[Hub]/) : Traits : Basal metabolic rate :

chr1:31,402,148-34,592,020

Best TWAS P=8.72e-22 · Best GWAS P=4.87e-22 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PEF1 0.04 0.04 lasso 4 0.03 2.8e-04 -6.2 6.2 6.8e-10 -0.01 0.10 0.88 FALSE
2 CommonMind Brain Pre-frontal Cortex S100PBP 0.05 0.04 enet 10 0.02 1.2e-03 -6.2 5.3 9.9e-08 -0.02 0.97 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex TMEM54 0.05 0.00 blup 281 0.02 4.5e-03 2.2 -8.9 4.5e-19 0.50 0.11 0.23 FALSE
4 CommonMind Brain Pre-frontal Cortex TXLNA 0.04 0.04 bslmm 221 0.03 1.8e-04 5.6 -5.2 2.4e-07 -0.01 0.68 0.19 FALSE
5 CommonMind Brain Pre-frontal Cortex ZNF362 0.05 0.06 lasso 1 0.06 2.2e-07 -9.6 -9.6 8.7e-22 0.98 0.01 0.99 TRUE
6 GTEx Artery Aorta PEF1 0.15 0.05 lasso 5 0.04 2.2e-03 -6.5 7.3 3.8e-13 -0.05 0.05 0.91 TRUE
7 GTEx Brain Cerebellum RP11-415J8.3 0.25 0.06 lasso 3 0.07 4.2e-03 5.2 -5.3 1.4e-07 0.53 0.14 0.06 FALSE
8 GTEx Cells EBV-transformed lymphocytes KPNA6 0.19 0.14 enet 18 0.10 4.9e-04 5.5 6.3 3.4e-10 -0.03 0.20 0.14 FALSE
9 GTEx Cells EBV-transformed lymphocytes PHC2 0.58 0.34 lasso 7 0.28 7.3e-10 -9.5 9.2 2.2e-20 -0.99 0.01 0.99 FALSE
10 GTEx Cells Transformed fibroblasts KPNA6 0.13 0.10 lasso 5 0.11 1.3e-08 5.6 5.6 2.3e-08 -0.03 0.87 0.13 FALSE
11 GTEx Colon Sigmoid PEF1 0.16 0.09 lasso 3 0.09 4.3e-04 -6.5 6.8 8.1e-12 -0.04 0.05 0.78 FALSE
12 GTEx Heart Atrial Appendage RN7SKP16 0.08 0.06 enet 11 0.03 1.9e-02 3.3 -5.3 9.3e-08 0.56 0.15 0.47 FALSE
13 GTEx Muscle Skeletal ZNF362 0.04 0.01 enet 7 0.02 4.9e-03 3.5 -5.8 8.8e-09 0.68 0.07 0.78 FALSE
14 GTEx Muscle Skeletal FNDC5 0.15 0.16 enet 5 0.16 1.9e-15 -5.8 -5.8 5.6e-09 0.06 1.00 0.00 FALSE
15 GTEx Skin Not Sun Exposed Suprapubic EIF3I 0.12 0.06 lasso 1 0.03 7.2e-03 5.6 -5.6 2.4e-08 0.03 0.09 0.05 FALSE
16 GTEx Skin Sun Exposed Lower leg PEF1 0.05 0.03 enet 9 0.02 4.6e-03 -6.5 5.6 2.2e-08 -0.06 0.04 0.93 FALSE
17 GTEx Testis RP4-622L5.7 0.12 0.11 lasso 5 0.08 2.3e-04 5.6 5.6 2.1e-08 -0.03 0.34 0.16 FALSE
18 METSIM Adipose KPNA6 0.07 0.06 lasso 10 0.06 1.8e-09 5.5 5.8 8.6e-09 -0.03 0.88 0.12 FALSE
19 METSIM Adipose PEF1 0.03 0.02 enet 17 0.02 7.9e-04 -6.3 6.1 1.0e-09 -0.02 0.05 0.89 FALSE
20 METSIM Adipose ZNF362 0.09 0.02 enet 32 0.03 1.5e-05 -9.6 -6.6 3.2e-11 0.70 0.01 0.98 FALSE
21 ROSMAP Brain Pre-frontal Cortex KPNA6 0.03 0.04 lasso 4 0.02 8.1e-04 5.6 5.6 1.9e-08 -0.02 0.62 0.19 FALSE
22 ROSMAP Brain Pre-frontal Cortex PHC2 0.11 0.07 lasso 3 0.05 2.2e-07 -9.5 -9.0 2.0e-19 0.99 0.01 0.99 FALSE
23 ROSMAP Brain Pre-frontal Cortex PEF1 0.04 0.04 lasso 3 0.02 4.2e-04 -6.2 6.1 9.2e-10 -0.01 0.11 0.86 FALSE
24 YFS Blood KPNA6 0.03 0.03 bslmm 236 0.04 1.1e-11 5.6 6.0 1.8e-09 0.01 0.87 0.13 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma FNDC5 0.02 0.01 blup 33 0.01 9.2e-03 -4.7 -5.2 1.8e-07 0.06 0.02 0.47 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma S100PBP 0.03 0.02 blup 46 0.02 6.6e-06 -6.2 6.0 1.9e-09 -0.07 0.01 0.99 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma ZNF362 0.03 0.01 blup 49 0.01 1.3e-03 3.9 -7.2 8.2e-13 0.72 0.01 0.32 FALSE
28 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma S100PBP 0.06 0.03 blup 48 0.06 6.8e-04 -5.8 6.8 7.7e-12 -0.06 0.01 0.82 TRUE
29 The Cancer Genome Atlas Glioblastoma Multiforme S100PBP 0.21 0.15 lasso 5 0.15 2.9e-05 -5.8 5.8 7.6e-09 -0.06 0.01 0.91 FALSE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma S100PBP 0.04 0.04 lasso 4 0.04 2.3e-05 -6.2 6.2 5.1e-10 -0.08 0.00 0.99 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FNDC5 0.03 0.04 enet 6 0.03 2.9e-04 -5.8 -5.5 3.0e-08 0.08 0.03 0.93 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HPCA 0.05 0.09 lasso 7 0.08 3.6e-09 -4.6 5.1 3.1e-07 -0.06 0.12 0.88 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma KPNA6 0.02 0.02 blup 29 0.02 1.9e-03 5.5 5.5 3.8e-08 -0.02 0.02 0.87 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma S100PBP 0.06 0.06 blup 47 0.05 5.2e-06 -6.2 6.2 4.7e-10 -0.07 0.00 1.00 FALSE
35 The Cancer Genome Atlas Testicular Germ Cell Tumors PTP4A2 0.09 -0.01 blup 26 0.00 4.1e-01 6.5 7.5 5.1e-14 0.00 0.01 0.56 TRUE
36 The Cancer Genome Atlas Thyroid Carcinoma KPNA6 0.03 0.03 blup 28 0.03 5.3e-04 5.6 5.4 7.1e-08 -0.02 0.02 0.90 FALSE