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chr1:31,402,148-34,592,020

Best TWAS P=8.72e-22 · Best GWAS P=4.87e-22 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	4	0.03	2.8e-04	-6.2	6.2	6.8e-10	-0.01	0.10	0.88	FALSE
2	CommonMind	Brain Pre-frontal Cortex	S100PBP	0.05	0.04	enet	10	0.02	1.2e-03	-6.2	5.3	9.9e-08	-0.02	0.97	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM54	0.05	0.00	blup	281	0.02	4.5e-03	2.2	-8.9	4.5e-19	0.50	0.11	0.23	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TXLNA	0.04	0.04	bslmm	221	0.03	1.8e-04	5.6	-5.2	2.4e-07	-0.01	0.68	0.19	FALSE
5	CommonMind	Brain Pre-frontal Cortex	ZNF362	0.05	0.06	lasso	1	0.06	2.2e-07	-9.6	-9.6	8.7e-22	0.98	0.01	0.99	TRUE
6	GTEx	Artery Aorta	PEF1	0.15	0.05	lasso	5	0.04	2.2e-03	-6.5	7.3	3.8e-13	-0.05	0.05	0.91	TRUE
7	GTEx	Brain Cerebellum	RP11-415J8.3	0.25	0.06	lasso	3	0.07	4.2e-03	5.2	-5.3	1.4e-07	0.53	0.14	0.06	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	KPNA6	0.19	0.14	enet	18	0.10	4.9e-04	5.5	6.3	3.4e-10	-0.03	0.20	0.14	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	PHC2	0.58	0.34	lasso	7	0.28	7.3e-10	-9.5	9.2	2.2e-20	-0.99	0.01	0.99	FALSE
10	GTEx	Cells Transformed fibroblasts	KPNA6	0.13	0.10	lasso	5	0.11	1.3e-08	5.6	5.6	2.3e-08	-0.03	0.87	0.13	FALSE
11	GTEx	Colon Sigmoid	PEF1	0.16	0.09	lasso	3	0.09	4.3e-04	-6.5	6.8	8.1e-12	-0.04	0.05	0.78	FALSE
12	GTEx	Heart Atrial Appendage	RN7SKP16	0.08	0.06	enet	11	0.03	1.9e-02	3.3	-5.3	9.3e-08	0.56	0.15	0.47	FALSE
13	GTEx	Muscle Skeletal	ZNF362	0.04	0.01	enet	7	0.02	4.9e-03	3.5	-5.8	8.8e-09	0.68	0.07	0.78	FALSE
14	GTEx	Muscle Skeletal	FNDC5	0.15	0.16	enet	5	0.16	1.9e-15	-5.8	-5.8	5.6e-09	0.06	1.00	0.00	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	EIF3I	0.12	0.06	lasso	1	0.03	7.2e-03	5.6	-5.6	2.4e-08	0.03	0.09	0.05	FALSE
16	GTEx	Skin Sun Exposed Lower leg	PEF1	0.05	0.03	enet	9	0.02	4.6e-03	-6.5	5.6	2.2e-08	-0.06	0.04	0.93	FALSE
17	GTEx	Testis	RP4-622L5.7	0.12	0.11	lasso	5	0.08	2.3e-04	5.6	5.6	2.1e-08	-0.03	0.34	0.16	FALSE
18	METSIM	Adipose	KPNA6	0.07	0.06	lasso	10	0.06	1.8e-09	5.5	5.8	8.6e-09	-0.03	0.88	0.12	FALSE
19	METSIM	Adipose	PEF1	0.03	0.02	enet	17	0.02	7.9e-04	-6.3	6.1	1.0e-09	-0.02	0.05	0.89	FALSE
20	METSIM	Adipose	ZNF362	0.09	0.02	enet	32	0.03	1.5e-05	-9.6	-6.6	3.2e-11	0.70	0.01	0.98	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	KPNA6	0.03	0.04	lasso	4	0.02	8.1e-04	5.6	5.6	1.9e-08	-0.02	0.62	0.19	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	PHC2	0.11	0.07	lasso	3	0.05	2.2e-07	-9.5	-9.0	2.0e-19	0.99	0.01	0.99	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	PEF1	0.04	0.04	lasso	3	0.02	4.2e-04	-6.2	6.1	9.2e-10	-0.01	0.11	0.86	FALSE
24	YFS	Blood	KPNA6	0.03	0.03	bslmm	236	0.04	1.1e-11	5.6	6.0	1.8e-09	0.01	0.87	0.13	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	FNDC5	0.02	0.01	blup	33	0.01	9.2e-03	-4.7	-5.2	1.8e-07	0.06	0.02	0.47	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	S100PBP	0.03	0.02	blup	46	0.02	6.6e-06	-6.2	6.0	1.9e-09	-0.07	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZNF362	0.03	0.01	blup	49	0.01	1.3e-03	3.9	-7.2	8.2e-13	0.72	0.01	0.32	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	S100PBP	0.06	0.03	blup	48	0.06	6.8e-04	-5.8	6.8	7.7e-12	-0.06	0.01	0.82	TRUE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	S100PBP	0.21	0.15	lasso	5	0.15	2.9e-05	-5.8	5.8	7.6e-09	-0.06	0.01	0.91	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	S100PBP	0.04	0.04	lasso	4	0.04	2.3e-05	-6.2	6.2	5.1e-10	-0.08	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FNDC5	0.03	0.04	enet	6	0.03	2.9e-04	-5.8	-5.5	3.0e-08	0.08	0.03	0.93	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HPCA	0.05	0.09	lasso	7	0.08	3.6e-09	-4.6	5.1	3.1e-07	-0.06	0.12	0.88	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	KPNA6	0.02	0.02	blup	29	0.02	1.9e-03	5.5	5.5	3.8e-08	-0.02	0.02	0.87	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	S100PBP	0.06	0.06	blup	47	0.05	5.2e-06	-6.2	6.2	4.7e-10	-0.07	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTP4A2	0.09	-0.01	blup	26	0.00	4.1e-01	6.5	7.5	5.1e-14	0.00	0.01	0.56	TRUE
36	The Cancer Genome Atlas	Thyroid Carcinoma	KPNA6	0.03	0.03	blup	28	0.03	5.3e-04	5.6	5.4	7.1e-08	-0.02	0.02	0.90	FALSE