TWAS hub - SH3BGRL3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0992	0.0295	1.2e-10	0.013	0.041	0.037	0.041	0.028	3.6e-05	2.2e-13	3.0e-12	1.7e-13	1.7e-09
2	TCGA	Prostate Adenocarcinoma	0.0501	0.0311	7.0e-03	0.026	0.018	0.022	NA	0.026	8.1e-04	4.7e-03	2.2e-03	NA	9.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Omeprazole	8.2	9.8	9.8	-3.1	-3.1
Forced vital capacity (FVC), Best measure	7.8	28.5	54.0	1.7	7.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.7	16.2	25.5	2.6	5.0
Medication: Omeprazole (e.g. Zanprol)	7.1	8.7	9.4	-3.1	-2.8
Forced expiratory volume in 1-second (FEV1), Best measure	6.3	20.1	37.8	1.5	6.1
Sitting height	5.0	35.2	70.1	0.7	8.4
Irritability	5.0	8.5	14.3	-1.7	-3.8
Forced vital capacity (FVC)	4.4	16.9	33.9	-0.1	5.8
Forced expiratory volume in 1-second (FEV1)	4.1	13.7	27.4	0.0	5.2
Arm fat-free mass (right)	4.1	20.9	39.3	1.6	6.3
Exposure to tobacco smoke at home	3.8	4.3	8.0	-0.8	-2.8
Arm predicted mass (right)	3.8	19.7	37.7	1.3	6.1
Arm fat-free mass (left)	3.8	19.4	36.2	1.6	6.0
Frequency of depressed mood in last 2 weeks	3.7	5.1	8.6	-1.3	-2.9
Trunk fat-free mass	3.7	21.3	41.0	1.2	6.4
Trunk predicted mass	3.7	21.1	40.6	1.3	6.4
Birth weight	3.7	8.1	12.7	1.8	3.6
Whole body water mass	3.6	20.5	39.1	1.4	6.2
Ulcerative Colitis	3.5	5.0	7.6	-1.6	-2.8
Fed-up feelings	3.5	6.3	11.6	-1.0	-3.4
Alcohol usually taken with meals	3.5	5.7	9.8	1.3	3.1
Diabetes (self-reported)	3.5	5.5	6.0	-2.2	-2.5
Whole body fat-free mass	3.5	19.8	37.9	1.3	6.2
Diabetes diagnosed by doctor	3.5	5.8	7.8	-2.0	-2.8
Alcohol drinker status: Previous	3.5	4.0	5.6	-1.6	-2.4
Arm predicted mass (left)	3.4	17.3	32.6	1.4	5.7
Hair/balding pattern: Pattern 4	3.3	8.0	15.9	-0.4	-4.0
Basal metabolic rate	3.0	16.7	31.9	1.2	5.7
Age at First Birth	2.9	4.2	4.9	2.2	1.9
Medication: Co-codamol	2.9	3.4	4.4	1.6	2.1
Neuroticism score	2.9	6.1	11.3	-1.0	-3.4
Height	2.8	53.6	104.0	-1.8	10.2
Type 2 Diabetes (T2D) (2018)	2.8	5.3	8.4	-1.5	-2.9
Medication: Metformin	2.8	4.0	6.6	-1.2	-2.6
Leg fat-free mass (left)	2.8	14.7	27.7	1.3	5.3
Leg predicted mass (left)	2.8	15.0	28.1	1.4	5.3
Pulse wave peak to peak time	2.8	3.3	4.8	1.4	2.2
Age at first live birth	2.7	4.9	9.7	0.2	3.1
Chest pain or discomfort	2.7	3.9	5.5	-2.3	-1.5
Commuting to job workplace: Public transport	2.7	3.2	4.9	-2.2	-1.2
Pain experienced in last month	2.7	4.5	7.7	-2.8	-1.1
Waist Hip Ratio (WHR)	2.6	11.5	19.0	-2.0	-4.4
Lung FVC	2.6	13.0	24.8	1.1	5.0
Standing height	2.6	26.0	50.3	-1.3	7.1
Pulse rate, automated reading	2.6	8.4	12.0	-2.2	-3.5
Comparative height size at age 10	2.6	14.2	28.2	-0.4	5.3
Leg fat-free mass (right)	2.6	13.8	25.9	1.3	5.1
Leg predicted mass (right)	2.6	13.8	25.8	1.3	5.1
Diabetes (mother)	2.5	3.1	6.3	-0.1	-2.5
Allergy	2.5	5.7	10.9	3.3	0.7
Sensitivity / hurt feelings	2.4	4.2	7.5	-0.9	-2.7
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	4.1	-1.2	-2.0
Peak expiratory flow (PEF)	2.4	5.5	11.0	-0.3	3.3
Medication: Atorvastatin	2.4	2.9	4.7	-2.2	-1.1
Age when periods started (menarche)	2.3	5.4	6.5	2.6	2.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.6	5.3	-0.1	-2.3
Happiness	2.3	2.8	3.9	-1.3	-2.0
Cholesterol lowering medication	2.3	3.3	4.8	-2.2	-1.3
Type 2 Diabetes (T2D) (2012)	2.2	2.6	5.1	-0.1	-2.3
Hearing difficulty/problems: Yes	2.2	3.4	6.4	-0.5	-2.5
Handedness (chirality/laterality): Left-handed	2.2	2.7	2.8	1.6	1.7
High cholesterol (Self-reported)	2.2	4.0	4.9	-2.2	-1.7
Blood Eosinophil Count	2.1	16.4	20.9	-4.6	-3.5
Hayfever, allergic rhinitis or eczema	2.1	4.5	8.2	-2.9	-0.9
Length of working week for main job	2.1	2.4	2.9	-1.4	1.7
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	7.6	-1.0	2.8
Ever taken oral contraceptive pill	2.1	2.3	2.5	-1.6	-1.4
Fasting Glucose	2.0	2.4	4.8	2.2	0.3
Asthma	2.0	3.9	7.7	-2.8	-0.4
Chronic bronchitis/emphysema (mother)	2.0	2.3	2.6	-1.4	-1.6
Long-standing illness, disability or infirmity	2.0	3.1	4.6	1.3	-2.1
Financial situation satisfaction	2.0	2.5	4.8	0.3	-2.2
LDL Cholesterol	1.9	3.1	4.6	-1.3	-2.1
Ever had hysterectomy (womb removed)	1.9	2.1	4.1	0.3	-2.0
Hand grip strength (right)	1.9	5.1	10.1	0.1	3.2
Pulse rate	1.9	3.2	4.7	-1.3	-2.2
Pulse wave Arterial Stiffness index	1.9	2.2	2.6	-1.4	-1.6
Illnesses of siblings: Diabetes	1.9	2.3	3.3	-1.1	-1.8
Mother’s age at death	1.9	2.3	3.2	1.8	1.2
Bipolar Disorder (2011)	1.8	1.7	3.4	-0.2	-1.8
Fluid intelligence score	1.8	3.8	7.6	-2.8	-0.1
Mean time to correctly identify matches	1.8	3.5	4.6	2.1	1.5
Suffer from ‘nerves’	1.8	2.8	5.6	-0.1	-2.4
Family relationship satisfaction	1.8	2.3	3.2	-1.1	-1.8
Current tobacco smoking	1.7	2.8	5.0	0.8	-2.2
Supplements: Glucosamine	1.7	2.2	3.1	1.8	1.1
Medication: Ramipril	1.7	2.1	2.7	-1.2	-1.6
Miserableness	1.7	2.9	5.2	-0.8	-2.3
Impedance of arm (right)	1.6	7.3	10.6	-2.0	-3.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.8	3.6	-0.2	-1.9
Depressed Affect (Nagel 2018)	1.5	3.1	6.0	-0.5	-2.4
Hand grip strength (left)	1.5	4.0	8.1	-0.1	2.8
Angina	1.5	1.9	2.7	-1.1	-1.6
Number of incorrect matches in round	1.5	2.4	3.1	1.3	1.7
Weight	1.5	7.6	14.1	1.0	3.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.7	-0.5	-2.2
Shortness of breath walking on level ground	1.5	1.8	3.6	-1.9	0.2
Medication: Allopurinol	1.5	2.0	2.3	-1.3	-1.5
Average weekly red wine intake	1.5	2.2	2.8	1.3	1.7
Mood swings	1.5	2.7	4.6	-0.8	-2.2
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.8	-1.9	-0.1
Neuroticism (2016)	1.4	2.0	3.2	-0.9	-1.8
Townsend deprivation index at recruitment	1.4	1.9	3.8	-0.4	-1.9
Maternal smoking around birth	1.4	2.1	2.4	-1.3	-1.5
Heart attack	1.4	1.8	3.6	-1.9	-0.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.4	0.1	2.1
Number of full sisters	1.4	1.8	3.0	-0.7	-1.7
Asthma (self-reported)	1.4	2.7	5.5	-2.3	-0.0
Medication: Aspirin	1.4	1.8	3.6	-1.9	-0.1
Impedance of whole body	1.4	7.0	8.6	-2.3	-2.9
Tense / ‘highly strung’	1.3	2.1	4.0	-0.5	-2.0
Hypothyroidism/myxoedema (self-reported)	1.3	2.4	3.8	2.0	1.0
Angina (self-reported)	1.3	1.8	2.6	-1.0	-1.6
Qualifications: nursing, teaching	1.3	2.0	2.5	-1.3	1.6
Smoking status: Current	1.3	2.1	3.4	0.8	-1.8
Average weekly champagne plus white wine intake	1.3	1.7	3.3	-1.8	-0.4
Ulcerative Colitis (UC)	1.2	2.2	3.5	-1.0	-1.9
HbA1C	1.2	1.3	1.4	-1.2	-1.1
Chronotype (morning person)	1.2	2.8	4.9	-0.8	-2.2
Average weekly fortified wine intake	1.2	1.4	2.8	0.3	1.7
Impedance of leg (left)	1.2	6.0	6.8	-2.3	-2.6
Hearing difficulty/problems with background noise	1.2	2.0	3.6	0.6	-1.9
Father’s age at death	1.2	1.6	3.1	0.1	1.8
Number of live births	1.2	1.6	3.0	0.5	-1.7
Number of full brothers	1.2	1.5	2.8	0.4	-1.7
Heart disease (mother)	1.2	1.5	2.0	-1.0	-1.4
Unable to work because of sickness or disability	1.2	1.5	2.7	0.7	-1.6
Body Mass Index (BMI) (2010)	1.1	1.5	2.8	1.7	0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.6	-0.3	-1.6
Diabetes (father)	1.1	1.4	1.7	-1.0	-1.3
Stomach or abdominal pain in last month	1.1	1.3	2.7	1.6	-0.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.6	-0.2	-1.6
Hip circumference	1.1	4.7	7.1	1.5	2.7
Impedance of arm (left)	1.1	5.1	7.3	-1.7	-2.7
Blood clot in the leg (DVT)	1.1	1.4	2.2	1.5	0.8
Qualifications: College or University degree	1.1	3.5	5.5	-1.2	2.4
Neck or shoulder pain in last month	1.1	1.6	2.0	1.4	-1.1
Supplements: Vitamin C	1.1	1.3	1.9	0.9	1.4
Knee pain experienced in last month	1.1	1.7	2.7	1.6	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.3	1.5	0.1
Neuroticism (Nagel 2018)	1.0	2.5	4.6	-0.6	-2.1
Heel T-Score	1.0	8.2	12.2	-2.1	-3.5
Impedance of leg (right)	1.0	4.8	4.9	-2.2	-2.2
Lung cancer (father)	1.0	1.1	2.2	0.3	-1.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	0.8	1.3
Heart disease (siblings)	1.0	1.3	2.2	0.6	1.5
Respiratory disease	0.9	1.9	3.1	-1.8	0.8
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	-0.4	-1.4
Chronic bronchitis/emphysema (father)	0.9	1.1	2.0	-0.4	-1.4
Breastfed as a baby	0.9	1.1	2.1	1.5	-0.1
Gout (self-reported)	0.9	1.2	2.2	-0.5	-1.5
Wheeze or whistling in the chest in last year	0.9	1.6	3.1	-0.1	-1.8
Back pain experienced in last month	0.9	1.3	2.7	1.6	0.2
Medication: Lisinopril	0.9	1.1	1.6	-0.8	1.2
Alcohol drinker status: Never	0.9	1.0	1.9	1.4	0.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.1	1.0	1.1
HDL Cholesterol	0.8	1.3	2.3	1.5	0.6
Rheumatoid Arthritis	0.8	1.2	2.3	-0.2	-1.5
Blood Platelet Count	0.8	8.8	11.2	-3.4	-2.5
Neuroticism	0.8	1.8	3.6	0.1	-1.9
Hair/balding pattern: Pattern 2	0.8	1.0	1.5	0.7	-1.2
Illnesses of siblings	0.8	1.1	2.2	-0.2	-1.5
Number of children fathered	0.8	0.9	1.5	0.5	1.2
Migraine (self-reported)	0.8	0.9	1.1	-1.0	-0.9
Medication: Aspirin	0.8	1.0	2.0	-1.4	0.2
Osteoarthritis (self-reported)	0.8	1.0	1.9	1.4	-0.3
Ever smoked	0.8	1.5	1.9	-1.4	-1.0
Ever depressed for a whole week	0.8	1.0	1.1	-0.9	-1.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	1.9	-1.2	1.4
Primary Biliary Cirrhosis	0.7	1.1	1.5	0.8	-1.2
Blood Red Count	0.7	6.5	11.6	-3.4	-1.2
Allergy or Eczema	0.7	1.8	3.6	-1.9	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	1.9	-1.1	-1.4
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.0	-0.3	1.7
Glaucoma (self-reported)	0.7	0.8	1.2	-1.1	-0.6
Overall health rating	0.7	1.6	1.6	1.3	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.0	1.0	0.8
Loneliness, isolation	0.7	1.0	2.0	0.1	-1.4
Commuting to job workplace: Walk	0.7	0.7	1.5	0.2	1.2
Number of self-reported non-cancer illnesses	0.7	1.1	1.2	-1.0	-1.1
Worry (Nagel 2018)	0.6	1.3	2.3	-0.6	-1.5
Reaction Time	0.6	1.2	1.8	0.8	1.3
Blood White Count	0.6	4.5	8.9	0.3	-3.0
Systolic Blood Pressure	0.6	3.2	4.4	-2.1	-1.4
Medication: Levothyroxine sodium	0.6	1.0	1.6	1.3	0.6
High blood pressure (mother)	0.6	0.9	1.7	-1.3	0.3
Hair/balding pattern: Pattern 3	0.6	0.9	1.8	-0.2	1.4
Medication: Lansoprazole	0.6	0.7	0.7	0.8	-0.8
Health satisfaction	0.6	0.7	1.1	0.6	1.1
Emphysema/chronic bronchitis	0.6	0.7	1.3	-0.1	-1.1
Leg fat mass (right)	0.6	2.3	3.5	1.1	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.5	-1.2	-0.1
Medication: Bendroflumethiazide	0.6	1.0	1.9	-1.4	-0.1
Age started oral contraceptive pill	0.6	0.7	1.3	1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.3	1.1	0.6
Depression (Nagel 2018)	0.5	0.8	1.4	-0.4	-1.2
Breast Cancer	0.5	1.3	2.5	-0.1	1.6
BMI	0.5	2.6	4.2	2.0	1.1
Smoking Status	0.5	1.2	2.1	0.6	-1.4
Cardiovascular Disease	0.5	1.8	3.5	-1.9	0.0
Medication for hormone replacement therapy	0.5	0.6	0.7	0.8	-0.7
Severe depression (siblings)	0.5	0.5	0.6	-0.7	-0.8
Nervous feelings	0.5	0.9	1.7	0.1	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.6	0.1	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.2	-1.1	0.2
High blood pressure (siblings)	0.5	0.7	0.9	-0.8	1.0
Comparative body size at age 10	0.5	1.4	1.7	1.3	1.1
Eye problems/disorders: None of the above	0.5	0.6	1.1	1.1	0.2
Leg pain on walking	0.5	0.6	1.2	1.1	0.2
Wears glasses or contact lenses	0.5	0.6	1.2	-1.1	0.1
Illnesses of father: High blood pressure	0.5	0.6	1.0	-1.0	-0.4
Leg fat mass (left)	0.5	1.8	2.5	1.0	1.6
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	-0.3	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	0.7	-0.8	-0.8
Irritable Bowel Disease (IBD)	0.4	1.0	1.9	-0.5	-1.4
Mean Putamen Volume	0.4	0.5	1.0	0.2	1.0
Lupus	0.4	0.6	1.1	1.1	0.3
Triglycerides	0.4	0.6	0.9	-0.6	-1.0
Relative age of first facial hair	0.4	0.7	1.2	-1.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	0.3	-1.0
High blood pressure	0.4	1.0	2.1	-1.4	-0.0
Body mass index (BMI)	0.4	1.7	3.0	1.7	0.7
Trunk fat mass	0.4	1.6	2.6	0.8	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.1	-0.8	-1.1
Qualifications: None of the above	0.4	0.8	1.3	0.6	-1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.8	-0.9	0.6
Time employed in main current job	0.4	0.5	0.8	0.9	0.5
Noisy workplace	0.4	0.5	0.9	0.4	-0.9
Depression (self-reported)	0.4	0.5	0.9	0.9	-0.2
Medication: Paracetamol	0.4	0.6	0.8	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	1.0	-0.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-1.0	-0.0
Medication: Blood pressure	0.4	0.6	1.2	-1.1	-0.3
Medication: Ibuprofen	0.4	0.5	0.6	0.7	0.8
Age at last live birth	0.4	0.6	1.2	-0.1	1.1
Hypertension (Self-reported)	0.4	1.2	2.3	-1.5	0.2
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	0.6	0.9
Medication for cholesterol	0.4	0.5	0.6	0.8	0.7
Mineral and other dietary supplements	0.4	0.5	0.6	-0.8	-0.6
Arm fat mass (left)	0.4	1.7	1.8	1.3	1.3
Eye problems/disorders: Glaucoma	0.4	0.4	0.6	-0.7	-0.5
Supplements: Calcium	0.4	0.4	0.8	-0.1	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.1	-0.9	1.0
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.5	0.6
Ovarian Cancer	0.3	0.4	0.5	-0.5	-0.7
Relative age voice broke	0.3	0.4	0.5	-0.5	-0.7
Taking other prescription medications	0.3	0.4	0.5	0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.2	-0.9
Pain all over the body in last month	0.3	0.3	0.6	0.8	0.0
Prospective memory result	0.3	0.4	0.7	-0.2	0.9
Arm fat mass (right)	0.3	1.2	1.2	1.1	1.0
Worry too long after embarrassment	0.3	0.4	0.6	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.4	0.6	-0.6
Whole body fat mass	0.3	1.3	2.1	0.8	1.4
Osteoporosis (self-reported)	0.3	0.3	0.6	0.8	-0.3
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	0.5	0.8
Guilty feelings	0.3	0.4	0.8	-0.0	-0.9
Medication: Blood pressure	0.3	0.5	1.0	-1.0	-0.0
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.2	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.3	-1.0
Schizophrenia (2018)	0.2	0.4	0.5	0.5	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.3	0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.7	-0.0
Schizophrenia (2014)	0.2	0.4	0.5	0.5	-0.7
Hypothyroidism (self reported)	0.2	0.4	0.8	0.9	0.1
Lung FEV1/FVC ratio	0.2	0.9	1.6	0.4	1.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	0.7	0.1
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.2	0.7
Past tobacco smoking	0.2	0.4	0.6	0.4	0.8
Arm fat percentage (right)	0.2	0.9	1.1	1.0	-0.9
Mouth/teeth dental problems: Dentures	0.2	0.3	0.5	0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	-0.1
Pulse wave reflection index	0.2	0.2	0.3	-0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.7	-0.1	-0.8
Medication: Amlodipine	0.2	0.2	0.4	-0.6	0.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	-0.2	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.7	0.3
Alcohol intake frequency.	0.2	0.4	0.6	0.3	-0.8
Had major operations	0.2	0.2	0.5	-0.2	-0.7
Arm fat percentage (left)	0.2	0.9	1.3	1.1	-0.7
Medication: Gliclazide	0.2	0.2	0.5	-0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.7	-0.3
Medication: Paracetamol	0.2	0.3	0.6	0.8	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.4	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.1	0.1	1.1
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.3	1.1	0.0
Crohns Disease (2017)	0.1	0.3	0.5	0.7	-0.2
Major Depression (MDD)	0.1	0.2	0.3	-0.5	-0.1
Prostate Cancer	0.1	0.1	0.1	-0.2	-0.3
Crohns Disease (2012)	0.1	0.2	0.4	-0.2	-0.6
Tanning	0.1	1.8	1.9	-1.4	-1.3
Number of treatments/medications taken	0.1	0.1	0.2	-0.5	-0.1
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.8	0.0
Vitamin and mineral supplements	0.1	0.2	0.4	-0.1	-0.6
Pack years adult smoking proportion	0.1	0.1	0.2	0.2	-0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.3	-0.5
Had menopause	0.1	0.2	0.3	0.6	-0.1
Had other major operations	0.1	0.1	0.2	0.4	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.1	0.2	-0.4
Mouth/teeth dental problems	0.1	0.2	0.2	-0.5	-0.2
Medication: Simvastatin	0.1	0.2	0.3	-0.3	-0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.7	-0.0
Falls in the last year	0.1	0.1	0.1	-0.2	0.4
Illnesses of mother	0.1	0.1	0.1	-0.3	0.2
Loud music exposure frequency	0.1	0.1	0.1	-0.2	-0.3
Headache pain in last month	0.1	0.2	0.3	-0.6	0.0
Body fat percentage	0.1	0.2	0.4	0.6	-0.3
Leg fat percentage (right)	0.1	0.5	0.9	1.0	0.0
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.3	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.1	0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.1	-0.3
Smoking status: Previous	0.1	0.1	0.2	0.0	-0.4
Ever had bowel cancer screening	0.1	0.2	0.3	0.2	0.6
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.2	0.6
Leg fat percentage (left)	0.1	0.5	0.8	0.9	-0.3
Number of operations (self-reported)	0.1	0.1	0.3	-0.5	0.2
Hair Pigment	0.0	1.4	1.9	-1.4	-0.9
Average weekly spirits intake	0.0	0.1	0.1	-0.2	0.3
Trunk fat percentage	0.0	0.2	0.3	0.6	-0.0
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.0	0.3
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	-0.1
Medication: Atenolol	0.0	0.0	0.1	-0.2	0.1
Waist circumference	0.0	0.1	0.2	0.2	-0.4
Worrier / anxious feelings	0.0	0.1	0.1	0.2	-0.3
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.2	-0.2
Birth weight of first child	0.0	0.0	0.1	-0.2	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	-0.1
Medication: Seretide 50 evohaler	0.0	0.1	0.1	-0.3	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.0	0.1	-0.2
Friendships satisfaction	0.0	0.0	0.0	0.1	0.0
Breast cancer (self-reported)	0.0	0.0	0.0	-0.2	-0.0
Hearing aid user	0.0	0.0	0.0	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.2	-0.2
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1
Risk taking	0.0	0.1	0.1	0.1	-0.3
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.3	0.1
Myopia	0.0	0.0	0.0	-0.1	0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	-0.2	-0.1
Pack years of smoking	0.0	0.0	0.1	-0.0	-0.2

Hub : Genes

SH3BGRL3

Models

Trait associations