free mass (right) 1.1 5.8 14.9 -2.2 -3.9 -1.8 1.7 -1.7
Exposure to tobacco smoke outside home 0.3 0.5 0.6 -0.7 -0.2 -0.8 0.7 -0.7
Comparative body size at age 10 0.1 0.2 0.4 0.2 0.7 0.1 -0.0 0.7
Number of full brothers 0.2 0.2 0.7 -0.5 -0.1 -0.9 0.1 -0.0
Worry too long after embarrassment 1.7 2.8 3.7 -1.9 -1.8 -1.9 1.5 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.8 -0.6 0.9 -0.4 0.9 0.3
Wheeze or whistling in the chest in last year 2.4 4.2 8.9 -2.0 -3.0 -2.1 1.5 -1.2
Number of children fathered 7.8 8.8 13.6 3.2 1.4 3.2 -3.7 2.8
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.3 1.5 0.1 1.5 -1.0 0.9
Age at first live birth 0.3 0.5 1.1 -0.8 0.9 -1.1 -0.3 0.1
Pulse wave peak to peak time 3.1 3.6 5.9 -1.8 -2.0 -1.9 1.0 -2.4
Health satisfaction 2.7 3.5 4.9 -2.1 -2.0 -1.6 2.2 -1.4
Shortness of breath walking on level ground 0.8 0.9 1.3 -1.0 -1.1 -1.1 0.2 -1.2
Qualifications: College or University degree 0.8 2.4 11.0 0.7 0.4 0.3 -3.3 0.2
Eye problems/disorders: None of the above 1.4 1.6 3.6 1.1 1.9 0.8 -1.0 1.2
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.8 -1.3 -0.1 -1.3 1.7 -0.3
Emphysema/chronic bronchitis 0.3 0.3 0.5 -0.7 0.4 -0.7 0.6 0.3
Medication for pain relief, constipation, heartburn 0.4 0.7 1.5 1.0 0.5 1.2 0.2 0.8
Neck or shoulder pain in last month 0.4 0.5 1.0 -0.2 -0.7 -0.4 0.9 -1.0
Medication: Blood pressure 0.6 1.1 2.8 1.0 -0.7 1.0 -1.7 0.3
Angina (self-reported) 0.3 0.3 1.0 0.6 0.5 0.4 -1.0 0.0
Migraine (self-reported) 0.3 0.4 1.1 -0.5 0.1 -0.4 1.1 -0.5
Medication: Ibuprofen 0.8 0.9 1.5 -1.2 -0.6 -1.0 1.0 -0.8
Medication: Allopurinol 0.4 0.5 1.2 0.7 0.2 0.8 -0.2 -1.1
Medication: Omeprazole 0.9 1.0 2.3 -0.8 -1.5 -0.8 1.0 -0.8
Medication: Seretide 50 evohaler 1.3 1.5 6.0 -0.4 0.3 -0.6 -0.9 2.5
Mean time to correctly identify matches 0.4 0.8 3.0 -0.2 -1.0 0.4 1.7 -0.2
Heart disease (mother) 0.4 0.5 1.5 -0.4 0.4 -0.5 0.7 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.3 1.2 1.8 1.1 -1.1 1.0
Whole body fat mass 2.7 11.2 18.3 -3.2 -4.3 -2.5 3.2 -3.3
Leg fat mass (right) 1.9 7.4 14.4 -2.5 -3.8 -1.8 2.6 -2.4
Arm predicted mass (right) 1.3 6.5 16.8 -2.4 -4.1 -2.1 1.5 -1.9
Pulse rate, automated reading 20.1 65.1 85.3 9.2 6.1 9.1 -8.3 7.1
Alcohol intake frequency. 7.7 18.0 22.0 -4.6 -3.4 -4.7 4.0 -4.4
Comparative height size at age 10 1.3 7.1 11.5 -2.8 -3.4 -2.4 1.8 -2.7
Number of full sisters 0.1 0.1 0.3 -0.5 0.1 -0.2 0.4 -0.5
Suffer from ‘nerves’ 4.7 7.4 12.0 -3.5 -1.8 -2.8 3.2 -1.8
Overall health rating 6.7 14.4 17.3 -4.2 -4.0 -4.1 3.5 -3.0
Chest pain or discomfort 2.9 4.1 7.4 -2.5 -1.0 -2.1 2.7 -1.3
Had major operations 1.3 1.6 3.1 -1.3 -0.3 -1.4 1.8 -1.0
Age at last live birth 1.1 1.6 3.0 -1.7 0.1 -1.7 1.5 -0.4
Family relationship satisfaction 2.4 3.0 4.5 -2.1 -1.1 -2.1 1.6 -1.5
Leg pain on walking 4.8 6.0 11.3 -2.6 -1.3 -2.1 3.4 -2.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.2 0.5 0.4 0.7 0.4
Commuting to job workplace: Car/motor vehicle 3.7 4.3 6.4 2.5 2.2 2.5 -1.3 1.3
Illness, injury, bereavement, stress in last 2 years 3.1 3.8 5.8 2.2 0.7 2.4 -2.0 1.8
Medication: Aspirin 0.4 0.5 2.0 0.1 -0.0 0.1 -1.4 0.6
Supplements: Vitamin C 0.7 0.9 2.4 -0.8 -1.5 -0.9 0.4 0.5
Knee pain experienced in last month 2.2 3.4 6.7 -1.7 -1.7 -1.3 2.6 -1.7
Hypertension (Self-reported) 0.4 1.1 3.1 -0.7 -1.3 -0.5 0.3 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.5 -0.5 -0.3 -0.4 1.6 -0.5
Illnesses of father: Heart disease 2.5 3.5 5.3 1.8 1.4 1.9 -2.3 1.8
Illnesses of siblings: Diabetes 0.1 0.1 0.5 -0.0 0.3 0.0 0.1 0.7
Smoking status: Previous 1.5 2.3 3.4 1.7 1.9 1.8 0.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.7 -1.5 -1.7 -1.4 0.0 -0.6
Whole body fat-free mass 1.6 9.3 21.9 -2.9 -4.7 -2.6 2.1 -2.2
Leg fat-free mass (right) 2.3 12.3 23.6 -3.5 -4.9 -3.1 2.8 -2.8
Arm fat percentage (left) 2.9 11.7 16.2 -3.4 -4.0 -2.8 3.4 -3.4
Average weekly red wine intake 0.7 1.1 3.3 1.0 -0.6 0.6 -1.8 -0.6
Handedness (chirality/laterality): Left-handed 3.4 4.1 8.2 2.3 2.9 2.0 -1.3 1.1
Mood swings 2.8 5.0 7.1 -2.6 -1.7 -2.7 2.0 -2.1
Loneliness, isolation 1.8 2.5 4.7 -1.9 -0.7 -2.2 1.4 -1.3
Long-standing illness, disability or infirmity 3.2 4.9 7.9 -2.7 -2.8 -2.6 0.9 -1.4
Ever had bowel cancer screening 0.3 0.4 1.2 -0.7 -0.2 -1.1 0.4 -0.1
Diabetes diagnosed by doctor 0.2 0.3 0.6 -0.7 0.0 -0.8 0.4 -0.5
Ever had stillbirth, spontaneous miscarriage or termination 3.6 3.9 5.2 -2.2 -2.1 -2.0 2.3 -1.0
Friendships satisfaction 1.1 1.3 3.1 -1.5 -0.9 -1.8 0.1 -0.6
Qualifications: nursing, teaching 1.6 2.5 6.2 -0.9 -1.5 -1.5 -0.9 -2.5
Commuting to job workplace: Walk 2.1 2.3 6.1 -1.5 -2.5 -1.8 0.2 0.1
Eye problems/disorders: Cataract 0.5 0.5 1.5 -0.7 -1.2 -0.7 -0.1 -0.5
Mouth/teeth dental problems: Mouth ulcers 2.3 3.6 6.0 -2.5 -1.0 -2.4 1.5 -1.6
Medication for cholesterol 1.4 2.1 3.7 1.9 1.4 1.9 -0.7 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.1 4.1 1.4 2.0 1.2 -1.5 0.8
Back pain experienced in last month 6.4 9.3 13.3 -3.0 -2.9 -2.7 3.7 -3.0
Mineral and other dietary supplements 0.7 0.9 1.6 0.7 0.9 0.6 -1.2 1.2
Breast cancer (self-reported) 0.3 0.4 1.2 0.1 1.1 0.1 -0.1 0.7
Asthma (self-reported) 0.6 1.1 2.1 -0.8 -1.5 -1.1 -0.4 1.2
Osteoporosis (self-reported) 0.7 0.9 1.6 -0.9 -1.1 -0.8 0.3 -1.3
Osteoarthritis (self-reported) 0.7 0.9 1.6 -1.3 -0.1 -1.2 0.9 -0.8
Medication: Aspirin 0.3 0.3 1.5 -0.0 -0.4 -0.1 -1.2 0.2
Medication: Gliclazide 1.1 1.2 2.6 -1.6 -0.5 -1.4 0.9 -0.6
Illnesses of father: None of the above (group 1) 1.7 2.1 5.2 -1.3 -1.1 -0.8 2.3 -1.3
Smoking status: Current 1.8 2.9 6.3 -2.0 -1.3 -1.6 2.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.2 0.4 0.4 0.1 -0.0 0.3
Whole body water mass 1.7 9.5 22.2 -3.0 -4.7 -2.7 2.2 -2.2
Leg predicted mass (right) 2.2 11.8 23.1 -3.4 -4.8 -3.1 2.7 -2.7
Arm fat mass (left) 2.7 11.0 17.5 -3.2 -4.2 -2.6 3.3 -3.1
Number of self-reported non-cancer illnesses 3.2 5.6 8.1 -2.5 -2.5 -2.8 1.5 -2.1
Average weekly champagne plus white wine intake 0.8 1.1 2.4 1.0 -1.6 0.9 -1.0 0.4
Miserableness 1.6 2.8 6.4 -1.8 -1.1 -1.6 2.5 -0.9
Guilty feelings 1.0 1.4 2.4 -1.2 1.5 -1.1 1.3 -0.6
Wears glasses or contact lenses 0.7 0.8 2.1 1.0 0.1 1.4 -0.7 0.7
Ever taken oral contraceptive pill 1.0 1.1 2.0 -1.0 -1.1 -1.4 -0.4 -1.1
Hearing aid user 0.3 0.4 0.8 -0.9 -0.7 -0.7 0.0 0.3
Mother’s age at death 0.2 0.3 0.7 0.4 0.8 0.3 -0.0 -0.6
Financial situation satisfaction 0.3 0.4 1.2 -0.6 0.4 -0.4 1.1 -0.0
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.2 -1.5 -0.4 -1.5 0.7 0.5
Commuting to job workplace: Public transport 1.1 1.4 2.5 -1.5 -0.2 -1.2 0.8 -1.6
Eye problems/disorders: Glaucoma 0.3 0.4 1.5 -0.4 0.2 -0.2 1.2 -0.4
Medication: Blood pressure 0.3 0.6 1.9 -0.6 -0.1 -0.9 0.4 -1.4
Pain type(s) experienced in last month: Hip pain 1.7 2.1 2.8 -1.5 -1.5 -1.5 1.7 -0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.8 0.1 -0.3 0.3 0.7 -1.4
High cholesterol (Self-reported) 0.1 0.1 0.4 -0.0 -0.0 0.2 0.6 -0.2
Medication: Bendroflumethiazide 0.9 1.4 3.4 -0.6 -1.8 -1.1 0.2 -1.5
Medication: Paracetamol 3.3 5.1 7.9 -2.5 -0.9 -2.6 2.0 -2.8
Medication: Lisinopril 1.3 1.7 4.2 -1.4 -0.1 -1.5 0.3 -2.0
Medication: Atorvastatin 0.1 0.2 0.5 0.0 -0.7 0.3 -0.5 -0.1
Illnesses of father: High blood pressure 1.3 1.6 3.7 -0.7 -1.9 -1.3 -0.5 -1.4
Alcohol drinker status: Never 0.8 1.0 1.8 -1.0 -0.8 -1.4 0.2 -1.2
Ever smoked 0.9 1.5 3.0 1.0 1.5 1.1 0.3 1.7
Basal metabolic rate 2.1 11.8 26.4 -3.3 -5.1 -2.9 2.4 -2.6
Leg fat percentage (left) 1.2 4.2 7.5 -1.7 -2.7 -1.0 2.4 -1.9
Arm fat-free mass (left) 1.1 5.4 15.5 -2.0 -3.9 -1.7 1.4 -1.6
Number of operations (self-reported) 3.1 4.7 6.2 -2.5 -2.0 -2.3 1.9 -2.0
Average weekly beer plus cider intake 0.8 1.1 2.8 0.7 1.7 1.1 0.6 0.9
Irritability 0.5 0.8 1.1 -1.0 -1.0 -0.8 0.8 -0.6
Risk taking 1.2 1.8 3.8 1.0 0.5 1.2 -1.5 1.9
Ever had prostate specific antigen (PSA) test 2.4 2.8 4.7 1.8 1.0 1.7 -2.2 1.5
Fractured/broken bones in last 5 years 5.4 7.0 10.2 -3.2 -2.2 -3.0 2.2 -2.5
Age started oral contraceptive pill 1.2 1.6 5.5 1.1 2.4 1.0 -0.2 -0.2
Diastolic blood pressure, automated reading 0.8 2.5 3.8 1.9 0.8 1.9 -1.9 1.1
Ever depressed for a whole week 1.6 2.0 3.3 -1.6 -1.8 -1.4 1.2 -0.7
Unable to work because of sickness or disability 1.0 1.3 1.6 -1.3 -1.2 -1.3 0.9 -1.1
Commuting to job workplace: Cycle 0.3 0.3 0.9 0.4 0.9 -0.3 -0.4 0.5
Myopia 0.3 0.4 1.3 0.3 0.5 0.3 -0.5 1.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 3.3 0.6 0.8 0.6 -0.3 1.8
Cholesterol lowering medication 0.2 0.3 0.7 -0.8 -0.3 -0.8 0.3 -0.1
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 2.8 -0.9 -1.7 -0.8 1.2 -0.9
Pain experienced in last month 1.9 3.2 4.4 1.8 1.8 1.8 -2.1 1.3
Supplements: Calcium 1.0 1.1 4.0 0.9 0.3 0.6 -2.0 0.3
Basal cell carcinoma (self-reported) 0.8 1.0 2.2 -1.2 -0.9 -1.5 -0.4 -0.4
Heart attack/myocardial infarction (self-reported) 3.8 4.9 10.0 1.9 1.7 1.6 -3.2 2.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.8 -0.7 0.1 -0.3 1.3 -1.3
Heart disease (siblings) 2.1 2.6 4.0 1.5 2.0 1.3 -1.6 1.5
Alcohol drinker status: Previous 1.8 2.1 5.3 -1.1 -0.6 -0.7 1.8 -2.3
Pack years of smoking 1.7 2.5 2.9 -1.7 -1.7 -1.2 1.6 -1.7
Impedance of whole body 0.1 0.6 1.9 0.3 1.4 0.1 -1.0 -0.2
Leg fat mass (left) 2.0 7.8 15.0 -2.6 -3.9 -1.9 2.8 -2.5
Arm predicted mass (left) 1.0 4.9 14.9 -1.9 -3.9 -1.5 1.4 -1.4